Expression of key hypoxia sensing prolyl-hydroxylases PHD1, -2 and -3 in pancreaticobiliary cancer

Histopathology

Volumn 56, Issue 7, 2010, Pages 908-920

  Gossage, Lucy ^a   Zaitoun, Abed ^b   Fareed, Khaleel R ^a   Turley, Helen ^c   Aloysius, Mark ^d   Lobo, Dileep N ^d   Harris, Adrian L ^e   Madhusudan, Srinivasan ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b QUEEN S MEDICAL CENTRE   (United Kingdom)

^c JOHN RADCLIFFE HOSPITAL   (United Kingdom)

^d NOTTINGHAM UNIVERSITY HOSPITALS NHS TRUST   (United Kingdom)

^e UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Ampullary adenocarcinoma; Cholangiocarcinoma; Immunohistochemistry; Pancreatic ductal adenocarcinoma; PHD2 and PHD3); Prolyly hydroxylase domain proteins (PHD1

Indexed keywords

FORMALDEHYDE; OXYGENASE; PROLYLY HYDROXYLASE 1; PROLYLY HYDROXYLASE 2; PROLYLY HYDROXYLASE 3; UNCLASSIFIED DRUG; DIOXYGENASE; EGLN1 PROTEIN, HUMAN; EGLN3 PROTEIN, HUMAN; HYPOXIA INDUCIBLE FACTOR PROLINE DIOXYGENASE; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE;

ADULT; ARTICLE; BILE DUCT CARCINOMA; CANCER SURVIVAL; CARCINOGENESIS; CONTROLLED STUDY; DUODENUM CARCINOMA; FEMALE; HUMAN; HYPOXIA; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MAJOR CLINICAL STUDY; MALE; OVERALL SURVIVAL; PANCREAS; PANCREAS ADENOCARCINOMA; PANCREAS DUCT; PHENOTYPE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; TISSUE MICROARRAY; ADENOCARCINOMA; AGED; BILIARY TRACT TUMOR; CHI SQUARE DISTRIBUTION; METABOLISM; MIDDLE AGED; MORTALITY; PANCREAS TUMOR; PATHOLOGY; PROGNOSIS;

ADENOCARCINOMA; ADULT; AGED; BILIARY TRACT NEOPLASMS; CHI-SQUARE DISTRIBUTION; DIOXYGENASES; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; PANCREATIC NEOPLASMS; PROCOLLAGEN-PROLINE DIOXYGENASE; PROGNOSIS; TISSUE ARRAY ANALYSIS; HYPOXIA-INDUCIBLE FACTOR-PROLINE DIOXYGENASES;

EID: 77953199740     PISSN: 03090167     EISSN: 13652559     Source Type: Journal    
DOI: 10.1111/j.1365-2559.2010.03566.x     Document Type: Article

References (37)

1. Pancreatic Section of the British Society of Gastroenterology, Pancreatic Society of Great Britain and Ireland, Association of Upper Gastrointestinal Surgeons of Great Britain and Ireland, Royal College of Pathologists, Special Interest Group for Gastro-Intestinal Radiology. Guidelines for the management of patients with pancreatic cancer periampullary and ampullary carcinomas. Gut 2005 54 (Suppl. 5 v1 v16.
2. Ghaneh P, Costello E, Neoptolemos JP. Biology and management of pancreatic cancer. Gut 2007 56 1134 1152.
3. Brown JM, Giaccia AJ. The unique physiology of solid tumors: opportunities (and problems) for cancer therapy. Cancer Res. 1998 58 1408 1416.
4. Graeber TG, Osmanian C, Jacks T et al. Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours. Nature 1996 379 88 91.
5. Gray LH, Conger AD, Ebert M, Hornsey S, Scott OC. The concentration of oxygen dissolved in tissues at the time of irradiation as a factor in radiotherapy. Br. J. Radiol. 1953 26 638 648.
6. Schofield CJ, Ratcliffe PJ. Oxygen sensing by HIF hydroxylases. Nat. Rev. Mol. Cell Biol. 2004 5 343 354.
7. Semenza GL. Targeting HIF-1 for cancer therapy. Nat. Rev. Cancer 2003 3 721 732.
8. Weidemann A, Johnson RS. Biology of HIF-1alpha. Cell Death Differ. 2008 15 621 627.
9. Willam C, Nicholls LG, Ratcliffe PJ, Pugh CW, Maxwell PH. The prolyl hydroxylase enzymes that act as oxygen sensors regulating destruction of hypoxia-inducible factor alpha. Adv. Enzyme Regul. 2004 44 75 92.
10. Bruick RK. Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia. Proc. Natl Acad. Sci. USA 2000 97 9082 9087.
11. Shoshani T, Faerman A, Mett I et al. Identification of a novel hypoxia-inducible factor 1-responsive gene, RTP801, involved in apoptosis. Mol. Cell. Biol. 2002 22 2283 2293.
12. Sowter HM, Ratcliffe PJ, Watson P, Greenberg AH, Harris AL. HIF-1-dependent regulation of hypoxic induction of the cell death factors BNIP3 and NIX in human tumors. Cancer Res. 2001 61 6669 6673.
13. Brahimi-Horn C, Berra E, Pouyssegur J. Hypoxia: the tumor's gateway to progression along the angiogenic pathway. Trends Cell Biol. 2001 11 S32 S36.
14. Appelhoff RJ, Tian YM, Raval RR et al. Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor. J. Biol. Chem. 2004 279 38458 38465.
15. Maynard MA, Ohh M. The role of hypoxia-inducible factors in cancer. Cell. Mol. Life Sci. 2007 64 2170 2180.
16. del Peso L, Castellanos MC, Temes E et al. The von Hippel Lindauhypoxia-inducible factor (HIF) pathway regulates the transcription of the HIF-proline hydroxylase genes in response to low oxygen. J. Biol. Chem. 2003 278 48690 48695.
17. Koong AC, Mehta VK, Le QT et al. Pancreatic tumors show high levels of hypoxia. Int. J. Radiat. Oncol. Biol. Phys. 2000 48 919 922.
18. Buchler P, Reber HA, Buchler M et al. Hypoxia-inducible factor 1 regulates vascular endothelial growth factor expression in human pancreatic cancer. Pancreas 2003 26 56 64.
19. Kitada T, Seki S, Sakaguchi H, Sawada T, Hirakawa K, Wakasa K. Clinicopathological significance of hypoxia-inducible factor-1alpha expression in human pancreatic carcinoma. Histopathology 2003 43 550 555.
20. Sun HC, Qiu ZJ, Liu J et al. Expression of hypoxia-inducible factor-1 alpha and associated proteins in pancreatic ductal adenocarcinoma and their impact on prognosis. Int. J. Oncol. 2007 30 1359 1367.
21. Shibaji T, Nagao M, Ikeda N et al. Prognostic significance of HIF-1 alpha overexpression in human pancreatic cancer. Anticancer Res. 2003 23 4721 4727.
22. Couvelard A, O'Toole D, Leek R et al. Expression of hypoxia-inducible factors is correlated with the presence of a fibrotic focus and angiogenesis in pancreatic ductal adenocarcinomas. Histopathology 2005 46 668 676.
23. Soilleux EJ, Turley H, Tian YM, Pugh CW, Gatter KC, Harris AL. Use of novel monoclonal antibodies to determine the expression and distribution of the hypoxia regulatory factors PHD-1, PHD-2, PHD-3 and FIH in normal and neoplastic human tissues. Histopathology 2005 47 602 610.
24. Kononen J, Bubendorf L, Kallioniemi A et al. Tissue microarrays for high-throughput molecular profiling of tumor specimens. Nat. Med. 1998 4 844 847.
25. Stolze IP, Tian YM, Appelhoff RJ et al. Genetic analysis of the role of the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (HIF) in regulating HIF transcriptional target genes. J. Biol. Chem. 2004 279 42719 42725.
26. Kato H, Inoue T, Asanoma K, Nishimura C, Matsuda T, Wake N. Induction of human endometrial cancer cell senescence through modulation of HIF-1alpha activity by EGLN1. Int. J. Cancer 2006 118 1144 1153.
27. Lee S, Nakamura E, Yang H et al. Neuronal apoptosis linked to EglN3 prolyl hydroxylase and familial pheochromocytoma genes: developmental culling and cancer. Cancer Cell 2005 8 155 167.
28. Fu J, Menzies K, Freeman RS, Taubman MB. EGLN3 prolyl hydroxylase regulates skeletal muscle differentiation and myogenin protein stability. J. Biol. Chem. 2007 282 12410 12418.
29. Fong GH, Takeda K. Role and regulation of prolyl hydroxylase domain proteins. Cell Death Differ. 2008 15 635 641.
30. Willam C, Masson N, Tian YM et al. Peptide blockade of HIFalpha degradation modulates cellular metabolism and angiogenesis. Proc. Natl Acad. Sci. USA 2002 99 10423 10428.
31. Giatromanolaki A, Koukourakis MI, Pezzella F et al. Expression of prolyl-hydroxylases PHD-1, 2 and 3 and of the asparagine hydroxylase FIH in non-small cell lung cancer relates to an activated HIF pathway. Cancer Lett. 2008 1 87 93.
32. Jokilehto T, Rantanen K, Luukkaa M et al. Overexpression and nuclear translocation of hypoxia-inducible factor prolyl hydroxylase PHD2 in head and neck squamous cell carcinoma is associated with tumor aggressiveness. Clin. Cancer Res. 2006 12 1080 1087.
33. Masson N, Appelhoff RJ, Tuckerman JR et al. The HIF prolyl hydroxylase PHD3 is a potential substrate of the TRiC chaperonin. FEBS Lett. 2004 570 166 170.
34. Beasley NJ, Leek R, Alam M et al. Hypoxia-inducible factors HIF-1alpha and HIF-2alpha in head and neck cancer: relationship to tumor biology and treatment outcome in surgically resected patients. Cancer Res. 2002 62 2493 2497.
35. Groulx I, Lee S. Oxygen-dependent ubiquitination and degradation of hypoxia-inducible factor requires nuclear-cytoplasmic trafficking of the von Hippel-Lindau tumor suppressor protein. Mol. Cell. Biol. 2002 22 5319 5336.
36. Terkhorn SP, Bohensky J, Shapiro IM, Koyama E, Srinivas V. Expression of HIF prolyl hydroxylase isozymes in growth plate chondrocytes: relationship between maturation and apoptotic sensitivity. J. Cell. Physiol. 2007 210 257 265.
37. Couvelard A, Deschamps L, Rebours V et al. Overexpression of the oxygen sensors PHD-1, PHD-2, PHD-3, and FIH Is associated with tumor aggressiveness in pancreatic endocrine tumors. Clin. Cancer Res. 2008 14 6634 6639.