An autoinhibitory effect of the homothorax domain of Meis2

FEBS Journal

Volumn 277, Issue 12, 2010, Pages 2584-2597

  Hyman Walsh, Cathy ^a   Bjerke, Glen A ^a   Wotton, David ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

Author keywords

Homeodomain; Meis; Pbx; Repression; Transcription

Indexed keywords

HOMEODOMAIN PROTEIN; MYELOID ECOTROPIC INSERTION SITE 2 PROTEIN; MYELOID ECOTROPIC INSERTION SITE 3.2 PROTEIN; TRANSCRIPTION FACTOR PBX1; UNCLASSIFIED DRUG;

ALTERNATIVE RNA SPLICING; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL STRAIN HEPG2; CONTROLLED STUDY; HUMAN; HUMAN CELL; MUTATIONAL ANALYSIS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; TRANSCRIPTION INITIATION;

EID: 77953183033     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2010.07668.x     Document Type: Article

References (46)

1. McGinnis W, Garber RL, Wirz J, Kuroiwa A Gehring WJ (1984) A homologous protein-coding sequence in Drosophila homeotic genes and its conservation in other metazoans. Cell 37, 403 408.
2. McGinnis W, Levine MS, Hafen E, Kuroiwa A Gehring WJ (1984) A conserved DNA sequence in homoeotic genes of the Drosophila antennapedia and bithorax complexes. Nature 308, 428 433.
3. Gehring WJ, Affolter M Burglin T (1994) Homeodomain proteins. Annu Rev Biochem 63, 487 526.
4. Chang CP, Shen WF, Rozenfeld S, Lawrence HJ, Largman C Cleary ML (1995) Pbx proteins display hexapeptide-dependent cooperative DNA binding with a subset of Hox proteins. Genes Dev 9, 663 674.
5. Gehring WJ, Qian YQ, Billeter M, Furukubo-Tokunaga K, Schier AF, Resendez-Perez D, Affolter M, Otting G Wuthrich K (1994) Homeodomain-DNA recognition. Cell 78, 211 223. (Pubitemid 24241090)
6. Passner JM, Ryoo HD, Shen L, Mann RS Aggarwal AK (1999) Structure of a DNA-bound Ultrabithorax-Extradenticle homeodomain complex. Nature 397, 714 719.
7. Piper DE, Batchelor AH, Chang C-P, Cleary ML Wolberger C (1999) Structure of a HoxB1-Pbx1 heterodimer bound to DNA: role of the hexapeptide and a fourth homeodomain helix in complex formation. Cell 96, 587 597.
8. Jacobs Y, Schnabel CA Cleary ML (1999) Trimeric association of hox and TALE homeodomain proteins mediates hoxb2 hindbrain enhancer activity. Mol Cell Biol 19, 5134 5142.
9. Shanmugam K, Green NC, Rambaldi I, Saragovi HU Featherstone MS (1999) PBX and MEIS as non-DNA-binding partners in trimeric complexes with HOX proteins. Mol Cell Biol 19, 7577 7588.
10. Chang CP, Brocchieri L, Shen WF, Largman C Cleary ML (1996) Pbx modulation of Hox homeodomain amino-terminal arms establishes different DNA-binding specificities across the Hox locus. Mol Cell Biol 16, 1734 1745.
11. Knoepfler PS Kamps MP (1995) The pentapeptide motif of Hox proteins is required for cooperative DNA binding with Pbx1, physically contacts Pbx1, and enhances DNA binding by Pbx1. Mol Cell Biol 15, 5811 5819.
12. Mann RS Chan SK (1996) Extra specificity from extradenticle: the partnership between HOX and PBX/EXD homeodomain proteins [published erratum appears in Trends Genet 1996; 12: 328].
13. Mann RS Chan SK (1996) Trends Genet 12, 258 262.
14. Bertolino E, Reimund B, Wildt-Perinic D Clerc R (1995) A novel homeobox protein which recognizes a TGT core and functionally interferes with a retinoid-responsive motif. J Biol Chem 270, 31178 31188.
15. Burglin TR (1997) Analysis of TALE superclass homeobox genes (MEIS, PBC, KNOX, Iroquois, TGIF) reveals a novel domain conserved between plants and animals. Nucleic Acids Res 25, 4173 4180.
16. Mukherjee K Burglin TR (2007) Comprehensive analysis of animal TALE homeobox genes: new conserved motifs and cases of accelerated evolution. J Mol Evol 65, 137 153.
17. Melhuish TA, Gallo CM Wotton D (2001) TGIF2 interacts with histone deacetylase 1 and represses transcription. J Biol Chem 276, 32109 32114.
18. Melhuish TA Wotton D (2000) The interaction of C-terminal binding protein with the Smad corepressor TG-interacting factor is disrupted by a holoprosencephaly mutation in TGIF. J Biol Chem 275, 39762 39766.
19. Wotton D, Lo RS, Swaby LA Massague J (1999) Multiple modes of repression by the smad transcriptional corepressor TGIF. J Biol Chem 274, 37105 37110.
20. Berthelsen J, Zappavigna V, Ferretti E, Mavilio F Blasi F (1998) The novel homeoprotein Prep1 modulates Pbx-Hox protein cooperativity. EMBO J 17, 1434 1445.
21. Liu Y, MacDonald RJ Swift GH (2001) DNA binding and transcriptional activation by a PDX1.PBX1b.MEIS2b trimer and cooperation with a pancreas-specific basic helix-loop-helix complex. J Biol Chem 276, 17985 17993.
22. Moskow JJ, Bullrich F, Huebner K, Daar IO Buchberg AM (1995) Meis1, a PBX1-related homeobox gene involved in myeloid leukemia in BXH-2 mice. Mol Cell Biol 15, 5434 5443.
23. Nakamura T, Jenkins NA Copeland NG (1996) Identification of a new family of Pbx-related homeobox genes. Oncogene 13, 2235 2242.
24. Oulad-Abdelghani M, Chazaud C, Bouillet P, Sapin V, Chambon P Dolle P (1997) Meis2, a novel mouse Pbx-related homeobox gene induced by retinoic acid during differentiation of P19 embryonal carcinoma cells. Dev Dyn 210, 173 183.
25. Schnabel CA, Jacobs Y Cleary ML (2000) HoxA9-mediated immortalization of myeloid progenitors requires functional interactions with TALE cofactors Pbx and Meis. Oncogene 19, 608 616.
26. Thorsteinsdottir U, Kroon E, Jerome L, Blasi F Sauvageau G (2001) Defining roles for HOX and MEIS1 genes in induction of acute myeloid leukemia. Mol Cell Biol 21, 224 234.
27. Wong P, Iwasaki M, Somervaille TC, So CW Cleary ML (2007) Meis1 is an essential and rate-limiting regulator of MLL leukemia stem cell potential. Genes Dev 21, 2762 2774.
28. Di Rosa P, Villaescusa JC, Longobardi E, Iotti G, Ferretti E, Diaz VM, Miccio A, Ferrari G Blasi F (2007) The homeodomain transcription factor Prep1 (pKnox1) is required for hematopoietic stem and progenitor cell activity. Dev Biol 311, 324 334.
29. Penkov D, Di Rosa P, Fernandez Diaz L, Basso V, Ferretti E, Grassi F, Mondino A Blasi F (2005) Involvement of Prep1 in the alphabeta T-cell receptor T-lymphocytic potential of hematopoietic precursors. Mol Cell Biol 25, 10768 10781.
30. Penkov D, Palazzolo M, Mondino A Blasi F (2008) Cytosolic sequestration of Prep1 influences early stages of T cell development. PLoS ONE 3, e2424.
31. Kamps MP, Look AT Baltimore D (1991) The human t(1;19) translocation in pre-B ALL produces multiple nuclear E2A-Pbx1 fusion proteins with differing transforming potentials. Genes Dev 5, 358 368.
32. Kamps MP, Murre C, Sun XH Baltimore D (1990) A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in pre-B ALL. Cell 60, 547 555.
33. Moens CB Selleri L (2006) Hox cofactors in vertebrate development. Dev Biol 291, 193 206.
34. Rieckhof GE, Casares F, Ryoo HD, Abu-Shaar M Mann RS (1997) Nuclear translocation of extradenticle requires homothorax, which encodes an extradenticle-related homeodomain protein. Cell 91, 171 183.
35. Chang CP, Jacobs Y, Nakamura T, Jenkins NA, Copeland NG Cleary ML (1997) Meis proteins are major in vivo DNA binding partners for wild-type but not chimeric Pbx proteins. Mol Cell Biol 17, 5679 5687.
36. Knoepfler PS, Calvo KR, Chen H, Antonarakis SE Kamps MP (1997) Meis1 and pKnox1 bind DNA cooperatively with Pbx1 utilizing an interaction surface disrupted in oncoprotein E2a-Pbx1. Proc Natl Acad Sci USA 94, 14553 14558.
37. Saleh M, Huang H, Green NC Featherstone MS (2000) A conformational change in PBX1A is necessary for its nuclear localization. Exp Cell Res 260, 105 115.
38. Diaz VM, Mori S, Longobardi E, Menendez G, Ferrai C, Keough RA, Bachi A Blasi F (2007) p160 Myb-binding protein interacts with Prep1 and inhibits its transcriptional activity. Mol Cell Biol 27, 7981 7990.
39. Noro B, Culi J, McKay DJ, Zhang W Mann RS (2006) Distinct functions of homeodomain-containing and homeodomain-less isoforms encoded by homothorax. Genes Dev 20, 1636 1650.
40. Yang Y, Hwang CK, D'Souza UM, Lee SH, Junn E Mouradian MM (2000) Tale homeodomain proteins Meis2 and TGIF differentially regulate transcription. J Biol Chem 275, 20734 20741.
41. Huang H, Rastegar M, Bodner C, Goh SL, Rambaldi I Featherstone M (2005) MEIS C termini harbor transcriptional activation domains that respond to cell signaling. J Biol Chem 280, 10119 10127.
42. Hyman CA, Bartholin L, Newfeld SJ Wotton D (2003) Drosophila TGIF proteins are transcriptional activators. Mol Cell Biol 23, 9262 9274.
43. Chinnadurai G (2002) CtBP, an unconventional transcriptional corepressor in development and oncogenesis. Mol Cell 9, 213 224.
44. Ast G (2004) How did alternative splicing evolve? Nat Rev Genet 5, 773 782.
45. Patel AA Steitz JA (2003) Splicing double: insights from the second spliceosome. Nat Rev Mol Cell Biol 4, 960 970.
46. Berthelsen J, Kilstrup-Nielsen C, Blasi F, Mavilio F Zappavigna V (1999) The subcellular localization of PBX1 and EXD proteins depends on nuclear import and export signals and is modulated by association with PREP1 and HTH. Genes Dev 13, 946 953.