Naturally occurring asteriscunolide A induces apoptosis and activation of mitogen-activated protein kinase pathway in human tumor cell lines

Molecular Carcinogenesis

Volumn 49, Issue 5, 2010, Pages 488-499

  Negrín, Gledy ^a   Eiroa, José L ^a   Morales, Manuel ^a   Triana, Jorge ^a   Quintana, José ^a   Estévez, Francisco ^a  

^a UNIVERSITY OF LAS PALMAS DE GRAN CANARIA   (Spain)

Author keywords

Apoptosis; c Jun N terminal kinases; Caspases; Cell cycle arrest; DNA fragmentation; Extracellular signal regulated kinases; Mitogen activated protein kinases; Reactive oxygen species; Sesquiterpene lactones

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ACETYLCYSTEINE; ASTERISCUNOLIDE A; BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; CASPASE 3; CYTOCHROME C; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PHOSPHATIDYLSERINE; POLY(ADENOSINE DIPHOSPHATE RIBOSE); PROTEIN BCL 2; PROTEIN BCL XL; REACTIVE OXYGEN METABOLITE; SESQUITERPENE LACTONE DERIVATIVE; UNCLASSIFIED DRUG; LACTONE; SESQUITERPENE;

APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL DEATH; CELL SURFACE; CELL VIABILITY; CYTOTOXICITY; DNA FRAGMENTATION; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IC 50; LEUKEMIA; LEUKEMIA CELL; MELANOMA; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TUMOR CELL LINE; CELL CYCLE; DRUG EFFECT; METABOLISM; TRANSMISSION ELECTRON MICROSCOPY; WESTERN BLOTTING;

APOPTOSIS; BLOTTING, WESTERN; CELL CYCLE; CELL LINE, TUMOR; ENZYME ACTIVATION; HUMANS; LACTONES; MAP KINASE SIGNALING SYSTEM; MICROSCOPY, ELECTRON, TRANSMISSION; REACTIVE OXYGEN SPECIES; SESQUITERPENES;

EID: 77953029184     PISSN: 08991987     EISSN: 10982744     Source Type: Journal    
DOI: 10.1002/mc.20629     Document Type: Article

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