Spindles losing their bearings: Does disruption of orientation in stem cells predict the onset of cancer?

BioEssays

Volumn 32, Issue 6, 2010, Pages 468-472

  Graham, Trevor A ^a   Jawad, Noor ^a,b   Wright, Nicholas A ^a,b  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^b QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Asymmetric division; Cell polarity; Mitotic spindle alignment; Stem cells; Tumourigenesis

Indexed keywords

ACTIVATED PROTEIN C;

CARCINOGENESIS; CARCINOGENICITY; CELL DISRUPTION; CELL DIVISION; CHROMATID; CHROMOSOMAL INSTABILITY; DNA REPLICATION; DNA TEMPLATE; GENE SEGREGATION; HUMAN; INTESTINE CRYPT; MITOSIS SPINDLE; MOLECULAR EVOLUTION; MOLECULAR MECHANICS; NONHUMAN; PROTEIN FUNCTION; REVIEW; SOMATIC MUTATION; STEM CELL; STEM CELL NICHE; TISSUE STRUCTURE;

ANIMALS; CELL POLARITY; HUMANS; MITOTIC SPINDLE APPARATUS; MODELS, BIOLOGICAL; NEOPLASMS; STEM CELLS;

EID: 77952727662     PISSN: 02659247     EISSN: 15211878     Source Type: Journal    
DOI: 10.1002/bies.201000032     Document Type: Review

References (35)

1. Quyn AJ, Appleton PL, Carey FA, et al. 2010. Spindle orientation bias in gut epithelial stem cell compartments is lost in precancerous tissue. Cell Stem Cell 6: 175-181
2. Barker N, van Es JH, Kuipers J, et al. 2007. Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature 449: 1003-1007
3. Lin D, Edwards AS, Fawcett JP, et al. 2000. A mammalian PAR-3-PAR-6 complex implicated in Cdc42/Rac1 and aPKC signalling and cell polarity. Nat Cell Biol 2: 540-547
4. Komarova NL. 2005. Cancer, aging and the optimal tissue design. Semin Cancer Biol 15: 494-505.
5. Yatabe Y, Tavaré S, Shibata D. 2001. Investigating stem cells in human colon by using methylation patterns. Proc Natl Acad Sci USA 98: 10839-10844
6. Pepper JW, Sprouffske K, Maley CC. 2007. Animal cell differentiation patterns suppress somatic evolution. PLoS Comput Biol 3: e250.
7. Lamlum H, Papadopoulou A, Ilyas M, et al. 2000. APC mutations are sufficient for the growth of early colorectal adenomas. Proc Natl Acad Sci USA 97: 2225-2228
8. Sansom OJ, Reed KR, Hayes AJ, et al. 2004. Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration. Genes Dev 18: 1385-1390
9. van Leeuwen IM, Byrne HM, Jensen OE, et al. 2006. Crypt dynamics and colorectal cancer: advances in mathematical modelling. Cell Prolif 39: 157-181
10. Barker N, Ridgway RA, van Es JH, et al. 2009. Crypt stem cells as the cells-of-origin of intestinal cancer. Nature 457: 608-611
11. Cairns J. 1975. Mutation selection and the natural history of cancer. Nature 255: 197-200.
12. Potten CS, Owen G, Booth D. 2002. Intestinal stem cells protect their genome by selective segregation of template DNA strands. J Cell Sci 115: 2381-2388
13. Ross HH, Levkoff LH, Marshall GP, et al. 2008. Bromodeoxyuridine induces senescence in neural stem and progenitor cells. Stem Cells 26: 3218-3227
14. Lansdorp PM. 2007. Immortal strands? Give me a break. Cell 129: 1244-1247
15. Falconer E, Chavez EA, Henderson A, et al. 2010. Identification of sister chromatids by DNA template strand sequences. Nature 463: 93-97
16. Salk JJ, Fox EJ, Loeb LA. Mutational heterogeneity in human cancers: origin and consequences. Annu Rev Pathol 5: 51-75.
17. Green RA, Kaplan KB. 2003. Chromosome instability in colorectal tumor cells is associated with defects in microtubule plus-end attachments caused by a dominant mutation in APC. J Cell Biol 163: 949-961
18. Tighe A, Johnson VL, Taylor SS. 2004. Truncating APC mutations have dominant effects on proliferation, spindle checkpoint control, survival and chromosome stability. J Cell Sci 117: 6339-6353
19. Fodde R, Kuipers J, Rosenberg C, et al. 2001. Mutations in the APC tumour suppressor gene cause chromosomal instability. Nat Cell Biol 3: 433-438
20. Kaplan KB, Burds AA, Swedlow JR, et al. 2001. A role for the adenomatous polyposis coli protein in chromosome segregation. Nat Cell Biol 3: 429-432
21. Lu B, Roegiers F, Jan LY, et al. 2001. Adherens junctions inhibit asymmetric division in the Drosophila epithelium. Nature 409: 522-525
22. McCartney BM, McEwen DG, Grevengoed E, et al. 2001. Drosophila APC2 and Armadillo participate in tethering mitotic spindles to cortical actin. Nat Cell Biol 3: 933-938
23. Yamashita YM, Jones DL, Fuller MT. 2003. Orientation of asymmetric stem cell division by the APC tumor suppressor and centrosome. Science 301: 1547-1550
24. Green RA, Wollman R, Kaplan KB. 2005. APC and EB1 function together in mitosis to regulate spindle dynamics and chromosome alignment. Mol Biol Cell 16: 4609-4622
25. Klaus A, Birchmeier W. 2008. Wnt signalling and its impact on development and cancer. Nat Rev Cancer 8: 387-398
26. Caussinus E, Gonzalez C. 2005. Induction of tumor growth by altered stem-cell asymmetric division in Drosophila melanogaster. Nat Genet 37: 1125-1129
27. Gönczy P. 2008. Mechanisms of asymmetric cell division: flies and worms pave the way. Nat Rev Mol Cell Biol 9: 355-366
28. Cicalese A, Bonizzi G, Pasi CE, et al. 2009. The tumor suppressor p53 regulates polarity of self-renewing divisions in mammary stem cells. Cell 138: 1083-1095
29. Gonzalez C. 2007. Spindle orientation, asymmetric division and tumour suppression in Drosophila stem cells. Nat Rev Genet 8: 462-472
30. Lopes CS, Sunkel CE. 2003. The spindle checkpoint: from normal cell division to tumorigenesis. Arch Med Res 34: 155-165
31. Rajagopalan H, Nowak MA, Vogelstein B, et al. 2003. The significance of unstable chromosomes in colorectal cancer. Nat Rev Cancer 3: 695-701.
32. Nowak MA, Komarova NL, Sengupta A, et al. 2002. The role of chromosomal instability in tumor initiation. Proc Natl Acad Sci USA 99: 16226-16231
33. Jones A, Thirlwell C, Howarth K, et al. 2007. Analysis of copy number changes suggests chromosomal instability in aminority of large colorectal adenomas. J Pathol 213: 249-256
34. Sieber OM, Heinimann K, Tomlinson IPM. 2003. Genomic instability - The engine of tumorigenesis? Nat Revi Cancer 3: 701-708
35. Beerenwinkel N, Antal T, Dingli D, et al. 2007. Genetic progression and the waiting time to cancer. PLoS Comput Biol 3: e225.