Lack of evidence for a pathogenic role of proteasome-directed autoimmunity in dilated cardiomyopathy

Basic Research in Cardiology

Volumn 105, Issue 4, 2010, Pages 557-567

  Voigt, Antje ^a   Trimpert, Christiane ^b   Bartel, Katrin ^a   Egerer, Karl ^a   Kuckelkorn, Ulrike ^a   Feist, Eugen ^a   Gericke, Christine ^a   Klingel, Karin ^c   Kandolf, Reinhard ^c   Felix, Stephan B ^b   Baumann, Gert ^a   Kloetzel, Peter M ^a   Stangl, Karl ^a   Staudt, Alexander ^b  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b UNIVERSITY OF GREIFSWALD   (Germany)

^c UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

Autoimmunity; Cardiomyopathy; Immunoadsorption; Proteasome

Indexed keywords

ANGIOTENSIN 1 RECEPTOR ANTAGONIST; AUTOANTIBODY; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; PROTEASOME;

ADULT; ANTIBODY DETECTION; ANTIBODY ISOLATION; ANTIGEN BINDING; ARTICLE; AUTOIMMUNITY; CELL MEMBRANE; CELL SURFACE; CELL VIABILITY; CONGESTIVE CARDIOMYOPATHY; CONTROLLED STUDY; FEMALE; FLUORESCENCE ACTIVATED CELL SORTING; HEART LEFT VENTRICLE EJECTION FRACTION; HEART MUSCLE CELL; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOADSORPTION; IMMUNOFLUORESCENCE; MAJOR CLINICAL STUDY; MALE; PATHOGENESIS;

ANIMALS; AUTOANTIBODIES; CARDIOMYOPATHY, DILATED; CELL NUCLEUS; CYTOPLASM; FEMALE; HUMANS; MALE; MIDDLE AGED; MYOCYTES, CARDIAC; PROTEASOME ENDOPEPTIDASE COMPLEX; RATS; SORPTION DETOXIFICATION;

EID: 77953119910     PISSN: 03008428     EISSN: 14351803     Source Type: Journal    
DOI: 10.1007/s00395-010-0096-1     Document Type: Article

References (47)

1. Arribas J, Rodriguez ML, Forno RAD, Castaño JG (1991) Autoantibodies against the multicatalytic proteinase in patients with systemic lupus-erythematosus. J Exp Med 173:423-427
2. Brychcy M, Kuckelkorn U, Hausdorf G, Egerer K, Kloetzel PM, Burmester GR, Feist E (2006) Anti-20S proteasome autoantibodies inhibit proteasome stimulation by proteasome activator PA28. Arthritis Rheum 54:2175-2183
3. Bureau JP, OlinkCoux M, Brouard N, BayleJulien S, Huesca M, Herzberg M, Scherrer K (1997) Characterization of prosomes in human lymphocyte subpopulations and their presence as surface antigens. Exp Cell Res 231:50-60
4. Buvall L, Bollano E, Chen J, Shultze W, Fu M (2006) Phenotype of early cardiomyopathic changes induced by active immunization of rats with a synthetic peptide corresponding to the second extracellular loop of the human beta(1)-adrenergic receptor. Clin Exp Immunol 143:209-215
5. Caforio ALP, Grazzini M, Mann JM, Keeling PJ, Bottazzo GF, McKenna WJ, Schiaffino S (1992) Identification of alpha-cardiac and beta-cardiac myosin heavy-chain isoforms as major autoantigens in dilated cardiomyopathy. Circulation 85:1734-1742
6. Caforio AL, Tona F, Bottaro S, Vinci A, Dequal G, Daliento L, Thiene G, Iliceto S (2008) Clinical implications of anti-heart autoantibodies in myocarditis and dilated cardiomyopathy. Autoimmunity 41:35-45
7. Colmegna I, Sainz B, Citera G, Maldonado-Cocco JA, Garry RF, Espinoza LR (2008) Anti-20S proteasome antibodies in psoriatic arthritis. J Rheum 35:674-676
8. Dorffel WV, Felix SB, Wallukat G, Brehme S, Bestvater K, Hofmann T, Kleber FX, Baumann G, Reinke P (1997) Short-term hemodynamic effects of immunoadsorption in dilated cardiomyopathy. Circulation 95:1994-1997
9. Feist E, Brychcy M, Hausdorf G, Hoyer B, Egerer K, Dorner T, Kuckelkorn U, Burmester GR (2007) Anti-proteasome autoantibodies contribute to anti-nuclear antibody patterns on human larynx carcinoma cells. Ann Rheum Dis 66:5-11
10. Feist E, Dorner T, Kuckelkorn U, Scheffler S, Burmester GR, Kloetzel PM (2000) Diagnostic importance of anti-proteasome antibodies. Int Arch Allergy Immunol 123:92-97
11. Feist E, Dorner T, Kuckelkorn U, Schmidtke G, Micheel B, Hiepe F, Burmester GR, Kloetzel PM (1996) Proteasome alphatype subunit C9 is a primary target of autoantibodies in sera of patients with myositis and systemic lupus erythematosus. J Exp Med 184:1313-1318
12. Feist E, Kuckelkorn U, Dorner T, Donitz H, Scheffler S, Hiepe F, Kloetzel PM, Burmester GR (1999) Autoantibodies in primary Sjogren's syndrome are directed against proteasomal subunits of the alpha and beta type. Arthritis Rheum 42:697-702
13. Felix SB, Staudt A, Baumann G (2002) Immunoadsorption as a new therapeutic principle for treatment of dilated cardiomyopathy. Eur Heart J 4:163-168
14. Felix SB, Staudt A, Dorffel WV, Stangl V, Merkel K, Pohl M, Docke WD, Morgera S, Neumayer HH, Wernecke KD, Wallukat G, Stangl K, Baumann G (2000) Hemodynamic effects of immunoadsorption and subsequent immunoglobulin substitution in dilated cardiomyopathy-three-month results from a randomized study. J Am Coll Cardiol 35:1590-1598
15. Felix SB, Staudt A, Landsberger M, Grosse Y, Stangl V, Spielhagen T, Wallukat G, Wernecke KD, Baumann G, Stangl K (2002) Removal of cardiodepressant antibodies in dilated cardiomyopathy by immunoadsorption. J Am Coll Cardiol 39:646-652
16. Fu MLX, Schulze W, Wallukat G, Hjalmarson A, Hoebeke J (1996) A synthetic peptide corresponding to the second extracellular loop of the human M2 acetylcholine receptor induces pharmacological and morphological changes in cardiomyocytes by active immunization after 6 months in rabbits. Clin Immunol Immunopathol 80:203-207
17. Goldberg AL (2003) Protein degradation and protection against misfolded or damaged proteins. Nature 426:895-899
18. Harris JR (1968) Release of a macromolecular protein component from human erythrocyte ghosts. Biochim Biophys Acta 150:534-537
19. Harris JR (1969) Isolation and purification of a macromolecular protein component from human erythrocyte ghost. Biochim Biophys Acta 188:31-112
20. Jahns R, Boivin V, Hein L, Triebel S, Angermann CE, Ertl G, Lohse MJ (2004) Direct evidence for a beta(1)-adrenergic receptor-directed autoimmune attack as a cause of idiopathic dilated cardiomyopathy. J Clin Invest 113:1419-1429
21. Jane-Wit D, Altuntas CZ, Johnson JM, Yong S, Wickley PJ, Clark P, Wang Q, Popovic ZB, Penn MS, Damron DS, Perez DM, Tuohy VK (2007) beta(1)-Adrenergic receptor autoantibodies mediate dilated cardiomyopathy by agonistically inducing cardiomyocyte apoptosis. Circulation 116:399-410
22. Jiang YC, Reynolds C, Xiao C, Feng WK, Zhou ZX, Rodriguez W, Tyagi SC, Eaton JW, Saari JT, Kang YJ (2007) Dietary copper supplementation reverses hypertrophic cardiomyopathy induced by chronic pressure overload in mice. J Exp Med 204:657-666
23. Kaya Z, Katus HA (2010) Role of autoimmunity in dilated cardiomyopathy. Basic Res Cardiol 105:7-8
24. Kindermann I, Kindermann M, Kandolf R, Klingel K, Bultmann B, Muller T, Lindinger A, Böhm M (2008) Predictors of outcome in patients with suspected myocarditis. Circulation 118:639-648
25. Kloetzel PM (2001) Antigen processing by the proteasome. Nat Rev Mol Cell Biol 2:179-187
26. Kordonouri O, Meyer K, Egerer K, Hartmann R, Scheffler S, Burmester SSGR, Kuckelhorn U (2004) Prevalence of 20S proteasome, anti-nuclear and thyroid antibodies in young patients at onset of type 1 diabetes mellitus and the risk of autoimmune thyroiditis. J Pediatr Endocrinol Metab 17:975-981
27. Kuhl U, Pauschinger M, Noutsias M, Seeberg B, Bock T, Lassner D, Poller W, Kandolf R, Schultheiss HP (2005) High prevalence of viral genomes and multiple viral infections in the myocardium of adults with " idiopathic" left ventricular dysfunction. Circulation 111:887-893
28. Landsberger M, Staudt A, Choudhury S, Trimpert C, Herda LR, Klingel K, Kandolf R, Schultheiss HP, Kroemer HK, Volker U, Felix SB (2008) Potential role of antibodies against cardiac Kv channel-interacting protein 2 in dilated cardiomyopathy. Am Heart J 156:92-99
29. Liu JH, Mao WK, Iwai CK, Fukuoka S, Vulapalli R, Huang HL, Wang TC, Sharma VK, Sheu SS, Fu M, Liang CS (2008) Adoptive passive transfer of rabbit beta(1)-adrenoceptor peptide immune cardiomyopathy into the Rag2(-/-) mouse: participation of the ER stress. J Mol Cell Cardiol 44:304-314
30. Maron BJ, Towbin JA, Thiene G, Antzelevitch C, Corrado D, Arnett D, Moss AJ, Seidman CE, Young JB (2006) Contemporary definitions and classification of the cardiomyopathies-an American Heart Association Scientific Statement from the Council on Clinical Cardiology, Heart Failure and Transplantation Committee; Quality of Care and Outcomes Research and Functional Genomics and Translations Biology Interdisciplinary Working Groups; and Council on Epidemiology and Prevention. Circulation 113:1807-1816
31. Matsui S, Fu MLX, Katsuda S, Hayase M, Yamaguchi N, Teraoka K, Kurihara T, Takekoshi N, Murakami E, Hoebeke J, Hjalmarson A (1997) Peptides derived from cardiovascular Gprotein-coupled receptors induce morphological cardiomyopathy changes in immunized rabbits. J Mol Cell Cardiol 29:641-655
32. Matsui S, Larsson L, Hayase M, Katsuda S, Teraoka K, Kurihara T, Murano H, Nishikawa K, Fu M (2006) Specific removal of beta 1-adrenoceptor autoantibodies by immunoabsorption in rabbits with autoimmune cardiomyopathy improved cardiac structure and function. J Mol Cell Cardiol 41:78-85
33. Mayo I, Arribas J, Villoslada P, DoForno RA, Rodriguez-Vilarino S, Montalban X, de Sagarra MR, Castano JG (2002) The proteasome is a major autoantigen in multiple sclerosis. Brain 125:2658-2667
34. Müller J, Wallukat G, Dandel M, Bieda H, Brandes K, Spiegelsberger S, Nissen E, Kunze R, Hetzer R (2000) Immunoglobulin adsorption in patients with idiopathic dilated cardiomyopathy. Circulation 101:385-391
35. Nishimura H, Okazaki T, Tanaka Y, Nakatani K, Hara M, Matsumori A, Sasayama S, Mizoguchi A, Hiai H, Minato N, Honjo T (2001) Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice. Science 291:319-322
36. Okazaki T, Tanaka Y, Nishio R, Mitsuiye T, Mizoguchi A, Wang J, Ishida M, Hiai H, Matsumori A, Minato N, Honjo T (2003) Autoantibodies against cardiac troponin I are responsible for dilated cardiomyopathy in PD-1-deficient mice. Nat Med 9:1477-1483
37. Rivett AJ, Palmer A, Knecht E (1992) Electron-microscopic localization of the multicatalytic proteinase complex in rat-liver and in cultured-cells. J Histochem Cytochem 40:1165-1172
38. Schultheiss HP, Kuhl U, Janda I, Melzner B, Ulrich G, Morad M (1988) Antibody-mediated enhancement of calcium permeability in cardiac myocytes. J Exp Med 168:2105-2119
39. Sixt SU, Dahlmann B (2008) Extracellular, circulating proteasomes and ubiquitin-incidence and relevance. Biochim Biophys Acta 1782:817-823
40. Staudt A, Böhm M, Knebel F, Staudt Y, Bischoff C, Hummel A, Borges A, Wallukat G, Delbrück M, Baumann G, Felix SB (2002) Potential role of autoantibodies belonging to the immunoglobulin G-3 subclass in cardiac dysfunction among patients suffering from dilated cardiomyopathy. Circulation 106:2448-2453
41. Staudt A, Dorr M, Staudt Y, Böhm M, Probst M, Empen K, Plotz S, Maschke HE, Hummel A, Baumann G, Felix SB (2005) Role of immunoglobulin G3 subclass in dilated cardiomyopathy: results from protein A immunoadsorption. Am Heart J 150:729-736
42. Staudt A, Eichler P, Trimpert C, Felix SB, Greinacher A (2007) Fc(gamma) receptors Ha on cardiomyocytes and their potential functional relevance in dilated cardiomyopathy. J Am Coll Cardiol 49:1684-1692
43. Staudt A, Hummel A, Ruppert J, Dorr M, Trimpert C, Birkenmeier K, Krieg T, Staudt Y, Felix SB (2006) Immunoadsorption in dilated cardiomyopathy: 6-month results from a randomized study. Am Heart J 152:712.e1-712.e6
44. Staudt A, Staudt Y, Dorr M, Böhm M, Knebel F, Hummel A, Wunderle L, Tiburcy M, Wernecke KD, Baumann G, Felix SB (2004) Potential role of humoral immunity in cardiac dysfunction of patients suffering from dilated cardiomyopathy. J Am Coll Cardiol 44:829-836
45. Szalay G, Meiners S, Voigt A, Lauber J, Spieth C, Speer N, Sauter M, Kuckelkorn U, Zell A, Klingel K, Stangl K, Kandolf R (2006) Ongoing coxsackievirus myocarditis is associated with increased formation and activity of myocardial immunoproteasomes. Am J Pathol 168:1542-1552
46. Voigt A, Bartel K, Egerer K, Trimpert C, Feist E, Gericke C, Kandolf R, Klingel K, Kuckelkorn U, Stangl K, Felix SB, Baumann G, Kloetzel PM, Staudt A (2010) Humoral anti-proteasomal autoimmunity in dilated cardiomyopathy. Basic Res Cardiol 105:9-18
47. Young GW, Wang YJ, Ping PP (2008) Understanding proteasome assembly and regulation: importance to cardiovascular medicine. Trends Cardiovasc Med 18:93-98