Using deep sequencing to characterize the biophysical mechanism of a transcriptional regulatory sequence

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 20, 2010, Pages 9158-9163

  Kinney, Justin B ^a,b   Murugan, Anand ^a   Callan Jr , Curtis G ^a,b   Cox, Edward C ^a  

^a PRINCETON UNIVERSITY   (United States)

^b Howard Hughes Medical Institute Cold Spring Harbor Laboratory Cold Spring Harbor   (United States)

Author keywords

Gene regulation; Lac promoter; Mutual information; Parallel tempering Monte Carlo; Thermodynamic models

Indexed keywords

CYCLIC AMP; RNA POLYMERASE;

ARTICLE; BINDING SITE; CHEMICAL ANALYSIS; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DNA TRANSCRIPTION; ESCHERICHIA COLI; FLOW CYTOMETRY; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; QUANTITATIVE ANALYSIS; SEQUENCE ANALYSIS; VALIDATION STUDY;

BASE SEQUENCE; BINDING SITES; BIOPHYSICS; COMPUTATIONAL BIOLOGY; ESCHERICHIA COLI; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; GREEN FLUORESCENT PROTEINS; LAC OPERON; LIKELIHOOD FUNCTIONS; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; MONTE CARLO METHOD; MUTATION; PROMOTER REGIONS, GENETIC; SEQUENCE ANALYSIS, DNA; THERMODYNAMICS;

ESCHERICHIA COLI;

EID: 77952706498     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1004290107     Document Type: Article

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