Direct autoregulation and gene dosage compensation by POU-domain transcription factor Brn3a

Development

Volumn 130, Issue 1, 2003, Pages 111-121

  Trieu, May ^a   Ma, Ann ^a   Eng, S Raisa ^a   Fedtsova, Natalia ^a   Turner, Eric E ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Autoregulation; Brn3a; Mouse; POU domain; Transcription factor

Indexed keywords

TRANSCRIPTION FACTOR;

ALLELE; ANIMAL EXPERIMENT; ANIMAL TISSUE; AUTOREGULATION; BINDING AFFINITY; BINDING SITE; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; EMBRYO; ENHANCER REGION; GENE DOSAGE; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE LOCUS; GENETIC TRANSCRIPTION; INTERNEURON; KNOCKOUT MOUSE; MOUSE; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PRIORITY JOURNAL; REPORTER GENE; REVIEW; SENSORY GANGLION; SENSORY NERVE CELL; TRANSGENE; TRIGEMINUS GANGLION;

ANIMALS; ANIMALS, NEWBORN; BASE SEQUENCE; CENTRAL NERVOUS SYSTEM; CLONING, MOLECULAR; CONSERVED SEQUENCE; DNA-BINDING PROTEINS; ENHANCER ELEMENTS (GENETICS); GANGLIA, SENSORY; GENE DOSAGE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HOMEOSTASIS; HUMANS; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; NEURONS, AFFERENT; PROTEIN STRUCTURE, TERTIARY; TRANSCRIPTION FACTOR BRN-3; TRANSCRIPTION FACTOR BRN-3A; TRANSCRIPTION FACTORS;

ANIMALIA;

EID: 0037232677     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: 10.1242/dev.00194     Document Type: Review

References (47)

1. Arber, S., Han, B., Mendelsohn, M., Smith, M., Jessell, T. M. and Sockanathan, S. (1999). Requirement for the homeobox gene Hb9 in the consolidation of motor neuron identity. Neuron 23, 659-674.
2. Brink, C., Chowdhury, K. and Gruss, P. (2001). Pax4 regulatory elements mediate beta cell specific expression in the pancreas. Mech. Dev. 100, 37-43.
3. Briscoe, J. and Ericson, J. (2001). Specification of neuronal fates in the ventral neural tube. Curr. Opin. Neurobiol. 11, 43-49.
4. Budhram-Mahadeo, V., Morris, P. J., Lakin, N. D., Theil, T., Ching, G. Y., Lillycrop, K. A., Moroy, T., Liem, R. K. and Latchman, D. S. (1995). Activation of the alpha-internexin promoter by the Brn-3a transcription factor is dependent on the N-terminal region of the protein. J. Biol. Chem. 270, 2853-2858.
5. Certel, S. J., Clyne, P. J., Carlson, J. R. and Johnson, W. A. (2000). Regulation of central neuron synaptic targeting by the Drosophila POU protein, Acj6. Development 127, 2395-2405.
6. Chi, N. and Epstein, J. A. (2002). Getting your Pax straight: Pax proteins in development and disease. Trends Genet. 18, 41-47.
7. Clyne, P. J., Certel, S. J., de Bruyne, M., Zaslavsky, L., Johnson, W. A. and Carlson, J. R. (1999a). The odor specificities of a subset of olfactory receptor neurons are governed by Acj6, a POU-domain transcription factor. Neuron 22, 339-347.
8. Clyne, P. J., Warr, C. G., Freeman, M. R., Lessing, D., Kim, J. and Carlson, J. R. (1999b). A novel family of divergent seven-transmembrane proteins: candidate odorant receptors in Drosophila. Neuron 22, 327-338.
9. DiMattia, G. E., Rhodes, S. J., Krones, A., Carriere, C., O'Connell, S., Kalla, K., Arias, C., Sawchenko, P. and Rosenfeld, M. G. (1997). The Pit-1 gene is regulated by distinct early and late pituitary-specific enhancers. Dev. Biol. 182, 180-190.
10. Eng, S., Gratwick, K., Rhee, J., Fedtsova, N., Gan, L. and Turner, E. (2001). Defects in sensory axon growth precede neuronal death in Brn3a-deficient mice. J. Neurosci. 21, 541-549.
11. Erkman, L., McEvilly, R. J., Luo, L., Ryan, A. K., Hooshmand, F., O'Connell, S. M., Keithley, E. M., Rapaport, D. H., Ryan, A. F. and Rosenfeld, M. G. (1996). Role of transcription factors Brn-3.1 and Brn-3.2 in auditory and visual system development. Nature 381, 603-606.
12. Erkman, L., Yates, P. A., McLaughlin, T., McEvilly, R. J., Whisenhunt, T., O'Connell, S. M., Krones, A. I., Kirby, M. A., Rapaport, D. H., Bermingham, J. R. et al. (2000). A POU domain transcription factor-dependent program regulates axon pathfinding in the vertebrate visual system. Neuron 28, 779-792.
13. Fedtsova, N. and Turner, E. (1995). Brn-3.0 Expression identifies early post-mitotic CNS neurons and sensory neural precursors. Mech. Dev. 53, 291-304.
14. Fedtsova, N. and Turner, E. (1997). Inhibitory effects of ventral signals on the development of Brn-3.0-expressing neurons in the dorsal spinal cord. Dev. Biol. 190, 18-31.
15. Fedtsova, N. and Turner, E. E. (2001). Signals from the ventral midline and isthmus regulate the development of Brn3.0-expressing neurons in the midbrain. Mech. Dev. 105, 129-144.
16. Gan, L., Xiang, M., Zhou, L., Wagner, D. S., Klein, W. H. and Nathans, J. (1996). POU-domain factor Brn-3b is required for the development of a large set of retinal ganglion cells. Proc. Natl. Acad. Sci. USA 93, 3920-3925.
17. Gan, L., Wang, S. W., Huang, Z. and Klein, W. H. (1999). POU domain factor Brn-3b is essential for retinal ganglion cell differentiation and survival but not for initial cell fate specification. Dev. Biol. 210, 469-480.
18. Gross, M. K., Dottori, M. and Goulding, M. (2002). Lbx1 specifies somatosensory association interneurons in the dorsal spinal cord. Neuron 34, 535-549.
19. Gruber, C., Rhee, J., Gleiberman, A. and Turner, E. (1997). POU-domain factors of the Brn-3 class recognize functional DNA elements which are distinctive, symmetrical, and highly conserved in evolution. Mol. Cell Biol. 17, 2391-2400.
20. Helms, A. W., Abney, A. L., Ben-Arie, N., Zoghbi, H. Y. and Johnson, J. E. (2000). Autoregulation and multiple enhancers control Math1 expression in the developing nervous system. Development 127, 1185-1196.
21. Huang, E., Zang, K., Schmidt, A., Saulys, A., Xiang, M. and Reichardt, L. (1999). POU domain factor Brn-3a controls the differentiation and survival of trigeminal neurons by regulating Trk receptor expression. Development 126, 2869-2882.
22. Huang, E. J., Liu, W, Fritzsch, B., Bianchi, L. M., Reichardt, L. F. and Xiang, M. (2001). Brn3a is a transcriptional regulator of soma size, target field innervation and axon pathfinding of inner ear sensory neurons. Development 128, 2421-2432.
23. Kammandel, B., Chowdhury, K., Stoykova, A., Aparicio, S., Brenner, S. and Gruss, P. (1999). Distinct cis-essential modules direct the time-space pattern of the Pax6 gene activity. Dev. Biol. 205, 79-97.
24. Keithley, E. M., Erkman, L., Bennett, T., Lou, L. and Ryan, A. F. (1999). Effects of a hair cell transcription factor, Brn-3.1, gene deletion on homozygous and heterozygous mouse cochleas in adulthood and aging. Hear. Res. 134,71-76.
25. Koop, K. E., MacDonald, L. M. and Lobe, C. G. (1996). Transcripts of Grg4, a murine groucho-related gene, are detected in adjacent tissues to other murine neurogenic gene homologues during embryonic development. Mech. Dev. 59, 73-87.
26. Lee, S. K. and Pfaff, S. L. (2001). Transcriptional networks regulating neuronal identity in the developing spinal cord. Nat. Neurosci. 4 Suppl., 1183-1191.
27. Liebl, D., Tessarolo, L., Palko, M. and Parada, L. (1997). Absence of sensory neurons before target innervation in brain-derived neurotrophic factor-, neurotrophin 3-, and trkC-deficient embryonic mice. J. Neurosci. 17, 9113-9121.
28. Marshak, S., Benshushan, E., Shoshkes, M., Havin, L., Cerasi, E. and Melloul, D. (2000). Functional conservation of regulatory elements in the pdx-1 gene: PDX-1 and hepatocyte nuclear factor 3beta transcription factors mediate beta-cell-specific expression. Mol. Cell. Biol. 20, 7583-7590.
29. McEvilly, R. J., Erkman, L., Luo, L., Sawchenko, P. E., Ryan, A. F. and Rosenfeld, M. G. (1996). Requirement for Brn-3.0 in differentiation and survival of sensory and motor neurons. Nature 384, 574-577.
30. Muhr, J., Andersson, E., Persson, M., Jessell, T. M. and Ericson, J. (2001). Groucho-mediated transcriptional repression establishes progenitor cell pattern and neuronal fate in the ventral neural tube. Cell 104, 861-873.
31. Nutt, S. L., Vambrie,, S., Steinlein, P., Kozmik, Z., Rolink, A., Weith, A. and Busslinger, M. (1999). Independent regulation of the two Pax5 alleles during B-cell development. Nat. Genet. 21, 390-395.
32. Parks, J. S., Brown, M. R., Hurley, D. L., Phelps, C. J. and Wajnrajch, M. P. (1999). Heritable disorders of pituitary development. J. Clin. Endocrinol. Metab. 84, 4362-4370.
33. Rhee, J., Gruber, C., Brodie, T. and Turner, E. (1998). Highly cooperative homodimerization is a conserved property of neural POU proteins. J. Biol. Chem. 273, 34196-34205.
34. Rhodes, S. J., Chen, R., DiMattia, G. E., Scully, K. M., Kalla, K. A., Lin, S. C., Yu, V. C. and Rosenfeld, M. G. (1993). A tissue-specific enhancer confers Pit-1-dependent morphogen inducibility and autoregulation on the pit-1 gene. Genes Dev. 7, 913-932.
35. Scardigli, R., Schuurmans, C., Gradwohl, G. and Guillemot, F. (2001). Crossregulation between Neurogenin2 and pathways specifying neuronal identity in the spinal cord. Neuron 31, 203-217.
36. Simmons, A. D., Horton, S., Abney, A. L. and Johnson, J. E. (2001). Neurogenin2 expression in ventral and dorsal spinal neural tube progenitor cells is regulated by distinct enhancers. Dev. Biol. 229, 327-339.
37. Smith, M. D., Dawson, S. J. and Latchman, D. S. (1997). The Brn-3a transcription factor induces neuronal process outgrowth and the coordinate expression of genes encoding synaptic proteins. Mol. Cell. Biol. 17, 345-354.
38. Smith, S. T. and Jaynes, J. B. (1996). A conserved region of engrailed, shared among all en-, gsc-, Nk1-, Nk2- and msh-class homeoproteins, mediates active transcriptional repression in vivo. Development 122, 3141-3150.
39. Sze, J. Y., Liu, Y. and Ruvkun, G. (1997). VP16-activation of the C. elegans neural specification transcription factor UNC-86 suppresses mutations in downstream genes and causes defects in neural migration and axon outgrowth. Development 124, 1159-1168.
40. Trieu, M., Rhee, J., Fedtsova, N. and Turner, E. (1999). Autoregulatory sequences are revealed by complex stability screening of the mouse brn-3.0 locus. J. Neurosci. 19, 6549-6558.
41. Turner, E. (1996). Similar DNA recognition properties of alternatively spliced Drosophila POU factors. Proc. Nat. Acad. Sci. USA 93, 15097-15101.
42. Turner, E., Jenne, K. and Rosenfeld, M. (1994). Brn-3.2: a POU-domain transcription factor with distinctive CNS expression and regulation by retinoic acid. Neuron 12, 205-218.
43. Vahava, O., Morell, R., Lynch, E. D., Weiss, S., Kagan, M. E., Ahituv, N., Morrow, J. E., Lee, M. K., Skvorak, A. B., Morton, C. C. et al. (1998). Mutation in transcription factor POU4F3 associated with inherited progressive hearing loss in humans. Science 279, 1950-1954.
44. Veitia, R. A. (2002). Exploring the etiology of haploinsufficiency. BioEssays 24, 175-184.
45. Wang, S. W., Mu, X., Bowers, W. J., Kim, D. S., Plas, D. J., Crair, M. C., Federoff, H. J., Gan, L. and Klein, W. H. (2002). Brn3b/Brn3c double knockout mice reveal an unsuspected role for Brn3c in retinal ganglion cell axon outgrowth. Development 129, 467-477.
46. Xiang, M., Lin, G., Zhou, L., Klein, W. H. and Nathans, J. (1996). Targeted deletion of the mouse POU-domain gene Brn-3a causes a selective loss of neurons in the brainstem and trigeminal ganglion, uncoordinated limb movement, and impaired suckling. Proc. Natl. Acad. Sci. USA 93, 11950-11955.
47. Xiang, M., Gan, L., Li, D., Chen, Z. Y., Zhou, L., O'Malley, B. W., Jr, Klein, W. and Nathans, J. (1997). Essential role of POU-domain factor Brn-3c in auditory and vestibular hair cell development. Proc. Natl. Acad. Sci. USA 94, 9445-9450.