Clinical implications of anti-heart autoantibodies in myocarditis and dilated cardiomyopathy

Autoimmunity

Volumn 41, Issue 1, 2008, Pages 35-45

  Caforio, Alida L P ^a   Tona, Francesco ^a   Bottaro, Stefania ^a   Vinci, Annalisa ^a   Dequal, Greta ^a   Daliento, Luciano ^a   Thiene, Gaetano ^a   Iliceto, Sabino ^a  

^a UNIVERSITY OF PADOVA   (Italy)

Author keywords

Antibodies; Cardiomyopathy; Immunology; Myocarditis

Indexed keywords

AUTOANTIBODY; CARDIOTOXIN; STRUCTURAL PROTEIN;

ARTICLE; AUTOIMMUNE DISEASE; CARDIOGENIC SHOCK; CHRONIC INFLAMMATION; CONGESTIVE CARDIOMYOPATHY; ENZYME LINKED IMMUNOSORBENT ASSAY; EXTRACORPOREAL CIRCULATION; FAMILIAL DISEASE; GENE MUTATION; GENERAL CONDITION IMPROVEMENT; GENETIC CORRELATION; GENETIC HETEROGENEITY; HEART FAILURE; HEART MUSCLE BIOPSY; HEART TRANSPLANTATION; HEART VENTRICLE EXTRASYSTOLE; HEART VENTRICLE FAILURE; HEART VENTRICLE FUNCTION; HUMAN; IDIOPATHIC DISEASE; IMMUNE RESPONSE; IMMUNIZATION; IMMUNOADSORPTION; IMMUNOASSAY; IMMUNOMODULATION; IMMUNOSUPPRESSIVE TREATMENT; INFLAMMATORY DISEASE; MYOCARDITIS; NONHUMAN; PATHOGENESIS; RISK REDUCTION; SUDDEN DEATH; SYNCOPE; TREATMENT FAILURE; VIRUS INFECTIVITY; WESTERN BLOTTING;

ANTIBODY SPECIFICITY; AUTOANTIBODIES; AUTOANTIGENS; AUTOIMMUNE DISEASES; CARDIAC MYOSINS; CARDIOMYOPATHY, DILATED; HUMANS; MYOCARDITIS; MYOCARDIUM;

EID: 38049082143     PISSN: 08916934     EISSN: 1607842X     Source Type: Journal    
DOI: 10.1080/08916930701619235     Document Type: Article

References (90)

1. Witebsky, E., Rose, NR and Terplan, K. (1957) Chronic thyroiditis and autoimmunization. JAMA, 164, pp. 1439-1447.
2. Rose, NR and Bona, C. (1993) Defining criteria for autoimmune diseases (Witebsky's postulates revisited). Immunol Today, 14, pp. 426-428.
3. Bottazzo, GF, Todd, I. and Mirakian, R. (1986) Organ-specific autoimmunity. A 1986 overview. Immunol Rev, 94, pp. 137-169.
4. MacLellan, RW and Lusis, AJ (2003) Dilated cardiomyopathy: Learning to live with yourself. Nat Med, 9, pp. 1455-1456.
5. Okazaki, T., Tanaka, Y. and Nishio, R. (2003) Autoantibodies against cardiac troponin I are responsible for dilated cardiomyopathy in PD-1-deficient mice. Nat Med, 9, pp. 1477-1483.
6. Eriksson, U., Ricci, R. and Hunziker, L. (2003) Dendritic cell-induced autoimmune heart failure requires cooperation between adaptive and innate immunity. Nat Med, 9, pp. 1484-1490.
7. Richardson, P., McKenna, WJ and Bristow, M. (1996) Report of the 1995 World Health Organization/International Society and Federation of Cardiology Task Force on the definition and classification of cardiomyopathies. Circulation, 93, pp. 841-842.
8. Centers for Disease Control and Prevention (1998) Changes in mortality from heart failure, United States. JAMA, 280, pp. 874-875.
9. Morita, H., Seidman, J. and Seidman, CE (2005) Genetic causes of human heart failure. J Clin Invest, 115, pp. 518-526.
10. Aretz, HT, Billingham, ME and Edwards, WE (1985) Myocarditis: A histopathologic definition and classification. Am J Cardiovasc Pathol, 1, pp. 1-10.
11. Caforio, ALP and McKenna, WJ (1996) Recognition and optimum treatment of myocarditis. Drugs, 52, pp. 515-525.
12. Caforio, ALP (1994) Role of autoimmunity in dilated cardiomyopathy. Br Heart J, 72, pp. S30-S34.
13. Baig, MK, Goldman, JH and Caforio, ALP (1998) Familial dilated cardiomyopathy: Cardiac abnormalities are common in asymptomatic relatives and may represent early disease. J Am Coll Cardiol, 31, pp. 195-201.
14. Anderson, JL, Carlquist, JF and Lutz, JR (1984) HLA A, B, and DR typing in idiopathic dilated cardiomyopathy: A search for immune response factors. Am J Cardiol, 53, pp. 1326-1330.
15. Caforio, ALP, Stewart, JT and Bonifacio, E. (1990) Inappropriate major histocompatibility complex expression on cardiac tissue in dilated cardiomyopathy. Relevance for autoimmunity?. J Autoimmun, 3, pp. 187-200.
16. Mahon, NG, Madden, B. and Caforio, ALP (2002) Immunohistochemical evidence of myocardial disease in apparently healthy relatives of patients with dilated cardiomyopathy. J Am Coll Cardiol, 39, pp. 455-462.
17. Caforio, ALP, Mahon, NJ and Tona, F. (2002) Circulating cardiac autoantibodies in dilated cardiomyopathy and myocarditis: Pathogenetic and clinical significance. Eur J Heart Fail, 4, pp. 411-417.
18. Caforio, ALP, Keeling, PJ and Zachara, E. (1994) Evidence from family studies for autoimmunity in dilated cardiomyopathy. Lancet, 344, pp. 773-777.
19. Caforio, ALP, Mahon, NG and Baig, KM (2007) Prospective familial assessment in dilated cardiomyopathy. Cardiac autoantibodies predict disease development in asymptomatic relatives. Circulation, 115, pp. 76-83.
20. Fletcher, GF and Wenger, NK (1968) Autoimmune studies in patients with primary myocardial disease. Circulation, 37, pp. 1032-1035.
21. Camp, FT, Hess, EV and Conway, G. (1969) Immunologic findings in idiopathic cardiomyopathy. Am Heart J, 77, pp. 610-615.
22. Kirsner, AB, Hess, EV and Fowler, NO (1973) Immunologic findings in idiopathic cardiomyopathy: A prospective serial study. Am Heart J, 86, pp. 625-630.
23. Maisch, B., Deeg, P. and Liebau, G. (1983) Diagnostic relevance of humoral and cytotoxic immune reactions in primary and secondary dilated cardiomyopathy. Am J Cardiol, 52, pp. 1071-1078.
24. Maisch, B., Deeg, P. and Liebau, G. (1983) Diagnostic relevance of humoral and cell-mediated immune reactions in patients with viral myocarditis. Clin Exp Immunol, 48, pp. 533-545.
25. Neumann, DA, Burek, CL and Baughman, KL (1990) Circulating heart-reactive antibodies in patients with myocarditis or cardiomyopathy. J Am Coll Cardiol, 16, pp. 839-846.
26. Caforio, ALP, Bonifacio, E. and Stewart, JT (1990) Novel organ-specific circulating cardiac autoantibodies in dilated cardiomyopathy. J Am Coll Cardiol, 15, pp. 1527-1534.
27. Caforio, ALP, Wagner, R. and Gill, JS (1991) Organ-specific cardiac antibodies: Serological markers for systemic hypertension in autoimmune polyendocrinopathy. Lancet, 337, pp. 1111-1115.
28. Caforio, ALP, Goldman, JH and Haven, AJ (1997) Circulating cardiac autoantibodies as markers of autoimmunity in clinical and biopsy-proven myocarditis. Eur Heart J, 18, pp. 270-275.
29. Betterle, C., Spadaccino, AC and Pedini, B. (1997) Autoanticorpi nelle malattie autoimmuni del muscolo scheletrico, della giunzione neuro-muscolare e del cuore. Gli autoanticorpi. Manuale-Atlante a colori di diagnostica, pp. 313-337. Piccin, Padova
30. Nicholson, GC, Dawkins, RL and McDonald, BL (1977) A classification of anti-heart antibodies: Differentiation between heart-specific and heterophile antibodies. Clin Immunol Immunopathol, 7, pp. 349-363.
31. Caforio, ALP, Grazzini, M. and Mann, JM (1992) Identification of α and β cardiac myosin heavy chain isoforms as major autoantigens in dilated cardiomyopathy. Circulation, 85, pp. 1734-1742.
32. Caforio, ALP, Goldman, JH and Baig, KM (1997) Cardiac autoantibodies in dilated cardiomyopathy become undetectable with disease progression. Heart, 77, pp. 62-67.
33. Lauer, B., Schannwell, M. and Kuhl, U. (2000) Antimyosin autoantibodies are associated with deterioration of systolic and diastolic left ventricular function in patients with chronic myocarditis. J Am Coll Cardiol, 35, pp. 11-18.
34. Latif, N., Baker, CS and Dunn, MJ (1993) Frequency and specificity of antiheart antibodies in patients with dilated cardiomyopathy detected using SDS-PAGE and western blotting. J Am Coll Cardiol, 22, pp. 1378-1384.
35. Goldman, JH, Keeling, PJ and Warraich, RS (1995) Autoimmunity to α-myosin in a subset of patients with idiopathic dilated cardiomyopathy. Br Heart J, 74, pp. 598-603.
36. Michels, VV, Moll, PP and Rodeheffer, RJ (1994) Circulating heart autoantibodies in familial as compared with nonfamilial idiopathic dilated cardiomyopathy. Mayo Clin Proc, 69, pp. 24-27.
37. Konstandoulakis, MM, Kroumbouzou, H., Tsiamis, E., Trikas, A. and Toutouzas, P. (1993) Clinical significance of antibodies against tropomyosin, actin and myosin in patients with dilated cardiomyopathy. J Clin Lab Immunol, 40, pp. 61-67.
38. Warraich, RS, Dunn, MJ and Yacoub, MH (1999) Subclass specificity of autoantibodies against myosin in patients with idiopathic dilated cardiomyopathy: Proinflammatory antibodies in dilated cardiomyopathy patients. Biochem Biophys Res Commun, 259, pp. 255-261.
39. Portig, I., Pankuweit, S. and Maisch, B. (1997) Antibodies against stress proteins in sera of patients with dilated cardomyopathy. J Mol Cell Cardiol, 29, pp. 2245-2251.
40. Latif, N., Smith, J. and Dunn, MJ (1994) Complement-mediated cytotoxic activity of anti-heart antibodies present in the sera of patients with dilated cardiomyopathy. Autoimmunity, 19, pp. 99-104.
41. Baba, A., Yoshikawa, T. and Ogawa, S. (2002) Autoantibodies against sarcolemmal Na-K-ATPase: Possible upstream targets of arrhythmias and sudden death in patients with dilated cardiomyopathy. J Am Coll Cardiol, 40, pp. 1153-1159.
42. Wolff, PG, Kuhl, U. and Schultheiss, HP (1989) Laminin distribution and autoantibodies to laminin in dilated cardiomyopathy and myocarditis. Am Heart J, 117, pp. 1303-1309.
43. Klein, R., Maisch, B. and Kochsiek, K. (1984) Demonstration of organ specific antibodies against heart mitochondria (anti-M7) in sera from patients with some forms of heart diseases. Clin Exp Immunol, 58, pp. 283-292.
44. Otto, A., Stahle, I. and Klein, R. (1998) Anti-mitochondrial antibodies in patients with dilated cardiomyopathy (anti-M7) are directed against flavoenzymes with covalently bound FAD. Clin Exp Immunol, 111, pp. 541-547.
45. Schultheiss, HP and Bolte, HD (1985) Immunological analysis of auto-antibodies against the adenine nucleotide translocator in dilated cardiomyopathy. J Mol Cell Cardiol, 17, pp. 603-617.
46. Schultheiss, HP, Kuhl, U. and Schwimmbeck, P. (1990) Biomolecular changes in dilated cardiomyopathy. Advances in cardiomyopathies, pp. 221-234. Springer Verlag, Berlin
47. Ansari, AA, Neckelmann, N. and Villinger, F. (1994) Epitope mapping of the branched chain α-ketoacid dehydrogenase dihydrolipoyl transacylase (BCKD-E2) protein that reacts with sera from patients with idiopathic dilated cardiomyopathy. J Immunol, 153, pp. 4754-4765.
48. Pohlner, K., Portig, I. and Pankuweit, S. (1997) Identification of mitochondrial antigens recognized by antibodies in sera of patients with idiopathic dilated cardiomyopathy by two-dimensional gel electrophoresis and protein sequencing. Am J Cardiol, 80, pp. 1040-1045.
49. Schultheiss, HP, Ulrich, G. and Janda, I. (1988) Antibody mediated enhancement of calcium permeability in cardiac myocytes. J Exp Med, 168, pp. 2105-2119.
50. Wallukat, G., Morwinski, M. and Kowal, K. (1991) Antibodies against the β-adrenergic receptor in human myocarditis and dilated cardiomyopathy: β-Adrenergic agonism without desensitization. Eur Heart J, 12, pp. 178-181.
51. Limas, CJ, Goldenberg, IF and Limas, C. (1989) Autoantibodies against β-adrenoceptors in idiopathic dilated cardiomyopathy. Circ Res, 64, pp. 97-103.
52. Limas, CJ and Limas, C. (1991) β-Receptor antibodies and genetics in dilated cardiomyopathy. Eur Heart J, 12, pp. 175-177.
53. Magnusson, Y., Marullo, S. and Hoyer, S. (1990) Mapping of a functional autoimmune epitope on the β-adrenergic receptor in patients with idiopathic dilated cardiomyopathy. J Clin Invest, 86, pp. 1658-1663.
54. 1-adrenoceptor with positive chronotropic effect. Circulation, 89, pp. 2760-2767.
55. Jahns, R., Boivin, V. and Siegmund, C. (1999) Autoantibodies activating human β1-adrenergic receptors are associated with reduced cardiac function in chronic heart failure. Circulation, 99, pp. 649-654.
56. Jahns, R., Boivin, V. and Krapf, T. (2000) Modulation of β1-adrenoceptor activity by domain-specific antibodies and heart-failure associated autoantibodies. J Am Coll Cardiol, 36, pp. 1280-1287.
57. Fu, LX, Magnusson, Y. and Bergh, CH (1993) Localization of a functional autoimmune epitope on the muscarinic acetylcholine receptor-2 in patients with idiopathic dilated cardiomyopathy. J Clin Invest, 91, pp. 1964-1968.
58. Marriott, JB, Goldman, JH, Keeling, PJ, Baig, MK, Dalgleish, AG and McKenna, WJ (1996) Abnormal cytokine profiles in patients with idiopathic dilated cardiomyopathy and their asymptomatic relatives. Heart, 75, pp. 287-290.
59. Rose, NR (2000) Viral damage or "molecular mimicry"-placing the blame in myocarditis. Nat Med, 6, pp. 631-632.
60. Kuan, AP, Zuckier, L. and Liao, L. (2000) Immunoglobulin isotype determines pathogenicity in antibody-mediated myocarditis in naïve mice. Circ Res, 86, pp. 281-285.
61. Neu, N., Rose, NR and Beisel, KW (1987) Cardiac myosin induces myocarditis in genetically predisposed mice. J Immunol, 139, pp. 3630-3636.
62. Smith, SC and Allen, PM (1991) Myosin-induced myocarditis is a T cell-mediated disease. J Immunol, 147, pp. 2141-2147.
63. Zweiman, B. and Arnason, BGW (1987) Immunologic aspects of neurological and neuromuscolar diseases. JAMA, 258, pp. 2970-2973.
64. Bonifacio, E., Bingley, PJ and Shattock, M. (1990) Quantitation of islet-cell antibodies and prediction of insulin-dependent diabetes. Lancet, 335, pp. 147-149.
65. Mahon, NG, Murphy, RT, MacRae, C., Caforio, ALP, Elliott, PM and McKenna, WJ (2005) Echocardiographic evaluation in asymptomatic relatives of dilated cardiomyopathy patients reveals preclinical disease. Ann Intern Med, 143, pp. 108-115.
66. Mrena, S., Savola, K. and Kulmala, P. (2003) Genetic modification of risk assessment based on staging of preclinical type 1 diabetes in siblings of affected children. J Clin Endocrinol Metab, 88, pp. 2682-2689.
67. Warraich, RS, Griffiths, E. and Falconar, A. (2006) Human cardiac myosin autoantibodies impair myocyte contractility: A cause-and-effect relationship. FASEB J, 20, pp. 651-660.
68. Horwitz, MS, La Cava, A. and Fine, C. (2000) Pancreatic expression of interferon-γ protects mice from lethal coxsackievirus B3 infection and subsequent myocarditis. Nat Med, 6, pp. 693-707.
69. Galvin, JE, Hemric, ME and Ward, K. (2000) Cytotoxic mAb from rheumatic carditis recognizes heart valves and laminin. J Clin Invest, 106, pp. 217-224.
70. Li, Y., Heuser, JS, Cunningham, LC, Kosanke, SD and Cunningham, MW (2006) Mimicry and antibody-mediated cell signaling in autoimmune myocarditis. J Immunol, 177, pp. 8234-8240.
71. Nishimura, H., Okazaki, T. and Tanaka, Y. (2001) Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice. Science, 291, pp. 319-322.
72. Mobini, R., Staudt, A. and Felix, SB (2003) Hemodynamic improvement and removal of autoantibodies against the β1-adrenergic receptor by immunoadsorption therapy in dilated cardiomyopathy. J Autoimmun, 20, pp. 345-350.
73. Okazaki, T. and Honjo, T. (2005) Pathogenic roles of cardiac autoantibodies in dilated cardiomyopathy. Trends Mol Med, 11, pp. 322-326.
74. Urayama, O., Shutt, H. and Sweadner, J. (1989) Identification of three isozyme proteins of the catalytic subunit of the Na, K-ATPase in rat brain. J Biol Chem, 264, pp. 8271-8280.
75. Muller-Ehmsen, J., Juvvadi, P. and Thompson, CB (2001) Ouabain and substrate affinities of human Na-K-ATPase α1β-1, α-2β-1, α-3β-1, when expressed separately in yeast cells. Am J Physiol Cell Physiol, 281, pp. C1355-C1364.
76. Schwinger, RH, Wang, J. and Frank, K. (1999) Reduced sodium pump α1-, α3-, β1-isoform protein levels and Na,K-ATPase activity but unchanged Na/Ca exchanger protein levels in human heart failure. Circulation, 99, pp. 2105-2112.
77. Matsui, S., Fu, ML and Katsuda, S. (1997) Peptides derived from cardiovascular G-protein-coupled receptors induce morphological cardiomyopathic changes in immunized rabbits. J Mol Cell Cardiol, 29, pp. 641-655.
78. Jahns, R., Boivin, V. and Hein, L. (2004) Direct evidence for a β1-adrenergic receptor directed autoimmune attack as a cause of idiopathic dilated cardiomyopathy. J Clin Invest, 113, pp. 1419-1429.
79. Jahns, R., Boivin, V. and Lohse, MJ (2006) β1-Adrenergic receptor function, autoimmunity and pathogenesis of dilated cardiomyopathy. Trends Cardiovasc Med, 16, pp. 20-24.
80. Eglen, RM, Reddy, H. and Watson, N. (1994) Muscarinic acetylcholine receptor subtypes in smooth muscle. Trend Pharmacol Sci, 15, pp. 114-119.
81. Elalouf, JM, Buhler, JM and Tessiot, C. (1993) Predominant expression of beta 1-adrenergic receptor in the thick ascending limb of rat kidney: Absolute mRNA quantitation by reverse trascription and polymerase chain reaction. J Clin Invest, 91, pp. 264-272.
82. Mason, JW, O'Connell, JB and Herskowitz, A. (1995) A clinical trial of immunosuppressive therapy for myocarditis. N Engl J Med, 333, pp. 269-275.
83. Wojnicz, R., Nowalany-Kozielska, E. and Wojciechowska, C. (2001) Randomized, placebo controlled study for immunosuppressive treatment of inflammatory dilated cardiomyopathy. Two-year follow-up results. Circulation, 104, pp. 39-45.
84. Frustaci, A., Chimenti, C., Calabrese, F., Pieroni, M., Thiene, G. and Maseri, A. (2003) Immunosuppressive therapy for active lymphocytic myocarditis: Virological and immunologic profile of responders versus nonresponders. Circulation, 107, pp. 857-863.
85. Muller, J., Wallukat, G. and Dandel, M. (2000) Immunoglobulin adsorption in patients with idiopathic dilated cardiomyopathy. Circulation, 101, pp. 385-391.
86. Schimke, I., Muller, J. and Priem, F. (2001) Decreased oxidative stress in patients with idiopathic dilated cardiomyopathy one year after immunoglobulin adsorption. J Am Coll Cardiol, 38, pp. 178-183.
87. Felix, SB, Staudt, A. and Landsberger, M. (2002) Removal of cardiodepressant antibodies in dilated cardiomyopathy by immunoadsorption. J Am Coll Cardiol, 39, pp. 646-652.
88. Staudt, A., Bohm, M. and Knebel, F. (2002) Potential role of autoantibodies belonging to the immunoglobulin G-3 subclass in cardiac dysfunction among patients with dilated cardiomyopathy. Circulation, 106, pp. 2448-2453.
89. Mann, DL (2001) Autoimmunity, immunoglobulin adsorption and dilated cardiomyopathy: Has the time come for randomized clinical trials?. J Am Coll Cardiol, 38, pp. 184-186.
90. Gullestad, L., Aass, H. and Fjeld, JG (2001) Immunomodulating therapy with intravenous immunoglobulin in patients with chronic heart failure. Circulation, 103, pp. 220-225.