Unraveling the mysteries of phospholipid scrambling

Thrombosis and Haemostasis

Volumn 86, Issue 1, 2001, Pages 266-275

  Sims, P J ^a   Wiedmer, T ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Phosphatidylserine; Phospholipid; Phospholipid asymmetry; Phospholipid scramblase; Plasma membrane

Indexed keywords

AMINOPHOSPHOLIPID; CALCIUM ION; PHOSPHATIDYLETHANOLAMINE; PHOSPHATIDYLSERINE; PHOSPHOLIPID; PROTEIN KINASE C; SCRAMBLASE;

BLOOD CLOTTING; CELL ACTIVATION; CELL MEMBRANE; CELL SURFACE; CLONE; CONFERENCE PAPER; DRUG ACTIVITY; ENZYME PHOSPHORYLATION; HUMAN; IN VITRO STUDY; NONHUMAN; ONCOGENE; PALMITOYLATION; PLASMA CLEARANCE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; RETICULOENDOTHELIAL SYSTEM; SCOTT SYNDROME; SEQUENCE HOMOLOGY; TRANSCRIPTION REGULATION;

EID: 0034911765     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0037-1616224     Document Type: Conference Paper

References (130)

1. Molecular architecture and dynamics of the plasma membrane lipid bilayer: The red blood cell as a model
2. Transbilayer movement of phospholipids in red cell and platelet membranes
3. Static and dynamic lipid asymmetry in cell membranes
4. 2+ induces transbilayer redistribution of all major phospholipids in human erythrocytes
5. Contribution of platelet microparticle formation and granule secretion to the transmembrane migration of phosphatidylserine
6. Translocation of spin-labeled phospholipids through plasma membrane during thrombin- and ionophore A23187-induced platelet activation
7. Bidirectional transbilayer movement of phospholipid analogs in human red blood cells. Evidence for an ATP-dependent and protein- mediated process
8. Loss of membrane phospholipid asymmetry in platelets and red cells may be associated with calcium-induced shedding of plasma membrane and inhibition of aminophospholipid translocase
9. Calcium-induced transbilayer scrambling of fluorescent phospholipid analogs in platelets and erythrocytes
10. Lipid translocation across the plasma membrane of mammalian cells
11. Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages
12. Activation of the alternative complement pathway by exposure of phosphatidylethanolamine and phosphatidylserine on erythrocytes from sickle cell disease patients
13. Multiple systems for recognition of apoptotic lymphocytes by macrophages
14. Transmembrane phospholipid distribution in blood cells: Control mechanisms and pathophysiological significance
15. Corpse clearance defines the meaning of cell death
16. Cofactor proteins in the assembly and expression of blood clotting enzymes
17. Role of the membrane surface in the activation of human coagulation factor X
18. Regulation of thrombin generation at cell surfaces
19. Platelet procoagulant activity: Physiological significance and mechanisms of exposure
20. Complement protein C5b-9 stimulate procoagulant activity through the platelet prothrombinase
21. Comparison of the abilities of synthetic and platelet-derived membranes to enhance thrombin formation
22. Specificity of phosphatidylserine-containing membrane binding sites for factor VIII. Studies with model membranes supported by glass microspheres (lipospheres)
23. Activation of the factor VIIIa-factor IXa enzyme complex of blood coagulation by membranes containing phosphatidyl L-serine
24. Platelet-derived microparticles express high affinity receptors for factor VIII
25. Collagen-induced exposure of anionic phospholipid in platelets and platelet-derived microparticles
26. Annexin V as a probe of aminophospholipid exposure and platelet membrane vesiculation: A flow cytometry study showing a role for free sulfhydryl groups
27. Deficiency of Factor-Xa-Factor Va binding sites on the platelets of a patient with a bleeding disorder
28. Impaired factor X and prothrombin activation associated with decreased phospholipid exposure in platelets from a patient with a bleeding disorder
29. Assembly of the platelet prothrombinase complex is linked to vesiculation of the platelet plasma membrane. Studies in Scott syndrome: An isolated defect in platelet procoagulant activity
30. Platelet receptors induced by factor VIII are deficient on platelets in Scott syndrome
31. Phosphatidylethanolamine augments factor VIIa-tissue factor activity: Enhancement of sensitivity to phosphatidylserine
32. The effect of membrane composition on the hemostatic balance
33. Transmembrane mobility of phospholipids in sickle erythrocytes: Effect of deoxygenation on diffusion and asymmetry
34. Complement proteins C5b-9 induce vesiculation of the endothelial plasma membrane and expose catalytic surface for assembly of the prothrombinase enzyme complex
35. Protection of porcine aortic endothelial cells from complement-mediated cell lysis and activation by recombinant human CD59
36. The complement system in xenotransplantation
37. Complement-induced vesiculation and exposure of membrane prothrombinase sites in platelets of paroxysmal nocturnal hemoglobinuria
38. Antigenic specificities of "/antiphospholipid" autoantibodies
39. Antiphospholipid antibodies accelerate plasma coagulation by inhibiting annexin-V binding to phospholipids: A "lupus procoagulant" phenomenon
40. Competition of annexin V and anticardiolipin antibodies for binding to phosphatidylserine containing membranes
41. Scott Syndrome: A disorder of platelet coagulant activity
42. Scott syndrome, characterized by impaired transmembrane migration of procoagulant phosphatidylserine and hemorrhagic complications, is an inherited disorder
43. 2+-induced microvesiculation and deficient expression of procoagulant activity in erythrocytes from a patient with a bleeding disorder: A study of the red blood cells of Scott syndrome
44. Production and characterization of transformed B-lymphocytes expressing the membrane defect of Scott syndrome
45. 2+ entry in the regulation of phosphatidylserine expression at the surface of stimulated cells
46. Scott syndrome: An inherited defect of the procoagulant activity of platelets
47. 2+ entry in stimulated cells
48. Expression of proteins controlling transbilayer movement of plasma membrane phospholipids in the B lymphocytes from a patient with Scott syndrome
49. Another-link between phospholipid transmembrane migration and ABC transporter gene family, inferred from a rare inherited disorder of phosphatidylserine externalization
50. Exposure of phosphatidylserine in the outer leaflet of human red blood cells. Relationship to cell density, cell age, and clearance by mononuclear cells
51. A receptor for phosphatidylserine-specific clearance of apoptotic cells
52. Phosphatidylserine as a determinant of reticuloendothelial recognition of liposome models of the erythrocyte surface
53. Differentiation-dependent expression of phophatidylserine in mammalian plasma membranes: Quantitative assessment of outer-leaflet lipid by prothrombinase complex formation
54. Transbilayer mobility and distribution of red cell phospholipids during storage
55. Loss of phospholipid asymmetry in human platelet plasma membrane after 1-12 days of storage. An ESR study
56. Generation of phenotypically aged phosphatidylserine-expressing erythrocytes by dilauroylphosphatidylcholine-induced vesiculation
57. The effect of storage on the expression of platelet membrane phosphatidylserine and the subsequent impact on the coagulant function of stored platelets
58. 2-glycoprotein I macrophage interactions - Implications for apoptotic cell clearance by phagocytes
59. Loss of phospholipid asymmetry and surface exposure of phosphatidylserine is required for phagocytosis of apoptotic cells by macrophages and fibroblasts
60. Engulfment of apoptotic cells involves the redistribution of membrane phosphatidylserine on phagocyte and prey
61. Surface expression of phosphatidylserine on macrophages is required for phagocytosis of apoptotic thymocytes
62. Sphingomyelin hydrolysis to ceramide during the execution phase of apoptosis results from phospholipid scrambling and alters cell-surface morphology
63. Mechanisms by which elevated intracellular calcium induces S49 cell membranes to become susceptible to the action of secretory phospholipase A2
64. 2S in regulating arachidonic acid release and prostaglandin generation - Implications of cyclooxygenase-2 induction and phospholipid scramblase-mediated cellular membrane perturbation
65. ATP-dependent asymmetric distribution of spin-labeled phospholipids in the erythrocyte membrane: Relation to shape changes
66. ATP-dependent aminophospholipid translocation in erythrocyte vesicles: Stoichiometry of transport
67. Maintenance and consequences of membrane phospholipid asymmetry
68. Outside-inside translocation of aminophospholipids in the human erthrocyte membrane is mediated by a specific enzyme
69. Ion regulation of phosphatidylserine and phosphatidylethanolamine outside-inside translocation in human erythrocytes
70. Role of translocases in the generation of phosphatidylserine asymmetry
71. A subfamily of P-type ATPases with aminophospholipid transporting activity
72. Cloning, expression, and chromosomal mapping of a human ATPase II gene, member of the third subfamily of P-type ATPases and orthologous to the presumed bovine and murine aminophospholipid translocase
73. Loss of Drs2p does not abolish transfer of fluorescence-labeled phospholipids across the plasma membrane of Saccharomyces cerevisiae
74. Identification and purification of aminophospholipid flippases
75. Evidence for a role of the multidrug resistance protein (MRP) in the outward translocation of NBD-phospholipids in the erythrocyte membrane
76. Transbilayer movement of NBD-labeled phospholipids in red blood cell membranes: Outward-directed transport by the multidrug resistance protein 1 (MRP1)
77. Multidrug resistance protein 1 regulates lipid asymmetry in erythrocyte membranes
78. Phosphatidylcholine and phosphatidylethanolamine behave as substrates of the human MDR1 P-glycoprotein
79. MDR1 P-glycoprotein is a lipid translocase of broad specificity, while MDR3 P-glycoprotein specifically translocates phosphatidylcholine
80. Biochemistry of multidrug resistance mediated by the multidrug transporter
81. The role of mdr2 P-glycoprotein in hepatobiliary lipid transport
82. Molecular cloning of the human ATP-binding cassette transporter 1 (hABC1): Evidence for sterol-dependent regulation in macrophages
83. The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier disease
84. ABC1 promotes engulfment of apoptotic cells and transbilayer redistribution of phosphatidylserine
85. ABC transporters in lipid transport
86. Platelet procoagulant activity and microvesicle formation. Its putative role in hemostasis and thrombosis
87. Rapid loss and restoration of lipid asymmetry by different pathways in resealed erythrocyte ghosts
88. Aminophospholipid translocation in erythrocytes: Evidence for the involvement of a specific transporter and an endofacial protein
89. Transverse redistribution of phospholipids during human platelet activation: Evidence for a vectorial outflux specific to aminophospholipids
90. Continuous analysis of the mechanism of activated transbilayer lipid movement in platelets
91. Polyamine inhibition of transbilayer movement of plasma membrane phospholipids in the erythrocyte ghost
92. Role of calcium and calpain in complement-induced vesiculation of the platelet plasma membrane and in the exposure of the platelet factor Va receptor
93. Complement proteins C5b-9 cause release of membrane vesicles from the platelet surface that are enriched in the membrane receptor for coagulation factor Va and express prothrombinase activity
94. Expression of coagulant activity in human platelets: Release of membranous vesicles providing platelet factor 1 and platelet factor 3
95. Modulation of membrane fusion by asymmetric transbilayer distributions of amino lipids
96. Phospholipid transverse mobility modifications in plasma membranes of activated platelets: An ESR study
97. 2+-ATPase inhibitors
98. Calcium induces phospholipid redistribution and microvesicle release in human erythrocyte membranes by independent pathways
99. Calcium- and magnesium-induced fusion of mixed phosphatidylserine/phosphatidylcholine vesicles: Effect of ion binding
100. Non-bilayer lipid structures in model and biological membranes
101. 2+-induced phospholipid redistribution in the human erythrocyte membrane
102. Effects of phosphatidyl-inositol diphosphate on phospholipid asymmetry in the human erythrocyte membrane
103. 2+-induced loss of phospholipid asymmetry in the human erythrocyte. A study in Scott Syndrome, a disorder of calcium-induced phospholipid scrambling
104. 2+ and spermine on phosphatidylinositol 4,5-bisphosphate-mediated transmembrane redistribution of phospholipids in large unilamellar vesicles and in erythrocytes
105. Phosphatidylinositol 4,5-bisphosphate domain inducers promote phospholipid transverse redistribution in biological membranes
106. Ultrastructural studies of the interaction of spectrin with phosphatidylserine liposomes
107. Human erythrocyte protein 4.1 is a phosphatidylserine binding protein
108. Interaction of erythrocyte protein 4.1 with phospholipids. A monolayer and liposome study
109. Transbilayer mobility of phospholipids in the erythrocyte membrane. Influence of the membrane skeleton
110. Interaction between phosphatidylserine and the isolated cytoskeleton of human blood platelets
111. Uncoupling of the membrane skeleton from the lipid bilayer. The cause of accelerated phospholipid flip-flop leading to an enhanced procoagulant activity of sickled cells
112. Reconstitution of phospholipid scramblase activity from human blood platelets
113. 2+-dependent transbilayer movement of phospholipid
114. Molecular cloning of human plasma membrane phospholipid scramblase - A protein mediating transbilayer movement of plasma membrane phospholipids
115. Identity of a conserved motif in phospholipid scramblase that is required for Ca2+-accelerated transbilayer movement of membrane phospholipids
116. 2+-dependent transbilayer migration of membrane phospholipids
117. Identification of three new members of the phospholipid scramblase gene family
118. 2+-activated transbilayer movement of membrane phospholipids
119. Regulation of phospholipid scramblase activity during apoptosis and cell activation by protein kinase Cd
120. Identification of genes differentially regulated by interferon α, β, or gamma using oligonucleotide arrays
121. Transcriptional control of the human plasma membrane phospholipid scramblase 1 gene is mediated by interferon-α
122. TRA1, a novel mRNA highly expressed in leukemogenic mouse monocytic sublines but not in non-leukemogenic sublines
123. Identity of human normal counterpart (MmTRA1b) of mouse leukemogenesis-associated gene (MmTRA1a) product as plasma membrane phospholipid scramblase and chromosome mapping of the human MmTRA1b phospholipid scramblase gene
124. Involvement of a novel IFN stimulated gene for phospholipid scramblase in IFN action
125. 2+ sensitivity of phospholipid scrambling in human red cell ghosts
126. 2+ binding site
127. Level of expression of phospholipid scramblase regulates induced movement of phosphatidylserine to the cell surface
128. Identification of a novel secretory leukocyte protease inhibitor-binding protein involved in membrane phospholipid movement
129. c-Abl tyrosine kinase binds and phosphorylates phospholipid scramblase
130. Phosphatidylserine exposure during apoptosis is a cell-type-specific event and does not correlate with plasma membrane phospholipid scramblase expression