Targeting efflux pumps-In vitro investigations with acridone derivatives and identification of a lead molecule for MDR modulation

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 12, 2010, Pages 4212-4223

  Singh, Palwinder ^a   Kaur, Jatinder ^a   Yadav, Bhawna ^b   Komath, Sneha Sudha ^b  

^a GURU NANAK DEV UNIVERSITY   (India)

^b JAWAHARLAL NEHRU UNIVERSITY   (India)

Author keywords

Acridone derivatives; ATP; Candida albicans; Mg2+; Multi drug resistance; P Glycoprotein cdr1p cdr2p

Indexed keywords

10 (3 DIETHYLAMINO 2 HYDROXYPROPYL) 9 OXO 9,10 DIHYDROACRIDINE 4 CARBOXYLIC ACID; 10 (3 DIISOPROPYLAMINO 2 HYDROXYPROPYL) 9 OXO 9,10 DIHYDROACRIDINE 4 CARBOXYLIC ACID; 4 CHLORO 10 [2 HYDROXY 3 (PIPERIDIN 1 YL)PROPYL]ACRIDIN 9(10H) ONE; 4 CHLORO 10 [2 HYDROXY 3 (PYRROLIDIN 1 YL)PROPYL]ACRIDIN 9(10H) ONE; 4 CHLORO 10 [2 HYDROXY 3 [4 (PIPERIDIN 1 YL)PIPERIDI 1 YL]PROPYL]ACRIDIN 9(10H) ONE; 4 CHLORO 10 [3 (DIETHYLAMINO) 2 HYDROXYPROPYL)ACRIDIN 9(10H) ONE; 4 CHLORO 10 [3 (DIISOPROPYLAMINO) 2 HYDROXYPROPYL)ACRIDIN 9(10H) ONE; 4 CHLORO 10(2 HYDROXY 3 MORPHOLINOPROPYL)ACRIDIN 9 (10H) ONE; ACRIDONE DERIVATIVE; ADENOSINE TRIPHOSPHATE; GLYCOPROTEIN P; MAGNESIUM ION; MULTIDRUG RESISTANCE PROTEIN; UNCLASSIFIED DRUG; ACRIDINE DERIVATIVE; ANTIFUNGAL AGENT; MAGNESIUM;

ARTICLE; BIOASSAY; CANDIDA ALBICANS; CHEMICAL INTERACTION; DRUG IDENTIFICATION; DRUG STRUCTURE; FUNGUS GROWTH; IN VITRO STUDY; MOLECULE; MULTIDRUG RESISTANCE; NONHUMAN; STRUCTURE ANALYSIS; ANTAGONISTS AND INHIBITORS; BINDING SITE; CHEMISTRY; COMPUTER SIMULATION; DRUG EFFECTS; METABOLISM; SYNTHESIS; ULTRAVIOLET SPECTROPHOTOMETRY;

ACRIDINES; ACRIDONES; ADENOSINE TRIPHOSPHATE; ANTIFUNGAL AGENTS; BINDING SITES; CANDIDA ALBICANS; COMPUTER SIMULATION; DRUG RESISTANCE, MULTIPLE, FUNGAL; MAGNESIUM; P-GLYCOPROTEINS; SPECTROPHOTOMETRY, ULTRAVIOLET;

CANDIDA ALBICANS;

EID: 77953127284     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.05.003     Document Type: Article

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