Cortical neurons from intrauterine growth retardation rats exhibit lower response to neurotrophin BDNF

Neuroscience Letters

Volumn 476, Issue 2, 2010, Pages 104-109

  Ninomiya, Midori ^a,b   Numakawa Tadahiro, T ^b,c   Adachi, Naoki ^b,c   Furuta, Miyako ^b   Chiba, Shuichi ^b   Richards, Misty ^b,d   Shibata, Shigenobu ^a   Kunugi, Hiroshi ^b,c  

^a WASEDA UNIVERSITY   (Japan)

^b NATIONAL INSTITUTE OF NEUROSCIENCE   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^d ALBANY MEDICAL COLLEGE   (United States)

Author keywords

BDNF; Cell death; Intrauterine growth retardation; TrkB

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; GLUTAMATE RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BCL 2; PROTEIN GLUA1; PROTEIN GLUN2A; PROTEIN KINASE B; THROMBOXANE A2; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CELL; BRAIN CORTEX; CELL SURVIVAL; CELL VIABILITY; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DOWN REGULATION; FEMALE; INTRAUTERINE GROWTH RETARDATION; LOW BIRTH WEIGHT; NERVE CELL PLASTICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; SCHIZOPHRENIA; SIGNAL TRANSDUCTION;

ANIMALS; BRAIN-DERIVED NEUROTROPHIC FACTOR; CELL DEATH; CELL SURVIVAL; CELLS, CULTURED; CEREBRAL CORTEX; FEMALE; FETAL GROWTH RETARDATION; NEURONS; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RATS, LONG-EVANS; RECEPTOR, TRKB; RECEPTORS, AMPA; RECEPTORS, N-METHYL-D-ASPARTATE;

EID: 77952890971     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2010.03.082     Document Type: Article

References (36)

1. Abdolmaleky H.M., Cheng K.H., Faraone S.V., Wilcox M., Glatt S.J., Gao F., Smith C.L., Shafa R., Aeali B., Carnevale J., Pan H., Papageorgis P., Ponte J.F., Sivaraman V., Tsuang M.T., Thiagalingam S. Hypomethylation of MB-COMT promoter is a major risk factor for schizophrenia and bipolar disorder. Hum. Mol. Genet. 2006, 15:3132-3145.
2. Abdolmaleky H.M., Cheng K.H., Russo A., Smith C.L., Faraone S.V., Wilcox M., Shafa R., Glatt S.J., Nguyen G., Ponte J.F., Thiagalingam S., Tsuang M.T. Hypermethylation of the reelin (RELN) promoter in the brain of schizophrenic patients: a preliminary report. Am. J. Med. Genet. B: Neuropsychiatr. Genet. 2005, 134B:60-66.
3. S. Akbarian, The molecular pathology of schizophrenia-Focus on histone and DNA modifications, Brain Res. Bull., in press.
4. Almeida R.D., Manadas B.J., Melo C.V., Gomes J.R., Mendes C.S., Grãos M.M., Carvalho R.F., Carvalho A.P., Duarte C.B. Neuroprotection by BDNF against glutamate-induced apoptotic cell death is mediated by ERK and PI3-kinase pathways. Cell Death Differ. 2005, 12:1329-1343.
5. Altar C.A. Neurotrophins and depression. Trends Pharmacol. Sci. 1999, 20:59-61.
6. Angelucci F., Brenè S., Mathé A.A. BDNF in schizophrenia, depression and corresponding animal models. Mol. Psychiatry 2005, 10:345-352.
7. Arancio O., Chao M.V. Neurotrophins, synaptic plasticity and dementia. Curr. Opin. Neurobiol. 2007, 17:325-330.
8. Boksa P. Animal models of obstetric complications in relation to schizophrenia. Brain Res. Brain Res. Rev. 2004, 45:1-17.
9. Dudek H., Datta S.R., Franke T.F., Birnbaum M.J., Yao R., Cooper G.M., Segal R.A., Kaplan D.R., Greenberg M.E. Regulation of neuronal survival by the serine-threonine protein kinase Akt. Science 1997, 275:661-665.
10. Durany N., Michel T., Zochling R., Boissl K.W., Cruz-Sanchez F.F., Riederer P., Thome J. Brain-derived neurotrophic factor and neurotrophin 3 in schizophrenic psychoses. Schizophr. Res. 2001, 52:79-86.
11. Durany N., Thome J. Neurotrophic factors and the pathophysiology of schizophrenic psychoses. Eur. Psychiatry 2004, 19:326-337.
12. Ernst C., Deleva V., Deng X., Sequeira A., Pomarenski A., Klempan T., Ernst N., Quirion R., Gratton A., Szyf M., Turecki G. Alternative splicing, methylation state, and expression profile of tropomyosin-related kinase B in the frontal cortex of suicide completers. Arch. Gen. Psychiatry 2009, 66:22-32.
13. Frankle W.G., Lerma J., Laruelle M. The synaptic hypothesis of schizophrenia. Neuron 2003, 39:205-216.
14. Fukami E., Nakayama A., Sasaki J., Mimura S., Mori N., Watanabe K. Underexpression of neural cell adhesion molecule and neurotrophic factors in rat brain following thromboxane A(2)-induced intrauterine growth retardation. Early Hum. Dev. 2000, 58:101-110.
15. Gavin D.P., Sharma R.P. Histone modifications, DNA methylation, and schizophrenia. Neurosci. Biobehav. Rev. 2010, 34:882-888.
16. Grayson D.R., Jia X., Chen Y., Sharma R.P., Mitchell C.P., Guidotti A., Costa E. Reelin promoter hypermethylation in schizophrenia. Proc. Natl. Acad. Sci. U.S.A. 2005, 102:9341-9346.
17. Harrison P.J., Law A.J., Eastwood S.L. Glutamate receptors and transporters in the hippocampus in schizophrenia. Ann. N. Y. Acad. Sci. 2003, 1003:94-101.
18. Harrison P.J., Weinberger D.R. Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence. Mol. Psychiatry 2005, 10:40-68.
19. Hashimoto R., Numakawa T., Ohnishi T., Kumamaru E., Yagasaki Y., Ishimoto T., Mori T., Nemoto K., Adachi N., Izumi A., Chiba S., Noguchi H., Suzuki T., Iwata N., Ozaki N., Taguchi T., Kamiya A., Kosuga A., Tatsumi M., Kamijima K., Weinberger D.R., Sawa A., Kunugi H. Impact of the DISC1 Ser704Cys polymorphism on risk for major depression, brain morphology and ERK signaling. Hum. Mol. Genet. 2006, 15:3024-3033.
20. Hayakawa M., Mimura S., Sasaki J., Watanabe K. Neuropathological changes in the cerebrum of IUGR rat induced by synthetic thromboxane A2. Early Hum. Dev. 1999, 55:125-136.
21. Iritani S., Niizato K., Nawa H., Ikeda K., Emson P.C. Immunohistochemical study of brain-derived neurotrophic factor and its receptor, TrkB, in the hippocampal formation of schizophrenic brains. Prog. Neuropsychopharmacol. Biol. Psychiatry 2003, 27:801-807.
22. Iwamoto K., Bundo M., Yamada K., Takao H., Iwayama-Shigeno Y., Yoshikawa T., Kato T. DNA methylation status of SOX10 correlates with its downregulation and oligodendrocyte dysfunction in schizophrenia. J. Neurosci. 2005, 25:5376-5381.
23. Kumamaru E., Numakawa T., Adachi N., Yagasaki Y., Izumi A., Niyaz M., Kudo M., Kunugi H. Glucocorticoid prevents brain-derived neurotrophic factor-mediated maturation of synaptic function in developing hippocampal neurons through reduction in the activity of mitogen-activated protein kinase. Mol. Endocrinol. 2008, 22:546-558.
24. Kunugi H. Obstetric and delivery complications as risk factors for schizophrenia: neurodevelopmental perspectives. Preventive Strategies for Schizophrenic Disorders: Basic Principles, Opportunities and Limits 2003, 159-187. Giovanni Floriti Editore. A. Grispini (Ed.).
25. Kunugi H., Nanko S., Murray R.M. Obstetric complications and schizophrenia: prenatal underdevelopment and subsequent neurodevelopmental impairment. Br. J. Psychiatry Suppl. 2001, 40:s25-29.
26. Matsumoto T., Numakawa T., Yokomaku D., Adachi N., Yamagishi S., Numakawa Y., Kunugi H., Taguchi T. Brain-derived neurotrophic factor-induced potentiation of glutamate and GABA release: different dependency on signaling pathways and neuronal activity. Mol. Cell. Neurosci. 2006, 31:70-84.
27. Numakawa T., Kumamaru E., Adachi N., Yagasaki Y., Izumi A., Kunugi H. Glucocorticoid receptor interaction with TrkB promotes BDNF-triggered PLC-gamma signaling for glutamate release via a glutamate transporter. Proc. Natl. Acad. Sci. U.S.A. 2009, 106:647-652.
28. Numakawa T., Yamagishi S., Adachi N., Matsumoto T., Yokomaku D., Yamada M., Hatanaka H. Brain-derived neurotrophic factor-induced potentiation of Ca(2+) oscillations in developing cortical neurons. J. Biol. Chem. 2002, 277:6520-6529.
29. Numakawa T., Yagasaki Y., Ishimoto T., Okada T., Suzuki T., Iwata N., Ozaki N., Taguchi T., Tatsumi M., Kamijima K., Straub R.E., Weinberger D.R., Kunugi H., Hashimoto R. Evidence of novel neuronal functions of dysbindin, a susceptibility gene for schizophrenia. Hum. Mol. Genet. 2004, 13:2699-2708.
30. Numakawa Y., Numakawa T., Matsumoto T., Yagasaki Y., Kumamaru E., Kunugi H., Taguchi T., Niki E. Vitamin E protected cultured cortical neurons from oxidative stress-induced cell death through the activation of mitogen-activated protein kinase and phosphatidylinositol 3-kinase. J. Neurochem. 2006, 97:1191-1202.
31. Saito A., Matsui F., Hayashi K., Watanabe K., Ichinohashi Y., Sato Y., Hayakawa M., Kojima S., Oohira A. Behavioral abnormalities of fetal growth retardation model rats with reduced amounts of brain proteoglycans. Exp. Neurol. 2009, 219:81-92.
32. Stoop R., Poo M.M. Synaptic modulation by neurotrophic factors: differential and synergistic effects of brain-derived neurotrophic factor and ciliary neurotrophic factor. J. Neurosci. 1996, 16:3256-3264.
33. Toyooka K., Asama K., Watanabe Y., Muratake T., Takahashi M., Someya T., Nawa H. Decreased levels of brain-derived neurotrophic factor in serum of chronic schizophrenic patients. Psychiatry Res. 2002, 110:249-257.
34. Weickert C.S., Hyde T.M., Lipska B.K., Herman M.M., Weinberger D.R., Kleinman J.E. Reduced brain-derived neurotrophic factor in prefrontal cortex of patients with schizophrenia. Mol. Psychiatry 2003, 8:592-610.
35. Zornberg G.L., Buka S.L., Tsuang M.T. Hypoxic-ischemia-related fetal/neonatal complications and risk of schizophrenia and other nonaffective psychoses: a 19-year longitudinal study. Am. J. Psychiatry 2000, 157:196-202.
36. Zorner B., Wolfer D.P., Brandis D., Kretz O., Zacher C., Madani R., Grunwald I., Lipp H.P., Klein R., Henn F.A., Gass P. Forebrain-specific trkB-receptor knockout mice: behaviorally more hyperactive than " depressive" Biol. Psychiatry 2003, 54:972-982.