Neural circuitry associated with risk for alcohol use disorders

Neuropsychology Review

Volumn 20, Issue 1, 2010, Pages 1-20

  Tessner, K D ^a   Hill, Shirley Y ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Amygdala; Cerebellum; High risk offspring; Limbic system; MRI; Neuropsychology

Indexed keywords

ALCOHOLISM; BIOLOGICAL MODEL; BRAIN; GENETIC PREDISPOSITION; GENETICS; HUMAN; NERVE TRACT; PATHOPHYSIOLOGY; REVIEW; RISK;

ALCOHOL-RELATED DISORDERS; BRAIN; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MODELS, NEUROLOGICAL; NEURAL PATHWAYS; RISK;

EID: 77953006435     PISSN: 10407308     EISSN: 15736660     Source Type: Journal    
DOI: 10.1007/s11065-009-9111-4     Document Type: Review

References (273)

1. Acheson, A., Robinson, J. L., Glalin, D. C., Lovallo, W. R., & Fox, P. T. (2009). Differential activation of the anterior cingulate cortex and caudate nucleus during a gambling simulation in persons with a family history of alcoholism: studies from the Oklahoma Family Health. Patterns Project Drug and Alcohol Dependence, 100(1-2), 17-23.
2. Alheid, G. F., & Heimer, L. (1988). New perspectives in basal forebrain organization of special relevance for neuropsychiatrie disorders: the striatopallidal, amygdaloid, and corticopetal components of substantia innominate. Neuroscience, 27(1), 1-39.
3. Anand, B. K., Malhotra, C. L., Singh, B., & Dua, S. (1959). Cerebellar projections to limbic system. Journal of Neurophysiology, 22(4), 451-457.
4. August, G. J., Winter's, K. C., Realmuto, G. M., Fahnhorst, T., Botzet, A., & Lee, S. (2006). Prospective study of adolescent drug use among community samples of ADHD and non-ADHD participants. American Journal of Medical Genetics Part B: Neuropsychiatric Genetici, 45(1), 824-832.
5. Babor, T. F., Hofmann, M., DelBoca, F. K., Hesseibrock, V., Meyer, R. E., Dolinsky, Z. S., et al. (1992). Types of alcoholics I. Evidence for an empirically derived typology based on indicators of vulnerability and severity. Archives of General Psychiatry, 49 (8), 599-608.
6. Badre, D., & Wagner, A. D. (2007). Left ventrolateral prefrontal cortex and the cognitive control of memory. Neuropsychologia, 45(13), 2883-2901.
7. Baillieux, H., De Smet, H. J., Paquier, P. F., De Deyn, P. P., & Marien, P. (2008). Cerebellar neurocognition: insights into the bottom of the brain. Clinical Neurology and Neurosurgery, 110 (8), 763-773.
8. Barkley, R. A. (2004). The executive functions and self regulation: An evolutionary neuropsychological perspective. Neuropsychology Review, 11, 1-20.
9. Barkley, R. A., Grodzinsky, G., & DuPaul, G. J. (1992). Frontal lobe functions in attention deficit disorder with and without hyperactivity: a review and research report. Journal of Abnormal Child Psychology, 20(2), 163-188.
10. Barkley, R. A., Fischer, M., Smallish, L., & Fletcher, K. (2004). Young adult follow-up of hyperactive children: antisocial activities and drug use. Journal of Child Psychology and Psychiatry, 45(2), 195-211.
11. Bates, M E., & Labouvie, E. W. (1994). Familial alcoholism and personality-environment fit. A developmental study of risk in adolescents. Annals of the New York Academy of Sciences, 708, 202-213.
12. Begleiter, H., & Porjesz, B. (1999). What is inherited in the predisposition toward alcoholism? A proposed model. Alcoholism, Clinical and Experimental Research, 23(1), 1125-1135.
13. Begleiter, H., Porjesz, B., Bihari, B., & Kissin, B. (1984). Eventrelated brain potentials in boys at risk for alcoholism. Science, 225(4669), 1493-1496.
14. Benegal, V., Antony, G., Venkatasubramanian, G., & Jayakumar, P. N. (2007). Gray matter volume abnormalities and externalizing symptoms in subjects at high risk for alcohol dependence. Addiction Biology, 12(1), 122-132.
15. Biederman, J., Newcorn, J., & Sprich, S. (1991). Comorbidity of attention deficit hyperactivity disorder with conduct, depressive, anxiety, and other disorders. American Journal of Psychiatry, 148 (5), 564-577.
16. Biederman, J., Wilens, T., Mick, E., Faraone, S. V., Weber, W., Curtis, S., et al. (1997). Is ADHD a risk factor for psychoactive substance use disorders? Findings from a four-year prospective follow-up study. Journal of Amer Acadedmy of Child and Adolescent Psychiatry, 36 (1), 21-29.
17. Biederman, J., Wilens, T. E., Mick, E., Faraone, S. V., & Spencer, T. (1998). Does attention-deficit hyperactivity disorder impact the developmental course of drug and alcohol abuse and dependence? Biological Psychiatry, 44(4), 269-273.
18. Biederman, J., Petty, C. R., Dolan, C., Hughes, S., Mick, E., Monuteaux, M. C., et al. (2008). The long-term longitudinal course of oppositional defiant disorder and conduct disorder in ADHD boys: findings from a controlled 10-year prospective longitudinal, followup study. Psychological Medicine, 38(1), 1027-1036.
19. Bjork, J. M., Knutson, B., & Hommer, D. W. (2008). Incentiveelicited striatal activation in adolescent children of alcoholics. Addiction, 103(8), 1308-1319.
20. Blair, R. J. (2001). Neurocognitive models of aggression, the antisocial personality disorders, and psychopathy. Journal of Neurology, Neurosurgery and Psychiatry, 71(6), 727-731.
21. Blair, R. J., Peschardt, K. S., Budhani, S., Mitchell, D. G., & Pine, D. S. (2006). The development of psychopathy. Journal of Child Psychology and Psychiatry, 47(3-4), 262-276.
22. Blum, K., Braverman, E. R., Holder, J. M., Lubar, J. F., Monastra, V. J., Miller, D., et al. (2000). Reward deficiency syndrome: a biogenetic model for the diagnosis and treatment of impulsive, addictive, and compulsive behaviors. Journal of Psychoactive Drugs, 32, 1-112.
23. Bohman, M. (1978). Some genetic aspects of alcoholism and criminality. A population of adoptees. Archives of General Psychiatry, 35(3), 269-276.
24. Bowirrat, A., & Oscar-Berman, M. (2005). Relationship between dopaminergic neurotransmission, alcoholism, and Reward Deficiency syndrome. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 132B(1), 29-37.
25. Brake, W. G., Flores, G., Francis, D., Meaney, M., Srivastava, L. K., & Gratton, A. (2000). Enhanced nucleus accumbens dopamine and plasma corticosterone stress responses in adult rats with neonatal excitotoxic lesions to the medial prefrontal cortex. Neuroscience, 96, 687-695.
26. Brown, L. L., Tomarken, A. J., Orth, D. N., Loosen, P. T., Kalin, N. H., & Davidson, R. J. (1996). Individual differences in repressivedefensiveness predict basal salivary Cortisol. Journal of Personality and Social Psychology, 70, 362-371.
27. Brückl, T. M., Wittchen, H. U., Höfler, M., Pfister, H., Schneider, S., & Lieb, R. (2007). Childhood separation anxiety and the risk of subsequent psychopathology: Results from, a community study. Psychotherapy and Psychosomatics, 76(1), 47-56.
28. Carmona, S., Vilarroya, O., Bielsa, A., Trèmols, V., Soliva, J. C., Rovira, M., et al. (2005). Global and regional gray matter reductions in ADHD: a voxel-based morphometric study. Neuroscience Letters, 389, 88-93.
29. Caspi, A., Moffitt, T. E., Newman, D. L., & Silva, P. A. (1996). Behavioral observations at age 3 years predict adult psychiatric disorders. Longitudinal evidence from a birth cohort. Archives of General Psychiatry, 53(11), 1033-1039.
30. Chassin, L., Pitts, S. C., DeLucia, C., & Todd, M. (1999). A longitudinal study of children of alcoholics: predicting young adult substance use disorders, anxiety, and depression. Journal Abnormal Psychology, 108(1), 106-119.
31. Clark, D. B., Moss, H. B., Kirisci, L., Mezzich, A. C., Miles, R., & Ott, P. (1997). Psychopathology in preadolescent sons of fathers with substance use disorders. Journal of Amer Academy of Child and Adolescent Psychiatry, 36(4), 495-502.
32. Clark, D. B., Cornelius, J., Wood, D. S., & Vanukov, M. (2004). Psychopathology risk transmission in children of parents with substance use disorders. American Journal of Psychiatry, 161, 685-691.
33. Cloninger, C. R. (1987). Neurogenetic adaptive mechanisms in alcoholism. Science, 236, 410-416.
34. Cloninger, C. R., Bohman, M., & Sigvardsson, S. (1981). Inheritance of alcohol abuse. Cross-fostering analysis of adopted men. Archives of General Psychiatry, 38(8), 861-868.
35. Cockerham, W. C., Kunz, G., & Lueschen, G. (1.989). Alcohol use and psychological distress: a comparison of Americans and West Germans. International Journal of the Addictions, 24( 10), 951-961.
36. Cohen, H. L., Porjesz, B., Begleiter, H., & Wang, W. (1997). Neurophysiologies, correlates of response production and inhibition in alcoholics. Alcoholism, Clinical and Experimental Research, 21(8), 1398-1406.
37. Colomina, M. T., Canals, J., Carbajo, G., & Domingo, J. L. (1997). Salivary Cortisol in a young population: Relationship with psychopathological disorders. Research Communications in Giological Psychology and Psychiatry, 22, 1-10.
38. Comings, D. E., & Blum, K. (2000). Reward deficiency syndrome: genetic aspects of behavioral disorders. Progress in Brain Research, 126, 325-341.
39. Corral, M. M., Holguin, S. R., & Cadaveira, F. (1999). Neuropsychological characteristics in children of alcoholics: familial density. Journal of Studies on Alcohol, 60(4), 509-513.
40. Corral, M., Holguin, S. R., & Cadaveira, F. (2003). Neuropsychological characteristics of young children from high-density alcoholism families: a three-year follow-up. Journal of Studies on Alcohol, 64 (2), 195-199.
41. Costa, L., Bauer, L., Kuperman, S., Porjesz, B., O'Connor, S., Hesselbrock, V., et al. (2000). Frontal P300 decrements, alcohol dependence, and antisocial personality disorder. Biological Psychiatry, 47(12), 1064-1071.
42. Crowe, S. L., & Blair, R. J. (2008). The development of antisocial behavior: what can we learn from functional neuroimaging studies? Development and Psychopathology, 20 (4), 1145-1159.
43. Crum, R. M., Green, K. M., Ston-, C. L., Chan, Y. F., Ialongo, N., Stuart, E. A., et al. (2008). Depressed mood in childhood and subsequent alcohol use through adolescence and young adulthood. Archives of General Psychiatry, 65(6), 702-712.
44. Dai, X., Thavundayil, J., & Gianoulakis, C. (2002). Response of the hypothalamic-pituitary-adrenal axis to stress in the absence and presence of ethanol in subjects at high and low risk of alcoholism. Neuropsychopharmacology, 27(3), 442-452.
45. Dai, X., Thavundayil, J., Santella, S., & Gianoulakis, C. (2007). Response of the HPA-axis to alcohol and stress as a function of alcohol dependence and family history of alcoholism. Psychoneuroendocrinology, 32(3), 293-305.
46. Dawes, M. A., Dorn, L. D., Moss, H. B., Yao, J. K., Kirisci, L., Ammerman, R. T., et al. (1999). Hormonal and behavioral, homeostasis in boys at risk for substance abuse. Drug and Alcohol Dependence, 55(1-2), 165-176.
47. Dawson, D. A., & Grant, B. F. (1998). Family history of alcoholism and gender: their combined effects on DSM-IV alcohol dependence and major depression. Journal of Studies on Alcohol, 59 (1), 97-106.
48. de Kloet, E., Vreugdenhil, E., Oitzl, M., & Joels, M. (1998). Brain corticoisteriod receptor balance in health and disease. Endocrine Reviews, 19(3), 269-301.
49. de Kloet, E., Oitzl, M., & Joels, M. (1999). Stress and cognition: are coricosteroids good or bad guys? Trends in Neuroscience, 22(10), 422-426.
50. de Olmos, J. S., & Heimer, L. (1999). The concepts of the ventral striatopallidal system and extended amygdala. Annals of the New York Academy of Sciences, 877, 1-32.
51. Diaz, R., Gual, A., García, M., Arnau, J., Pascual, F., Cañuelo, B., et al. (2008). Children of alcoholics in Spain: from risk to pathology. Results from the ALFIL program. Social Psychiatry and Psychiatric Epidemiology, 43(1), 1-10.
52. Dick, D. M., Bierut, L., Hinrichs, A., Fox, L., Bucholz, K. K., Kramer, J., et al. (2006). The role of GABRA2 in risk for conduct disorder and alcohol and drug dependence across developmental stages. Behavior Genetics, 36, 577-590.
53. Diorio, D., Viau, V., & Meaney, M. (1993). The role of the medial prefrontal cortex (cingulate cortex) in the regulation of hypothalamic- pituitary-adrenal responses to stress. Journal of Neuroscience, 13, 3839-3847.
54. Dom, G., Sabbe, B., Hulstijn, W., & van den Brink, W. (2005). Substance use disorders and the orbitofrontal cortex: systematic review of behavioural, decision-making and neuroimaging studies. British Journal of Psychiatry, 187, 209-220.
55. Doyle, A. E. (2006). Executive functions in attention-deficit/ hyperactivity disorder. Journal of Clinical Psychiatry, 67, 21-26.
56. Drejer, K., Theilgaard, A., Teasdale, T. W., Schulsinger, F., & Goodwin, D. W. (1985). A prospective study of young men at high risk for alcoholism: neuropsychological assessment. Alcoholism, Clinical and Experimental Research, 9(6), 498-502.
57. Drevets, W. C., Price, J. L., & Furey, M. L. (2008). Brain structural and functional abnormalities in mood, disorders: implications for neurocircuitry models of depression. Brain Structure and Function, 213(1-2), 93-118.
58. Earls, F., & Powell, J. (1988). Patterns of substance use and abuse in inner-city adolescent medical patients. Yale Journal of Biology & Medicine, 61(3), 233-242.
59. Earls, F., Reich, W., Jung, K. G., & Cloninger, C. R. (1988). Psychopathology in children of alcoholic and antisocial parents. Alcoholism, Clinical and Experimental Research, 12(4), 481-487.
60. Edenberg, H. J., & Foroud, T. (2006). The genetics of alcoholism.: identifying specific genes through family studies. Addiction Biology, 11(3-4), 386-396.
61. Edenberg, H. J., Dick, D. M., Xuei, X., Tian, H., Almasy, L., Bauer, L. O., et al. (2004). Variations in GABRA2, encoding the alpha 2 subunit of the GABA(A) receptor, are associated with alcohol dependence and with brain oscillations. American Journal of Human Genetics, 74, 705-714.
62. Elkins, I. J., McGue, M., & Iacono, W. G. (2007). Prospective effects of attention-deficit/hyperactivity disorder, conduct disorder, and sex on adolescent substance use and abuse. Archives of General Psychiatry, 64(10), 1145-1152.
63. Enoch, M. A., & Goldman, D. (1999). Genetics of alcoholism and substance abuse. Psychiatric Clinics of North America, 22(2), 289-299.
64. Etkin, A., & Wager, T. D. (2007). Functional neuroimaging of anxiety: a meta-analysis of emotional processing in PTSD, social anxiety disorder, and specific phobia. American Journal of Psychiatry, 164(10), 1476-1488.
65. Fairchild, G., van Goozen, S. H., Stollery, S. J., Brown, J., Gardiner, J., Herbert, J., et al. (2008). Cortisol diurnal rhythm and stress reactivity in male adolescents with early-onset or adolescence-onset conduct disorder. Biological Psychiatry, 64 (1), 599-606.
66. Fellows, L. K. (2007). Advances in understanding ventromedial prefrontal function: the accountant joins the executive. Neurology, 55(13), 991-995.
67. Fine, E. Q., Yudin, L. W., Holmes, J., & Heinemann, S. (1976). Behavioral disorders in children with parental alcoholism. Annals of the New York Academy of Sciences, 273, 507-517.
68. Finn, P. R., & Pihl, R. O. (1988). Risk for alcoholism: a comparison between two different groups of sons of alcoholics on cardiovascular reactivity and sensitivity to alcohol. Alcoholism, Clinical and Experimental Research, 12(6), 742-747.
69. Finn, P. R., Zeitouni, N. C., & Pihl, R. O. (1990). Effects of alcohol on psychophysiological hyperreactivity to nonaversive and aversive stimuli in men at high risk for alcoholism. Journal of Abnormal Psychology, 99(1), 19-85.
70. Finn, P. R., Sharkansky, E. J., Viken, R., West, T. L., Sandy, J., & Bufferd, G. M. (1997). Heterogeneity in the families of sons of alcoholics: the impact of familial vulnerability type on offspring characteristics. Journal of Abnormal Psychology, 106(1), 26-36.
71. Fite, P. J., Colder, C. R., & O'Connor, R. M. (2006). Childhood behavior problems and peer selection and socialization: risk for adolescent alcohol use. Addictive Behaviors, 31(8), 1454-1459.
72. Foreman, D. M., & Goodyer, I. M. (1988). Salivary Cortisol hypersecretion in juvenile depression. Journal of Child Psychology and Psychiatry and Allied Disciplines, 311-320.
73. Foroud, T., Edenberg, H. J., Goate, A., Rice, J., Flury, L., Koller, D. L., et al. (2000). Alcoholism susceptibility loci: confirmation studies in a replicate sample and further mapping. Alcoholism, Clinical and Experimental Research, 24(1), 933-945.
74. Frodl, T., Meisenzahl, E. M., Zill, P., Baghai, T., Rujescu, D., Leinsinger, G., et al. (2004). Reduced hippocampal volumes associated with the long variant of the serotonin ransporter polymorphism in major depression. Archives of General Psychiatry, 61(2), 177-183.
75. Frodl, T., Koutsouleris, N., Bottlender, R., Born, C., Jäger, M., Mörgenthaler, M., et al. (2008). Reduced gray matter brain volumes are associated with variants of the serotonin transporter gene in major depression. Molecular Psychiatry, 13(12), 1093-1101.
76. Giancola, P. R., & Moss, H. B. (1998). Executive cognitive functioning in alcohol use disorders. Recent Developments in Alcoholism, 14, 227-251.
77. Glahn, D. C., Lovallo, W. R., & Fox, P. T. (2007). Reduced amygdala activation in young adults at high risk of alcoholism.: studies from, the Oklahoma family health patterns project. Biological Psychiatry, 61(11), 1306-1309.
78. Goldstein, R. Z., & Volkow, N. D. (2002). Drug addiction and its underlying neurobiological basis: neuroimaging evidence for the involvement of the frontal cortex. American Journal of Psychiatry, 59(10), 1642-1652.
79. Goodwin, D. W., Schulsinger, F, Hermansen, L., Guze, S. B., & Winokur, G. (1973). Alcohol problems in adoptees raised apart from alcoholic biological parents. Archives of General Psychiatry, 28(2), 238-243.
80. Grant, B. F., & Dawson, D. A. (1997). Age at onset of alcohol use and its association with DSM-IV alcohol abuse and dependence: results from the National Longitudinal Alcohol Epidemiologic Survey. Journal of Substance Abuse, 9, 103-110.
81. Habeych, M. E., Folan, M. M., Luna, B., & Tarter, R. E. (2006). Impaired oculomotor response inhibition in children of alcoholics: The role of attention deficit hyperactivity disorder. Drug and Alcohol Dependence, 82(1), 11-17.
82. Hanisch, C., Radách, R., Holtkamp, K., Herpertz-Dahlmann, B., & Konrad, K. (2006). Oculomotor inhibition in children with and without attention-deficit hyperactivity disorder (ADHD). Journal of Neural Transmission, 113(5), 671-684.
83. Harden, P. W., & Pihl, R. O. (1995). Cognitive function, cardiovascular reactivity, and behavior in boys at high risk for alcoholism. Journal of Abnormal Psychology, 104(1), 94-103.
84. Harper, J. W., & Heath, R. G. (1973). Anatomic connections of the fastigial nucleus to the rostral fbrebrain in the cat. Experimental Neurology, 39(2), 285-292.
85. Harper, C., & Matsumoto, I. (2005). Ethanol and brain damage. Current Opinion in Pharmacology, 5(1), 73-78.
86. Harper, C., Dixon, G., Sheedy, D., & Garrick, T. (2003). Neuropathological alterations in alcoholic brains. Studies arising from the New South Wales Tissue Resource Centre. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 27(6), 951-961.
87. Hastings PD, Fortier I, Utendale WT, Simard LR, Robaey P (2009). Adrenocortical Functioning in Boys with Attention-Deficit/ Hyperactivity Disorder: Examining Subtypes of ADHD and Associated Comorbid Conditions. J Abnorm Child Psychol, Jan 9, ahead of print.
88. Hawkins, J. D., Graham, J. W., Maguin, E., Abbott, R., Hill, K. G., & Catalano, R. F. (1997). Exploring the effects of age of alcohol use initiation and psychosocial risk factors on subsequent alcohol misuse. Journal of Studies Alcohol, 58(3), 280-290.
89. Heath, A. C., Meyer, J., Jardine, R., & Martin, N. G. (1991). The inheritance of alcohol consumption patterns in a general population twin sample: II Determinants of consumption frequency and quantity consumed. Journal of Studies Alcohol, 52 (5), 425-433.
90. Heath, A. C., Bucholz, K. K., Madden, P. A., Dinwiddie, S. H., Slutske, W. S., Bierut, L. J., et al. (1997). Genetic and environmental contributions to alcohol dependence risk in a national twin sample: consistency of findings in women and men. Psychological Medicine, 27(6), 1381-1396.
91. Hegedus, A. M., Tarter, R. E., Hill, S. Y., Jacob, T., & Winsten, N. E. (1984). Static ataxia: a possible marker for alcoholism. Alcoholism, Clinical and Experimental Research, 8(6), 580-582.
92. Heimer, L. (2003). A new anatomical framework for neuropsychiatrie disorders and drug abuse. American Journal of Psychiatry, 160, 1726-1739.
93. Heimer, L., & Van Hoesen, G. W. (2006). The limbic lobe and its output channels: implications for emotional functions and adaptive behavior. Neuroscience and Biobehavioral Reviews, 30 (2), 126-147.
94. Heimer, L., Zahm, D. S., Churchill, L., Kalivas, P. W., & Wohltmann, C. (1991). Specificity in the projection patterns of accumbal core and shell in the rat. Neuroscience, 41(1), 89-125.
95. Heitzeg, M. M., Nigg, J. T., Yau, W. Y., Zubieta, J. K., & Zucker, R A. (2008). Affective circuitry and risk for alcoholism in late adolescence: differences in frontostriatal responses between vulnerable and resilient children of alcoholic parents. Alcoholism, Clinical and Experimental Research, 32(3), 414-426.
96. Herba, C. M., Tranah, T., Rubia, K., & Yule, W. (2006). Conduct problems in adolescence: three domains of inhibition and effect of gender. Developmental Neuropsychology, 30(2), 659-695.
97. Herman, J. P., Ostrander, M. M., Mueller, N. K., Figueiredo, H. (2005). Limbic system mechanisms of stress regulation: hypothalamo-pituitary- adrenocortical axis. Biological Psychiatry, 29 (8), 1201-1213.
98. Hesselbrock, V., Bauer, L., O'Connor, S., & Gillen, R. (1993). Reduced P300 amplitude in relation to family history of alcoholism and antisocial personality disorder among young men at risk for alcoholism. Alcohol and Alcoholism. Supplement, 2, 95-100.
99. Hesslinger, B., Tebartz van Eist, L., Thiel, T., Haegele, K., Hennig, J., & Ebert, D. (2002). Frontoorbital volume reductions in adult patients with attention deficit hyperactivity disorder. Neuroscience Letters, 328, 319-321.
100. Hibberd, C., Yau, J. L., & Seckl, J. R. (2000). Glucocorticoids and the ageing hippocampus. Journal of Anatomy, 197, 553-562.
101. Hill, S. Y. (1992). Absence of paternal, sociopathy in the etiology of severe alcoholism: is there a type III alcoholism? Journal of Studies Alcohol, 53(2), 161-169.
102. Hill, S. Y., & Muka, D. (1996). Childhood psychopathology in children from families of alcoholic female probands. Journal of the American Academy of Child and Adolescent Psychiatry, 35 (6), 725-733.
103. Hill, S. Y., & Steinhauer, S. R. (1993). Postural sway in children from pedigrees exhibiting a high density of alcoholism. Biological Psychiatry, 55(5), 313-325.
104. Hill, S. Y., & Yuan, H. (1999). Familial density of alcoholism and onset of adolescent drinking. Journal of Studies on Alcohol, 60 (1), 7-17.
105. Hill, S. Y., & Shen, S. (2002). Neurodevelopmental patterns of visual P3b in association with familial risk for alcohol dependence and childhood diagnosis. Biological Psychiatry, 57(8), 621-631.
106. Hill, S. Y., Steinhauer, S. R., & Zubin, J. (1987a). Biological markers for alcoholism: A vulnerability model conceptualization. In P. C. Rivers (Ed.), Alcohol and Addictive Behavior, Nebraska Symposium on Motivation, 1986 (pp. 207-256). Lincoln and London: University of Nebraska Press.
107. Hill, S. Y., Armstrong, J., Steinhauer, S. R., Baughman, T., & Zubin, J. (1987b). Static ataxia as a psychobiological marker for alcoholism. Alcoholism, Clinical and Experimental Research, 11(4), 345-348.
108. Hill, S. Y., Steinhauer, S. R., & Zubin, J. (1992). Cardiac responsivity in individuals at high risk for alcoholism. Journal of Studies Alcohol, 53(4), 378-388.
109. Hill, S. Y., Steinhauer, S., Lowers, L., & Locke, J. (1995). Eight-year longitudinal follow-up of P300 and clinical outcome in children from high-risk for alcoholism families. Biological Psychiatry, 37 (11), 823-827.
110. Hill, S. Y., Locke, J., Lowers, L., & Connolly, J. (1999a). Psychopathology and achievement in children at high risk for developing alcoholism. Journal of the American Academy of Child and Adolescent Psychiatry, 38(1), 883-891.
111. Hill, S. Y., Lowers, L., Locke, J., Snidman, N., & Kagan, J. (1999b). Behavioral inhibition in children from families at high risk for developing alcoholism. Journal of the American Academy of Child and Adolescent Psychiatry, 38(4), 410-417.
112. Hill, S. Y., Shen, S., Locke, J., Steinhauer, S. R., Konicky, C., Lowers, L., et al. (1999c). Developmental delay in P300 production in children at high risk for developing alcohol-related disorders. Biological Psychiatry, 46(1), 970-981.
113. Hill, S. Y., Shen, S., Lowers, L., & Locke, J. (2000a). Factors predicting the onset of adolescent drinking in families at high risk for developing alcoholism. Biological Psychiatry, 48(4), 265-275.
114. Hill, S. Y., Shen, S., Locke, J., Lowers, L., Steinhauer, S., & Konicky, C. (2000b). Developmental changes in postural sway in children at high and low risk for developing alcohol-related disorders. Biological Psychiatry, 47(6), 501-511.
115. Hill, S. Y., De Bellis, M. D., Keshavan, M. S., Lowers, L., Shen, S., Hall, J., et al. (2001). Right amygdala volume in adolescent and young adult offspring from families at high risk for developing alcoholism. Biological Psychiatry, 49(11), 894-905.
116. Hill, S. Y., Shen, S., Zezza, N., Hoffman, E. K., Perlin, M., & Allan, W. (2004). A genome wide search for alcoholism, susceptibility genes. American Journal of Medical Genetics Part B: Neuropsychiatr Genetics, 128B(1), 102-113.
117. Hill, S. Y., Muddasani, S., Prasad, K., Nutche, J., Steinhauer, S. R., Scanlon, J., et al. (2007a). Cerebellar volume in offspring from multiplex alcohol dependence families. Biological Psychiatry, 61 (1), 41-47.
118. Hill, S. Y., Kostelnik, B., Holmes, B., Goradia, D., McDermott, M., Diwadkar, V., et al. (2007b). fMRI BOLD response to the eyes task, in offspring from multiplex alcohol dependence families. Alcoholism, Clinical and Experimental Research, 31(12), 2028-2035.
119. Hill, S. Y., Shen, S., Lowers, L., Locke-Wellman, J., Matthews, A. G., & McDermott, M. (2008). Psychopathology in offspring from multiplex alcohol dependence families with and without parental alcohol dependence: a prospective study during childhood, and adolescence. Psychiatry Research, 160(2), 155-166.
120. Hill, S. Y., Wang, S., Kostelnik, B., Carter, H., Holmes, B., McDermott, M., et al. (2009a). Disruption of orbitofrontal cortex laterality in offspring from multiplex alcohol dependence families. Biological Psychiatry, 65(2), 129-136.
121. Hill, S. Y., Steinhauer, S. R., Locke-Wellman, J., Ulrich, R. (2009b). Childhood risk factors for young adult substance dependence in offspring from multiplex alcohol dependence families: A prospective study. doi:10.1016/j. biopsych.2009.04.030.
122. Iacono, W. G., & McGue, M. (2006). Association between P3 event-related brain potential amplitude and adolescent problem behavior. Psychophysiology, 43(5), 465-469.
123. Iacono, W. G., Malone, S. M., & McGue, M. (2008). Behavioral disinhibition and the development of early-onset addiction: common and specific influences. Annual Review of Clinical Psychology, 4, 325-348.
124. Jacobson, L., & Sapolsky, R. (1991). The role of the hippocampus in feedback, regulation of the hypothalamic - pituitary - adrenocortical axis. Endocrine Reviews, 12, 118-134.
125. lessor, R., Donovan, J. E., & Costa, F. (1991). Beyond Adolescence: Problem Behavior and Young Adult Development. New York: Cambridge University Press.
126. Johnson, J. L., & Leff, M. (1999). Children of substance abusers: overview of research findings. Pediatrics, 103(5 Pt 2), 1085-1099.
127. Kagan, J., Reznick, J. S., Clarke, C., Snidman, N., & Garcia-Coll, C. (1984). Behavioral inhibition to the unfamiliar. Child Development, 55, 2212-2225.
128. Kamarajan, C., Porjesz, B., Jones, K. A., Choi, K., Chorlian, D. B., Padmanabhapillai, A., et al. (2005). Alcoholism is a disinhibitory disorder: neurophysiological evidence from a Go/No-Go task. Biological Psychology, 69(3), 353-373.
129. Kamarajan, C., Porjesz, B., Jones, K., Chorlian, D., Padmanabhapillai, A., Rangaswamy, M., et al. (2006). Event-related oscillations in offspring of alcoholics: neurocognitive disinhibition as a risk for alcoholism. Biological Psychiatry, 59(1), 625-634.
130. Kandel, D. B., Yamaguchi, K., & Chen, K. (1992). Stages of progression in drug involvement from adolescence to adulthood: further evidence for the gateway theory. Journal of Studies Alcohol, 53(5), 447-457.
131. Kellam, S. G., Ensminger, M. E., & Simon, M. B. (1980). Mental health in first grade and teenage drug, alcohol, and cigarette use. Drug and Alcohol Dependence, 5(4), 273-304.
132. Kendler, K. S., Neale, M. C., Heath, A. C., Kessler, R. C., & Eaves, L. J. (1994). A twin-family study of alcoholism in women. American Journal of Psychiatry, 151(5), 707-715.
133. Kendler, K. S., Prescott, C. A., Neale, M. C., & Pedersen, N. L. (1997). Temperance board, registration for alcohol abuse in a national sample of Swedish male twins, born 1902 to 1949. Archives of General Psychiatry, 54(2), 178-184.
134. Kendler, K. S., Schmitt, E., Aggen, S. H., & Prescott, C. A. (2008). Genetic and environmental influences on alcohol, caffeine, cannabis, and nicotine use from early adolescence to middle adulthood. Archives of General Psychiatry, 65(6), 674-682.
135. Kiefer, J. C. (2007). Epigenetics in development. Developmental Dynamics, 236(4), 1144-1156.
136. King, K. M., & Chassin, L. (2004). Mediating and moderated effects of adolescent behavioral undercontrol and parenting in the prediction of drug use disorders in emerging adulthood. Psychology of Addictive Behaviors, 18(3), 239-249.
137. King, K. M., & Chassin, L. (2008). Adolescent stressors, psycho- pathology, and young adult substance dependence: a prospec- tive study. Journal of Studies on Alcohol and Drugs, 69(5), 629-638.
138. King, J. A., Barkley, R. A., & Barrett, S. (1998). Attention-deficit hyperactivity disorder and the stress response. Biological Psychiatry, 44(1), 72-74. (Pubitemid 28305545)
139. King SM, Keyes M, Malone SM, Elkins I, Legrand LN, Iacono WG, McGue M (2009). Parental alcohol dependence and the trans- mission of adolescent behavioral disinhibition: a study of adoptive and non-adoptive families. Addiction, Feb 10, ahead of print.
140. Klimes-Dougan, B., Hastings, P. D., Granger, D. A., Usher, B. A., & Zahn-Waxier, C. (2001). Adrenocortical activity in at-risk and normally developing adolescents: individual differences in salivary Cortisol basal levels, diurnal variation, and responses to social challenges. Development Psychopathology, 13(3), 695-719. (Pubitemid 33406350)
141. Knopik, V. S., Heath, A. C., Madden, P. A., Bucholz, K. K., Slutske, W S., Nelson, E. C., et al. (2004). Genetic effects on alcohol dependence risk: re-evaluating the importance of psychiatric and other heritable risk factors. Psychological Medicine, 54(8), 1519-1530.
142. Koob, G. F. (1996). Hedonic valence, dopamine and motivation. Molecular Psychiatry, 1(3), 186-189.
143. Koob, G. F. (2003). Neuroadaptive mechanisms of addiction: studies on the extended amygdala. European Neuropsvchopharmacol- ogy, 13(6), 442-1152
144. Koob, G. F., & Le Moal, M. (2008). Addiction and the brain antireward system. Annual Review of Psycholog, 59, 29-53.
145. Kramer, J. R., Chan, G., Dick, D. M., Kuperman, S., Bucholz, K. K., Edenberg, H. J., et al. (2008). Multiple-domain predictors of problematic alcohol use in young adulthood. Journal of Studieson Alcohol and Drugs, 69(5), 649-659.
146. Krauzlis, R. J. (2004). Recasting the smooth pursuit eye movement system. Journal of Neurophysiology, 91(2), 591-603. (Pubitemid 38168834)
147. Kuo, P. H., Aggen, S. H., Prescott, C. A., Kendler, K. S., & Neale, M. C. (2008). Using a factor mixture modeling approach in alcohol dependence in a general population sample. Drug and Alcohol Dependence, 98(1-2), 105-114.
148. Kuperman, S., Schlosser, S. S., Lidral, J., & Reich, W (1999). Relationship of child psychopathology to parental alcoholism and antisocial personality disorder. Journal of the American Academy of Child and Adolescent Psychiatry, 38, 686-692. (Pubitemid 29250139)
149. Kuperman, S., Chan, G., Kramer, J. R., Bierut, L., Bucholz, K. K., Fox, L., et al. (2005). Relationship of age of first drink to child, behavioral, problems and family psychopathology. Alcoholism, Clinical and Experimental Research, 2P(10), 1869-1876. (Pubitemid 41579137)
150. Lipscomb, T., Carpenter, J., & Nathan, P. (1979). Static ataxia: a predictor of alcoholism? British Journal of Addiction, 74, 289-294. (Pubitemid 10235965)
151. Lipsky, R. H., & Marini, A. M. (2007). Brain-derived neurotrophic factor in neuronal survival and behavior-related plasticity. Annals of the New York Academy of Sciences, 1122, 130-143. (Pubitemid 350249544)
152. Lovallo, W. R., Yechiam, E., Sorocco, K. H., Vincent, A. S., & Collins, F. L. (2006). Working memory and decision-making biases in young adults with a family history of alcoholism: studies from the Oklahoma family health patterns project. Alcoholism, Clinical and Experimental Research, 30(5), 763-773.
153. Mackie, S., Shaw, P., Lenroot, R., Pierson, R., Greenstein, D. K., Nugent, T. F., 3rd, et al. (2007). Cerebellar development and clinical outcome in attention deficit hyperactivity disorder. American Journal of Psychiatry, 164(4), 647-655. (Pubitemid 46650197)
154. MacLullich, A. M., Ferguson, K. J., Wardlaw, J. M., Starr, J. M., Deary, I. J., & Seckl, J. R. (2006). Smaller left anterior cingulate cortex volumes are associated with impaired hypothalamic-pituitary-adrenal axis regulation in healthy elderly men. Journalof Clinical Endocrinology and Metabolism, 91, 1591-1594.
155. Makris, N., Oscar-Berman, M., Jaffin, S. K., Hodge, S. M., Kennedy, D. N., Caviness, V. S., et al. (2008). Decreased volume of the brain reward system
156. Man, M. S., Clarke, H. F., & Roberts, A. C. (2009). The role of the orbitofrontal cortex and medial striatum in the regulation of prepotent responses to food rewards. Cerebral Cortex, 19(4), 899-906.
157. Mangelsdorf; S. C., Schoppe, S. J., & Buur, H. (2000). The meaning of parental reports: A contextual approach to the study of temperament and behavior problems in childhood. In V. J. Molfese & D. L. Molfese (Eds.), Temperament and Personality Development Across the Lifespan (pp. 121- 140). London UK: Erlbaum.
158. Mann, K., Agartz, I., Harper, C., Shoaf, S., Rawlings, R. R., Momenan, R., et al. (2001). Neuroimaging in alcoholism: ethanol and brain damage. Alcoholism, Clinical and Experimental Research, 25, 104S-109S. (Pubitemid 32545022)
159. Mannuzza, S., Klein, R. G., Bessler, A., Malloy, P., & LaPadula, M. (1993). Adult outcome of hyperactive boys. Educational achieve- ment, occupational rank, and psychiatric status. Archives of General Psychiatry, 50(7), 565-576. (Pubitemid 23203567)
160. Manzardo, A. M., Penick, E. C., Knop, J., Nickel, E. J., Hall, S., Jensen, P., et al. (2005). Developmental differences in childhood motor coordination predict adult alcohol dependence: proposed role for the cerebellum in alcoholism. Alcoholism, Clinical and Experimental Research, 29(3), 353-357. (Pubitemid 40446127)
161. Marshal, M. P., Molina, B. S., Pelham, W. E., & Cheong, J. (2007). Attention-deficit hyperactivity disorder moderates the life stress pathway to alcohol problems in children of alcoholics. Alcoholism, Clinical and Experimental Research, 31(4), 564-574.
162. Masten, A. S., Faden, V. B., Zucker, R. A., & Spear, L. P. (2008). Underage drinking: a developmental framework. Pediatrics, 121 (Suppl 4), S235-S251.
163. Matsuo K, Nicoletti M, Nemoto K, Hatch JP, Peluso MA, Nery FG, Soares JC (2008) A voxel-based morphometry study of frontal gray matter correlates of impulsivity. Hum Brain Mapp, May 8, ahead, of print.
164. McBurnett, K., Rame, A., Stouthamer-Loeber, M., Loeber, R., Kumar, A. M., Kumar, M., et al. (2005). Mood and hormone responses to psychological challenge in adolescent males with conduct problems. Biological Psychiatry, 57(10), 1109-1116. (Pubitemid 40615772)
165. McGue, M., Iacono, W. G., Legrand, L. N., Malone, S., & Elkins, I. (2001a). Origins and consequences of age at first drink. I. Associations with substance-use disorders, disinhibitory behavior and psychopathology, and P3 amplitude. Alcoholism, Clinical and Experimental Research, 25(8), 1156-1165. (Pubitemid 32758467)
166. McGue, M., Iacono, W. G., Legrand, L. N., & Elkins, I. (2001b). Origins and consequences of age at first drink. II. Familial risk and heritability. Alcoholism, Clinical and Experimental Research, 25(8), 1166-1173. (Pubitemid 32758468)
167. McNamee, R. L., Dunfee, K. L., Luna, B., Clark, D. B., Eddy, W. F., & Tarter, R. E. (2008). Brain activation, response inhibition, and increased risk for substance use disorder. Alcoholism, Clinical and Experimental Research, 32(3), 405-413. (Pubitemid 351301003)
168. Meaney, M. J., O'Donnell, D., Rowe, W., Tannenbaum, B., Steverman, A., Walker, M., et al. (1995). Individual differences in ypothalamic - pituitary-adrenal activity in later life and hippocampal aging. Experimental Gerontology, 30, 229-251.
169. Meaney, M. J., Diorio, J., Francis, D., Widdowson, J., LaPlante, P., Caldji, D., et al. (1996). Early environmental regulation of forebrain glucocorticoid receptor gene expression: implications for adrenocortical responses to stress. Developmental Neuro- science, 18, 49-72. (Pubitemid 26257908)
170. Merikangas, K. R., Stolar, M., Stevens, D. E., Goulet, J., Preisig, M. A., Fenton, B., et al. (1998). Familial transmission of substance use disorders. Archives of General Psychiatry, 55(11), 973-979. (Pubitemid 28506838)
171. Monk, C. S. (2008). The development of emotion-related neural circuitry in health and psychopathology. Development and Psychopathol, 20(4), 1231-1250.
172. Moos, R. H., & Billings, A. G. (1982). Children of alcoholics during the recovery process: alcoholic and matched, control families. Addictive Behaviors, 7(2), 155-163. (Pubitemid 12063530)
173. Moss, H. B., Vanyukov, M. M., & Martin, C. S. (1995). Salivary Cortisol responses and the risk for substance abuse in prepubertal boys. Biological Psychiatry, 38(8), 547-555.
174. Moss, H. B., Vanyukov, M., Yao, J. K., & Kirillova, G. P. (1999). Salivary Cortisol responses in prepubertal boys: the effects of parental substance abuse and association with drug use behavior during adolescence. Biological Psychiatry, 45(10), 1293-1299. (Pubitemid 29292505)
175. Moss, H. B., Chen, C. M., & Ye, H. Y (2007). Subtypes of alcohol dependence in a nationally representative sample. Drug and Alcohol Dependence, 91, 149-158. (Pubitemid 47539724)
176. Mostofsky, S. H., Lasker, A. G., Cutting, L. E., Denckla, M. B., & Zee, D. S. (2001). Oculomotor abnormalities in attention deficit hyperactivity disorder: a preliminary study. Neurology, 57(3), 423-430. (Pubitemid 32757587)
177. Nagai, M., Kishi, K., & Kato, S. (2007). Insular cortex and neuropsy- chiatrie disorders: a review of recent literature. Europian Psychiatry, 22(6), 387-394. (Pubitemid 47391217)
178. Nelson, J. C., & Davis, J. M. (1997). DST studies in psychotic depression: A meta-analysis. American Journal of Psychiatry, 154, 1497-1503.
179. Nemoto, K., Ohnishi, T., Mori, T., Moriguchi, Y., Hashimoto, R., Asada, T., et al. (2006). The Val66Met polymorphism of the brain-derived neurotrophic factor gene affects age-related brain morphology. Neuroscience Letters, 397(1-2), 25-29. (Pubitemid 43340452)
180. Newcomb, M. D., & Bentler, P. M. (1989). Substance use and abuse among children and teenagers. American Psychologist, 44(2), 242-248.
181. Nigg, J. T., & Casey, B. J. (2005). An integrative theory of attention- deficit/ hyperactivity disorder based on the cognitive and affective neuro sciences. Development and Psychopathol, 17(3), 785-806.
182. Nigg, J. T., Glass, J. M., Wong, M. M., Poon, E., Jester, J. M., Fitzgerald, H. E., et al. (2004). Neuropsychological executive functioning in children at elevated risk for alcoholism: indings in early adolescence. Journal of Abnormal Psychology, 113(2), 302-314. (Pubitemid 38552845)
183. Nock, M. K., Kazdin, A. E., Hiripi, E., & Kessler, R. C. (2006). Prevalence, subtypes, and correlates of DSM-IV conduct disorder in the National Comorbidity Survey Replication. Psychological Medicine, 36(5), 699-710.
184. Nock, M. K., Kazdin, A. E., Hiripi, E., & Kessler, R. C. (2007). Lifetime prevalence, correlates, and persistence of oppositional defiant disorder: results from the National Comorbidity Survey Replication. Journal of Child Psychology and Psychiatry, 48(1), 703-713. (Pubitemid 46978050)
185. Ohannessian, C. M., & Hesselbrock, V. M. (1995). Temperament and personality typologies in adult offspring of alcoholics. Journal of Studies on Alcohol, 56(3), 318-327.
186. Ohannessian, C. M., Stabenau, J. R., & Hesselbrock, V. M. (1995). Childhood and adulthood temperament and problem behaviors and adulthood substance use. Addictive Behaviors, 20(1), 77- 86.
187. Ohannessian, C. M., Hesselbrock, V. M., Kramer, J., Kuperman, S., Bucholz, K. K., Schuckit, M. A., et al. (2004). The relationship between parental alcoholism and adolescent psychopathology: a systematic examination of parental comorbid psychopathology. Journal of Abnormal Psychology, 32, 519-533.
188. O'Leary, M. M., Loney, B. R., & Eckel, L. A. (2007). Gender differences in the association between psychopathic personality traits and Cortisol response to induced, stress. Psychoneuroendoc- rinology, 32(2), 183-191.
189. Oscar-Berman, M. M., & Marinkovic, K. (2007). Alcohol: effects on neurobehavioral functions and the brain. Neuropsychology Review, 17(3), 239-257.
190. Ozkaragoz, T., Satz, P., & Noble, E. P. (1997). Neuropsychological functioning in sons of active alcoholic, recovering alcoholic, and social drinking fathers. Alcohol, 14(1), 31-37. (Pubitemid 27052107)
191. Padmanabhapillai, A., Tang, Y., Ranganathan, M., Rangaswamy, M., Jones, K. A., Chorlian, D. B., et al. (2006). Evoked gamma band response in male adolescent subjects at high risk for alcoholism during a visual oddball task. International Journal of Psycho- physiology, 62(2), 262-271. (Pubitemid 44468131)
192. Pagan, J. L., Rose, R. J., Viken, R. L., Pulkkinen L., Kaprio, J., & Dick, D. M. (2006). Genetic and environmental influences on stages of alcohol use across adolescence and into young adulthood. Behavior Genetics, 36(4), 483-497. (Pubitemid 43967645)
193. Pajer, K., Chung, J., Leininger, L., Wang, W., Gardner, W., & Yeates, K. (2008). Neuropsychological function in adolescent girls with conduct disorder. Journal of the American Academy of Child and Adolescent Psychiatry, 47(4), 416-425. (Pubitemid 351450738)
194. Pariante, C. M., & Lightman, S. L. (2008). The HPA axis in major depression: classical theories and new developments. Trends in Neurosciences, 31(9), 464-468.
195. Paus, T. (2001). Primate anterior cingulate cortex: where motor control, drive and cognition interface. Nature Reviews Neuro- science, 2(6), 417-424.
196. Peper, J. S., Brouwer, R. M., Boomsma, D. I., Kahn, R. S., & Hulshoff Pol, H. E. (2007). Genetic influences on human brain structure: a review of brain imaging studies in twins. Human Brain Mapping, 28(6), 464-473.
197. Peterson, J. B., Finn, P. R., & Pihl, R. O. (1992). Cognitive dysfunction and the inherited predisposition to alcoholism. Journal of Studies on Alcohol, 53(2), 154-160.
198. Peterson, J. B., Pihl, R. O., Séguin, J. R., Finn, P. R., & Stewart, S. H. (1993). Heart-rate reactivity and alcohol consumption among sons of male alcoholics and sons of non-alcoholics. Journal of Psychiatry & Neuroscience, 18(4), 190-198.
199. Peterson, J. B., Pihl, R. O., Gianoulakis, C., Conrad, P., Finn, P. R., Stewart, S. H., et al. (1996). Ethanol-induced change in cardiac and endogenous opiate function and risk for alcoholism. Alcohol- ism, Clinical and Experimental Research, 20(9), 1542-1552. (Pubitemid 26428103)
200. Pihl, R. O., Peterson, J., & Finn, P. (1990). Inherited predisposition to alcoholism: characteristics of sons of male alcoholics. Journal of Abnormal Psychology, 99(3), 291-301. (Pubitemid 20274088)
201. Poon, E., Ellis, D. A., Fitzgerald, H. E., & Zucker, R. A. (2000). Intellectual, cognitive, and academic performance among sons of alcoholics, during the early school years: differences related to subtypes of familial alcoholism. Alcoholism, Clinical and Experimental Research, 24(7), 1020-1027. (Pubitemid 30604321)
202. Porjesz, B., & Rangaswamy, M. (2007). Neurophysiological endo- phenotypes, CNS disinhibition, and risk for alcohol dependence and related disorders. ScientificWorldJournal, 7, 131-141. (Pubitemid 350277589)
203. Porjesz, B., Begleiter, H., Reich, T., Van Eerdewegh, P., Edenberg, H. J., Foroud, T., et al. (1998). Amplitude of visual P3 event-related potential as a phenotypic marker for a predisposition to alcoholism: preliminary results from the COGA Project Collaborative Study on the Genetics of Alcoholism. Alcoholism, Clinical and Experimental Research, 22(6), 1317-1323.
204. Porjesz, B., Rangaswamy, M., Kamarajan, C., Jones, K. A., Padmanabhapillai, A., & Begleiter, H. (2005). The utility of neurophysiological markers in the study of alcoholism.. Clinical Neurophysiology, 116(5), 993-1018. (Pubitemid 40501780)
205. Puig-Antich, J., Goetz, D., Davies, M., & Kaplan, T. (1989). A controlled family history study of prepubertal major depressive disorder. Archives of General Psychiatry, 46, 406- 418.
206. Rangaswamy, M., Jones, K. A., Porjesz, B., Chorlian, D. B., Padmanabhapillai, A., Kamarajan, C., et al. (2007). Delta and theta oscillations as risk markers in adolescent offspring of alcoholics. International Journal of Psychophysiology, 63(1), 3-15. (Pubitemid 46026880)
207. Reich, W., Earls, F., Frankel, O., & Shayka, J. J. (1993). Psychopa- thology in children of alcoholics. Journal of the American Academy of Child and Adolescent Psychiatry, 32(5), 995-1002.
208. Reich, T., Edenberg, H. J., Goate, A., Williams, J. T., Rice, J. P., Van Eerdewegh, P., et al. (1998). Genome-wide search for genes affecting the risk for alcohol dependence. American Journal of Medical Genetics, 81(3), 207-215. (Pubitemid 28211180)
209. Rhee, S. H., Hewitt, J. K., Young, S. E., Corley, R. P., Crowley, T. J., & Stallings, M. C. (2003). Genetic and environmental influences on substance initiation, use, and problem use in adolescents. Archives of General Psychiatry, 60(12), 1256-1264. (Pubitemid 37494079)
210. Rommelse, N. N., Van der Stigchel, S., Witlox, J., Geldof, C., Deijen, J. B., Theeuwes, J., et al. (2008). Deficits in visuo-spatial working memory, inhibition and oculomotor control in oys with ADHD and their non-affected brothers. Journal of Neural Transmission, 115(2), 249-260.
211. Rose, R. J., Dick, D. M., Viken, R. J., Pulkkinen, L., & Kaprio, J. (2001). Drinking or abstaining at age 14? A genetic epidemio- logical study. Alcoholism, Clinical and Experimental Research, 25(11), 1594-1604. (Pubitemid 33104922)
212. Rose, R. J., Dick, D. M., Viken, R. J., Pulkkinen, L., & Kaprio, J. (2004). Genetic and environmental effects on conduct disorder and alcohol dependence symptoms and their covariation at age 14. Alcoholism., Clinical and Experimental Research, 28(10), 1541-1548. (Pubitemid 39390476)
213. Rosenbaum, J. F., Biederman, J., Hirshfeld, D. R., Bolduc, E. A., Faraone, S. V., Kagan, J., et al. (1991). Further evidence of an association between behavioral inhibition and anxiety disorders: results from a family study of children from a non-clinical sample. Journal of Psychiatric Research, 25, 49-65.
214. Ross, R. G., Hommer, D., Breiger, D., Varley, C., & Radant, A. (1994). Eye movement task, related to frontal lobe functioning in children with attention deficit disorder. Journal of the American Academy of Child and Adolescent Psychiatry, 33(6), 869-874. (Pubitemid 24196911)
215. Rothman, E. F., Edwards, E. M., Heeren, T., & Hingson, R. W. (2008). Adverse childhood experiences predict earlier age of drinking onset: results from a representative US sample of current or former drinkers. Pediatrics, 122(2), e298-e304.
216. Rubia, K., Taylor, E., Smith, A. B., Oksanen, H., Overmeyer, S., & Newman, S. (2001). Neuropsychological analyses of impulsive- ness in childhood hyperactivity. British Journal of Psychiatry, 179, 138-143. (Pubitemid 32756495)
217. Rubia, K., Smith, A. B., Halari, R., Matsukura, F., Mohammad, M., Taylor, E., et al. (2008). Disorder-Specific dissociation of orbitofrontal dysfunction in boys with pure conduct disorder during reward and ventrolateral prefrontal dysfunction in boys with pure ADHD during sustained attention. American Journal of Psychiatry, 166(1), 83-94.
218. Rush, A. J., Ones, D. E., Schlesser, M. A., Orsulak, P. J., Parker, C. R., Weissenburger, J. E., et al. (1996). The dexamethasone suppression test in patients with mood disorders. Journal of Clinical Psychiatry, 57(10), 470-484. (Pubitemid 26362312)
219. Sartor, C. E., Lynskey, M. T., Heath, A. C., Jacob, T., & True, W. (2007). The role of childhood, risk factors in initiation of alcohol use and progression to alcohol dependence. Addiction, 102(2), 216-225. (Pubitemid 46096282)
220. Saunders, B., Farag, N., Vincent, A. S., Collins, F. L., Jr., Sorocco, K. H., & Lovallo, W. R. (2008). Impulsive errors on a Go-NoGo reaction time task: disinhibitory traits in relation to a family history of alcoholism. Alcoholism, Clinical and Experimental Research, 32 (5), 888-894. (Pubitemid 351596392)
221. Schmahmann, J. D., & Pandya, D. N. (1997). The cerebrocerebellar system. International Review of Neurobiology, 41, 31-60.
222. Schmidt, L. A., Fox, N. A., Rubin, K. H., Sternberg, E. M., Gold, P. W., Smith, C. C., et al. (1997). Behavioral and neuroendocrine responses in shy children. Developmental Psychobiology, 30 (2), 127-140.
223. Schuckit, M. A. (1994). Low level of response to alcohol as a predictor of future alcoholism. American Journal of Psychiatry, 151(2), 184-189.
224. Schuckit, M. A. (1998). Biological, psychological and environmental predictors of the alcoholism risk: a longitudinal study. Journal of Studies on Alcohol, 59(5), 485-494.
225. Schuckit, M. A., & Smith, T. L. (1997). Assessing the risk for alcoholism among sons of alcoholics. Journal of Studies on Alcohol, 58(2), 141-145.
226. Schuckit, M. A., Tsuang, J. W., Anthenelli, R. M., Tipp, J. E., & Nurnberger, J. I., Jr. (1996). Alcohol challenges in young men from alcoholic pedigrees and control families: a report from the COGA project. Journal of Studies on Alcohol, 57(4), 368-377. (Pubitemid 26184025)
227. Schwartz, C. E., Snidman, N., & Kagan, J. (1999). Adolescent social anxiety as an outcome of inhibited temperament in childhood. Journal of the American Academy of Child and Adolescent Psychiatry, 38, 1008-1015. (Pubitemid 29353036)
228. Schweinsburg, A. D., Paulus, M. P., Barlett, V. C., Killeen, L. A., Caldwell, L. C., Pulido, C., et al. (2004). An FMRI study of response inhibition in youths with a family history of alcoholism. Annals of the New York Academy of Sciences, 1021, 391-394.
229. Seitz, R. J., Stephan, K. M., & Binkofski, F. (2000). Control of action as mediated by the human frontal lobe. Experimental Brain Research, 133(1), 71-80.
230. Sher, K. J. (1991). Children of alcoholics : a critical appraisal of theory and research. Chicago: University of Chicago Press.
231. Sher, K. J., & Trull, T. J. (1994). Personality and disinhibitory psychopathology: alcoholism and antisocial personality disorder. Journal of Abnormal Psychology, 103, 92-102.
232. Sher, K. J., Walitzer, K. S., Wood, P. K., & Brent, E. E. (1991). Characteristics of children of alcoholics: putative risk factors, substance use and abuse, and psychopathology. Journal of Abnormal Psychology, 100(4), 427-448.
233. Shin, D. W., & Lee, S. H. (2007). Blunted hypothalamo-pituitary- adrenal axis reactivity is associated, with the poor intelligence performance in children with attention- deficit/hyperactivity dis- order. Neuropediatrics, 38(6), 298-303.
234. Shirtcliff, E. A., Granger, D. A., Booth, A., & Johnson, D. (2005). Low salivary Cortisol levels and externalizing behavior problems in youth. Development and Psychopathol, 17(1), 167-184. (Pubitemid 41388334)
235. Silveri, M. M., McCaffrey, A., Rogowska, J., & Yurgelun-Todd, D. A. (2009). Frontolimbic responses in adolescents at risk, for substance abuse: FMRI brain activation during Stroop perfor- mance and the viewing of fearful affect. Alcoholism, Clinical and Experimental Research, 33(6), 276A.
236. Sorocco, K. H., Lovallo, W. R., Vincent, A. S., & Collins, F. L. (2006). Blunted hypothalamic-pituitary-adrenocortical axis responsivity to stress in persons with a family history of alcoholism. International Journal of Psychophysiology, 59(3), 210-217. (Pubitemid 43316017)
237. Spadoni, A. D., McGee, C. L., Fryer, S. L., & Riley, E. P. (2007). Neuroimaging and fetal alcohol spectrum disorders. Neurosci- ence and Biobehavioral Reviews, 31(2), 239-245. (Pubitemid 46074148)
238. Spadoni, A. D., Norman, A. L., Schweinsburg, A. D., & Tapert, S. F. (2008). Effects of family history of alcohol use disorders on spatial working memory BOLD response in adolescents. Alcoholism, Clinical and Experimental Research, 32(7), 1135-1145.
239. Stansbury, K., & Gunnar, M. R. (1994). Adrenocortical activity and emotion regulation. Monographs of the Society for Research in Child Development, 59(2-3), 108-134.
240. Starkman, M., Giordani, B., Berent, S., Schork, M., & Schteingart, D. (2001). Elevated Cortisol levels in Cushing's Disease are associated with, cognitive decrements. Psychosomatic Medicine, 63, 985-993. (Pubitemid 33101385)
241. Steinhausen, H. C., Göbel, D., & Nestler, V. (1984). Psychopathology in the offspring of alcoholic parents. Journal of the American Academy of Child Psychiatry, 23(4), 465-471.
242. Steinlin, M. (2008). Cerebellar disorders in childhood: cognitive problems. Cerebellum, 7(4), 607-610.
243. Stevens, M. C., Kaplan, R. F., & Hesselbrock, V. M. (2003). Executive- cognitive functioning in the development of antisocial personality disorder. Addictive Behaviors, 28(2), 285-300.
244. Stewart, S. H., Finn, P. R., & Pihl, R. O. (1992). The effects of alcohol on the cardiovascular stress response in men at high risk for alcoholism: a dose response study. Journal of Studies on Alcohol, 53(5), 499-506.
245. Stice, E., Barrera, M., Jr., & Chassin, L. (1998). Prospective differential prediction of adolescent alcohol use and problem use:examining the mechanisms of effect. Journal of Abnormal Psychology, 107(4), 616-628. (Pubitemid 28527575)
246. Strick, P. L., Dum, R. P., & Fiez, J. A. (2009). Cerebellum and nonmotor function. Annual Review of Neuroscience, 32, 413-434.
247. Sullivan, E. V. (2003). Compromised pontocerebellar and cerebello- thalamocortical systems: speculations on their contributions to cognitive and motor impairment in nonamnesic alcoholism. Alcoholism, Clinical and Experimental Research, 27(9), 1409-1419.
248. Sullivan, R. M., & Gratton, A. (2002). Prefrontal cortical regulation of hypothalamic- pituitary-adrenal function in the rat and impli- cations for psychopathology: side matters. Psychoneuroendocri- nology, 27, 99-114.
249. Sullivan, E. V., & Pfefferbaum, A. (2005). Neurocircuitry in alcoholism: a substrate of disruption and repair. Psychopharma- cology (Berl), 180(4), 583-594.
250. Sullivan, E. V., Harding, A. J., Pentney, R., Dlugos, C., Martin, P. R., Parks, M. H., et al. (2003). Disruption of frontocerebellar circuitry and function in alcoholism. Alcoholism, Clinical and Experimental Research, 27(2), 301-309. (Pubitemid 36236654)
251. Sullivan, E. V., Rose, J., & Pfefferbaum, A. (2006). Effect of vision, touch and stance on cerebellar vermian-related sway and tremor: a quantitative physiological and MRI study. Cerebral Cortex, 16 (8), 1077-1086. (Pubitemid 44025377)
252. Susman, E. J. (2006). Psychobiology of persistent antisocial behavior: stress, early vulnerabilities and the attenuation hypothesis. Neuroscience and Biobehavioral Reviews, 30(3), 376-389.
253. Tan, H. Y., Callicott, J. H., & Weinberger, D. R. (2008). Intermediate phenotypes in schizophrenia genetics redux: is it a no brainer? Molecular Psychiatry, 13(3), 233-238.
254. Tanji, J., & Hoshi, E. (2001). Behavioral planning in the prefrontal cortex. Current Opinion in Neurobiology, 11(2), 164-170.
255. Tanji, J., & Hoshi, E. (2008). Role of the lateral prefrontal cortex in executive behavioral control. Physiological Reviews, 88(1), 37-57.
256. Tapert, S. F., & Brown, S. A. (2000). Substance dependence, family history of alcohol dependence and neuropsychological function- ing in adolescence. Addiction, 95(1), 1043-1053.
257. Tarter, R. E., Kirisci, L., Mezzich, A., Cornelius, J. R., Pajer, K., Vanyukov, M., et al. (2003). Neurobehavioral disinhibition in childhood predicts early age at onset of substance use disorder. American Journal of Psychiatry, 160(6), 1078-1085. (Pubitemid 41070966)
258. Tarter, R. E., Kirisci, L., Reynolds, M., & Mezzich, A. (2004). Neurobehavior disinhibition in childhood, predicts suicide poten- tial and substance use disorder by young adulthood. Drug and Alcohol Dependence, 76 Suppl, S45-S52. (Pubitemid 39540011)
259. Tessner, K. D., Walker, E. F., Dhruv, S., Hochman, K., & Hamann, S. (2007). The relation of Cortisol levels with hippocampus volumes under baseline and challenge conditions. Brain Research, 1179, 70-78. (Pubitemid 47633503)
260. Thier, P., & Hg, U. J. (2005). The neural basis of smooth-pursuit eye movements. Current Opinion in Neurobiology, 15(6), 645-652. (Pubitemid 41682304)
261. Tranel, D., Damasio, H., Denburg, N. L., & Bechara, A. (2005). Does gender play a role in functional asymmetry of ventromedial prefrontal cortex? Brain, 128, 2872-2881. (Pubitemid 41746640)
262. Uhart, M., Oswald, L., McCaul, M. E., Chong, R., & Wand, G. S. (2006). Hormonal responses to psychological stress and family history of alcoholism. Neuropsychopharmacology, 31(10), 2255-2263. (Pubitemid 44413204)
263. Vaglum, S., Vaglum, P., & Larsen, O. (1987). Depression and alcohol consumption in non alcoholic and alcoholic women. A clinical study. Acta Psychiatrica Scand., 75(6), 577-584. (Pubitemid 17115295)
264. Waldrop, A. E., Ana, E. J., Saladin, M. E., McRae, A. L., & Brady, K. T. (2007). Differences in early onset alcohol use and heavy drinking among persons with childhood and adulthood trauma. American Journal on Addictions, 16(6), 439-442.
265. Walker, E., Mittel, V., & Tessner, K. (2008). Stress and the hypothalamic pituitary adrenal axis in the developmental course of schizophrenia. Annual Reveiw of Clinical Psychology, 4, 189-216.
266. Weinhold, B. (2006). Epigeneties: the science of change. Environ- mental Health Perspectives, 3, A160-A167.
267. Wesner, R. B. (1990). Alcohol use and abuse secondary to anxiety. Psychiatric Clinics of North America, 13(4), 699-713.
268. Wiedenmayer, C. P., Bansal, R., Anderson, G. M., Zhu, H., Amat, J., Whiteman, R., et al. (2006). Cortisol levels and hippocampus volumes in healthy preadolescent children. Biological Psychiatry, 60, 856-861. (Pubitemid 44527885)
269. Wiers, R. W., Gunning, W. B., & Sergeant, J. A. (1998). Is a mild deficit in executive functions in boys related to childhood ADHD or to parental multigenerational alcoholism? Journal of Abnor- mal Child Psychology, 26(6), 415-430.
270. Williams, J. T., Begleiter, H., Porjesz, B., Edenberg, H. J., Foroud, T., Reich, T., et al. (1999). Joint multipoint linkage analysis of multivariate qualitative and quantitative traits II. Alcoholism and event-related potentials. American Journal of Human Genetics, 65(4), 1148-1160. (Pubitemid 30462972)
271. Windle, M. (1994). Temperamental inhibition and activation: Hor- monal and psychosocial correlates and associated psychiatric disorders. Personality and Individual Differences, 17, 61-70.
272. Zimmermann, U., Spring, K., Kunz-Ebrecht, S. R., Uhr, M., Wittchen, H. U., & Holsboer, F. (2004). Effect of ethanol on hypothalamic- pituitary-adrenal system response to psychosocial stress in sons of alcohol- dependent fathers. Neuropsychopharmacology, 29(6), 1156-1165. (Pubitemid 38670052)
273. Zucker, R. A. (2008). Anticipating problem, alcohol use developmen- telly from childhood, into middle adulthood: what have we learned? Addiction, ;05(Suppl 1), 100-108.