Regulation of the voltage-insensitive step of HERG activation by extracellular pH

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 298, Issue 6, 2010, Pages

  Zhou, Qinlian ^a   Bett, Glenna C L ^a,b  

^a UNIVERSITY AT BUFFALO   (United States)

^b UNIVERSITY AT BUFFALO   (United States)

Author keywords

Gating kinetics; Human ether go go gene; Kv11.1; Potassium channels; Voltage gated channels

Indexed keywords

POTASSIUM CHANNEL HERG;

ACIDOSIS; ANIMAL CELL; ARTICLE; CELL ACTIVATION; CELL PH; CHANNEL GATING; FEMALE; HIDDEN MARKOV MODEL; MATHEMATICAL MODEL; MEMBRANE CHANNEL; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; XENOPUS LAEVIS;

ACTION POTENTIALS; ALGORITHMS; ANIMALS; CELL MEMBRANE; ELECTRIC STIMULATION; ETHER-A-GO-GO POTASSIUM CHANNELS; FEMALE; HUMANS; HYDROGEN-ION CONCENTRATION; MODELS, BIOLOGICAL; MODELS, THEORETICAL; OOCYTES; PATCH-CLAMP TECHNIQUES; XENOPUS LAEVIS;

EID: 77952616398     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.01246.2009     Document Type: Article

References (38)

1. Anumonwo JM, Horta J, Delmar M, Taffet SM, Jalife J. Proton and zinc effects on HERG currents. Biophys J 77: 282-298, 1999. (Pubitemid 29305228)
2. Arcangeli A. Expression and role of hERG channels in cancer cells. Novartis Found Symp 266: 225-232, 2005.
3. Berube J, Chahine M, Daleau P. Modulation of HERG potassium channel properties by external pH. Pflügers Arch 438: 419-422, 1999.
4. Bethell HW, Vandenberg JI, Smith GA, Grace AA. Changes in ventricular repolarization during acidosis and low-flow ischemia. Am J Physiol Heart Circ Physiol 275: H551-H561, 1998.
5. Bett GC, Rasmusson RL. Functionally-distinct proton-binding in HERG suggests the presence of two binding sites. Cell Biochem Biophys 39: 183-193, 2003.
6. Bezanilla F. The voltage sensor in voltage-dependent ion channels. Physiol Rev 80: 555-592, 2000. (Pubitemid 30164943)
7. Chiesa N, Rosati B, Arcangeli A, Olivotto M, Wanke E. A novel role for HERG K+ channels: spike-frequency adaptation. J Physiol 501: 313-318, 1997. (Pubitemid 27280806)
8. Farrelly AM, Ro S, Callaghan BP, Khoyi MA, Fleming N, Horowitz B, Sanders KM, Keef KD. Expression and function of KCNH2 (HERG) in the human jejunum. Am J Physiol Gastrointest Liver Physiol 284: G883-G895, 2003. (Pubitemid 36597330)
9. Ganapathi SB, Kester M, Elmslie KS. State-dependent block of HERG potassium channels by R-roscovitine: implications for cancer therapy. Am J Physiol Cell Physiol 296: C701-C710, 2009.
10. Ks play a role in the reverse rate dependence of class III agents? Circ Res 78: 26-37, 1996.
11. Hoshi T, Zagotta WN, Aldrich RW. Shaker potassium channel gating. I. Transitions near the open state. J Gen Physiol 103: 249-278, 1994. (Pubitemid 24068560)
12. Janse MJ, Wit AL. Electrophysiological mechanisms of ventricular arrhythmias resulting from myocardial ischemia and infarction. Physiol Rev 69: 1049-1169, 1989. (Pubitemid 19255835)
13. Jiang M, Dun W, Tseng GN. Mechanism for the effects of extracellular acidification on HERG-channel function. Am J Physiol Heart Circ Physiol 277: H1283-H1292, 1999.
14. +. Pflügers Arch 438: 23-29, 1999.
15. Kagiyama Y, Hill JL, Gettes LS. Interaction of acidosis and increased extracellular potassium on action potential characteristics and conduction in guinea pig ventricular muscle. Circ Res 51: 614-623, 1982. (Pubitemid 13236148)
16. Kiehn J, Lacerda AE, Brown AM. Pathways of HERG inactivation. Am J Physiol Heart Circ Physiol 277: H199-H210, 1999.
17. Liu S, Rasmusson RL, Campbell DL, Wang S, Strauss HC. Activation and inactivation kinetics of an E-4031-sensitive current from single ferret atrial myocytes. Biophys J 70: 2704-2715, 1996. (Pubitemid 26000969)
18. Mazhari R, Greenstein JL, Winslow RL, Marban E, Nuss HB. Molecular interactions between two long-QT syndrome gene products, HERG and KCNE2, rationalized by in vitro and in silico analysis. Circ Res 89: 33-38, 2001. (Pubitemid 34135489)
19. + current in rabbit atrial myocytes. Am J Physiol Heart Circ Physiol 269: H524-H532, 1995.
20. Sale H, Wang J, O'Hara TJ, Tester DJ, Phartiyal P, He JQ, Rudy Y, Ackerman MJ, Robertson GA. Physiological properties of hERG 1a/1b heteromeric currents and a hERG 1b-specific mutation associated with long-QT syndrome. Circ Res 103: e81-e95, 2008.
21. +-channel dysfunction in an inherited cardiac arrhythmia. Proc Natl Acad Sci USA 93: 2208-2212, 1996.
22. Kr potassium channel. Cell 81: 299-307, 1995.
23. Sansom MS. Potassium channels: watching a voltage-sensor tilt and twist. Curr Biol 10: R206-R209, 2000.
24. 2+ channel. J Biol Chem 277: 6813-6821, 2002.
25. Shibasaki T. Conductance and kinetics of delayed rectifier potassium channels in nodal cells of the rabbit heart. J Physiol 387: 227-250, 1987.
26. Shirokov R, Ferreira G, Yi J, Rios E. Inactivation of gating currents of L-type calcium channels. Specific role of the alpha 2 delta subunit. J Gen Physiol 111: 807-823, 1998. (Pubitemid 28265648)
27. Smith PL, Baukrowitz T, Yellen G. The inward rectification mechanism of the HERG cardiac potassium channel. Nature 379: 833-836, 1996. (Pubitemid 26067726)
28. Kr channel. J Gen Physiol 107: 611-619, 1996.
29. Terai T, Furukawa T, Katayama Y, Hiraoka M. Effects of external acidosis on HERG current expressed in Xenopus oocytes. J Mol Cell Cardiol 32: 11-21, 2000. (Pubitemid 30064300)
30. Trudeau MC, Warmke JW, Ganetzky B, Robertson GA. HERG, a human inward rectifier in the voltage-gated potassium channel family. Science 269: 92-95, 1995.
31. + currents. Am J Physiol Cell Physiol 291: C165-C175, 2006.
32. Wang S, Liu S, Morales MJ, Strauss HC, Rasmusson RL. A quantitative analysis of the activation and inactivation kinetics of HERG expressed in Xenopus oocytes. J Physiol 502: 45-60, 1997. (Pubitemid 27322975)
33. Wang S, Morales MJ, Liu S, Strauss HC, Rasmusson RL. Time, voltage and ionic concentration dependence of rectification of h-erg expressed in Xenopus oocytes. FEBS Lett 389: 167-173, 1996. (Pubitemid 26226493)
34. Warmke JW, Ganetzky B. A family of potassium channel genes related to eag in Drosophila and mammals. Proc Natl Acad Sci USA 91: 3438-3442, 1994. (Pubitemid 24130252)
35. Woodhull AM. Ionic blockage of sodium channels in nerve. J Gen Physiol 61: 687-708, 1973.
36. Yan GX, Kleber AG. Changes in extracellular and intracellular pH in ischemic rabbit papillary muscle. Circ Res 71: 460-470, 1992.
37. Zhang JF, Ellinor PT, Aldrich RW, Tsien RW. Molecular determinants of voltage-dependent inactivation in calcium channels. Nature 372: 97-100, 1994. (Pubitemid 24339490)
38. Zhou Q, Zygmunt AC, Cordeiro JM, Siso-Nadal F, Miller RE, Buzzard GT, Fox JJ. Identification of Ikr kinetics and drug binding in native myocytes. Ann Biomed Eng 37: 1294-1309, 2009.