2′,3′-Dideoxynucleoside 5′-β,γ- (difluoromethylene) triphosphates with α-P-thio or α-P-seleno modifications: Synthesis and their inhibition of HIV-1 reverse transcriptase

Nucleosides, Nucleotides and Nucleic Acids

Volumn 24, Issue 10-12, 2005, Pages 1651-1664

  Boyle, Nicholas A ^a,b   Fagan, Patrick ^a   Brooks, Jennifer L ^a   Prhavc, Marija ^a   Lambert, John ^a   Cook, P Dan ^a  

^a Biota Inc   (United States)

^b NONE   (United States)

Author keywords

AZT; Drug resistance; HIV 1; Polymerase selectivity; Reverse transcriptase; Seleno triphosphate; Thio triphosphate; Triphosphate mimic

Indexed keywords

2',3' DIDEOXY 3' AZIDOTHYMIDINE 5' ALPHA 4 SELENO BETA,GAMMA (DIFLUOROMETHYLENE)TRIPHOSPHATE; 2',3' DIDEOXY 3' FLUOROTHYMIDINE 5' ALPHA 4 THIO BETA,GAMMA (DIFLUOROMETHYLENE)TRIPHOSPHATE; 2',3' DIDEOXYNUCLEOSIDE DERIVATIVE; ANTIVIRUS AGENT; NUCLEOSIDE TRIPHOSPHATE; NUCLEOTIDE; PHOSPHATE; PRODRUG; RNA DIRECTED DNA POLYMERASE; RNA DIRECTED DNA POLYMERASE INHIBITOR; UNCLASSIFIED DRUG; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; ORGANOSELENIUM DERIVATIVE; SULFIDE;

ARTICLE; BIOLOGICAL ACTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION; PHOSPHORYLATION; CHEMISTRY; DRUG ANTAGONISM; SYNTHESIS;

HUMAN IMMUNODEFICIENCY VIRUS 1;

ANTI-HIV AGENTS; DIDEOXYNUCLEOSIDES; HIV-1 REVERSE TRANSCRIPTASE; ORGANOSELENIUM COMPOUNDS; REVERSE TRANSCRIPTASE INHIBITORS; SULFIDES;

EID: 29244487909     PISSN: 15257770     EISSN: 15322335     Source Type: Journal    
DOI: 10.1080/15257770500267055     Document Type: Article

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