Proteasome α-type subunit C9 is a primary target of autoantibodies in sera of patients with myositis and systemic lupus erythematosus

Journal of Experimental Medicine

Volumn 184, Issue 4, 1996, Pages 1313-1318

  Feist, E ^a   Dorner T ^a   Kuckelkorn, U ^a   Schmidtke, G ^a   Micheel, B ^b   Hiepe, F ^a   Burmester, G R ^a   Kloetzel, P M ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; PROTEASOME;

ANTIGEN ANTIBODY REACTION; ARTICLE; AUTOIMMUNITY; DERMATOMYOSITIS; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; IMMUNE RESPONSE; MAJOR HISTOCOMPATIBILITY COMPLEX; MYOSITIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; SYSTEMIC LUPUS ERYTHEMATOSUS;

EID: 0029952778     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.184.4.1313     Document Type: Article

References (28)

1. Rivett, A.J. 1993. Proteasomes: multicatalytic proteinase complexes. Biochem. J. 291:1-10.
2. Amsterdam, A., F. Pitzer, and W. Baumeister. 1993. Changes in intracellular localization of proteasomes in immortalized ovarian granulosa cells during mitosis associated with a role in cell cycle control. Proc Natl. Acad. Sci. USA. 90:99-103.
3. Dawson S.P., J.E. Arnold, N.J. Mayer, S.E. Reynolds, M.A. Billett, C. Gordon, L. Colleaux, P.M. Kloetzel, K. Tanaka, and R.J. Mayer. 1995. Developmental changes of the 26S proteasome in abdominal intersegmental muscles of Manduca sexta during programmed cell death. J. Biol. Chem. 270: 1850-1858.
4. Palombella, V.J., O.J. Rando, A.L. Goldberg, and T. Maniatis. 1994. The ubiquitin-proteasome pathway is required for processing the NF-kappa B1 precursor protein and the activation of NF-kappa B. Cell. 78:773-785.
5. Ahn, J.Y., N. Tanahashi, K. Akiyama, H. Hisamatsu, C. Noda, K. Tanaka, C.H. Chung, N. Shibmara, P.J. Willy, J.D. Mott, et al. 1995. Primary structures of two homologous subunits of PA28, a gamma-interferon-inducible protein activator of the 20S proteasome. FEBS Lett. 366:37-42.
6. Fehling, H.J., W. Swat, C. Laplace, R. Kuhn, K. Rajewsky, U. Muller, and H. von Boehmer. 1994. MHC class I expression in mice lacking the proteasome subunit LMP-7. Science (Wash. DC). 265:1234-1237.
7. Kania, M.A., G.N. Demartino, W. Baumeister, and A.L. Goldberg. 1996. The proteasome subunit, C2, contains an important site for binding of the PA28 (11S) activator. Eur. J. Biochem. 236:510-516.
8. Groettrup, M., A. Soza, M. Eggers, L. Kuehn, T.B. Dick, H. Schild, H.-G. Rammensee, U.H. Koszinowski, and P.M. Kloetzel. 1996. A role for the proteasome regulator PA28 in antigen presentation. Nature (Lond.). 381:166-168.
9. Nederlof, P.M., H.R. Wang, and W. Baumeister. 1995. Nuclear localization signals of human and Thermoplasma proteasomal alpha subunits are functional in vitro. Proc. Natl. Acad. Sci. USA. 92:12060-12064.
10. Puhler, G., S. Weinkauf, L. Bachmann, S. Muller, A. Engel, R. Hegerl, and W. Baumeister. 1992. Subunit stoichiometry and three-dimensional arrangement in proteasomes from Thermoplasma acidophilum. EMBO (Eur. Mol. Biol. Organ.) J. 11:1607-1616.
11. Seemüller, E., A. Lupas, D. Stock, J. Löwe, R. Huber, and W. Baumeister. 1995. Proteasome from Thermoplasma acidophilum: a threonine protease. Science (Was. DC). 268: 579-582.
12. Dalakas, M.C. 1991. Polymyositis, dermatomyositis and inclusion-body myositis. N. Engl. J. Med. 325:1487-1498.
13. Bernstein, R.M., S.H. Morgan, J. Chapman, C.C. Bunn, M.B. Mathews, M. Turner Warwick, and G.R. Hughes. 1984. Anti-Jo-1 antibody: a marker for myositis with interstitial lung disease. Br. Med. J. Clin. Res. Ed. 289:151-152.
14. Bohan, A., and J.B. Peter. 1975. I. Polymyositis and dermatomyositis. N. Engl. J. Med. 292:344-347.
15. Bohan, A., and J.B. Peter. 1975. II. Polymyositis and dermatomyositis. N. Engl. J. Med. 292:403-407.
16. Tan, E.M., A.S. Cohen, J.F. Fries, A.T. Masi, D.J. McShane, N.F. Rochfield, J.G. Schaller, N. Talal, and R.J. Winchester. 1982. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum. 25:1271-1277.
17. Sharp, G.C., W.S. Irvin, C.M. May, H.R. Holman, F.C. McDuffie, E.V. Hess, and F.R. Schmid. 1976. Association of antibodies to ribonucleoprotein and Sm antigens with mixed connective-tissue disease, systematic lupus erythematosus and other rheumatic diseases. N. Engl. J. Med. 295:1149-1154.
18. Arnett, F.C., S.M. Edworthy, D.A. Bloch, D.J. McShane, J.F. Fries, N.S. Cooper, L.A. Healey, S.R. Kaplan, M.H. Liang, H.S. Luthra, et al. 1988. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum. 31:315-324.
19. Kuckelkorn, U., S. Frentzel, R. Kraft, S. Kostka, M. Groettrup, and P.-M. Kloetzel. 1995. Incorporation of major histocompatibility complex-encoded subunits LMP2 and LMP7 changes the quality of the 20S proteasome polypeptide processing products independent of interferon-γ. Eur. J. Immunol. 25:2605-2611.
20. O'Farrell, P.Z., H.M. Goodman, and P.H. O'Farrell. 1977. High resolution two-dimensional electrophoresis of basic as well as acidic proteins. Cell. 12:1133-1141.
21. Böttger, V., B. Micheel, G. Scharte, G. Kaiser, G. Wolf, and H. Schmechta. 1996. Monoclonal antibodies to human chorionic gonadotropin (HCG) and their use in two-site binding enzyme immunoassay. Hybridoma. (In press).
22. Micheel, B., P. Jantscheff, V. Böttger, G. Scharte, G. Kaiser, P. Stolley, and L. Karawajew. 1988. The production and radioimmunoassay application of monoclonal antibodies to fluorescein isothiocyanate (FITC). J. Immunol. Methods. 111:89-94.
23. + T cell clone from a myasthenia gravis patient. J. Neuroimmunol. 46:57-65.
24. Targoff, I.N. 1994. Immune manifestations of inflammatory muscle disease. Rheum. Dis. Clin. N. Am. 20:857-880.
25. Targoff, I.N., E.P. Trieu, and F.W. Miller. 1993. Reaction of anti-OJ autoantibodies with components of the multi-enzyme complex of aminoacyl-tRNA synthetases in addition to isoleucyl-tRNA synthetase. J. Clin. Invest. 91:2556-2564.
26. Arribas, J., M. Luz Rodriguez, R. Alvarez Do Forno, and J.G. Castano. 1991. Autoantibodies against the multicatalytic proteinase in patients with systemic lupus erythematosus. J. Exp. Med. 173:423-427.
27. von Mühlen, C.A., and E.M. Tan. 1995. Autoantibodies in the diagnosis of systemic rheumatic diseases. Semin. Arthritis Rheum. 24:323-358.
28. Alarcón-Segovia, D., A. Ruiz-Argüelles, and L. Llorente. 1996. Broken dogma: penetration of autoantibodies into living cells. Immunol. Today 17:163-164.