Activation of signal transducer and activator of transcription-3 in the spinal cord of sporadic amyotrophic lateral sclerosis patients

Neurodegenerative Diseases

Volumn 6, Issue 3, 2009, Pages 118-126

  Shibata, Noriyuki ^a   Kakita, Akiyoshi ^b   Takahashi, Hitoshi ^b   Ihara, Yuetsu ^c   Nobukuni, Keigo ^c   Fujimura, Harutoshi ^d   Sakoda, Saburo ^e   Sasaki, Shoichi ^a   Iwata, Makoto ^a   Morikawa, Shunichi ^a   Hirano, Asao ^f   Kobayashi, Makio ^a  

^a TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

^b NIIGATA UNIVERSITY   (Japan)

^c Department of Internal Medicine   (Japan)

^d TONEYAMA NATIONAL HOSPITAL   (Japan)

^e OSAKA UNIVERSITY   (Japan)

^f MONTEFIORE MEDICAL CENTER   (United States)

Author keywords

Amyotrophic lateral sclerosis; Immunoblotting; Immunohistochemistry; Inflammation; Microglia; Neuroinflammation; Signal transducer and activator of transcription

Indexed keywords

NUCLEAR PROTEIN; STAT3 PROTEIN;

ADULT; AGED; AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; AUTOPSY; CELLULAR DISTRIBUTION; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOPLASM; DEATH; DENSITOMETRY; DISEASE DURATION; ENZYME ACTIVATION; FEMALE; GENE TRANSLOCATION; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPOTHESIS; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MALE; MICROGLIA; PHENOTYPE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SPINAL CORD; UPREGULATION;

ADULT; AGED; AGED, 80 AND OVER; AMYOTROPHIC LATERAL SCLEROSIS; BLOTTING, WESTERN; ENZYME ACTIVATION; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MICROGLIA; MIDDLE AGED; PHOSPHORYLATION; PROTEIN TRANSPORT; SPINAL CORD; STAT3 TRANSCRIPTION FACTOR; UP-REGULATION;

EID: 64549164008     PISSN: 16602854     EISSN: 16602862     Source Type: Journal    
DOI: 10.1159/000213762     Document Type: Article

References (47)

1. Goodall EF, Morrison KE: Amyotrophic lateral sclerosis (motor neuron disease): proposed mechanisms and pathways to treatment. Expert Rev Mol Med 2006; 8: 1-22.
2. Kwong LK, Uryu K, Trojanowski JQ, Lee VM: TDP-43 proteinopathies: neurodegenerative protein misfolding diseases without amyloidosis. Neurosignals 2008; 16: 41-51.
3. Ledere CW, Santama N: Amyotrophic lateral sclerosis - the tools of trait. Biotechnol J 2007; 2: 608-621.
4. Andersen JK: Oxidative stress in neurodegeneration: cause or consequence? Nat Med 2004; 10(suppl):S18-S25.
5. Carri MT, Ferri A, Cozzolino M, Calabrese L, Rotilio G: Neurodegeneration in amyotrophic lateral sclerosis: the role of oxidative stress and altered homeostasis of metals. Brain Res Bull 2003; 61: 365-374.
6. Reynolds A, Laurie R, Mosley RL, Gendelman HE: Oxidative stress and the pathogenesis of neurodegenerative disorders. Int Rev Neurobiol 2007; 82: 297-325.
7. Van Den Bosch L, Van Damme P, Bogaert E, Robberecht W: The role of excitotoxicity in the pathogenesis of amyotrophic lateral sclerosis. Biochim Biophys Acta 2006; 1762: 1068-1082.
8. Bendotti C, Bao Cutrona M, Cheroni C, Grignaschi G, Lo Coco D, Peviani M, Tortarolo M, Veglianese P, Zennaro E: Inter- and intracellular signaling in amyotrophic lateral sclerosis: role of p38 mitogen-activated protein kinase. Mol Signal 2005; 2: 128-134.
9. Neusch C, Bähr M, Schneider-Gold C: Glia cells in amyotrophic lateral sclerosis: new clues to understanding an old disease? Muscle Nerve 2007; 35: 712-724.
10. Sargsyan SA, Monk PN, Shaw PJ: Microglia as potential contributors to motor neuron injury in amyotrophic lateral sclerosis. Glia 2005; 51: 241-253.
11. Sekine Y, Takeda K, Ichijo H: The ASK1-MAP kinase signaling in ER stress and neurodegenerative diseases. Curr Mol Med 2006; 6: 87-97.
12. Kiaei M, Kipiani K, Petri S, Choi DK, Chen J, Calingasan NY, Beal MF: Intregrative role of cPLA 2 with COX-2 and the effect of nonsteroidal anti-inflammatory drugs in transgenic mouse model of amyotrophic lateral sclerosis. J Neurochem 2005; 93: 403-411.
13. Henkel JS, Engelhardt JL, Siklós L, Simpson EP, Kim SH, Pan T, Goodman JC, Siddique T, Beers DR, Appel SH: Presence of dendritic cells, MCP-1, and activated microglia/macrophages in amyotrophic lateral sclerosis spinal cord tissue. Ann Neurol 2004; 55: 221-235.
14. Karamouzis MV, Konstantinopoulos PA, Papavassiliou AG: The role of STATs in lung carcinogenesis: an emerging target for novel therapeutics. J Mol Med 2007; 85: 427-436.
15. O'Shea JJ, Gadina M, Schreiber RD: Cytokine signaling in 2002: new surprises in the Jak/Stat pathway. Cell 2002; 109:S121-S131.
16. Murray PJ: The JAK-STAT signaling pathway: input and output integration. J Immunol 2007; 178: 2623-2629.
17. Quensnelle KM, Boehm AL, Grandis JR: STAT-mediated EGFR signaling in cancer. J Cell Biochem 2007; 102: 311-319.
18. Schindler C, Levy DE, Decker T: JAK-STAT signaling: from interferons to cytokines. J Biol Chem 2007; 282: 20059-20063.
19. Silva CM: Role of STATs as downstream signal transducers in Src family kinase-mediated tumorigenesis. Oncogene 2004; 23: 8017-8023.
20. Ambrosini E, Aloisi F: Chemokines and glial cells: a complex network in the central nervous system. Neurochem Res 2004; 29: 1017-1038.
21. Garden GA, Möller T: Microglia biology in health and disease. J Neuroimmune Pharmacol 2006; 1: 127-137.
22. John GR, Lee SC, Brosnan CF: Cytokines: powerful regulators of glial cell activation. Neuroscientist 2003; 9: 10-22.
23. k B activation precedes glial reactivity in the excitotoxically injured young cortex but not in the corresponding distal thalamic nuclei. J Neuropathol Exp Neurol 2000; 59: 151-163.
24. Jee Y, Kim G, Tanuma N, Matsumto Y: STAT expression and localization in the central nervous system during autoimmune encephalomyelitis in Lewis rats. J Neuroimmunol 2001; 114: 40-47.
25. Satriotomo I, Bowen KK, Vemuganti R: JAK2 and STAT3 activation contributes to neuronal damage following transient focal cerebral ischemia. J Neurochem 2006; 98: 1353-1368.
26. Shibata N, Kawaguchi-Niida M, Yamamoto T, Toi S, Hirano A, Kobayashi M: Effects of the PPAR activator pioglitazone on p38 MAP kinase and I B in the spinal cord of a transgenic mouse model of amyotrophic lateral sclerosis. Neuropathology 2008; 28: 387-398.
27. Sapan CV, Lundblad RL, Price NC: Colorimetric protein assay techniques. Biotechnol Appl Biochem 1999; 29: 99-108.
28. Cao D, Tal TL, Graves LM, Gilmour I, Linak W, Reed W, Bromberg PA, Samet JM: Diesel exhaust particulate-induced activation of Stat3 requires activities of EGFR and Src in airway epithelial cells. Am J Physiol Lung Cell Mol Physiol 2007; 292:L422-L429.
29. Carballo M, Conde M, Bekay RE, Martin-Nieto J, Camacho MJ, Monteseirín J, CondeJ, Bedoya FJ, Sobrino F: Oxidative stress triggers STAT3 tyrosine phosphorylation and nuclear translocation in human lymphocytes. J Biol Chem 1999; 274: 17580-17586.
30. Dikdan GS, Saha SC, Dela Torre AN, Roth J, Wang S, Koneru B: Role of oxidative stress in the increased activation of signal transducers and activators of transcription-3 in the fatty livers of obese Zucker rats. Surgery 2004; 136: 677-685.
31. Madamanchi NR, Li S, Patterson C, Runge MS: Reactive oxygen species regulate heatshock protein 70 via the JAK/STAT pathway. Arterioscler Thromb Vasc Biol 2001; 21: 321-326.
32. Mazière C, Conte MA, Mazière JC: Activation of Jak2 by the oxidative stress generated with oxidized low-density lipoprotein. Free Radic Biol Med 2001; 31: 1334-1340.
33. Platt DH, Bartoli M, El-Remessy A, Al-Shabrawey M, Lemtalsi T, Fulton D, Caldwell RB: Peroxynitrite increases VEGF expression in vascular endothelial cells via STAT3. Free Radic Biol Med 2005; 39: 1353-1361.
34. Schieffer B, Luchtefeld M, Braun S, Hilfiker A, Hilfiker-Kleiner D, Drexler H: Role of NAD(P)H oxidase in angiotensin II-induced JAK/STAT signaling and cytokine induction. Circ Res 2000; 87: 1195-1201.
35. Beal MF, Ferrante RJ, Browne SE, Matthews RT, Kowall NW, Brown RH Jr: Increased 3-nitrotyrosine in both sporadic and familial amyotrophic lateral sclerosis. Ann Neurol 1997; 42: 646-654.
36. Ferrante RJ, Browne SE, Shinobu LA, Bowling AC, Baik MJ, MacGarvey U, Kowall NW, Brown RH Jr, Beal MF: Evidence of increased oxidative damage in both sporadic and familial amyotrophic lateral sclerosis. J Neurochem 1997; 69: 2064-2074.
37. Fitzmaurice PS, Shaw IC, Kleiner HE, Miller RT, Monks TJ, Lau SS, Mitchell JD, Lynch PG: Evidence for DNA damage in amyotrophic lateral sclerosis. Muscle Nerve 1996; 19: 797-798.
38. Shibata N, Nagai R, Uchida K, Horiuchi S, Yamada S, Hirano A, Kawaguchi M, Yamamoto T, Sasaki S, Kobayashi M: Morphological evidence for lipid peroxidation and protein glycoxidation in spinal cords from sporadic amyotrophic lateral sclerosis patients. Brain Res 2001; 917: 97-104.
39. Shibata N, Yamada S, Uchida K, Hirano A, Sakoda S, Fujimura H, Sasaki S, Iwata M, Toi S, Kawaguchi M, Yamamoto T, Kobayashi M: Accumulation of protein-bound 4-hydroxy-2-hexenal in spinal cords from patients with sporadic amyotrophic lateral sclerosis. Brain Res 2004; 1019: 170-177.
40. Shibata T, Iio K, Kawai Y, Shibata N, Kawaguchi M, Toi S, Kobayahi M, Kobayahi M, Yamamoto K, Uchida K: Identification of a lipid peroxidation product as a potential trigger of the p53 pathway. J Biol Chem 2006; 281: 1196-1204.
41. Chappell VL, Le LX, LaGrone L, Mileski WJ: Stat proteins play a role in tumor necrosis factor alpha gene expression. Shock 2000; 14: 400-402.
42. Dronadula N, Liu Z, Wang C, Cao H, Rao GN: STAT-3-dependent cytosolic phospholipase A 2 expression is required for thrombin-induced vascular smooth muscle cell motility. J Biol Chem 2005; 280: 3112-3120.
43. Kim OS, Park EJ, Joe EH, Jou I: JAK-STAT signaling mediates gangliosides-induced inflammatory responses in brain microglial cells. J Biol Chem 2002; 277: 40594-40601.
44. Monroe RK, Halvorsen SW: Cadmium blocks receptor-mediated Jak/STAT signaling in neurons by oxidative stress. Free Radic Biol Med 2006; 41: 493-502.
45. Suzuki S, Tanaka K, Nogawa S, Dembo T, Kosakai A, Fukuuchi Y: Phosphorylation of signal transducer and activator of transcription-3 (Stat3) after focal cerebral ischemia in rats. Exp Neurol 2001; 170: 63-71.
46. Yu HM, Zhi JL, Cui Y, Tang EH, Sun SN, Feng JQ, Chen PX: Role of the JAK/STAT pathway in protection of hydrogen peroxide preconditioning against apoptosis induced by oxidative stress in PC12 cells. Apoptosis 2006; 11: 931-941.
47. Larsen L, Röpke C: Suppressors of cytokine signalling: SOCS. Acta Pathol Microbiol Immunol Scand 2002; 10: 833-844.