Prevalence of 20S proteasome, anti-nuclear and thyroid antibodies in young patients at onset of type 1 diabetes mellitus and the risk of autoimmune thyroiditis

Journal of Pediatric Endocrinology and Metabolism

Volumn 17, Issue 7, 2004, Pages 975-981

  Kordonouri, Olga ^a   Meyer, Kathrin ^a   Egerer, Karl ^a   Hartmann, Reinhard ^a   Scheffler, Sonja ^a   Burmester, Gerd R ^a   Kuckelkorn, Ulrike ^a   Danne, Thomas ^b   Feist, Eugen ^a  

^a HUMBOLDT UNIVERSITY   (Germany)

^b Children's Hospital Auf der Bult   (Germany)

Author keywords

Anti nuclear antibodies; Anti proteasome antibodies; Anti TPO antibodies; Children; GADA; IA2 A

Indexed keywords

ANTINUCLEAR ANTIBODY; B LYMPHOCYTE ANTIGEN; GLUTAMATE DECARBOXYLASE; INSULIN; PROTEASOME; PROTEIN SUBUNIT; PROTEIN TYROSINE PHOSPHATASE; THYROGLOBULIN; THYROID ANTIBODY; THYROID PEROXIDASE; THYROTROPIN;

ADOLESCENT; ADULT; ARTICLE; CHILD; CONTROLLED STUDY; DISEASE COURSE; ECHOGRAPHY; FEMALE; FOLLOW UP; GOITER; HASHIMOTO DISEASE; HIGH RISK PATIENT; HUMAN; HUMAN TISSUE; IMMUNOFLUORESCENCE TEST; INSULIN DEPENDENT DIABETES MELLITUS; JUVENILE DIABETES MELLITUS; MAJOR CLINICAL STUDY; MALE; PREVALENCE; RADIOIMMUNOASSAY; THYROTROPIN BLOOD LEVEL;

EID: 4344639685     PISSN: 0334018X     EISSN: None     Source Type: Journal    
DOI: 10.1515/JPEM.2004.17.7.975     Document Type: Article

References (25)

1. Mandrup-Poulsen T. Diabetes. Br Med J 1998; 316: 1221-1225.
2. Batstra MR, Aanstoot HJ, Herbrink P. Prediction and diagnosis of type 1 diabetes using beta-cell autoantibodies. Clin Lab 2001; 47: 497-507.
3. Presotto F, Betterle C. Insulin-dependent diabetes mellitus: a constellation of autoimmune diseases. J Pediatr Endocrinol Metab 1997; 10: 455-469.
4. Burek CL, Rose NR, Guire KE, Hoffmann WH. Thyroid autoantibodies in Black and White children and adolescents with type 1 diabetes mellitus and their first-degree relatives. Autoimmunity 1990; 7: 157-167.
5. Holl RW, Böhm B, Loos U, Grabert M, Heinze E, Homoki J. Thyroid autoimmunity in children and adolescents with type 1 diabetes mellitus. Effect of age, gender and HLA type. Horm Res 1999; 52: 113-118.
6. Lorini R, d'Annunzio G, Vitali L, Scaramuzza A. IDDM and autoimmune thyroid disease in the pediatric age group. J Pediatr Endocrinol Metab 1996; 9 (Suppl 1): 89-94.
7. Cronin CC, Shanahan F. Insulin-dependent diabetes mellitus and coeliac disease. Lancet 1999; 349: 1096-1097.
8. Seufert W, Jentsch S. In vivo function of the proteasome in the ubiquitin pathway. EMBO J 1992; 11: 3077-3080.
9. Richter-Ruoff RB, Heinemeyer W, Wolf DH. The proteasome/multicatalytic-multifunctional proteinase. In vivo function in the ubiquitin-dependent N-end rule pathway of protein degradation in eukaryotes. FEBS Lett 1992; 302: 192-196.
10. Feist E, Dörner T, Kuckelkorn U, Schmidtke G, Micheel B, Hiepe F, Burmester GR, Kloetzel PM. Proteasome beta-type subunit C9 is a primary target of autoantibodies in sera of patients with myositis and systemic lupus erythematosus. J Exp Med 1996; 184: 1313-1318.
11. Feist E, Kuckelkorn U, Dörner T, Dönitz H, Scheffler S, Hiepe F, Kloetzel PM, Burmester GR. Autoantibodies in primary Sjögren's syndrome are directed against proteasomal subunits of the alpha- and beta-type. Arthritis Rheum 1999; 42: 697-702.
12. Liesenkötter KP, Kiebler A, Stach B, Willgerodt H, Grüters A. Small thyroid volumes and normal iodine excretion in Berlin schoolchildren indicate full normalization of iodine supply. Exp Clin Endocrinol Diabetes 1997; 105 (Suppl 4): 46-50.
13. Kordonouri O, Hartmann R, Grüters-Kieslich A, Knip M, Danne T. Age-specific levels of diabetes-related GAD and IA-2 antibodies in healthy children and adults. J Pediatr Endocrinol Metab 2002; 15: 47-52.
14. Kabelitz M. Die Autoimmun-Thyreoiditis bei Kindern und Jugendlichen in Berlin. Eine prospektive klinischexperimentelle Studie zur Prävalenz von Schilddrüsen-Autoantikörpern bei Kindern und Jugendlichen in Berlin in Korrelation zur verbesserten Jod-Versorgung [Thesis]. Munich: Academus Verlag, 2001.
15. Kuckelkorn U, Frentzel S, Kraft R, Kostka S, Groettrup M, Kloetzel PM. Incorporation of major histocompatibility complex-encoded subunits LMP2 and LMP7 changes the quality of the 20S proteasome polypeptide processing products independent of interferon-gamma. Eur J Immunol 1995; 25: 2605-2611.
16. O'Farrell PZ, Goodman HM, O'Farrell PH. High resolution two-dimensional electrophoresis of basic as well as acidic proteins. Cell 1977; 12: 1133.
17. Bonifacio E, Genovese S, Braghi S, Bazzigaluppi E, Lampasona V, Bingley PJ, Rogge L, Pastore MR, Bognetti E, Bottazzo GF, et al. Islet autoantibody markers in IDDM: risk assessment strategies yielding high sensitivity. Diabetologia 1995; 38: 816-822.
18. Lorini R, Larizza D, Livieri C, Cammareri V, Martini A, Plebani A, Zanaboni D, Severi F. Autoimmunity in children with diabetes mellitus and in their relatives. Eur J Pediatr 1986; 145: 182-184.
19. Vahasalo P, Petays T, Knip M, Miettinen A, Saukkonen T, Karjalainen J, Savilahti E, Åkerblom HK. Relation between antibodies to islet cell antigens, other auto-antigens and cow's milk proteins in diabetic children and unaffected siblings at the clinical manifestation of IDDM. The Childhood Diabetes in Finland Study Group. Autoimmunity 1996; 23: 165-174.
20. Inamo Y, Harada K. Antinuclear antibody positivity in paediatric patients with autoimmune thyroid disease. J Rheumatol 1997; 24: 576-578.
21. Morita S, Arima T, Matsuda M. Prevalence of non-specific autoantibodies in autoimmune thyroid diseases. J Clin Endocrinol Metab 1995; 80: 1203-1206.
22. Weetman AP, Walport MJ. The association of autoimmmune thyroiditis with systemic lupus erythematosus. Br J Rheum 1987; 26: 359-361.
23. Green LM, LaBue M, Lazarus JP, Colbrun KK. Characterization of autoimmune thyroiditis in MRL-lpr/lpr mice. Lupus 1995; 4: 187-196.
24. Watanabe-Fukunaga R, Brannan CI, Copeland NG, Jenkins NA, Nagata S. Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis. Nature 1992; 356: 314-317.
25. DeFranco S, Bonissoni S, Cerutti F, Bona G, Bottarel F, Cadario F, Brusco A, Loffredo G, Rabbone I, Corrias A, Pignata C, Ramenghi U, Dianzani U. Defective function of Fas in patients with type 1 diabetes associated with other autoimmune diseases. Diabetes 2001; 50: 483-488.