Glucose induces early growth response gene (Egr-1) expression in pancreatic beta cells

Diabetologia

Volumn 42, Issue 2, 1999, Pages 195-203

  Josefsen, K ^a   Sorensen L R ^a   Buschard, K ^a   Birkenbach, M ^b  

^a Kommunehospitalet ^*  (Denmark)

^b UNIVERSITY OF CHICAGO   (United States)

Author keywords

Beta cell line; Egr 1; Glucose stimulation; MIN6; Transcription factor

Indexed keywords

ANIMAL CELL; ARTICLE; FIBROBLAST; GENE EXPRESSION REGULATION; GENE INDUCTION; GENE ISOLATION; GENETIC REGULATION; GLUCOSE HOMEOSTASIS; GLUCOSE METABOLISM; IMMEDIATE EARLY GENE; INSULIN SYNTHESIS; MEMBRANE DEPOLARIZATION; MOLECULAR CLONING; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSCRIPTION REGULATION;

3T3 CELLS; ANIMALS; CALCIUM; CELL LINE, TRANSFORMED; CHELATING AGENTS; DNA-BINDING PROTEINS; EARLY GROWTH RESPONSE PROTEIN 1; EDETIC ACID; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENES, FOS; GENES, JUN; GLUCOSE; IMMEDIATE-EARLY PROTEINS; ISLETS OF LANGERHANS; KINETICS; LIVER; MICE; RATS; RNA, MESSENGER; SIMIAN VIRUS 40; TRANSCRIPTION FACTORS;

EID: 0032955739     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001250051139     Document Type: Article

References (61)

1. 1. Ashcroft SJH (1980) Glucoreceptor mechanisms and the control of insulin release and biosynthesis. Diabetologia 18: 5-15
2. 2. Itoh N, Okamoto H (1980) Transiational control of proinsulin synthesis by glucose. Nature 283: 100-102
3. 3. Welsh M, Nielsen DA, MacKrell AJ, Steiner DF (1985) Control of insulin gene expression in pancreatic beta-cells and in an insulin-producing cell line, RIN-F cells. II Regulation of insulin mRNA stability. J Biol Chem 260: 13590-13594
4. 4. Clark SA, Burnham BL, Chick WL (1990) Modulation of glucose-induced insulin secretion from a rat clonal beta-cell line. Endocrinology 127: 2779-2788
5. 5. Nielsen DA, Welsh M, Casadaban MJ, Steiner DF (1985) Control of insulin gene expression in pancreatic beta-cells and in an insulin-producing cell line, RIN-F cells. I. Effects of glucose and cAMP on the transcription of insulin mRNA. J Biol Chem 260: 13585-13589
6. 6. Yasuda K, Yamada Y, Inagaki N et al. (1992) Expression of GLUT1 and GLUT2 glucose transporter isoforms in rat islets of Langerhans and their regulation by glucose. Diabetes 41: 76-81
7. 7. Marie S, Diaz-Guerra MJ, Miquerol L, Kahn A, Iynedjian PB (1993) The pyruvate kinase gene as a model for studies of glucose-dependent regulation of gene expression in the endocrine pancreatic beta-cell type. J Biol Chem 268: 23881-23890
8. 8. Brun T, Roche E, Kim KH, Prentki M (1993) Glucose regulates acetyl-CoA carboxylase gene expression in a pancreatic beta-cell line (INS-1). J Biol Chem 268: 18905-18911
9. 9. Björk E, Kämpe O, Karlsson FA et al. (1992) Glucose regulation of the autoantigen GAD65 in human pancreatic islets. J Clin Endocrinol Metab 75: 1574-1576
10. 10. Marshak S, Totary H, Cerasi E, Melloul D (1996) Purification of the beta-cell glucose-sensitive factor that transactivates the insulin gene differentially in normal and transformed islet cells. Proc Natl Acad Sci USA 93: 15057-15062
11. 11. German MS, Wang J (1994) The insulin gene contains multiple transcriptional elements that respond to glucose. Mol Cell Biol 14: 4067-4075
12. 12. Sharma A, Stein R (1994) Glucose-induced transcription of the insulin gene is mediated by factors required for beta-cell-type-specific expression. Mol Cell Biol 14: 871-879
13. 13. MacFarlane WM, Read ML, Gilligan M, Bujalska I, Docherty K (1994) Glucose modulates the binding activity of the beta-cell transcriptioin factor IUF1 in a phosphorylation-dependent manner. Biochem J 303: 625-631
14. 14. Zhang S, Kim KH (1997) Protein kinase CK2 down-regulates glucose-activated expression of the acetyl-CoA carboxylase gene. Arch Biochem Biophys 338: 227-232
15. 15. Zangen DH, Bonner-Weir W, Lee CH et al. (1997) Reduced insulin, GLUT2, and IDX-1 in beta cells after partial pancreatectomy. Diabetes 46: 258-264
16. 16. Sharma A, Olson LK, Robertson RP, Stein R (1995) The reduction of insulin gene transcription in HIT-T15 beta cells chronically exposed to high glucose concentration is associated with the loss of RIPE3b1 and STF-transription factor expression. Mol Endocrinol 9: 1127-1134
17. 17. Tokuyama Y, Sturis J, DePaoli AM et al. (1995) Evolution of beta-cell dysfunction in the male Zucker diabetic fatty rat. Diabetes 44: 1447-1457
18. 18. Miyazaki J, Araki K, Yamato E et al. (1990) Establishment of a pancreatic beta cell line that retains glucose-inducible insulin secretion: Special reference to expression of glucose transporter isoforms. Endocrinology 127: 126-132
19. 19. Asfari M, Janjic D, Meda P, Li G, Halban PA, Wollheim CB (1992) Establishment of 2-mercaptoethanol differentiated insulin-secreting cell lines. Endocrinology 130: 167-178
20. 20. Santerre RF, Cook RA, Crisel RM et al. (1981) Insulin synthesis in a clonal cell line of simian virus 40-transformed hamster pancreatic beta cells. Proc Natl Acad Sci USA 78: 4339-4343
21. 21. Dich J, Grunnet N (1990) Primary cultures of rat hepatocytes. Methods Mol Biol 5: 161-176
22. 22. Rasmussen ÅK, Kayser L, Perrild H, Brandt M, Beck K, Feldt-Rasmussen U (1996) Human thyroid epithelial cells cultured in monolayers. I. Decreased thyroglobulin and cAMP response to TSH in 12-week-old secondary and tertiary cultures. Mol Cell Endocrinol 116: 165-172
23. 23. Chomczynski P, Sacchi N (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate phenol chloroform extraction. Anal Biochem 162: 156-159
24. 24. Sambrook J, Fritsch EF, Maniatis T (1989) Molecular cloning. A laboratory manual, 2nd edn. Cold Spring Harbor Laboratory Press, Cold Spring Harbor
25. 25. Poitout V, Olson LK, Robertson RP (1996) Insulin-secreting cell lines: classification, characteristics and potential applications. Diabetes Metab 22: 7-14
26. 26. Newgard CB, McGarry JD (1995) Metabolic coupling factors in pancreatic beta cell signal transduction. Ann Rev Biochem 64: 689-719
27. 27. Skelly RH, Schuppin GT, Ishihara H, Oka Y, Rhodes CJ (1996) Glucose-regulated translational control of proinsulin biosynthesis with that of the proinsulin endopeptidases PC2 and PC3 in the insulin-processing MIN6 cell line. Diabetes 45: 37-43
28. 28. Ishihara H, Asano T, Tsukuda K et al. (1993) Pancreatic beta cell line MIN6 exhibits characteristics of glucose metabolism and glucose-stimulated insulin secretion similar to those of normal islets. Diabetologia 36: 1139-1145
29. 28a. Josefsen K, Buschard K, Sørensen LR et al. (1998) Glucose stimulation of pancreatic β-cells lines induces expression and secretion of dynorphin. Endocrinology 139: 4329-4336
30. 29. Sukhatme VP, Kartha S, Toback FG, Taub R, Hoover RG, Tsai-Morris CH (1987) A novel early growth response gene rapidly induced by fibroblast, epithelial cell and lymphocyte mitogens. Oncogene Res 1: 343-355
31. 30. Cao XM, Guy GR, Sukhatme VP, Tan YH (1992) Regulation of the Egr-1 gene by tumor necrosis factor and interferons in primary human fibroblasts. J Biol Chem 267: 1345-1349
32. 31. Gashler A, Sukhatme VP (1995) Early growth response protein 1 (EGR-1): prototype of a zinc-finger family of transcription factors. Prog Nucleic Acid Res Mol Biol 50: 191-224
33. 32. Liang Y, Najafi H, Smith RM et al. (1992) Concordant glucose induction of glucokinase, glucose usage, and glucose-stimulated insulin release in pancreatic islets maintained in organ culture. Diabetes 41: 792-806
34. 33. Cao XM, Koski RA, Gashler A et al. (1990) Identification and characterization of the Egr-1 gene product, a DNA-binding zinc finger protein induced by differentiation and growth signals. Mol Cell Biol 10: 1931-1939
35. 34. Semenkovich CF, Coleman T, Goforth R (1993) Physiologic concentrations of glucose regulate fatty acid synthase activity in HepG2 cells by mediating fatty acid synthase mRNA stability. J Biol Chem 268: 6961-6970
36. 35. Wolf G, Sharma K, Chen Y, Ericksen M, Ziyadeh FN (1992) High glucose-induced proliferation in mesangial cells is reversed by autocrine TGF-beta. Kidney Int 42: 647-656
37. 36. Lau LF, Nathans D (1987) Expression of a set of growth-related immediate early genes in BALB/c 3T3 cells: coordinate regulation with c-fos or c-myc. Proc Natl Acad Sci USA 84: 1182-1186
38. 37. Inagaki N, Maekawa T, Sudo T, Ishii S, Seino Y, Imura H (1992) c-Jun represses the human insulin promotor activity that depends on multiple cAMP response elements. Proc Natl Acad Sci USA 89: 1045-1049
39. 38. Alexander-Bridges M, Buggs C, Giere L et al. (1992) Models of insulin action on metabolic and growth response genes. Mol Cell Biochem 109: 99-105
40. 39. Arkhammar P, Nilsson T, Welch M, Welch N, Berggren PO (1989) Effects of protein kinase C activation on the stimulus-secretion coupling in pancreatic beta-cells. Biochem J 264: 207-215
41. 40. Quantin B, Breathnach R (1988) Epidermal growth factor stimulates transcription of the c-jun proto-oncogene in rat fibroblasts. Nature 334: 538-539
42. 41. Bartel DP, Sheng M, Lau LF, Greenberg ME (1989) Growth factors and membrane depolarization activate distinct programs of early response gene expression: dissociation of fos and jun induction. Genes Dev 3: 304-313
43. 42. Marais R, Wynne J, Treisman R (1993) The SRF accessory protein Elk-contains a growth factor-regulated transcriptional activation domain. Cell 73: 381-393
44. 43. Hipskind RA, Baccarini M, Nordheim A (1994) Transient activation of RAF-1, MEK, and ERK2 coincides kinetically with ternary complex factor phosphorylation and immediate-early gene promoter activity in vivo. Mol Cell Biol 14: 6219-6231
45. 44. Frodin M, Sekine N, Roche E et al. (1995) Glucose, other secretagogues, and nerve growth factor stimulate mitogen-activated protein kinase in the insulin-secreting beta-cell line, INS-1. J Biol Chem 270: 7882-7889
46. 45. Rosen LB, Ginty DD, Weber MJ, Greenberg ME (1994) Membrane depolarization and calcium influx stimulate MEK and MAP kinase via activation of Ras. Neuron 12: 1207-1221
47. 46. Khoo S, Cobb MH (1997) Activation of mitogen-activating protein kinase by glucose is not required for insulin secretion. Proc Natl Acad Sci USA 94: 5599-5604
48. 47. Persaud SJ, Wheeler-Jones CP, Jones PM (1996) The mitogen-activated protein kinase pathway in rat islets of Langerhans: studies on the regulation of insulin secretion. Biochem J 313: 119-124
49. 48. Madden SL, Rauscher F (1993) Positive and negative regulation of transcription and cell growth mediated by the EGR family of zinc-finger gene products. Ann NY Acad Sci 684: 75-84
50. 49. Huang RP, Adamson ED (1993) Characterization of the DNA-binding properties of the early growth response-1 (egr-1) transcription factor: evidence for modulation by a redox mechanism. DNA Cell Biol 12: 265-273
51. 50. Abate C, Patel L, Rauscher FJ3, Curran T (1990) Redox regulation of fos and jun DNA-binding activity in vitro. Science 249: 1157-1161
52. 51. Dukes ID, McIntyre MS, Mertz RJ et al. (1994) Dependence on NADH produced during glycolysis for beta-cell glucose signaling. J Biol Chem 269: 10979-10982
53. 52. Nehlin JO, Ronne H (1990) Yeast MIG1 repressor is related to the mammalian early growth response and Wilms' tumour finger proteins. EMBO J 9: 2891-2898
54. 53. Estruch F, Carlson M (1993) Two homologous zinc finger genes identified by multicopy suppression in a SNF1 protein kinase mutant of Saccharomyces cerevisiae. Mol Cell Biol 13: 3872-3881
55. 54. Molnar G, Crozat A, Pardee AB (1994) The immediate early gene Egr-1 regulates the activity of the thymidine kinase promotor at the G0-to-G1 transition of the cell cycle. Mol Cell Biol 14: 5242-5248
56. 55. Khachigian LM, Lindner V, Williams AJ, Collins T (1996) Egr-1-induced endothelial gene expression: a common theme in vascular injury. Science 271: 1427-1431
57. 56. Maltzman JS, Carman JA, Monroe JG (1996) Transcriptional regulation of the ICAM-q gene in antigen receptor-and phorbol ester-stimulated B lymphocytes: role for transcription factor EGR-1. J Exp Med 183: 1747-1759
58. 57. Maltzman JS, Carman JA, Monroe JG (1996) Role of EGR1 in regulation of stimulus-dependent CD44 transcription in B lymphocytes. Mol Cell Biol 16: 2283-2294
59. 58. Abraham WC, Dragunow M, Tate WP (1991) The role of immediate genes in the stabilization of long-term potentiation. Mol Neurobiol 5: 297-314
60. 59. Petersohn D, Schoch S, Brinkmann DR, Thiel G (1995) Possible role for the transcription factor zif286/egr-1, polyoma enhancer activator 3, and AP-2. J Biol Chem 270: 24361-24369
61. 60. Atouf F, Czernichow P, Scharfmann R (1997) Expression of neuronal traits in pancreatic beta cells. Implication of neuron-restrictive silencing factor/repressor element silencing transcription factor, a neuron-restrictive silencer. J Biol Chem 272: 1929-1934