Increased expression and activation of cytosolic phospholipase A 2 in the spinal cord of patients with sporadic amyotrophic lateral sclerosis

Acta Neuropathologica

Volumn 119, Issue 3, 2010, Pages 345-354

  Shibata, Noriyuki ^a   Kakita, Akiyoshi ^b   Takahashi, Hitoshi ^b   Ihara, Yuetsu ^c   Nobukuni, Keigo ^c   Fujimura, Harutoshi ^d   Sakoda, Saburo ^e   Kobayashi, Makio ^a  

^a TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

^b NIIGATA UNIVERSITY   (Japan)

^c Department of Internal Medicine   (Japan)

^d TONEYAMA NATIONAL HOSPITAL   (Japan)

^e OSAKA UNIVERSITY   (Japan)

Author keywords

Amyotrophic lateral sclerosis; Arachidonate; Glial activation; Inflammation; Motor neuron death; Oxidative stress; Phospholipase A 2; Plasma membrane injury

Indexed keywords

PHOSPHOLIPASE A2;

ADULT; AGE DISTRIBUTION; AGED; AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; ASTROCYTE; CELL ACTIVATION; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOSOL; DENSITOMETRY; DISEASE DURATION; ENZYME ACTIVATION; FEMALE; HISTOPATHOLOGY; HUMAN; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; IN VIVO STUDY; MALE; MICROGLIA; MOTONEURON; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; SPINAL CORD;

ADULT; AGED; AGED, 80 AND OVER; AMYOTROPHIC LATERAL SCLEROSIS; ANTIBODIES; ASTROCYTES; AUTOPSY; BLOTTING, WESTERN; CYTOSOL; DENSITOMETRY; ENZYME ACTIVATION; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MICROGLIA; MIDDLE AGED; MOTOR NEURONS; PHOSPHOLIPASES A2; PHOSPHORYLATION; SPINAL CORD;

EID: 77953021561     PISSN: 00016322     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00401-009-0636-7     Document Type: Article

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