Excitation of rat spinal ventral horn neurons by purinergic P2X and P2Y receptor activation

Brain Research

Volumn 1340, Issue , 2010, Pages 10-17

  Aoyama, Takahiro ^a   Koga, Syugo ^a   Nakatsuka, Terumasa ^a   Fujita, Tsugumi ^a   Goto, Masaaki ^a   Kumamoto, Eiichi ^a  

^a SAGA UNIVERSITY   (Japan)

Author keywords

ATP; Excitatory transmission; Patch clamp; Rat; Spinal cord slice; Spinal ventral horn

Indexed keywords

2' 3' O (4 BENZOYLBENZOYL)ADENOSINE 5' TRIPHOSPHATE TRIETHYLAMMONIUM; 2' DEOXY 6 N METHYLADENOSINE 3',5' BISPHOSPHATE; ADENOSINE 5' [GAMMA THIO]TRIPHOSPHATE TETRALITHIUM; ADENOSINE TRIPHOSPHATE; ALPHA,BETA METHYLENEADENOSINE TRIPHOSPHATE; PURINERGIC P2X RECEPTOR; PURINERGIC P2Y RECEPTOR; PURINERGIC RECEPTOR STIMULATING AGENT; PYRIDOXAL PHOSPHATE 6 AZOPHENYL 2',4' DISULFONIC ACID; TETRODOTOXIN; UNCLASSIFIED DRUG; URIDINE DIPHOSPHATE; URIDINE TRIPHOSPHATE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; EXCITATORY POSTSYNAPTIC POTENTIAL; INHIBITORY POSTSYNAPTIC POTENTIAL; ION CURRENT; MEMBRANE DEPOLARIZATION; NERVE CELL EXCITABILITY; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; RAT; SPINAL CORD VENTRAL HORN; SYNAPTIC TRANSMISSION;

ANIMALS; ANTERIOR HORN CELLS; EXCITATORY POSTSYNAPTIC POTENTIALS; ORGAN CULTURE TECHNIQUES; PURINERGIC P2X RECEPTOR AGONISTS; PURINERGIC P2X RECEPTOR ANTAGONISTS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, PURINERGIC; RECEPTORS, PURINERGIC P2Y1; SPINAL CORD;

RATTUS;

EID: 77953122296     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2010.04.053     Document Type: Article

References (27)

1. Abbracchio M.P., Burnstock G., Boeynaems J.-M., Barnard E.A., Boyer J.L., Kennedy C., Knight G.E., Fumagalli M., Gachet C., Jacobson K.A., and Weisman G.A. International union of pharmacology LVIII: update on the P2Y G protein-coupled nucleotide receptors: from molecular mechanisms and pathophysiology to therapy. Pharmacol. Rev. 58 (2006) 281-341
2. + currents in Xenopus spinal neurons by p2y receptors: a role for ATP and ADP in motor pattern generation. J. Physiol. 540 (2002) 843-850
3. Ceruti S., Villa G., Genovese T., Mazzon E., Longhi R., Rosa P., Bramanti P., Cuzzocrea S., and Abbracchio M.P. The P2Y-like receptor GPR17 as a sensor of damage and a new potential target in spinal cord injury. Brain 132 (2009) 2206-2218
4. 7 purinoceptor in mouse NTW8 microglial cells. Br. J. Pharmacol. 121 (1997) 1429-1437
5. 6 receptors and the distribution and properties of an extended family of ATP-gated ion channels. J. Neurosci. 16 (1996) 2495-2507
6. Fields R.D., and Stevens B. ATP: an extracellular signaling molecule between neurons and glia. Trends Neurosci. 23 (2000) 625-633
7. Fujita T., and Kumamoto E. Inhibition by endomorphin-1 and endomorphin-2 of excitatory transmission in adult rat substantia gelatinosa neurons. Neuroscience 139 (2006) 1095-1105
8. Gu J.G., and MacDermott A.B. Activation of ATP P2X receptors elicits glutamate release from sensory neuron synapses. Nature 389 (1997) 749-753
9. Hussl S., and Boehm S. Functions of neuronal P2Y receptors. Pflügers Arch. 452 (2006) 538-551
10. 2+ mobilization in cultured rat spinal neurons. Eur. J. Pharmacol. 302 (1996) 163-169
11. Khakh B.S., and North R.A. P2X receptors as cell-surface ATP sensors in health and disease. Nature 442 (2006) 527-532
12. Kobayashi K., Fukuoka T., Yamanaka H., Dai Y., Obata K., Tokunaga A., and Noguchi K. Neurons and glial cells differentially express P2Y receptor mRNAs in the rat dorsal root ganglion and spinal cord. J. Comp. Neurol. 498 (2006) 443-454
13. Kwon B.K., Tetzlaff W., Grauer J.N., Beiner J., and Vaccaro A.R. Pathophysiology and pharmacologic treatment of acute spinal cord injury. Spine J. 4 (2004) 451-464
14. Li J., and Perl E.R. ATP modulation of synaptic transmission in the spinal substantia gelatinosa. J. Neurosci. 15 (1995) 3357-3365
15. 2X receptors and sensory synaptic transmission between primary afferent fibers and spinal dorsal horn neurons in rats. J. Neurophysiol. 80 (1998) 3356-3360
16. 2+ independent manner in differentiated human skeletal muscle cells. Biochem. Pharmacol. 71 (2006) 1497-1509
17. Müller M., Henrich A., Klockenhoff J., Dierkes P.W., and Schlue W.-R. Effects of ATP and derivatives on neuropile glial cells of the leech central nervous system. Glia 29 (2000) 191-201
18. Nakatsuka T., and Gu J.G. ATP P2X receptor-mediated enhancement of glutamate release and evoked EPSCs in dorsal horn neurons of the rat spinal cord. J. Neurosci. 21 (2001) 6522-6531
19. Nakatsuka T., Park J.-S., Kumamoto E., Tamaki T., and Yoshimura M. Plastic changes in sensory inputs to rat substantia gelatinosa neurons following peripheral inflammation. Pain 82 (1999) 39-47
20. Nashmi R., Velumian A.A., Chung I., Zhang L., Agrawal S.K., and Fehlings M.G. Patch-clamp recordings from white matter glia in thin longitudinal slices of adult rat spinal cord. J. Neurosci. Methods 117 (2002) 159-166
21. North R.A. Molecular physiology of P2X receptors. Physiol. Rev. 82 (2002) 1013-1067
22. North R.A., and Barnard E.A. Nucleotide receptors. Curr. Opin. Neurobiol. 7 (1997) 346-357
23. Peng W., Cotrina M.L., Han X., Yu H., Bekar L., Blum L., Takano T., Tian G.-F., Goldman S.A., and Nedergaard M. Systemic administration of an antagonist of the ATP-sensitive receptor P2X7 improves recovery after spinal cord injury. Proc. Natl. Acad. Sci. U.S.A. 106 (2009) 12489-12493
24. Shiokawa H., Nakatsuka T., Furue H., Tsuda M., Katafuchi T., Inoue K., and Yoshimura M. Direct excitation of deep dorsal horn neurones in the rat spinal cord by the activation of postsynaptic P2X receptors. J. Physiol. 573 (2006) 753-763
25. Sipski M.L., and Pearse D.D. Methylprednisolone and other confounders to spinal cord injury clinical trials. Nat. Clin. Pract. Neurol. 2 (2006) 402-403
26. 4 receptors induced in spinal microglia gate tactile allodynia after nerve injury. Nature 424 (2003) 778-783
27. Wang X., Arcuino G., Takano T., Lin J., Peng W.G., Wan P., Li P., Xu Q., Liu Q.S., Goldman S.A., and Nedergaard M. P2X7 receptor inhibition improves recovery after spinal cord injury. Nat. Med. 10 (2004) 821-827