A causative role for redox cycling of myoglobin and its inhibition by alkalinization in the pathogenesis and treatment of rhabdomyolysis-induced renal failure

Journal of Biological Chemistry

Volumn 273, Issue 48, 1999, Pages 31731-31737

  Moore, Kevin P ^a   Holt, Steve G ^a   Patel, Rakesh P ^b   Svistunenko, Dimitri A ^e   Zackert, William ^c   Goodier, David ^a   Reeder, Brandon J ^e   Clozel, Martine ^d   Anand, Radhi ^a   Cooper, Christopher E ^e   Morrow, Jason D ^c   Wilson, Michael T ^e   Darley Usmar, Victor ^b   Jackson Roberts II, L ^c  

^a ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^c VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^d Preclinical Research   (Switzerland)

^e UNIVERSITY OF ESSEX   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALI; ISOPROSTANE; LOW DENSITY LIPOPROTEIN; MYOGLOBIN;

ALKALINIZATION; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ELECTRON SPIN RESONANCE; KIDNEY FAILURE; LIPID PEROXIDATION; NONHUMAN; OXIDATION REDUCTION REACTION; PH; PRIORITY JOURNAL; RAT; RHABDOMYOLYSIS; ULTRAVIOLET SPECTROSCOPY;

ANIMALS; BICARBONATES; DINOPROST; DISEASE MODELS, ANIMAL; ELECTRON SPIN RESONANCE SPECTROSCOPY; GLYCEROL; HUMANS; HYDROGEN-ION CONCENTRATION; KIDNEY; KIDNEY FAILURE; LIPOPROTEINS, LDL; METMYOGLOBIN; MYOGLOBIN; OXIDATION-REDUCTION; POTASSIUM COMPOUNDS; RATS; RHABDOMYOLYSIS; SPECTROPHOTOMETRY; VASOCONSTRICTION;

ANIMALIA;

EID: 0033610847     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.273.48.31731     Document Type: Article

References (15)

1. Bywaters, E. G., and Beall, D. (1941) Br. Med. J. 1, 427-432
2. Better, O. S., and Stein, J. H. (1990) N. Engl. J. Med. 322, 825-829
3. Grossman, R. A., Hamilton, R. W., Morse, B. M., Penn, A. S., and Goldberg, M. (1974) N. Engl. J. Med. 291, 807-811
4. Ayer, G., Grandchamp, A., Wyler, T., and Truniger, B. (1971) Circ. Res. 29, 128-135
5. Kurtz, T. W., Maletz, R. M., and Hsu, C. H. (1976) Circ. Res. 38, 30-35
6. Venkatachalam, M. A., Rennke, H. G., and Sandstrom, D. J. (1976) Circ. Res. 38, 267-279
7. Shah, S. V., and Walker, P. D. (1988) Am. J. Physiol. 255, F438-F443
8. Salahudeen, A. K., Wang, C., Bigler, S. A., Dai, Z., and Tachikawa, H. (1996) Nephrol. Dial. Transplant. 11, 635-642
9. Paller, M. S. (1988) Am. J. Physiol. 255, F539-F544
10. Nath, K A., Dvergsten, J., Correa-Rotter, R., Hosteller, T. H., Manivel, J. C., and Rosenberg, M. E. (1994) Lab. Invest. 71, 209-218
11. Abul-Ezz, S. R., Walker, P. D., and Shah, S. V. (1991) Proc. Natl. Acad. Sci. U. S. A. 88, 9833-9837
12. Zager, R. A. (1989) Lab. Invest. 60, 619-629
13. Zager, R. A., and Foerder, C. A. (1992) J. Clin. Invest. 89, 989-995
14. Zager, R. A., and Burkhart, K. (1997) Kidney Int. 51, 728-738
15. Zager, R. A. (1992) J. Clin. Invest. 90, 711-719