Activated scramblase and inhibited aminophospholipid translocase cause phosphatidylserine exposure in a distinct platelet fraction

Cellular and Molecular Life Sciences

Volumn 62, Issue 13, 2005, Pages 1514-1525

  Wolfs, J L N ^a   Comfurius, P ^a   Rasmussen, J T ^b   Keuren, J F W ^c   Lindhout, T ^a   Zwaal, R F A ^a   Bevers, E M ^a  

^a MAASTRICHT UNIVERSITY   (Netherlands)

^b AARHUS UNIVERSITY   (Denmark)

^c Sanquin   (Netherlands)

Author keywords

Aminophospholipid translocase; Collagen; Microparticle; Phosphatidylserine; Platelet; Procoagulant activity; Scramblase; Thrombin

Indexed keywords

AMINOPHOSPHOLIPID; AMINOPHOSPHOLIPID TRANSLOCASE; BLOOD CLOTTING FACTOR 10A; BLOOD CLOTTING FACTOR 5A; CALCIUM ION; CARRIER PROTEIN; COLLAGEN; IONOPHORE; PHOSPHATIDYLSERINE; PROCOAGULANT; PROTHROMBIN; SCRAMBLASE; THROMBIN; UNCLASSIFIED DRUG;

ARTICLE; CELL STIMULATION; CELL TRANSPORT; ENZYME ACTIVATION; ENZYME ACTIVITY; PARTICLE SIZE; THROMBOCYTE ACTIVATION;

ANNEXIN A5; ANTIGENS, SURFACE; BLOOD PLATELETS; COLLAGEN; FLOW CYTOMETRY; FLUORESCEIN-5-ISOTHIOCYANATE; HUMANS; IONOMYCIN; MEMBRANE PROTEINS; MILK PROTEINS; PHOSPHATIDYLSERINES; PHOSPHOLIPID TRANSFER PROTEINS; PLATELET ACTIVATION; THROMBIN; THROMBOPLASTIN;

EID: 21544447825     PISSN: 1420682X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00018-005-5099-y     Document Type: Article

References (40)

1. Sims P. J. and Wiedmer T. (2001) Unraveling the mysteries of phospholipid scrambling. Thromb. Haemost. 86: 266-275
2. Bevers E. M., Comfurius P., Dekkers D. W. and Zwaal R. F. (1999) Lipid translocation across the plasma membrane of mammalian cells. Biochim. Biophys. Acta 1439: 317-330
3. Heemskerk J. W., Bevers E. M. and Lindhout T. (2002) Platelet activation and blood coagulation. Thromb. Haemost. 88: 186-193
4. Sims P. J., Wiedmer T., Esmon C. T., Weiss H. J. and Shattil S. J. (1989) Assembly of the platelet prothrombinase complex is linked to vesiculation of the platelet plasma membrane. Studies in Scott syndrome: an isolated defect in platelet procoagulant activity. J Biol Chem 264: 17049-17057
5. Comfurius P., Senden J. M., Tilly R. H., Schroit A. J. and Bevers E. M., Zwaal, R. F. (1990) Loss of membrane phospholipid asymmetry in platelets and red cells may be associated with calcium-induced shedding of plasma membrane and inhibition of aminophospholipid translocase. Biochim. Biophys. Acta 1026: 153-160
6. Morel O., Toti F., Hugel B. and Freyssinet J. M. (2004) Cellular microparticles: a disseminated storage pool of bioactive vascular effectors. Curr. Opin. Hematol. 11: 156-164
7. Fadok V. A., Xue D. and Henson P. (2001) If phosphatidylserine is the death knell, a new phosphatidylserine-specific receptor is the bellringer. Cell Death Differ. 8: 582-587
8. Schlegel R. A. and Williamson P. (2001) Phosphatidylserine, a death knell. Cell Death Differ. 8: 551-563
9. Bevers E. M., Comfurius P. and Zwaal R. F. (1983) Changes in membrane phospholipid distribution during platelet activation. Biochim. Biophys. Acta 736: 57-66
10. Dachary-Prigent J., Freyssinet J. M., Pasquet J. M., Carron, J. C. and Nurden A. T. (1993) Annexin V as a probe of aminophospholipid exposure and platelet membrane vesiculation: a flow cytometry study showing a role for free sulfhydryl groups. Blood 81: 2554-2565
11. Diaz C. and Schroit A. J. (1996) Role of translocases in the generation of phosphatidylserine asymmetry. J. Membr. Biol. 151: 1-9
12. Monroe D. M., Hoffman M. and Roberts H. R. (2002) Platelets and thrombin generation. Arterioscler. Thromb. Vasc. Biol. 22: 1381-1389
13. Larson P. J., Camire R. M., Wong D., Fasano N. C., Monroe D. M. Tracy P. B. et al. (1998) Structure/function analyses of recombinant variants of human factor Xa: factor Xa incorporation into prothrombinase on the thrombin-activated platelet surface is not mimicked by syntheti phospholipid vesicles. Biochemistry 37: 5029-5038.
14. Thiagarajan, P. and Tait J. F. (1991) Collagen-induced exposure of anionic phospholipid in platelets and platelet-derived microparticles. J Biol Chem 266: 24302-24307
15. Thiagarajan P. and Tait J. F. (1990) Binding of annexin V/placental anticoagulant protein I to platelets: evidence for phosphatidylserine exposure in the procoagulant response of activated platelets. J. Biol. Chem. 265: 17420-17423
16. Pasquet J. M., Toti F., Nurden A. T. and Dachary-Prigent J. (1996) Procoagulant activity and active calpain in platelet-derived microparticles. Thromb Res 82: 509-522
17. Shi J., Heegaard C. W., Rasmussen J. T. and Gilbert G. E. (2004) Lactadherin binds selectively to membranes containing phosphatidyl-1-serine and increased curvature. Biochim. Biophys. Acta 1667: 82-90
18. Gilbert G. E., Shi J., Rasmussen J. T., Heegaard C. W., Zhao J. and Price P. (2003) Limited exposure of phosphatidylserine on stimulated platelets is necessary for procoagulant activity and provides binding sites for lactadherin. J. Thromb. Haemost. 1(S1): Abstr. P1274
19. Dörmann D., Clemetson K. J. and Kehrel B. E. (2000) The GPIb thrombin-binding site is essential for thrombin-induced platelet procoagulant activity. Blood 96: 2469-2478
20. Dorsam R. T., Tuluc M. and Kunapuli S. P. (2004) Role of protease-activated and ADP receptor subtypes in thrombin generation on human platelets. J. Thromb. Haemost. 2: 804-812
21. Williamson P., Bevers E. M., Smeets E. F., Comfurius P., Schlegel R. A. and Zwaal R. F. (1995) Continuous analysis of the mechanism of activated transbilayer lipid movement in platelets. Biochemistry 34: 10448-10455
22. Tilly R. H., Senden J. M., Comfurius P., Bevers E. M. and Zwaal R. F. (1990) Increased aminophospholipid translocase activity in human platelets during secretion. Biochim. Biophys. Acta 1029: 188-190
23. Rosing J., Rijn J. L. van, Bevers E. M., Dieijen G. van, Comfurius P. and Zwaal R. F. (1985) The role of activated human platelets in prothrombin and factor X activation. Blood 65:319-332
24. Hvarregaard J., Andersen M. H., Berglund L., Rasmussen J. T., Petersen T. E. (1996) Characterization of glycoprotein PAS-6/7 from membranes of bovine milk fat globules. Eur. J. Biochem. 240: 628-636
25. Heemskerk J. W., Comfurius P., Feijge M. A. and Bevers E. M. (2004) Measurement of the platelet procoagulant response. Methods Mol. Biol. 272: 135-144
26. Connor J., Pak C. H., Zwaal R. F. and Schroit A. J. (1992) Bidirectional transbilayer movement of phospholipid analogs in human red blood cells: evidence for an ATP-dependent and protein-mediated process. J. Biol. Chem. 267: 19412-19417
27. Stuart M. C., Bevers E. M., Comfurius P., Zwaal R. F., Reutelingsperger C. P. and Frederik P. M. (1995) Ultrastructural detection of surface exposed phosphatidylserine on activated blood platelets. Thromb. Haemost. 74: 1145-1151
28. Jong K. de, Geldwerth D. and Kuypers F. A. (1997) Oxidative damage does not alter membrane phospholipid asymmetry in human erythrocytes. Biochemistry 36: 6768-6776
29. Connor J. and Schroit A. J. (1991) Transbilayer movement of phosphatidylserine in erythrocytes. Inhibitors of aminophospholipid transport block the association of photolabeled lipid to its transporter. Biochim. Biophys. Acta 1066: 37-42
30. Rijn J. van, Rosing J. and Dieijen G. van (1983) Activity of human blood platelets in prothrombin and in factor X activation induced by ionophore A23187. Eur. J. Biochem. 133: 1-10
31. London F. S., Marcinkiewicz M. and Walsh P. N. (2004) A subpopulation of platelets responds to thrombin- or SFLLRN-stimulation with binding sites for factor IXa. J. Biol. Chem. 279: 19854-19859
32. Alberio L., Safa O., Clemetson K. J., Esmon C. T. and Dale G. L. (2000) Surface expression and functional characterization of alpha-granule factor V in human platelets: effects of ionophore A23187, thrombin, collagen, and convulxin. Blood 95: 1694-1702
33. Dale G. L., Friese P., Batar P., Hamilton S. F., Reed G. L., Jackson K. W. et al. (2002) Stimulated platelets use serotonin to enhance their retention of procoagulant proteins on the cell surface. Nature 415: 175-179
34. Smeets E. F., Heemskerk J. W., Comfurius P., Bevers E. M. and Zwaal R. F. (1993) Thapsigargin amplifies the platelet procoagulant response caused by thrombin. Thromb. Haemost. 70: 1024-1029
35. 2+-ATPase inhibitors. Biochemistry 34: 11625-11634
36. Bevers E. M., Wiedmer T., Comfurius P., Zhao J., Smeets E. F., Schlegel R. A. et al. (1995) The complex of phosphatidylinositol 4,5-bisphosphate and calcium ions is not responsible for Ca(2+)-induced loss of phospholipid asymmetry in the human erythrocyte: a study in Scott syndrome, a disorder of calcium-induced phospholipid scrambling. Blood 86: 1983-1991
37. Augereau O., Rossignol R., DeGiorgi F., Mazat J. P., Letellier T. and Dachary-Prigent J. (2004) Apoptotic-like mitochondrial events associated to phosphatidylserine exposure in blood platelets induced by local anaesthetics. Thromb. Haemost. 92: 104-113
38. Williamson P., Christie A., Kohlin T., Schlegel R. A., Comfurius P., Harmsma M. et al. (2001) Phospholipid scramblase activation pathways in lymphocytes. Biochemistry 40: 8065-8072
39. Hsu-Lin S., Berman C. L., Furie B. C., August D. and Furie B. (1984) A platelet membrane protein expressed during platelet activation and secretion: studies using a monoclonal antibody specific for thrombin-activated platelets. J. Biol. Chem. 259: 9121-9126
40. Chap H. J., Zwaal R. F. and Deenen L. L. van (1977) Action of highly purified phospholipases on blood platelets: evidence for an asymmetric distribution of phospholipids in the surface membrane. Biochim. Biophys. Acta 467: 146-164