A synthetic peptide corresponding to the second extracellular loop of the human M2 acetylcholine receptor induces pharmacological and morphological changes in cardiomyocytes by active immunization after 6 months in rabbits

Clinical Immunology and Immunopathology

Volumn 78, Issue 2, 1996, Pages 203-207

  Fu, Michael L X ^a   Schulze, Wolfgang ^b   Wallukat, Gerd ^b   Hjalmarson, Åke ^a   Hoebeke, Johan ^c  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^c CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; CHOLINERGIC RECEPTOR; CHOLINERGIC RECEPTOR ANTIBODY; MYELIN; SYNTHETIC PEPTIDE;

ANIMAL EXPERIMENT; ARTICLE; AUTOIMMUNITY; CARDIOTOXICITY; CELL INFILTRATION; ENZYME LINKED IMMUNOSORBENT ASSAY; ETIOLOGY; HISTOPATHOLOGY; IMMUNIZATION; MUSCLE CELL; NONHUMAN; PRIORITY JOURNAL; RABBIT; RAT; ULTRASTRUCTURE;

EID: 0029915086     PISSN: 00901229     EISSN: None     Source Type: Journal    
DOI: 10.1006/clin.1996.0030     Document Type: Article

References (21)

1. Wallukat, G., and Wollenberger, A., Effects of the gamma-globulin fraction of patients with allergic asthma and dilated cardiomyopathy on chronotropic β-adrenoceptor function in cultured neonatal rat heart myocytes. Biomed. Biochim. Acta 46, 634-639, 1987.
2. Limas, C. J., Goldenberg, I. F., and Limas, C., Autoantibodies against β-adrenoceptors in human dilated cardiomyopathy. Circ. Res. 64, 97-103, 1989.
3. Borda, E., Pascual, J., Cossio, P., De La Vega, M., Araña, R., and Sterin-Borda, L., A circulating IgG in Chagas' disease which binds to β-adrenoceptors of myocardium and modulates their activity. Clin. Exp. Immunol. 57, 679-686, 1984.
4. Goin, C. G., Borda, E., Segovia, A., and Sterin-Borda, L., Distribution of antibodies against β-adrenoceptors in the course of human Trypanosoma cruzi infection. Proc. Soc. Exp. Biol. Med. 197, 186-192, 1991.
5. Hoebeke, J., Guillet, J. G., and Strosberg, A. D., Use of receptors expressed in Escherichia coli to study autoimmunity against G-protein coupled membrane proteins. In "Methods in Neurosciences" (S. C. Sealfon, Ed.), pp. 345-365, Academic Press, San Diego, 1995.
6. Fu, L. X. M., Magnusson, Y., Bergh, C-H, Waagstein, F., Hjalmarson, A., and Hoebeke, J., Localization of a functional autoimmune epitope on the second extracellular loop of the human muscarinic receptor in patients with idiopathic dilated cardiomyopathy. J. Clin. Invest. 91, 1964-1968, 1993.
7. Fu, L. X. M., Wallukat, G., Hjalmarson, A., and Hoebeke, J., Agonist-like activity of anti-peptide antibodies to an autoimmune epitope on the second extracellular loop of the human heart muscarinic receptor. Receptors Channels 2, 121-130, 1994.
8. Peralta, E. G., Winslow, J. W., Peterson, G. L., Smith, D. H., Ashkenazi, A., Ramachandran, J., Schimerlik, M. I., and Capon, D. J., Primary structure and biochemical properties of an M2 muscarinic receptor. Science 230, 600-605, 1987.
9. Wallukat, G., and Wollenberger, A., Differential α- and β-adrenergic responsiveness of beating rat heart myocytes after stationary or non-stationary cultivation. Acta Biol. Med. Germ. 39, K7-K13, 1980.
10. Fu, L. X. M., Bergh, C-H., Hoebeke, J., Liang, Q. M., Sjögren, K. G., Waagstein, F., and Hjalmarson, Å., Effect of metoprolol on activity of receptors coupled to G-proteins in adriamycin-induced cardiotoxicity. Basic Res. Cardiol. 86, 117-126, 1991.
11. McPherson, G. A., Kinetic, EBDA, Ligand, Lowry (Manual). "Biosoft," Elsevier, Amsterdam, 1985.
12. Fu, L. X. M., Schulze, W., Wolf, W. P., Hjalmarson, Å., and Hoebeke, J., Immunocytochemical localization of M2 muscarinic receptor in rat ventricles using anti-peptide antibodies. J. Histochem. Cytochem. 42, 337-343, 1994.
13. Schulze, W., Fu, L. X. M., Hoebeke, J., and Hjalmarson, Å., Localization of muscarinic receptors in human heart biopsies using rabbit anti-peptide antibodies. J. Mol. Cell. Cardiol. 27, 1757-1764, 1995.
14. Fu, L. X. M., Hoebeke, J., Matsui, S., Matoba, M., Magnusson, Y., Hedner, T., Herlitz, H., and Hjalmarson, Å., Autoantibodies against cardiac G-protein-coupled receptors define different populations with cardiomyopathies but not with hypertension. Clin. Immunol. Immunopathol. 72, 15-20, 1994.
15. Mastui, S., Fu, L. X. M., Shimizu, M., Fukuoka, T., Asaji, T., Teraoka, K., Hirakawa, T., Takekoshi, N., and Murakami, E., Serum autoantibodies against G-protein coupled cardiac receptors in patients with dilated cardiomyopathy. Autoimmunity 21, 85-88, 1995.
16. Magnusson, Y., Wallukat, G., Waagstein, F., Hjalmarson, Å., and Hoebeke, J., Autoimmunity in idiopathic dilated cardiomyopathy. Characterization of antibodies against the β1-adrenoceptor with positive chronotropic effect. Circulation 89, 2760-2767, 1994.
17. Wallukat, G., Morwinski, M., Kowal, K., Foerster, A., Boewer, V., and Wollenberger, A., Autoantibodies against the β-adrenergic receptor in human myocarditis and dilated cardiomyopathy: β-Adrenergic agonism without desensitization. Eur. Heart J. 12(Suppl. D), 178-181, 1991.
18. McKinney, B., "Pathology of the Cardiomyopathy," pp. 29-47, Butterworth, Bath, UK, 1974.
19. Neu, N., Rose, N. R., Beisel, K. W., Herskowitz, A., Gurri-Glass, G., and Craig, S. W., Cardiac myosin induces myocarditis in genetically predisposed mice. J. Immunol. 139, 3630-3636, 1987.
20. Goodwin, J. F., Mechanisms in cardiomyopathies. J. Mol. Cell. Cardiol. 17, 5-9, 1985.
21. Rose, N. R., and Bona, C., Defining criteria for autoimmune diseases (Witebsky's postulates revisited). Immunol. Today 14, 426-430, 1993.