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Volumn 274, Issue 1, 2009, Pages 1-9

Imatinib resistance in CML

Author keywords

Chronic myeloid leukaemia; Imatinib; Imatinib resistance

Indexed keywords

2 [2 METHOXY 5 (2,4,6 TRIMETHOXYSTYRYLSULFONYLMETHYL)ANILINO]PROPIONIC ACID; 3 BENZYL 7 CYANO 2,3,4,5 TETRAHYDRO 1 (1H IMIDAZOL 4 YLMETHYL) 4 (2 THIENYLSULFONYL) 1H 1,4 BENZODIAZEPINE; 4 (3 DIMETHYLAMINO 1 PYRROLIDINYLMETHYL) 3 TRIFLUOROMETHYL N [4 METHYL 3 [[4 (5 PYRIMIDINYL) 2 PYRIMIDINYL]AMINO]PHENYL]BENZAMIDE; 4 [N (2 HYDROXYETHYL) N [2 (3 INDOLYL)ETHYL]AMINOMETHYL]CINNAMOHYDROXAMIC ACID; 7 [4 [2 (2 METHOXYETHYLAMINO)ETHOXY]PHENYL] 5 (4 METHOXYPHENYL) 7H PYRROLO[2,3 D]PYRIMIDIN 4 AMINE; ALPHA INTERFERON; BAG 956; BCR ABL PROTEIN; BOSUTINIB; CD34 ANTIGEN; CYCLOPROPANECARBOXYLIC ACID [4 [4 (4 METHYL 1 PIPERAZINYL) 6 (5 METHYL 2H PYRAZOL 3 YLAMINO) 2 PYRIMIDINYLTHIO]PHENYL]AMIDE; DASATINIB; ENZYME INHIBITOR; EVEROLIMUS; IMATINIB; N (5 CHLORO 1,3 BENZODIOXOL 4 YL) 7 [2 (4 METHYL 1 PIPERAZINYL)ETHOXY] 5 (TETRAHYDRO 2H PYRAN 4 YLOXY) 4 QUINAZOLINAMINE; NILOTINIB; PHA 739358; PROTEIN TYROSINE KINASE INHIBITOR; UNCLASSIFIED DRUG; WT1 PROTEIN; [4 [2 CYCLOPENTYL 9 (3 HYDROXYPHENETHYL)PURIN 6 YLAMINO]PHENYL]DIMETHYLPHOSPHINE OXIDE;

EID: 57849109399     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2008.06.003     Document Type: Review
Times cited : (68)

References (64)
  • 3
    • 35448967331 scopus 로고    scopus 로고
    • Mechanisms of resistance to imatinib in chronic myeloid leukaemia
    • Apperley J.F. Mechanisms of resistance to imatinib in chronic myeloid leukaemia. Lancet Oncol. 8 (2007) 1018-1029
    • (2007) Lancet Oncol. , vol.8 , pp. 1018-1029
    • Apperley, J.F.1
  • 4
    • 3242800443 scopus 로고    scopus 로고
    • Clonal evolution in chronic myelogenous leukaemia
    • Cortes J., and O'Dwyer M.E. Clonal evolution in chronic myelogenous leukaemia. Hematol. Oncol. Clin. North Am. 18 (2004) 671-684
    • (2004) Hematol. Oncol. Clin. North Am. , vol.18 , pp. 671-684
    • Cortes, J.1    O'Dwyer, M.E.2
  • 5
    • 34447628963 scopus 로고    scopus 로고
    • German Chronic Myelogenous Leukemia (CML) Study Group. Heterogeneous prognostic impact of derivative chromosome 9 deletions in chronic myelogenous leukemia
    • Kreil S., Pfirrmann M., Haferlach C., et al. German Chronic Myelogenous Leukemia (CML) Study Group. Heterogeneous prognostic impact of derivative chromosome 9 deletions in chronic myelogenous leukemia. Blood 110 (2007) 1283-1290
    • (2007) Blood , vol.110 , pp. 1283-1290
    • Kreil, S.1    Pfirrmann, M.2    Haferlach, C.3
  • 9
    • 0036202470 scopus 로고    scopus 로고
    • Cytogenetic and molecular genetic evolution of chronic myeloid leukaemia
    • Johansson B., Fioretos T., and Mitelman F. Cytogenetic and molecular genetic evolution of chronic myeloid leukaemia. Acta Haematol. 107 (2002) 76-94
    • (2002) Acta Haematol. , vol.107 , pp. 76-94
    • Johansson, B.1    Fioretos, T.2    Mitelman, F.3
  • 10
    • 0037438640 scopus 로고    scopus 로고
    • BCR-ABL independence and LYN kinase overexpression in chronic myelogenous leukemia cells selected for resistance to STI571
    • Donato N.J., Wu J.Y., Stapley J., Gallick G., Lin H., Arlinghaus R., and Talpaz M. BCR-ABL independence and LYN kinase overexpression in chronic myelogenous leukemia cells selected for resistance to STI571. Blood 101 (2003) 690-698
    • (2003) Blood , vol.101 , pp. 690-698
    • Donato, N.J.1    Wu, J.Y.2    Stapley, J.3    Gallick, G.4    Lin, H.5    Arlinghaus, R.6    Talpaz, M.7
  • 11
    • 37049028176 scopus 로고    scopus 로고
    • Most CML patients who have a suboptimal response to imatinib have low OCT-1 activity: higher doses of imatinib may overcome the negative impact of low OCT-1 activity
    • White D.L., Saunders V.A., Dang P., Engler Venables J.A., Zrim S., Zannettino A., Lynch K., Manley P.W., and Hughes T. Most CML patients who have a suboptimal response to imatinib have low OCT-1 activity: higher doses of imatinib may overcome the negative impact of low OCT-1 activity. Blood 110 (2007) 4064-4072
    • (2007) Blood , vol.110 , pp. 4064-4072
    • White, D.L.1    Saunders, V.A.2    Dang, P.3    Engler Venables, J.A.4    Zrim, S.5    Zannettino, A.6    Lynch, K.7    Manley, P.W.8    Hughes, T.9
  • 12
    • 1342287959 scopus 로고    scopus 로고
    • High incidence of BCR-ABL kinase domain mutations and absence of mutations of the PDGFR and KIT activation loops in CML patients with secondary resistance to imatinib
    • Al Ali H.K., Heinrich M.C., Lange T., Krahl R., Mueller M., Muller C., Niederwieser D., Druker B.J., and Deininger M.W. High incidence of BCR-ABL kinase domain mutations and absence of mutations of the PDGFR and KIT activation loops in CML patients with secondary resistance to imatinib. Hematol. J. 5 (2004) 55-60
    • (2004) Hematol. J. , vol.5 , pp. 55-60
    • Al Ali, H.K.1    Heinrich, M.C.2    Lange, T.3    Krahl, R.4    Mueller, M.5    Muller, C.6    Niederwieser, D.7    Druker, B.J.8    Deininger, M.W.9
  • 14
    • 34247470836 scopus 로고    scopus 로고
    • Second generation inhibitors of BCR-ABL for the treatment of imatinib-resistant chronic myeloid leukaemia
    • Weisberg E., Manley P.W., Cowan-Jacob S.W., Hochhaus A., and Griffin J.D. Second generation inhibitors of BCR-ABL for the treatment of imatinib-resistant chronic myeloid leukaemia. Nat. Rev. Cancer 7 (2007) 345-356
    • (2007) Nat. Rev. Cancer , vol.7 , pp. 345-356
    • Weisberg, E.1    Manley, P.W.2    Cowan-Jacob, S.W.3    Hochhaus, A.4    Griffin, J.D.5
  • 15
    • 10744232328 scopus 로고    scopus 로고
    • Detection of BCR-ABL mutations in patients with CML treated with imatinib is virtually always accompanied by clinical resistance, and mutations in the ATP phosphate-binding loop (P-loop) are associated with a poor prognosis
    • Branford S., Rudzki Z., Walsh S., Parkinson I., Grigg A., Szer J., Taylor K., Herrmann R., Seymour J.F., Arthur C., Joske D., Lynch K., and Hughes T. Detection of BCR-ABL mutations in patients with CML treated with imatinib is virtually always accompanied by clinical resistance, and mutations in the ATP phosphate-binding loop (P-loop) are associated with a poor prognosis. Blood 102 (2003) 276-283
    • (2003) Blood , vol.102 , pp. 276-283
    • Branford, S.1    Rudzki, Z.2    Walsh, S.3    Parkinson, I.4    Grigg, A.5    Szer, J.6    Taylor, K.7    Herrmann, R.8    Seymour, J.F.9    Arthur, C.10    Joske, D.11    Lynch, K.12    Hughes, T.13
  • 18
    • 0037677447 scopus 로고    scopus 로고
    • Sensitive and quantitative detection of mutations associated with clinical resistance to STI-571
    • Liu W.H., and Makrigiorgos G.M. Sensitive and quantitative detection of mutations associated with clinical resistance to STI-571. Leuk. Res. 27 (2003) 979-982
    • (2003) Leuk. Res. , vol.27 , pp. 979-982
    • Liu, W.H.1    Makrigiorgos, G.M.2
  • 19
    • 0036682481 scopus 로고    scopus 로고
    • Several types of mutations of the Abl gene can be found in chronic myeloid leukemia patients resistant to STI571, and they can pre-exist to the onset of treatment
    • Roche-Lestienne C., Soenen-Cornu V., Grardel-Duflos N., Lai J.L., Philippe N., Facon T., Fenaux P., and Preudhomme C. Several types of mutations of the Abl gene can be found in chronic myeloid leukemia patients resistant to STI571, and they can pre-exist to the onset of treatment. Blood 100 (2002) 1014-1018
    • (2002) Blood , vol.100 , pp. 1014-1018
    • Roche-Lestienne, C.1    Soenen-Cornu, V.2    Grardel-Duflos, N.3    Lai, J.L.4    Philippe, N.5    Facon, T.6    Fenaux, P.7    Preudhomme, C.8
  • 20
    • 0038514851 scopus 로고    scopus 로고
    • Preexistence and evolution of imatinib mesylate-resistant clones in chronic myelogenous leukemia detected by a PNA-based PCR clamping technique
    • Kreuzer K.A., Le Coutre P., Landt O., Na I.K., Schwarz M., Schultheis K., Hochhaus A., and Dörken B. Preexistence and evolution of imatinib mesylate-resistant clones in chronic myelogenous leukemia detected by a PNA-based PCR clamping technique. Ann. Hematol. 82 (2003) 284-289
    • (2003) Ann. Hematol. , vol.82 , pp. 284-289
    • Kreuzer, K.A.1    Le Coutre, P.2    Landt, O.3    Na, I.K.4    Schwarz, M.5    Schultheis, K.6    Hochhaus, A.7    Dörken, B.8
  • 22
    • 4344675788 scopus 로고    scopus 로고
    • Detection of ABL kinase domain mutations with denaturing high-performance liquid chromatography
    • Deininger M.W., McGreevey L., Willis S., Bainbridge T.M., Druker B.J., and Heinrich M.C. Detection of ABL kinase domain mutations with denaturing high-performance liquid chromatography. Leukemia 18 (2004) 864-871
    • (2004) Leukemia , vol.18 , pp. 864-871
    • Deininger, M.W.1    McGreevey, L.2    Willis, S.3    Bainbridge, T.M.4    Druker, B.J.5    Heinrich, M.C.6
  • 23
    • 3042612211 scopus 로고    scopus 로고
    • Italian Cooperative Study Group on Chronic Myeloid Leukemia; European LeukemiaNet-6th Framework Program of the European Community, denaturing-HPLC-based assay for detection of ABL mutations in chronic myeloid leukemia patients resistant to Imatinib
    • Soverini S., Martinelli G., Amabile M., Poerio A., Bianchini M., Rosti G., Pane F., Saglio G., and Baccarani M. Italian Cooperative Study Group on Chronic Myeloid Leukemia; European LeukemiaNet-6th Framework Program of the European Community, denaturing-HPLC-based assay for detection of ABL mutations in chronic myeloid leukemia patients resistant to Imatinib. Clin. Chem. 50 (2004) 1205-1213
    • (2004) Clin. Chem. , vol.50 , pp. 1205-1213
    • Soverini, S.1    Martinelli, G.2    Amabile, M.3    Poerio, A.4    Bianchini, M.5    Rosti, G.6    Pane, F.7    Saglio, G.8    Baccarani, M.9
  • 24
    • 0001686739 scopus 로고    scopus 로고
    • Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia
    • Shah N.P., Nicoll J.M., Nagar B., Gorre M.E., Paquette R.L., Kuriyan J., and Sawyers C.L. Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia. Cancer Cell 2 (2002) 117-125
    • (2002) Cancer Cell , vol.2 , pp. 117-125
    • Shah, N.P.1    Nicoll, J.M.2    Nagar, B.3    Gorre, M.E.4    Paquette, R.L.5    Kuriyan, J.6    Sawyers, C.L.7
  • 25
    • 0036566540 scopus 로고    scopus 로고
    • High frequency of point mutations clustered within the adenosine triphosphate-binding region of BCR/ABL in patients with chronic myeloid leukemia or Ph-positive acute lymphoblastic leukemia who develop imatinib (STI571) resistance
    • Branford S., Rudzki Z., Walsh S., Grigg A., Arthur C., Taylor K., Herrmann R., Lynch K.P., and Hughes T.P. High frequency of point mutations clustered within the adenosine triphosphate-binding region of BCR/ABL in patients with chronic myeloid leukemia or Ph-positive acute lymphoblastic leukemia who develop imatinib (STI571) resistance. Blood 99 (2002) 3472-3475
    • (2002) Blood , vol.99 , pp. 3472-3475
    • Branford, S.1    Rudzki, Z.2    Walsh, S.3    Grigg, A.4    Arthur, C.5    Taylor, K.6    Herrmann, R.7    Lynch, K.P.8    Hughes, T.P.9
  • 29
    • 34547868676 scopus 로고    scopus 로고
    • Monitoring disease response
    • Melo J.V., and Goldman J.M. (Eds), Springer-Verlag, Berlin, Heidelberg
    • Hughes T., and Branford S. Monitoring disease response. In: Melo J.V., and Goldman J.M. (Eds). Myeloproliferative Disorders (2007), Springer-Verlag, Berlin, Heidelberg 143-164
    • (2007) Myeloproliferative Disorders , pp. 143-164
    • Hughes, T.1    Branford, S.2
  • 30
    • 33750327903 scopus 로고    scopus 로고
    • Rationale for the recommendations for harmonizing current methodology for detecting BCR-ABL transcripts in patients with chronic myeloid leukaemia
    • Branford S., Cross N.C., Hochhaus A., Radich J., Saglio G., Kaeda J., Goldman J., and Hughes T. Rationale for the recommendations for harmonizing current methodology for detecting BCR-ABL transcripts in patients with chronic myeloid leukaemia. Leukemia 20 (2006) 1925-1930
    • (2006) Leukemia , vol.20 , pp. 1925-1930
    • Branford, S.1    Cross, N.C.2    Hochhaus, A.3    Radich, J.4    Saglio, G.5    Kaeda, J.6    Goldman, J.7    Hughes, T.8
  • 31
    • 10744229080 scopus 로고    scopus 로고
    • International Randomised Study of Interferon versus STI571 (IRIS) Study Group, frequency of major molecular responses to imatinib or interferon alfa plus cytarabine in newly diagnosed chronic myeloid leukaemia
    • Hughes T.P., Kaeda J., Branford S., Rudzki Z., Hochhaus A., Hensley M.L., Gathmann I., Bolton A.E., van Hoomissen I.C., Goldman J.M., and Radich J.P. International Randomised Study of Interferon versus STI571 (IRIS) Study Group, frequency of major molecular responses to imatinib or interferon alfa plus cytarabine in newly diagnosed chronic myeloid leukaemia. N. Engl. J. Med. 349 (2003) 1423-1432
    • (2003) N. Engl. J. Med. , vol.349 , pp. 1423-1432
    • Hughes, T.P.1    Kaeda, J.2    Branford, S.3    Rudzki, Z.4    Hochhaus, A.5    Hensley, M.L.6    Gathmann, I.7    Bolton, A.E.8    van Hoomissen, I.C.9    Goldman, J.M.10    Radich, J.P.11
  • 34
    • 33644516935 scopus 로고    scopus 로고
    • The role of serial BCR-ABL transcript monitoring in predicting the emergence of BCR-ABL kinase mutations in imatinib-treated patients with chronic myeloid leukaemia
    • Wang L., Knight K., Lucas C., and Clark R.E. The role of serial BCR-ABL transcript monitoring in predicting the emergence of BCR-ABL kinase mutations in imatinib-treated patients with chronic myeloid leukaemia. Haematologica 9 (2006) 1235-1239
    • (2006) Haematologica , vol.9 , pp. 1235-1239
    • Wang, L.1    Knight, K.2    Lucas, C.3    Clark, R.E.4
  • 38
    • 33744486584 scopus 로고    scopus 로고
    • Dasatinib (BMS-354825) targets an earlier progenitor population than imatinib in primary CML but does not eliminate the quiescent fraction
    • Copland M., Hamilton A., Elrick L.J., Baird J.W., Allan E.K., Jordanides N., Barow M., Mountford J.C., and Holyoake T.L. Dasatinib (BMS-354825) targets an earlier progenitor population than imatinib in primary CML but does not eliminate the quiescent fraction. Blood 107 (2006) 4532-4539
    • (2006) Blood , vol.107 , pp. 4532-4539
    • Copland, M.1    Hamilton, A.2    Elrick, L.J.3    Baird, J.W.4    Allan, E.K.5    Jordanides, N.6    Barow, M.7    Mountford, J.C.8    Holyoake, T.L.9
  • 39
    • 0345874513 scopus 로고    scopus 로고
    • No correlation between the proliferative status of Bcr-Abl positive cell lines and the proapoptotic activity of imatinib mesylate (Gleevec/Glivec)
    • La Rosée P., Shen L., Stoffregen E.P., Deininger M., and Druker B.J. No correlation between the proliferative status of Bcr-Abl positive cell lines and the proapoptotic activity of imatinib mesylate (Gleevec/Glivec). Hematol. J. 4 (2003) 413-419
    • (2003) Hematol. J. , vol.4 , pp. 413-419
    • La Rosée, P.1    Shen, L.2    Stoffregen, E.P.3    Deininger, M.4    Druker, B.J.5
  • 40
    • 33847193212 scopus 로고    scopus 로고
    • Leukemic stem cells of chronic phase CML patients consistently display very high BCR-ABL transcript levels and reduced responsiveness to imatinib mesylate in addition to generating a rare subset that produce imatinib mesylate-resistant differentiated progeny
    • Jiang X., Zhao Y., Chan W.Y., Pang E., Eaves A., and Eaves C. Leukemic stem cells of chronic phase CML patients consistently display very high BCR-ABL transcript levels and reduced responsiveness to imatinib mesylate in addition to generating a rare subset that produce imatinib mesylate-resistant differentiated progeny. Blood 104 (2004) 711
    • (2004) Blood , vol.104 , pp. 711
    • Jiang, X.1    Zhao, Y.2    Chan, W.Y.3    Pang, E.4    Eaves, A.5    Eaves, C.6
  • 41
    • 14944367962 scopus 로고    scopus 로고
    • + cells from chronic myelogenous leukaemia patients in complete cytogenetic remission on imatinib mesylate treatment
    • + cells from chronic myelogenous leukaemia patients in complete cytogenetic remission on imatinib mesylate treatment. Blood 105 (2005) 2093-2098
    • (2005) Blood , vol.105 , pp. 2093-2098
    • Chu, S.1    Xu, H.2    Shah, N.P.3    Snyder, D.S.4    Forman, S.J.5    Sawyers, C.L.6    Bhatia, R.7
  • 42
    • 57849128615 scopus 로고    scopus 로고
    • + cells by the histone deacetylase inhibitor LAQ824 in combination with imatinib
    • + cells by the histone deacetylase inhibitor LAQ824 in combination with imatinib. Blood 110 (2007) 1031
    • (2007) Blood , vol.110 , pp. 1031
    • Strauss, A.C.1    Chu, S.2    Holyoake, T.3    Bhatia, R.4
  • 43
    • 41949088658 scopus 로고    scopus 로고
    • BMS-214662 potently induces apoptosis of chronic myeloid leukemia stem and progenitor cells and synergises with tyrosine kinase inhibitors
    • Copland M., Pellicano F., Richmond L., Allan E.K., Hamilton A., Lee F.Y., Weinmann R., and Holyoake T.L. BMS-214662 potently induces apoptosis of chronic myeloid leukemia stem and progenitor cells and synergises with tyrosine kinase inhibitors. Blood 111 (2008) 2843-2853
    • (2008) Blood , vol.111 , pp. 2843-2853
    • Copland, M.1    Pellicano, F.2    Richmond, L.3    Allan, E.K.4    Hamilton, A.5    Lee, F.Y.6    Weinmann, R.7    Holyoake, T.L.8
  • 47
    • 34848911943 scopus 로고    scopus 로고
    • Sequential ABL kinase inhibitor therapy selects for compound drug-resistant BCR-ABL mutations with altered oncogenic potency
    • Shah N.P., Skaggs B.J., Branford S., Hughes T.P., Nicoll J.M., Paquette R.L., and Sawyers C.L. Sequential ABL kinase inhibitor therapy selects for compound drug-resistant BCR-ABL mutations with altered oncogenic potency. J. Clin. Invest. 117 (2007) 2562-2569
    • (2007) J. Clin. Invest. , vol.117 , pp. 2562-2569
    • Shah, N.P.1    Skaggs, B.J.2    Branford, S.3    Hughes, T.P.4    Nicoll, J.M.5    Paquette, R.L.6    Sawyers, C.L.7
  • 50
    • 27144467127 scopus 로고    scopus 로고
    • Combination of imatinib with rapamycin or RAD001 acts synergistically only in Bcr-Abl positive cells with moderate resistance to imatinib
    • Dengler J., von Bubnoff N., Decker T., Peschel C., and Duyster J. Combination of imatinib with rapamycin or RAD001 acts synergistically only in Bcr-Abl positive cells with moderate resistance to imatinib. Leukemia 19 (2005) 1835-1838
    • (2005) Leukemia , vol.19 , pp. 1835-1838
    • Dengler, J.1    von Bubnoff, N.2    Decker, T.3    Peschel, C.4    Duyster, J.5
  • 52
    • 43549112362 scopus 로고    scopus 로고
    • E. Weisberg, L. Banerji, R.D. Wright, R. Barrett, A. Ray, D. Moreno, L. Catley, J. Jiang, E. Hall-Meyers, M. Sauveur-Michel, R. Stone, I. Galinsky, E. Fox, A.L. Kung, J.D. Griffin, Potentiation of anti-leukemic therapies by the dual PI3K/PDK-1 inhibitor, BAG956: effects on BCR-ABL- and mutant FLT3-expressing cells, Blood (2008), January 9 [Epub ahead of print] DOI 10.1182/blood-2007-09-114454.
    • E. Weisberg, L. Banerji, R.D. Wright, R. Barrett, A. Ray, D. Moreno, L. Catley, J. Jiang, E. Hall-Meyers, M. Sauveur-Michel, R. Stone, I. Galinsky, E. Fox, A.L. Kung, J.D. Griffin, Potentiation of anti-leukemic therapies by the dual PI3K/PDK-1 inhibitor, BAG956: effects on BCR-ABL- and mutant FLT3-expressing cells, Blood (2008), January 9 [Epub ahead of print] DOI 10.1182/blood-2007-09-114454.
  • 53
    • 17044386266 scopus 로고    scopus 로고
    • Synergy between imatinib and mycophenolic acid in inducing apoptosis in cell lines expressing Bcr-Abl
    • Gu J.J., Santiago L., and Mitchell B.S. Synergy between imatinib and mycophenolic acid in inducing apoptosis in cell lines expressing Bcr-Abl. Blood 105 (2005) 3270-3277
    • (2005) Blood , vol.105 , pp. 3270-3277
    • Gu, J.J.1    Santiago, L.2    Mitchell, B.S.3
  • 54
    • 0031031721 scopus 로고    scopus 로고
    • Chronic myeloid leukemia as an immunological target
    • Lim S.H., and Coleman S. Chronic myeloid leukemia as an immunological target. Am. J. Hematol. 54 (1997) 61-67
    • (1997) Am. J. Hematol. , vol.54 , pp. 61-67
    • Lim, S.H.1    Coleman, S.2
  • 55
    • 0033866145 scopus 로고    scopus 로고
    • CML vaccines as a paradigm of the specific immunotherapy of cancer
    • Pinilla-Ibarz J., Cathcart K., and Scheinberg D.A. CML vaccines as a paradigm of the specific immunotherapy of cancer. Blood Rev. 14 (2000) 111-120
    • (2000) Blood Rev. , vol.14 , pp. 111-120
    • Pinilla-Ibarz, J.1    Cathcart, K.2    Scheinberg, D.A.3
  • 57
    • 13844312036 scopus 로고    scopus 로고
    • Effect of a p210 multipeptide vaccine associated with imatinib or interferon in patients with chronic myeloid leukaemia and persistent residual disease: a multicentre observational trial
    • Bocchia M., Gentili S., Abruzzese E., Fanelli A., Iuliano F., Tabilio A., Amabile M., Forconi F., Gozzetti A., Raspadori D., Amadori S., and Lauria F. Effect of a p210 multipeptide vaccine associated with imatinib or interferon in patients with chronic myeloid leukaemia and persistent residual disease: a multicentre observational trial. Lancet 365 (2005) 657-662
    • (2005) Lancet , vol.365 , pp. 657-662
    • Bocchia, M.1    Gentili, S.2    Abruzzese, E.3    Fanelli, A.4    Iuliano, F.5    Tabilio, A.6    Amabile, M.7    Forconi, F.8    Gozzetti, A.9    Raspadori, D.10    Amadori, S.11    Lauria, F.12
  • 58
    • 0033826799 scopus 로고    scopus 로고
    • Evidence that specific T lymphocytes may participate in the elimination of chronic myelogenous leukaemia
    • Molldrem J.J., Lee P.P., Wang C., Felio K., Kantarjian H.M., Champlin R.E., and Davis M.M. Evidence that specific T lymphocytes may participate in the elimination of chronic myelogenous leukaemia. Nat. Med. 6 (2000) 1018-1023
    • (2000) Nat. Med. , vol.6 , pp. 1018-1023
    • Molldrem, J.J.1    Lee, P.P.2    Wang, C.3    Felio, K.4    Kantarjian, H.M.5    Champlin, R.E.6    Davis, M.M.7
  • 61
    • 41849113648 scopus 로고    scopus 로고
    • Leukemia-associated antigen specific T-cell responses following combined PR1 and WT1 peptide vaccination in patients with myeloid malignancies
    • Rezvani K., Yong A.S.M., Mielke S., Savani B.N., Musse L., Superata J., Jafarpour B., Boss C., and Barrett A.J. Leukemia-associated antigen specific T-cell responses following combined PR1 and WT1 peptide vaccination in patients with myeloid malignancies. Blood 110 (2007) 287
    • (2007) Blood , vol.110 , pp. 287
    • Rezvani, K.1    Yong, A.S.M.2    Mielke, S.3    Savani, B.N.4    Musse, L.5    Superata, J.6    Jafarpour, B.7    Boss, C.8    Barrett, A.J.9
  • 63
    • 0035925608 scopus 로고    scopus 로고
    • Heat shock proteins: the 'Swiss Army Knife' vaccines against cancers and infectious agents
    • Srivastava P.K., and Amato R.J. Heat shock proteins: the 'Swiss Army Knife' vaccines against cancers and infectious agents. Vaccine 19 (2001) 2590-2597
    • (2001) Vaccine , vol.19 , pp. 2590-2597
    • Srivastava, P.K.1    Amato, R.J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.