Activity-dependent regulation of brain-derived neurotrophic factor transcription

Transcriptional Regulation by Neuronal Activity: To the Nucleus and Back

Volumn , Issue , 2008, Pages 155-173

  West, Anne E ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 77953184820     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-0-387-73609-9_8     Document Type: Chapter

References (93)

1. Aid, T., Kazantseva, A., Piirsoo, M., Palm, K., and Timmusk, T. (2007) Mouse and rat BDNF gene structure revisited. J Neurosci Res. 85: 525-535.
2. Aliaga, E., Arancibia, S., Givalois, L. and Tapia-Arancibia, L. (2002) Osmotic stress increases brain-derived neurotrophic factor messenger RNA expression in the hypothalamic supraoptic nucleus with differential regulation of its transcripts. Relation to arginine-vasopressin content. Neuroscience 112, 841-850.
3. Aoyama, M., Asai, K., Shishikura, T., Kawamoto, T., Miyachi, T., Yokoi, T., Togari, H., Wada, Y., Kato, T. and Nakagawara, A. (2001) Human neuroblastomas with unfavorable biologies express high levels of brain-derived neurotrophic factor mRNA and a variety of its variants. Cancer Lett. 164, 51-60.
4. Ballarin, M., Ernfors, P., Lindefors, N. and Persson, H. (1991) Hippocampal damage and kainic acid injection induce a rapid increase in mRNA for BDNF and NGF in the rat brain. Exp. Neurol. 114, 35-43.
5. Ballas, N., Grunseich, C., Lu, D. D., Speh, J. C. and Mandel, G. (2005) REST and its corepressors mediate plasticity of neuronal gene chromatin throughout neurogenesis. Cell 121, 645-657.
6. Belfield, J. L., Whittaker, C., Cader, M. Z. and Chawla, S. (2006) Differential effects of Ca2+ and cAMP on transcription mediated by MEF2D and cAMP-response element-binding protein in hippocampal neurons. J. Biol. Chem. 281, 27724-27732.
7. Berchtold, N. C., Oliff, H. S., Isackson, P. and Cotman, C. W. (1999) Hippocampal BDNF mRNA shows a diurnal regulation, primarily in the exon III transcript. Brain Res. Mol. Brain Res. 71, 11-22.
8. Bienvenu, T. and Chelly, J. (2006) Molecular genetics of Rett syndrome: When DNA methylation goes unrecognized. Nat. Rev. Genet. 7, 415-426.
9. Bishop, J. F., Mueller, G. P. and Mouradian, M. M. (1994) Alternate 5' exons in the rat brainderived neurotrophic factor gene: differential patterns of expression across brain regions. Brain Res. Mol. Brain Res. 26, 225-232.
10. Carninci, P., Sandelin, A., Lenhard, B., Katayama, S., Shimokawa, K., Ponjavic, J., Semple, C. A., Taylor, M. S., Engstrom, P. G., Frith, M. C., Forrest, A. R., Alkema, W. B., Tan, S. L., Plessy, C., Kodzius, R., Ravasi, T., Kasukawa, T., Fukuda, S., Kanamori-Katayama, M., Kitazume, Y., Kawaji, H., Kai, C., Nakamura, M., Konno, H., Nakano, K., Mottagui-Tabar, S., Arner, P., Chesi, A., Gustincich, S., Persichetti, F., Suzuki, H., Grimmond, S. M., Wells, C. A., Orlando, V., Wahlestedt, C., Liu, E. T., Harbers, M., Kawai, J., Bajic, V. B., Hume, D. A. and Hayashizaki, Y. (2006) Genome-wide analysis of mammalian promoter architecture and evolution. Nat. Genet. 38, 626-635.
11. Castren, E., Zafra, F., Thoenen, H. and Lindholm, D. (1992) Light regulates expression of brainderived neurotrophic factor mRNA in rat visual cortex. Proc. Natl. Acad. Sci. USA 89, 9444-9448.
12. Chen, W. G., Chang, Q., Lin, Y., Meissner, A., West, A. E., Griffith, E. C., Jaenisch, R. and Greenberg, M. E. (2003a) Derepression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2. Science 302, 885-889.
13. Chen, W. G., West, A. E., Tao, X., Corfas, G., Szentirmay, M., Sawadogo, M., Vinson, C. and Greenberg, M. E. (2003b) Upstream stimulatory factors are mediators of calcium-responsive transcription in neurons. J. Neurosci. 23, 2572-2581.
14. Dennis, K. E. and Levitt, P. (2005) Regional expression of brain derived neurotrophic factor (BDNF) is correlated with dynamic patterns of promoter methylation in the developing mouse forebrain. Brain Res. Mol. Brain Res. 140, 1-9.
15. Dias, B. G., Banerjee, S. B., Duman, R. S. and Vaidya, V. A. (2003) Differential regulation of brain derived neurotrophic factor transcripts by antidepressant treatments in the adult rat brain. Neuropharmacology 45, 553-563.
16. Ernfors, P., Bengzon, J., Kokaia, Z., Persson, H. and Lindvall, O. (1991) Increased levels of messenger RNAs for neurotrophic factors in the brain during kindling epileptogenesis. Neuron 7, 165-176.
17. Fan, G., Beard, C., Chen, R. Z., Csankovszki, G., Sun, Y., Siniaia, M., Biniszkiewicz, D., Bates, B., Lee, P. P., Kuhn, R., Trumpp, A., Poon, C., Wilson, C. B. and Jaenisch, R. (2001) DNA hypomethylation perturbs the function and survival of CNS neurons in postnatal animals. J. Neurosci. 21, 788-797.
18. Fuks, F., Hurd, P. J., Wolf, D., Nan, X., Bird, A. P. and Kourzarides, T. (2003) The Methyl-CpGbinding protein MeCP2 links DNA methylation to histone methylation. J. Biol. Chem. 278, 4035-4040.
19. Fukuchi, M., Tabuchi, A. and Tsuda, M. (2005) Transcriptional regulation of neuronal genes and its effect on neural functions: cumulative mRNA expression of PACAP and BDNF genes controlled by calcium and cAMP signals in neurons. J. Pharmacol. Sci. 98, 212-218.
20. Funakoshi, H., Frisen, J., Barbany, G., Timmusk, T., Zachrisson, O., Verge, V. M. and Persson, H. (1993) Differential expression of mRNAs for neurotrophins and their receptors after axotomy of the sciatic nerve. J. Cell Biol. 123, 455-465.
21. Grimm, J. W., Lu, L., Hayashi, T., Hope, B. T., Su, T. P. and Shaham, Y. (2003) Time-dependent increases in brain-derived neurotrophic factor protein levels within the mesolimbic dopamine system after withdrawal from cocaine: Implications for incubation of cocaine craving. J. Neurosci. 23, 742-747.
22. Hall, J., Thomas, K. L. and Everitt, B. J. (2000) Rapid and selective induction of BDNF expression in the hippocampus during contextual learning. Nat. Neurosci. 3, 533-535.
23. Hansson, A. C., Sommer, W. H., Metsis, M., Stromberg, I., Agnati, L. F. and Fuxe, K. (2006) Corticosterone actions on the hippocampal brain-derived neurotrophic factor expression are mediated by exon IV promoter. J. Neuroendocrinol. 18, 104-114.
24. Heinrich, G. and Pagtakhan, C. J. (2004) Both 5' and 3' flanks regulate Zebrafish brain-derived neurotrophic factor gene expression. BMC Neurosci. 5, 19.
25. Huang, Y., Doherty, J. J. and Dingledine, R. (2002) Altered histone acetylation at glutamate receptor 2 and brain-derived neurotrophic factor genes is an early event triggered by status epilepticus. J. Neurosci. 22, 8422-8428.
26. Isackson, P. J., Huntsman, M. M., Murray, K. D. and Gall, C. M. (1991) BDNF mRNA expression is increased in adult rat forebrain after limbic seizures: Temporal patterns of induction distinct from NGF. Neuron 6, 937-948.
27. Jenuwein, T. and Allis, C. D. (2001) Translating the histone code. Science 293, 1074-1080.
28. Katoh-Semba, R., Takeuchi, I. K., Inaguma, Y., Ichisaka, S., Hata, Y., Tsumoto, T., Iwai, M., Mikoshiba, K. and Kato, K. (2001) Induction of brain-derived neurotrophic factor by convulsant drugs in the rat brain: Involvement of region-specific voltage-dependent calcium channels. J. Neurochem. 77, 71-83.
29. Katz, A. and Meiri, N. (2006) Brain-derived neurotrophic factor is critically involved in thermalexperience- dependent developmental plasticity. J Neurosci 26, 3899-3907.
30. Kobayashi, N. R., Bedard, A. M., Hincke, M. T. and Tetzlaff, W. (1996) Increased expression of BDNF and trkB mRNA in rat facial motoneurons after axotomy. Eur. J. Neurosci. 8, 1018-1029.
31. Kokaia, Z., Metsis, M., Kokaia, M., Bengzon, J., Elmer, E., Smith, M. L., Timmusk, T., Siesjo, B. K., Persson, H. and Lindvall, O. (1994) Brain insults in rats induce increased expression of the BDNF gene through differential use of multiple promoters. Eur. J. Neurosci. 6, 587-596.
32. Kornhauser, J. M., Cowan, C. W., Shaywitz, A. J., Dolmetsch, R. E., Griffith, E. C., Hu, L. S., Haddad, C., Xia, Z. and Greenberg, M. E. (2002) CREB transcriptional activity in neurons is regulated by multiple, calcium-specific phosphorylation events. Neuron 34, 221-233.
33. Kumar, A., Choi, K. H., Renthal, W., Tsankova, N.M., Theobald, D. E., Truong, H. T., Russo, S. J., Laplant, Q., Sasaki, T. S., Whistler, K. N., Neve, R. L., Self, D. W. and Nestler, E. J. (2005) Chromatin remodeling is a key mechanism underlying cocaine-induced plasticity in striatum. Neuron 48, 303-314.
34. Lachner, M. and Jenuwein, T. (2002) The many faces of histone lysine methylation. Curr. Opin. Cell Biol. 14, 286-298.
35. Lauterborn, J. C., Rivera, S., Stinis, C. T., Haynes, V. Y., Isackson, P. J. and Gall, C. M. (1996) Differential effects of protein synthesis inhibition on the activity-dependent expression of BDNF transcripts: evidence for immediate-early gene responses from specific promoters. J. Neurosci. 16, 7428-7436.
36. Lee, P. R., Cohen, J. E., Becker, K. G. and Fields, R. D. (2005) Gene expression in the conversion of early-phase to late-phase long-term potentiation. Ann. N. Y. Acad. Sci. 1048, 259-271.
37. Leibrock, J., Lottspeich, F., Hohn, A., Hofer, M., Hengerer, B., Masiakowski, P., Thoenen, H. and Barde, Y.-A. (1989) Molecular cloning and expression of brain-derived neurotrophic factor. Nature 341, 149-152.
38. Levenson, J. M., Roth, T. L., Lubin, F. D., Miller, C. A., Huang, I-C., Desai, P., Malone, L. M., and Sweatt, J. D. (2006) Evidence that DNA (Cytosine-5) methyltransferase regulates synaptic plasticity in the hippocampus. J. Biol. Chem. 23: 15763-15773.
39. Lewin, G. R. and Barde, Y. A. (1996) Physiology of the neurotrophins. Annu. Rev. Neurosci. 19, 289-317.
40. Lewis, B. P., Shih, I. H., Jones-Rhoades, M. W., Bartel, D. P. and Burge, C. B. (2003) Prediction of mammalian microRNA targets. Cell 115, 787-798.
41. Li, X. C., Jarvis, E. D., Alvarez-Borda, B., Lim, D. A. and Nottebohm, F. (2000) A relationship between behavior, neurotrophin expression, and new neuron survival. Proc. Natl. Acad. Sci. U S A 97, 8584-8589.
42. Liang, F. Q., Walline, R. and Earnest, D. J. (1998) Circadian rhythm of brain-derived neurotrophic factor in the rat suprachiasmatic nucleus. Neurosci. Lett. 242, 89-92.
43. Lindvall, O., Ernfors, P., Bengzon, J., Kokaia, Z., Smith, M. L., Siesjo, B. K. and Persson, H. (1992) Differential regulation of mRNAs for nerve growth factor, brain-derived neurotrophic factor, and neurotrophin 3 in the adult rat brain following cerebral ischemia and hypoglycemic coma. Proc. Natl. Acad. Sci. U S A 89, 648-652.
44. Lipsky, R. H., Xu, K., Zhu, D., Kelly, C., Terhakopian, A., Novelli, A. and Marini, A. M. (2001) Nuclear factor kappaB is a critical determininat in N-methyl-D-aspartate receptor-mediated neuroprotection. J. Neurochem. 78, 254-264.
45. Liu, Q. R., Walther, D., Drgon, T., Polesskaya, O., Lesnick, T. G., Strain, K. J., De Andrade, M., Bower, J. H., Maraganore, D. M. and Uhl, G. R. (2005) Human brain derived neurotrophic factor (BDNF) genes, splicing patterns, and assessments of associations with substance abuse and Parkinson's Disease. Am. J. Med. Genet. B Neuropsychiatr Genet 134, 93-103.
46. Liu, Q. R., Lu, L., Zhu, X. G., Gong, J. P., Shaham, Y. and Uhl, G. R. (2006) Rodent BDNF genes, novel promoters, novel splice variants, and regulation by cocaine. Brain Res. 1067, 1-12.
47. Maisonpierre, P. C., Belluscio, L., Friedman, B., Alderson, R. F., Wiegand, S. J., Furth, M. E., Lindsay, R. M. and Yancopoulos, G. D. (1990) NT-3, BDNF, and NGF in the developing rat nervous system: parallel as well as reciprocal patterns of expression. Neuron 5, 501-509.
48. Malkovska, I., Kernie, S. G. and Parada, L. F. (2006) Differential expression of the four untranslated BDNF exons in the adult mouse brain. J. Neurosci. Res. 83, 211-221.
49. Marmigere, F., Givalois, L., Rage, F., Arancibia, S. and Tapia-Arancibia, L. (2003) Rapid induction of BDNF expression in the hippocampus during immobilization stress challenge in adult rats. Hippocampus 13, 646-655.
50. Martinowich, K., Hattori, D., Wu, H., Fouse, S., He, F., Hu, Y., Fan, G. and Sun, Y. E. (2003) DNA methylation-related chromatin remodeling in activity-dependent BDNF gene regulation. Science 302, 890-893.
51. Metsis, M., Timmusk, T., Arenas, E. and Persson, H. (1993) Differential usage of multiple brainderived neurotrophic factor promoters in the rat brain following neuronal activation. Proc. Natl. Acad. Sci. USA 90, 8802-8806.
52. Michael, G. J., Averill, S., Shortland, P. J., Yan, Q. and Priestley, J. V. (1999) Axotomy results in major changes in BDNF expression by dorsal root ganglion cells: BDNF expression in large trkB and trkC cells, in pericellular baskets, and in projections to deep dorsal horn and dorsal column nuclei. Eur. J. Neurosci. 11, 3539-3551.
53. Nakayama, M., Gahara, Y., Kitamura, T. and Ohara, O. (1994) Distictive four promoters collectively direct expression of brain-derived neurotrophic factor gene. Mol. Brain Res. 21, 206-218.
54. Nan, X., Ng, H. H., Johnson, C. A., Laherty, C. D., Turner, B. M., Eisenman, R. N. and Bird, A. (1998) Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex. Nature 393, 386-389.
55. Nanda, S. and Mack, K. J. (1998) Multiple promoters direct stimulus and temporal specific expression of brain-derived neurotrophic factor in the somatosensory cortex. Mol. Brain Res. 62, 216-219.
56. Nanda, S. A. and Mack, K. J. (2000) Seizures and sensory stimulation result in different patterns of brain derived neurotrophic factor protein expression in the barrel cortex and hippocampus. Brain Res. Mol. Brain Res. 78, 1-14.
57. Neeper, S. A., Gomez-Pinilla, F., Choi, J. and Cotman, C. W. (1996) Physical activity increases mRNA for brain-derived neurotrophic factor and nerve growth factor in rat brain. Brain Res. 726, 49-56.
58. Nibuya, M., Morinobu, S. and Duman, R. S. (1995) Regulation of BDNF and trkB mRNA in rat brain by chronic electroconvulsive seizure and antidepressant drug treatments. J. Neurosci. 15, 7539-7547.
59. Numan, S., Lane-Ladd, S. B., Zhang, L., Lundgren, K. H., Russell, D. S., Seroogy, K. B. and Nestler, E. J. (1998) Differential regulation of neurotrophin and trk receptor mRNAs in catecholaminergic nuclei during chronic opiate treatment and withdrawal. J. Neurosci. 18, 10700-10708.
60. Ohara, O., Gahara, Y., Teraoka, H. and Kitamura, T. (1992) A rat brain neurotrophic factorencoding gene generates multiple transcripts through alternative use of 5' exons and polyadenylation sites. Gene 121, 383-386.
61. Palm, K., Belluardo, N., Metsis, M. and Timmusk, T. (1998) Neuronal expression of zinc finger transcription factor REST/NRSF/XBR gene. J. Neurosci. 18, 1280-1296.
62. Park, S. Y., Lee, J. Y., Choi, J. Y., Park, M. J. and Kim, D. S. (2006) Nerve growth factor activates brain-derived neurotrophic factor promoter IV via extracellular signal-regulated protein kinase 1/2 in PC12 cells. Mol. Cells 21, 237-243.
63. Pattabiraman, P. P., Tropea, D., Chiaruttini, C., Tongiorgi, E., Cattaneo, A. and Domenici, L. (2005) Neuronal activity regulates the developmental expression and subcellular localization of cortical BDNF mRNA isoforms in vivo. Mol. Cell. Neurosci. 28, 556-570.
64. Patterson, S. L., Grover, L.M., Schwartzkroin, P. A. and Bothwell, M. (1992) Neurotrophin expression in rat hippocampal slices: A stimulus paradigm inducing LTP in CA1 evokes increases in BDNF and NT-3 mRNAs. Neuron 9, 1081-1088.
65. Pizarro, J.M., Lumley, L. A., Medina, W., Robison, C. L., Chang, W. E., Alagappan, A., Bah, M. J., Dawood, M. Y., Shah, J. D., Mark, B., Kendall, N., Smith, M. A., Saviolakis, G. A. and Meyerhoff, J. L. (2004) Acute social defeat reduces neurotrophin expression in brain cortical and subcortical areas in mice. Brain Res. 1025, 10-20.
66. Poo, M.-M. (2001) Neurotrophins as synaptic modulators. Nat. Rev. Neurosci. 2, 1-9.
67. Poulsen, F. R., Lauterborn, J., Zimmer, J. and Gall, C. M. (2004) Differential expression of brainderived neurotrophic factor transcripts after pilocarpine-induced seizure-like activity is related to mode of Ca2+ entry. Neuroscience 126, 665-676.
68. Rattiner, L. M., Davis, M., French, C. T. and Ressler, K. J. (2004) Brain-derived neurotrophic factor and tyrosine kinase receptor B involvement in amygdala-dependent fear conditioning. J. Neurosci. 24, 4796-4806.
69. Rocamora, N., Welker, E., Pascual, M. and Soriano, E. (1996) Upregulation of BDNF mRNA expression in the barrel cortex of adult mice after sensory stimulation. J. Neurosci. 16, 4411-4419.
70. Russo-Neustadt, A. A., Beard, R. C., Huang, Y.M. and Cotman, C.W. (2000) Physical activity and antidepressant treatment potentiate the expression of specific brain-derived neurotrophic factor transcripts in the rat hippocampus. Neuroscience 101, 305-312.
71. Shieh, P. B., Hu, S.-C., Bobb, K., Timmusk, T. and Ghosh, A. (1998) Identification of a signaling pathway involved in calcium regulation of BDNF expression. Neuron 20, 727-740.
72. Smale, S. T. (2001) Core promoters: Active contributors to combinatorial gene regulation. Genes Dev. 15, 2503-2508.
73. Smith, M. A., Makino, S., Kim, S. Y. and Kvetnansky, R. (1995a) Stress increases brain-derived neurotropic factor messenger ribonucleic acid in the hypothalamus and pituitary. Endocrinology 136, 3743-3750.
74. Smith, M. A., Makino, S., Kvetnansky, R. and Post, R. M. (1995b) Stress and glucocorticoids affect the expression of brain-derived neurotrophic factor and neurotrophin-3 mRNAs in the hippocampus. J. Neurosci. 15, 1768-1777.
75. Tabuchi, A., Sakaya, H., Kisukeda, T., Fushiki, H. and Tsuda, M. (2002) Involvement of an upstream stimulatory factor as well as cAMP-responsive element-binding protein in the activation of brain-derived neurotrophic factor gene promoter I. J. Biol. Chem. 277, 35920-35931.
76. Takeuchi, Y., Miyamoto, E. and Fukunaga, K. (2002) Analysis of the promoter region of exon IV brain-derived neurotrophic factor in NG108-15 cells. J. Neurochem. 83, 67-79.
77. Tao, X., Finkbeiner, S., Arnold, D. B., Shaywitz, A. J. and Greenberg, M. E. (1998) Ca2+ influx regulates BDNF transcription by a CREB family transcription factor-dependent mechanism. Neuron 20, 709-726.
78. Tao, X., West, A. E., Chen, W. G., Corfas, G. and Greenberg, M. E. (2002) A calcium-responsive transcription factor, CaRF, that regulates neuronal activity-dependent expression of BDNF. Neuron 33, 383-395.
79. Timmusk, T., Palm, K., Metsis, M., Reintam, T., Paalme, V., Saarma, M. and Persson, H. (1993) Multiple promoters direct tissue-specific expression of the rat BDNF gene. Neuron 10, 475-489.
80. Timmusk, T., Belluardo, N., Persson, H. and Metsis, M. (1994a) Developmental regulation of brain-derived neurotrophic factor messenger RNAs transcribed from different promoters in the rat brain. Neuroscience 60, 287-291.
81. Timmusk, T., Persson, H. and Metsis, M. (1994b) Analysis of transcriptional initiation and translatability of brain-derived neurotrophic factor mRNAs in the rat brain. Neurosci. Lett. 177, 27-31.
82. Timmusk, T., Palm, K., Lendahl, U. and Metsis, M. (1999) Brain-derived neurotrophic factor expression in vivo is under the control of neuron-restrictive silencer element. J. Biol. Chem. 274, 1078-1084.
83. Tokuyama, W., Okuno, H., Hashimoto, T., Li, Y. X. and Miyashita, Y. (2000) BDNF upregulation during declarative memory formation in monkey inferior temporal cortex. Nat. Neurosci. 3, 1134-1142.
84. Tongiorgi, E., Righi, M. and Cattaneo, A. (1997) Activity-dependent dendritic targeting of BDNF and TrkB mRNAs in hippocampal neurons. J. Neurosci. 17, 9492-9505.
85. Tongiorgi, E., Armellin, M., Giulianini, P. G., Bregola, G., Zucchini, S., Paradiso, B., Steward, O., Cattaneo, A. and Simonato, M. (2004) Brain-derived neurotrophic factor mRNA and protein are targeted to discrete dendritic laminas by events that trigger epileptogenesis. J. Neurosci. 24, 6842-6852.
86. Tsankova, N. M., Kumar, A. and Nestler, E. J. (2004) Histone modifications at gene promoter regions in rat hippocampus after acute and chronic electroconvulsive seizures. J. Neurosci. 24, 5603-5610.
87. Tsankova, N. M., Berton, O., Renthal, W., Kumar, A., Neve, R. L. and Nestler, E. J. (2006) Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action. Nat. Neurosci. 9, 519-525.
88. West, A. E., Chen, W. G., Dalva, M. B., Dolmetsch, R. E., Kornhauser, J. M., Shaywitz, A. J., Takasu, M. A., Tao, X. and Greenberg, M. E. (2001) Calcium regulation of neuronal gene expression. Proc. Natl. Acad. Sci. USA 98, 11024-11031.
89. West, A. E., Griffith, E. C. and Greenberg, M. E. (2002) Regulation of transcription factors by neuronal activity. Nat. Rev. Neurosci. 3, 921-931.
90. Zafra, F., Hengerer, B., Leibrock, J., Thoenen, H. and Lindholm, D. (1990) Activity dependent regulation of BDNF and NGF mRNAs in the rat hippocampus is mediated by non-NMDA glutamate receptors. EMBO J. 9, 3545-3550.
91. Zhou, Z., Hong, E. J., Cohen, S., Zhao, W. N., Ho, H. Y., Schmidt, L., Chen, W. G., Lin, Y., Savner, E., Griffith, E. C., Hu, L., Steen, J. A., Weitz, C. J. and Greenberg, M. E. (2006) Brainspecific phosphorylation of MeCP2 regulates activity-dependent Bdnf transcription, dendritic growth, and spine maturation. Neuron 52, 255-269.
92. Zuccato, C., Ciammola, A., Rigamonti, D., Leavitt, B. R., Goffredo, D., Conti, L., Macdonald, M. E., Friedlander, R. M., Silani, V., Hayden, M. R., Timmusk, T., Sipione, S. and Cattaneo, E. (2001) Loss of huntingtin-mediated BDNF gene transcription in Huntington's disease. Science 293, 493-498.
93. Zuccato, C., Tartari, M., Crotti, A., Goffredo, D., Valenza, M., Conti, L., Cataudella, T., Leavitt, B. R., Hayden, M. R., Timmusk, T., Rigamonti, D. and Cattaneo, E. (2003) Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes. Nat. Genet. 35, 76-83.