Autoregulatory sequences are revealed by complex stability screening of the mouse brn-3.0 Locus

Journal of Neuroscience

Volumn 19, Issue 15, 1999, Pages 6549-6558

  Trieu, May ^a,b   Rhee, Jerry M ^a   Fedtsova, Natalia ^a   Turner, Eric E ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b VA SAN DIEGO HEALTHCARE SYSTEM   (United States)

Author keywords

Autoregulation; Brn 3; Dissociation kinetics; Habenula; Homeodomain; Inferior olive; POU domain; Retina; Tectum; Transcription factor

Indexed keywords

DNA; TRANSCRIPTION FACTOR;

ANIMAL CELL; ARTICLE; AUTOREGULATION; DISSOCIATION; DNA BINDING; DNA SEQUENCE; ELECTROPHORETIC MOBILITY; IMMUNOHISTOCHEMISTRY; MOUSE; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 0033179568     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.19-15-06549.1999     Document Type: Article

References (33)

1. Affolter M, Percival-Smith A, Muller M, Leupin W, Ghering WJ (1990) DNA binding properties of the purified Antennapedia homeodomain. Proc Natl Acad Sci USA 87:4093-4097.
2. Artinger KB, Fedtsova N, Rhee JM, Bronner-Fraser M, Turner EE (1998) Placodal origin of Brn-3-expressing cranial sensory neurons. J Neurobiol 36:572-585.
3. Bateman E (1998) Autoregulation of eukaryotic transcription factors. Prog Nucleic Acids Res Mol Biol 60:133-163.
4. Budhram-Mahadeo V, Morris PJ, Lakin ND, Theil T, Ching GY, Lillycrop KA, Moroy T, Liem RK, Latchman DS (1995) Activation of the a-internexin promoter by the Brn-3a transcription factor is dependent on the N-terminal region of the protein. J Biol Chem 270:2853-2858.
5. Chen R, Ingraham HA, Treacy MN, Albert VR, Wilson L, Rosenfeld MG (1990) Autoregulation of pit-1 gene expression mediated by two cis-active promoter elements. Nature 346:583-586.
6. DiMattia GE, Rhodes SJ, Krones A, Carriere C, O'Connell S, Kalla K, Arias C, Sawchenko P, Rosenfeld MG (1997) The Pit-1 gene is regulated by distinct early and late pituitary enhancers. Dev Biol 182:180-190.
7. Ekker SC, Young KE, von Kessler DP, Beachy PA (1991) Optimal DNA sequence recognition by the ultrabithorax homeodomain of Drosophila. EMBO J 10:1179-1186.
8. Erkman L, McEvilly RJ, Luo L, Ryan AK, Hooshmand F, O'Connell SM, Keithley EM, Rapaport DH, Ryan AF, Rosenfeld MG (1996) Role of transcription factors Brn-3.1 and Brn-3.2 in auditory and visual system development. Nature 381:603-606.
9. Ericson J, Thor S, Edlund T, Jessel T, Yamada T (1992) Early stages of motor neuron differentiation revealed by expression of homeobox gene Islet-1. Science 256:1555-1560.
10. Fedtsova N, Turner EE (1995) Brn-3.0 Expression identifies early post-mitotic CNS neurons and sensory neural precursors. Mech Dev 53:291-304.
11. Fedtsova N, Turner EE (1997) Inhibitory effects of ventral signals on the development of Brn-3.0-expressing neurons in the dorsal spinal cord. Dev Biol 190:18-31.
12. Gan L, Xiang M, Zhou L, Wagner DS, Klein WH, Nathans J (1996) POU-domain factor Brn-3b is required for the development of a large set of retinal ganglion cells. Proc Natl Acad Sci USA 93:3920-3925.
13. Gruber CA, Rhee JM, Gleiberman A, Turner EE (1997) POU-domain factors of the Brn-3 class recognize functional DNA elements which are distinctive symmetrical and highly conserved in evolution. Mol Cell Biol 17:2391-2400.
14. Han W, Yu Y, Altan N, Pick L (1993) Multiple proteins interact with the fushi tarazu proximal enhancer. Mol Cell Biol 13:5549-5559.
15. Li P, He X, Gerrero MR, Mok M, Aggarwal A, Rosenfeld MG (1993) Spacing and orientation of bipartite DNA-binding motifs as potential functional determinants for POU-domain factors. Genes Dev 7:2483-2496.
16. McEvilly RJ, Erkman L, Luo L, Sawchenko PE, Ryan AF, Rosenfeld MG (1996) Requirement for Brn-3.0 in differentiation and survival of sensory and motor neurons. Nature 384:574-577.
17. Morris PJ, Theil T, Ring CT, Lillycrop K, Moroy T, Latchman DS (1994) The opposite and antagonistic effects of the closely related POU family transcription factors Brn-3a and Brn-3b on the activity of target promoters are dependent on differences in the POU domain. Mol Cell Biol 14:6907-6914.
18. Morris PJ, Lakin ND, Dawson SJ, Ryabinin AE, Kilimann MW, Wilson MC, Latchman DS (1996) Differential regulation of genes encoding synaptic proteins by members of the Brn-3 subfamily of POU transcription factors. Mol Brain Res 43:279-285.
19. Pfaff SL, Mendelsohn M, Stewart CL, Edlund T, Jessell TM (1996) Requirement for LIM homeobox gene Isl-1 in motor neuron generation reveals a motor neuron-dependent step in interneuron differentiation. Cell 84:309-320.
20. Pick L, Schier A, Affolter M, Schmidt-Glenewinkel T, Gehring WJ (1990) Analysis of the ftz upstream element: gem layer-specific enhancers are independently autoregulated. Genes Dev 4:1224-1239.
21. Rhee JM, Gruber CA, Brodie TB, Trieu M, Turner EE (1998) Highly cooperative homodimerization is a conserved property of neural POU proteins. J Biol Chem 273:34196-34205.
22. Rhodes SJ, Chen R, DiMattia GE, Scully KM, Kalla KA, Lin SC, Yu VC, Rosenfeld MG (1993) A tissue-specific enhancer confers Pit-1-dependent morphogen inducibility and autoregulation on the Pit-1 gene. Genes Dev 7:913-932.
23. Ryan AK, Rosenfeld MG (1997) POU domain family values: flexibility partnerships, and developmental codes. Genes Dev 11:1207-1225.
24. Schier AF, Gehring WJ (1992) Direct homeodomain-DNA interaction in the autoregulation of the fushi tarazu gene. Nature 356:804-807.
25. Theil T, McLean-Hunter S, Zornig M, Moroy T (1993) Mouse Brn-3 family of POU transcription factors: a new aminoterminal domain is crucial for the oncogenic activity of Brn-3a. Nucleic Acids Res 21:5921-5929.
26. Theil T, Rodel B, Spiegelhalter F, Moroy T (1995) Short isoform of POU factor Brn-3b can form a heterodimer with Brn-3a that is inactive for octamer motif binding. J Biol Chem 270:30958-30964.
27. Thor S, Ericson J, Brannstrom T, Edlund T (1991) The homeodomain LIM protein Isl-1 is expressed in subsets of neurons and endocrine cells in the adult rat. Neuron 7:881-889.
28. Turner EE, Jenne K, Rosenfeld MG (1994) Brn-3.2: A POU-domain transcription factor with distinctive CNS expression and regulation by retinoic acid. Neuron 12:205-218.
29. Verrijzer CP, Alkema MJ, vanWeperen WW, VanLeeuwen HC, Strating MJ, van der Vliet PC (1992) The DNA binding specificity of the bipartite POU domain and its subdomains. EMBO J 11:4993-5003.
30. XiangM (1998) Requirement for Brn-3b in early differentiation of post-mitotic retinal ganglion cell precursors. Dev Biol 197:155-169.
31. Xiang M, Zhou L, Peng Y-W, Eddy R, Shows TB, Nathans J (1993) Brn-3b: a POU domain gene expressed in a subset of retinal ganglion cells. Neuron 11:689-701.
32. Xiang M, Zhou L, Macke JP, Yoshioka T, Hendry S, Eddy RL, Shows TB, Nathans J (1995) The Brn-3 family of POU-domain factors: primary structure binding specificity and expression in subsets of retinal ganglion cells and somatosensory neurons. J Neurosci 15:4762-4785.
33. Xiang M, Lin G, Zhou L, Klein WH, Nathans J (1996) Targeted deletion of the mouse POU-domain gene Brn-3a causes a selective loss of neurons in the brainstem and trigeminal ganglion uncoordinated limb movement and impaired suckling. Proc Natl Acad Sci USA 93:11950-11955.