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Volumn 29, Issue 21, 2010, Pages 3134-3145

EWS/ETS proteins promote expression and regulate function of the homeodomain transcription factor BRN3A

Author keywords

BRN3A; EFT; Ewing's sarcoma; EWS ETS; POU4F1

Indexed keywords

RNA BINDING PROTEIN EWS; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR ETS; TRANSCRIPTION FACTOR FLI 1; TRANSCRIPTION FACTOR POU4F1; TUMOR MARKER;

EID: 77952959074     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2010.72     Document Type: Article
Times cited : (4)

References (50)
  • 1
    • 0035839938 scopus 로고    scopus 로고
    • Biology of EWS/ETS fusions in Ewing's family tumors
    • Arvand A, Denny CT. (2001). Biology of EWS/ETS fusions in Ewing's family tumors. Oncogene 20: 5747-5754.
    • (2001) Oncogene , vol.20 , pp. 5747-5754
    • Arvand, A.1    Denny, C.T.2
  • 2
    • 0028209984 scopus 로고
    • Dna-binding and transcriptional activation properties of the Ews-Fli-1 fusion protein resulting from the T(11;22) translocation in Ewing sarcoma
    • Bailly RA, Bosselut R, Zucman J, Cormier F, Delattre O, Roussel M et al. (1994). Dna-binding and transcriptional activation properties of the Ews-Fli-1 fusion protein resulting from the T(11;22) translocation in Ewing sarcoma. Mol Cell Biol 14: 3230-3241.
    • (1994) Mol Cell Biol , vol.14 , pp. 3230-3241
    • Bailly, R.A.1    Bosselut, R.2    Zucman, J.3    Cormier, F.4    Delattre, O.5    Roussel, M.6
  • 5
    • 0031037986 scopus 로고    scopus 로고
    • Interaction of Ets-1 and the POU-homeodomain protein GHF-1/Pit-1 reconstitutes pituitary-specific gene expression
    • Bradford AP, Wasylyk C, Wasylyk B, GutierrezHartmann A. (1997). Interaction of Ets-1 and the POU-homeodomain protein GHF-1/Pit-1 reconstitutes pituitary-specific gene expression. Mol Cell Biol 17: 1065-1074.
    • (1997) Mol Cell Biol , vol.17 , pp. 1065-1074
    • Bradford, A.P.1    Wasylyk, C.2    Wasylyk, B.3    Gutierrezhartmann, A.4
  • 6
    • 0026714692 scopus 로고
    • A novel Pou homeodomain gene specifically expressed in cells of the developing mammalian nervous-system
    • Collum RG, Fisher PE, Datta M, Mellis S, Thiele C, Huebner K et al. (1992). A novel Pou homeodomain gene specifically expressed in cells of the developing mammalian nervous-system. Nucleic Acids Res 20: 4919-4925.
    • (1992) Nucleic Acids Res , vol.20 , pp. 4919-4925
    • Collum, R.G.1    Fisher, P.E.2    Datta, M.3    Mellis, S.4    Thiele, C.5    Huebner, K.6
  • 7
    • 0034968428 scopus 로고    scopus 로고
    • Analysis of the expression of cell cycle regulators in Ewing cell lines: EWS-FLI-1 modulates p57(KIP2) and c-Myc expression
    • Dauphinot L, De Oliveira C, Melot T, Sevenet N, Thomas V, Weissman BE et al. (2001). Analysis of the expression of cell cycle regulators in Ewing cell lines: EWS-FLI-1 modulates p57(KIP2) and c-Myc expression. Oncogene 20: 3258-3265.
    • (2001) Oncogene , vol.20 , pp. 3258-3265
    • Dauphinot, L.1    De Oliveira, C.2    Melot, T.3    Sevenet, N.4    Thomas, V.5    Weissman, B.E.6
  • 8
    • 0026686674 scopus 로고
    • Gene fusion with an Ets Dna-binding domain caused by chromosome- translocation in human tumors
    • Delattre O, Zucman J, Plougastel B, Desmaze C, Melot T, Peter M et al. (1992). Gene fusion with an Ets Dna-binding domain caused by chromosome-translocation in human tumors. Nature 359: 162-165.
    • (1992) Nature , vol.359 , pp. 162-165
    • Delattre, O.1    Zucman, J.2    Plougastel, B.3    Desmaze, C.4    Melot, T.5    Peter, M.6
  • 9
    • 0037218795 scopus 로고    scopus 로고
    • Alteration of mesodermal cell differentiation by EWS/FLI-1, the oncogene implicated in Ewing's sarcoma
    • Eliazer S, Spencer J, Ye D, Olson E, Ilaria RL. (2003). Alteration of mesodermal cell differentiation by EWS/FLI-1, the oncogene implicated in Ewing's sarcoma. Mol Cell Biol 23: 482-492.
    • (2003) Mol Cell Biol , vol.23 , pp. 482-492
    • Eliazer, S.1    Spencer, J.2    Ye, D.3    Olson, E.4    Ilaria, R.L.5
  • 10
    • 0035862968 scopus 로고    scopus 로고
    • Defects in sensory axon growth precede neuronal death in Brn3a-deficient mice
    • Eng SR, Gratwick K, Rhee JM, Fedtsova N, Gan L, Turner EE. (2001). Defects in sensory axon growth precede neuronal death in Brn3a-deficient mice. J Neurosci 21: 541-549.
    • (2001) J Neurosci , vol.21 , pp. 541-549
    • Eng, S.R.1    Gratwick, K.2    Rhee, J.M.3    Fedtsova, N.4    Gan, L.5    Turner, E.E.6
  • 11
    • 0035895956 scopus 로고    scopus 로고
    • The BRN-3A transcription factor protects sensory but not sympathetic neurons from programmed cell death/apoptosis
    • Ensor E, Smith MD, Latchman DS. (2001). The BRN-3A transcription factor protects sensory but not sympathetic neurons from programmed cell death/apoptosis. J Biol Chem 276: 5204-5212.
    • (2001) J Biol Chem , vol.276 , pp. 5204-5212
    • Ensor, E.1    Smith, M.D.2    Latchman, D.S.3
  • 12
    • 0028868470 scopus 로고
    • Brn-3.0 expression identifies early postmitotic CNS neurons and sensory neural precursors
    • Fedtsova NG, Turner EE. (1995). Brn-3.0 expression identifies early postmitotic CNS neurons and sensory neural precursors. Mech Dev 53: 291-304.
    • (1995) Mech Dev , vol.53 , pp. 291-304
    • Fedtsova, N.G.1    Turner, E.E.2
  • 13
    • 0037069750 scopus 로고    scopus 로고
    • Gene expression of the POU factor Brn-3a is regulated by two different promoters
    • Frass B, Vassen L, Moroy T. (2002). Gene expression of the POU factor Brn-3a is regulated by two different promoters. Biochim Biophys Acta 1579: 207-213.
    • (2002) Biochim Biophys Acta , vol.1579 , pp. 207-213
    • Frass, B.1    Vassen, L.2    Moroy, T.3
  • 14
    • 0037427070 scopus 로고    scopus 로고
    • Upregulation of Id2, an oncogenic helix-loop-helix protein, is mediated by the chimeric EWS/ets protein in Ewing sarcoma
    • Fukuma M, Okita H, Hata J, Umezawa A. (2003). Upregulation of Id2, an oncogenic helix-loop-helix protein, is mediated by the chimeric EWS/ets protein in Ewing sarcoma. Oncogene 22: 1-9.
    • (2003) Oncogene , vol.22 , pp. 1-9
    • Fukuma, M.1    Okita, H.2    Hata, J.3    Umezawa, A.4
  • 15
    • 2342635751 scopus 로고    scopus 로고
    • The effects of Brn-3a on neuronal differentiation and apoptosis are differentially modulated by EWS and its oncogenic derivative EWS/Fli-1
    • Gascoyne DM, Thomas GR, Latchman DS. (2004). The effects of Brn-3a on neuronal differentiation and apoptosis are differentially modulated by EWS and its oncogenic derivative EWS/Fli-1. Oncogene 23: 3830-3840.
    • (2004) Oncogene , vol.23 , pp. 3830-3840
    • Gascoyne, D.M.1    Thomas, G.R.2    Latchman, D.S.3
  • 16
    • 10744222923 scopus 로고    scopus 로고
    • Imatinib inhibits proliferation of Ewing tumor cells mediated by the stem cell Factor/KIT receptor pathway, and sensitizes cells to vincristine and doxorubicin-induced apopto-sis
    • Gonzalez I, Andreu EJ, Panizo A, Inoges S, Fontalba A, Fernandez-Luna JL et al. (2004). Imatinib inhibits proliferation of Ewing tumor cells mediated by the stem cell Factor/KIT receptor pathway, and sensitizes cells to vincristine and doxorubicin-induced apopto-sis. Clin Cancer Res 10: 751-761.
    • (2004) Clin Cancer Res , vol.10 , pp. 751-761
    • Gonzalez, I.1    Andreu, E.J.2    Panizo, A.3    Inoges, S.4    Fontalba, A.5    Fernandez-Luna, J.L.6
  • 17
    • 0032848660 scopus 로고    scopus 로고
    • Repression of the gene encoding the TGF-beta type II receptor is a major target of the EWS-FLI1 oncoprotein
    • Hahm KB, Cho KN, Lee C, Im YH, Chang J, Choi SG et al. (1999). Repression of the gene encoding the TGF-beta type II receptor is a major target of the EWS-FLI1 oncoprotein. Nat Genet 23: 222-227.
    • (1999) Nat Genet , vol.23 , pp. 222-227
    • Hahm, K.B.1    Cho, K.N.2    Lee, C.3    Im, Y.H.4    Chang, J.5    Choi, S.G.6
  • 18
    • 21844436782 scopus 로고    scopus 로고
    • A developmental switch in the response of DRG neurons to ETS transcription factor signaling
    • Hippenmeyer S, Vrieseling E, Sigrist M, Portmann T, Laengle C, Ladle DR et al. (2005). A developmental switch in the response of DRG neurons to ETS transcription factor signaling. PLoS Biol 3: 878-890.
    • (2005) PLoS Biol , vol.3 , pp. 878-890
    • Hippenmeyer, S.1    Vrieseling, E.2    Sigrist, M.3    Portmann, T.4    Laengle, C.5    Ladle, D.R.6
  • 19
    • 25444482607 scopus 로고    scopus 로고
    • Sequence-specific knockdown of EWS-FLI1 by targeted, nonviral delivery of small interfering RNA inhibits tumor growth in a murine model of metastatic Ewing's sarcoma
    • Hu-Lieskovan S, Heidel JD, Bartlett DW, Davis ME, Triche TJ. (2005a). Sequence-specific knockdown of EWS-FLI1 by targeted, nonviral delivery of small interfering RNA inhibits tumor growth in a murine model of metastatic Ewing's sarcoma. Cancer Res 65: 8984-8992.
    • (2005) Cancer Res , vol.65 , pp. 8984-8992
    • Hu-Lieskovan, S.1    Heidel, J.D.2    Bartlett, D.W.3    Davis, M.E.4    Triche, T.J.5
  • 20
    • 19644386697 scopus 로고    scopus 로고
    • EWS-FLI1 fusion protein up-regulates critical genes in neural crest development and is responsible for the observed phenotype of Ewing's family of tumors
    • Hu-Lieskovan S, Zhang JS, Wu LT, Shimada H, Schofield DE, Triche TJ. (2005b). EWS-FLI1 fusion protein up-regulates critical genes in neural crest development and is responsible for the observed phenotype of Ewing's family of tumors. Cancer Res 65: 4633-4644.
    • (2005) Cancer Res , vol.65 , pp. 4633-4644
    • Hu-Lieskovan, S.1    Zhang, J.S.2    Wu, L.T.3    Shimada, H.4    Schofield, D.E.5    Triche, T.J.6
  • 21
    • 0033619101 scopus 로고    scopus 로고
    • Transforming activity of EWS/FLI is not strictly dependent upon DNA-binding activity
    • Jaishankar S, Zhang J, Roussel MF, Baker SJ. (1999). Transforming activity of EWS/FLI is not strictly dependent upon DNA-binding activity. Oncogene 18: 5592-5597.
    • (1999) Oncogene , vol.18 , pp. 5592-5597
    • Jaishankar, S.1    Zhang, J.2    Roussel, M.F.3    Baker, S.J.4
  • 22
    • 33645237099 scopus 로고    scopus 로고
    • Cooperative DNA binding with AP-1 proteins is required for transformation by EWS-Ets fusion proteins
    • Kim S, Denny CT, Wisdom R. (2006). Cooperative DNA binding with AP-1 proteins is required for transformation by EWS-Ets fusion proteins. Mol Cell Biol 26: 2467-2478.
    • (2006) Mol Cell Biol , vol.26 , pp. 2467-2478
    • Kim, S.1    Denny, C.T.2    Wisdom, R.3
  • 23
    • 0033634872 scopus 로고    scopus 로고
    • The metastatic ability of Ewing's sarcoma cells is modulated by stem cell factor and by its receptor c-kit
    • Landuzzi L, De Giovanni C, Nicoletti G, Rossi I, Ricci C, Astolfi A et al. (2000). The metastatic ability of Ewing's sarcoma cells is modulated by stem cell factor and by its receptor c-kit. Am J Pathol 157: 2123-2131.
    • (2000) Am J Pathol , vol.157 , pp. 2123-2131
    • Landuzzi, L.1    De Giovanni, C.2    Nicoletti, G.3    Rossi, I.4    Ricci, C.5    Astolfi, A.6
  • 24
    • 33846872161 scopus 로고    scopus 로고
    • Brn3a target gene recognition in embryonic sensory neurons
    • Lanier J, Quina LA, Eng SR, Cox E, Turner EE. (2007). Brn3a target gene recognition in embryonic sensory neurons. Dev Biol 302: 703-716.
    • (2007) Dev Biol , vol.302 , pp. 703-716
    • Lanier, J.1    Quina, L.A.2    Eng, S.R.3    Cox, E.4    Turner, E.E.5
  • 26
    • 33947262154 scopus 로고    scopus 로고
    • Preclinical in vivo study of new insulin-like growth factor-1 receptor\specific inhibitor in Ewing's sarcoma
    • Manara MC, Landuzzi L, Nanni P, Nicoletti G, Zambelli D, Lollini PL et al. (2007). Preclinical in vivo study of new insulin-like growth factor-1 receptor\specific inhibitor in Ewing's sarcoma. Clin Cancer Res 13: 1322-1330.
    • (2007) Clin Cancer Res , vol.13 , pp. 1322-1330
    • Manara, M.C.1    Landuzzi, L.2    Nanni, P.3    Nicoletti, G.4    Zambelli, D.5    Lollini, P.L.6
  • 28
    • 0027230568 scopus 로고
    • Ewing sarcoma 11-22 translocation produces a chimeric transcription factor that requires the Dna-binding domain encoded by fli1 for transformation
    • May WA, Gishizky ML, Lessnick SL, Lunsford LB, Lewis BC, Delattre O et al. (1993). Ewing sarcoma 11-22 translocation produces a chimeric transcription factor that requires the Dna-binding domain encoded by fli1 for transformation. Proc Natl Acad Sci USA 90: 5752-5756.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 5752-5756
    • May, W.A.1    Gishizky, M.L.2    Lessnick, S.L.3    Lunsford, L.B.4    Lewis, B.C.5    Delattre, O.6
  • 29
    • 0029808591 scopus 로고    scopus 로고
    • Requirement for Brn-3.0 in differentiation and survival of sensory and motor neurons
    • McEvilly RJ, Erkman L, Luo L, Sawchenko PE, Ryan AF, Rosenfeld MG. (1996). Requirement for Brn-3.0 in differentiation and survival of sensory and motor neurons. Nature 384: 574-577.
    • (1996) Nature , vol.384 , pp. 574-577
    • McEvilly, R.J.1    Erkman, L.2    Luo, L.3    Sawchenko, P.E.4    Ryan, A.F.5    Rosenfeld, M.G.6
  • 30
    • 0038689323 scopus 로고    scopus 로고
    • Identification of p21(WAF1/CIP1) as a direct target of EWS-Fli1 oncogenic fusion protein
    • Nakatani F, Tanaka K, Sakimura R, Matsumoto Y, Matsunobu T, Li X et al. (2003). Identification of p21(WAF1/CIP1) as a direct target of EWS-Fli1 oncogenic fusion protein. J Biol Chem 278: 15105-15115.
    • (2003) J Biol Chem , vol.278 , pp. 15105-15115
    • Nakatani, F.1    Tanaka, K.2    Sakimura, R.3    Matsumoto, Y.4    Matsunobu, T.5    Li, X.6
  • 31
    • 0037112732 scopus 로고    scopus 로고
    • Distinct promoter elements mediate the co-operative effect of Brn-3a and p53 on the p21 promoter and their antagonism on the Bax promoter
    • Perez-Sanchez C, Budhram-Mahadeo VS, Latchman DS. (2002). Distinct promoter elements mediate the co-operative effect of Brn-3a and p53 on the p21 promoter and their antagonism on the Bax promoter. Nucleic Acids Res 30: 4872-4880.
    • (2002) Nucleic Acids Res , vol.30 , pp. 4872-4880
    • Perez-Sanchez, C.1    Budhram-Mahadeo, V.S.2    Latchman, D.S.3
  • 32
    • 3543026281 scopus 로고    scopus 로고
    • EWS/FLI-1 silencing and gene profiling of Ewing cells reveal downstream oncogenic pathways and a crucial role for repression of insulin-like growth factor binding protein 3
    • Prieur A, Tirode F, Cohen P, Delattre O. (2004). EWS/FLI-1 silencing and gene profiling of Ewing cells reveal downstream oncogenic pathways and a crucial role for repression of insulin-like growth factor binding protein 3. Mol Cell Biol 24: 7275-7283.
    • (2004) Mol Cell Biol , vol.24 , pp. 7275-7283
    • Prieur, A.1    Tirode, F.2    Cohen, P.3    Delattre, O.4
  • 34
    • 29244447707 scopus 로고    scopus 로고
    • Development of Ewing's sarcoma from primary bone marrow-derived mesenchymal progenitor cells
    • Riggi N, Cironi L, Provero P, Suva ML, Kaloulis K, Garcia-Echeverria C et al. (2005). Development of Ewing's sarcoma from primary bone marrow-derived mesenchymal progenitor cells. Cancer Res 65: 11459-11468.
    • (2005) Cancer Res , vol.65 , pp. 11459-11468
    • Riggi, N.1    Cironi, L.2    Provero, P.3    Suva, M.L.4    Kaloulis, K.5    Garcia-Echeverria, C.6
  • 35
    • 42049089299 scopus 로고    scopus 로고
    • EWS-FLI-1 expression triggers a Ewing's sarcoma initiation program in primary human mesenchymal cells
    • Riggi N, Suva ML, Cironi L, Provero P, Tercier S, Joseph JM et al. (2008). EWS-FLI-1 expression triggers a Ewing's sarcoma initiation program in primary human mesenchymal cells. Cancer Res 68: 2176-2185.
    • (2008) Cancer Res , vol.68 , pp. 2176-2185
    • Riggi, N.1    Suva, M.L.2    Cironi, L.3    Provero, P.4    Tercier, S.5    Joseph, J.M.6
  • 36
    • 1242293672 scopus 로고    scopus 로고
    • The Ews/Fli-1 fusion gene switches the differentiation program of neuroblastomas to ewing sarcoma/peripheral primitive neuroectodermal tumors
    • Rorie CJ, Thomas VD, Chen PC, Pierce HH, O'Bryan JP, Weissman BE. (2004). The Ews/Fli-1 fusion gene switches the differentiation program of neuroblastomas to ewing sarcoma/peripheral primitive neuroectodermal tumors. Cancer Res 64: 1266-1277.
    • (2004) Cancer Res , vol.64 , pp. 1266-1277
    • Rorie, C.J.1    Thomas, V.D.2    Chen, P.C.3    Pierce, H.H.4    O'Bryan, J.P.5    Weissman, B.E.6
  • 37
    • 0031031287 scopus 로고    scopus 로고
    • The Brn-3a transcription factor induces neuronal process outgrowth and the coordinate expression of genes encoding synaptic proteins
    • Smith MD, Dawson SJ, Latchman DS. (1997). The Brn-3a transcription factor induces neuronal process outgrowth and the coordinate expression of genes encoding synaptic proteins. Mol Cell Biol 17: 345-354.
    • (1997) Mol Cell Biol , vol.17 , pp. 345-354
    • Smith, M.D.1    Dawson, S.J.2    Latchman, D.S.3
  • 38
    • 33646366123 scopus 로고    scopus 로고
    • Expression profiling of EWS/FLI identifies NKX2.2 as a critical target gene in Ewing's sarcoma
    • Smith R, Owen LA, Trem DJ, Wong JS, Jennifer SW, Golub TR et al. (2006). Expression profiling of EWS/FLI identifies NKX2.2 as a critical target gene in Ewing's sarcoma. Cancer Cell 9: 405-416.
    • (2006) Cancer Cell , vol.9 , pp. 405-416
    • Smith, R.1    Owen, L.A.2    Trem, D.J.3    Wong, J.S.4    Jennifer, S.W.5    Golub, T.R.6
  • 39
    • 0031025207 scopus 로고    scopus 로고
    • EWS-FLi1 antisense oligodeoxynucleotide inhibits proliferation of human Ewing's sarcoma and primitive neuroectodermal tumor cells
    • Tanaka K, Iwakuma T, Harimaya K, Sato H, Iwamoto Y. (1997). EWS-FLi1 antisense oligodeoxynucleotide inhibits proliferation of human Ewing's sarcoma and primitive neuroectodermal tumor cells. J Clin Invest 99: 239-247.
    • (1997) J Clin Invest , vol.99 , pp. 239-247
    • Tanaka, K.1    Iwakuma, T.2    Harimaya, K.3    Sato, H.4    Iwamoto, Y.5
  • 40
    • 0027731751 scopus 로고
    • Mouse Brn-3 family of pou transcription factors\a new aminoterminal domain is crucial for the oncogenic activity of Brn-3A
    • Theil T, Mcleanhunter S, Zornig M, Moroy T. (1993). Mouse Brn-3 family of pou transcription factors\a new aminoterminal domain is crucial for the oncogenic activity of Brn-3A. Nucleic Acids Res 21: 5921-5929.
    • (1993) Nucleic Acids Res , vol.21 , pp. 5921-5929
    • Theil, T.1    McLeanhunter, S.2    Zornig, M.3    Moroy, T.4
  • 41
    • 0025691624 scopus 로고
    • Pediatric peripheral neuroectodermal tumors, oncogenes, and differentiation
    • Thiele CJ. (1990). Pediatric peripheral neuroectodermal tumors, oncogenes, and differentiation. Cancer Invest 8: 629-639.
    • (1990) Cancer Invest , vol.8 , pp. 629-639
    • Thiele, C.J.1
  • 42
    • 0037742405 scopus 로고    scopus 로고
    • Ewing tumor fusion proteins block the differentiation of pluripotent marrow stromal cells
    • Torchia EC, Jaishankar S, Baker SJ. (2003). Ewing tumor fusion proteins block the differentiation of pluripotent marrow stromal cells. Cancer Res 63: 3464-3468.
    • (2003) Cancer Res , vol.63 , pp. 3464-3468
    • Torchia, E.C.1    Jaishankar, S.2    Baker, S.J.3
  • 43
    • 0037232677 scopus 로고    scopus 로고
    • Direct autoregulation and gene dosage compensation by POU-domain transcription factor Brn3a
    • Trieu M, Ma A, Eng SR, Fedtsova N, Turner EE. (2003). Direct autoregulation and gene dosage compensation by POU-domain transcription factor Brn3a. Development 130: 111-121.
    • (2003) Development , vol.130 , pp. 111-121
    • Trieu, M.1    Ma, A.2    Eng, S.R.3    Fedtsova, N.4    Turner, E.E.5
  • 44
    • 0033179568 scopus 로고    scopus 로고
    • Autoregulatory sequences are revealed by complex stability screening of the mouse brn-3.0 locus
    • Trieu M, Rhee JM, Fedtsova N, Turner EE. (1999). Autoregulatory sequences are revealed by complex stability screening of the mouse brn-3.0 locus. J Neurosci 19: 6549-6558.
    • (1999) J Neurosci , vol.19 , pp. 6549-6558
    • Trieu, M.1    Rhee, J.M.2    Fedtsova, N.3    Turner, E.E.4
  • 45
    • 0035834675 scopus 로고    scopus 로고
    • DNA binding domain-independent pathways are involved in EWS/FLI1-mediated oncogenesis
    • Welford SM, Hebert SP, Deneen B, Arvand A, Denny CT. (2001). DNA binding domain-independent pathways are involved in EWS/FLI1-mediated oncogenesis. J Biol Chem 276: 41977-41984.
    • (2001) J Biol Chem , vol.276 , pp. 41977-41984
    • Welford, S.M.1    Hebert, S.P.2    Deneen, B.3    Arvand, A.4    Denny, C.T.5
  • 47
    • 0029964874 scopus 로고    scopus 로고
    • Targeted deletion of the mouse POU domain gene Brn-3a causes a selective loss of neurons in the brainstem and trigeminal ganglion, uncoordinated limb movement, and impaired suckling
    • Xiang MQ, Gan L, Zhou LJ, Klein WH, Nathans J. (1996). Targeted deletion of the mouse POU domain gene Brn-3a causes a selective loss of neurons in the brainstem and trigeminal ganglion, uncoordinated limb movement, and impaired suckling. Proc Natl Acad Sci USA 93: 11950-11955.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 11950-11955
    • Xiang, M.Q.1    Gan, L.2    Zhou, L.J.3    Klein, W.H.4    Nathans, J.5
  • 49
    • 25444507396 scopus 로고    scopus 로고
    • Expression of the EWS/FLI-1 oncogene in murine primary bone-derived cells results in EWS/FLI-1-dependent, Ewing sarcoma-like tumors
    • Yeny CT, Eliazer S, Xiang LL, Richardson JA, Ilaria RL. (2005). Expression of the EWS/FLI-1 oncogene in murine primary bone-derived cells results in EWS/FLI-1-dependent, Ewing sarcoma-like tumors. Cancer Res 65: 8698-8705.
    • (2005) Cancer Res , vol.65 , pp. 8698-8705
    • Yeny, C.T.1    Eliazer, S.2    Xiang, L.L.3    Richardson, J.A.4    Ilaria, R.L.5
  • 50


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