Pancreatic cystic neoplasm

Current Problems in Surgery

Volumn 47, Issue 6, 2010, Pages 459-510

  Roggin, Kevin K ^a   Chennat, Jennifer ^a   Oto, Aytekin ^a   Noffsinger, Amy ^b   Briggs, Alexandra ^c   Matthews, Jeffrey B ^a  

^a UNIVERSITY OF CHICAGO MEDICAL CENTER   (United States)

^b UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INHIBIN; CA 19-9 ANTIGEN; CALCIUM BINDING PROTEIN; CYTOKERATIN 18; CYTOKERATIN 19; CYTOKERATIN 7; CYTOKERATIN 8; DNA; FLUORODEOXYGLUCOSE F 18; INHIBIN; K RAS PROTEIN; MUCIN 1; MUCIN 2; MUCIN 5AC; MUCIN 6; NEURON SPECIFIC ENOLASE; PROSTAGLANDIN E2; PROTEIN S 100P; SYNAPTOPHYSIN; UNCLASSIFIED DRUG; VON HIPPEL LINDAU PROTEIN;

ACINAR CELL; ANTIGEN DETECTION; ARTICLE; ASPIRATION BIOPSY; CANCER INVASION; COMPARATIVE GENOMIC HYBRIDIZATION; CONTRAST ENHANCEMENT; CYST FLUID; CYSTADENOMA; DIAGNOSTIC ACCURACY; DIFFERENTIAL DIAGNOSIS; ENDOSCOPIC ECHOGRAPHY; GENE EXPRESSION; GENE MUTATION; GENE TECHNOLOGY; HETEROZYGOSITY LOSS; HISTOPATHOLOGY; HUMAN; INTRADUCTAL ONCOCYTIC PAPILLARY NEOPLASM; INTRADUCTAL PAPILLARY MUCINOUS TUMOR; INTRADUCTAL TUBULAR NEOPLASM; INVASIVE CARCINOMA; MAGNETIC RESONANCE CHOLANGIOPANCREATOGRAPHY; MALIGNANT TRANSFORMATION; MEDICAL DECISION MAKING; METASTASIS; MUCINOUS CYSTIC NEOPLASM; MULTIDETECTOR COMPUTED TOMOGRAPHY; NUCLEAR MAGNETIC RESONANCE IMAGING; ONCOGENE K RAS; PANCREAS RESECTION; PANCREAS TUMOR; PANCREATIC CYSTIC NEOPLASM; PANCREATICODUODENECTOMY; POSITRON EMISSION TOMOGRAPHY; PROTEIN EXPRESSION; SEROUS CYSTIC NEOPLASM; SOLID PSEUDOPAPILLARY NEOPLASM; SPLENECTOMY; SURVIVAL RATE; SYMPTOM; TUMOR CLASSIFICATION; TUMOR DIFFERENTIATION; TUMOR LOCALIZATION; TUMOR VOLUME; CYSTADENOCARCINOMA; PANCREAS; PANCREAS CYST; PATHOLOGY; REVIEW;

CYSTADENOCARCINOMA, SEROUS; CYSTADENOMA, MUCINOUS; CYSTADENOMA, PAPILLARY; CYSTADENOMA, SEROUS; HUMANS; PANCREAS; PANCREATIC CYST; PANCREATIC NEOPLASMS; POSITRON-EMISSION TOMOGRAPHY;

EID: 77952557236     PISSN: 00113840     EISSN: None     Source Type: Journal    
DOI: 10.1067/j.cpsurg.2010.02.002     Document Type: Article

References (178)

1. Buisine M.P., Devisme L., Degand P., Dieu M.C., Gosselin B., Copin M.C., et al. Developmental mucin gene expression in the gastroduodenal tract and accessory digestive glands. II. Duodenum and liver, gallbladder, and pancreas. J Histochem Cytochem 2000, 48:1667-1676.
2. Kosmahl M., Wagner J., Peters K., Sipos B., Klöppel G. Serous cystic neoplasms of the pancreas: an immunohistochemical analysis revealing alpha-inhibin, neuron-specific enolase, and MUC6 as new markers. Am J Surg Pathol 2004, 28:339-346.
3. Horaguchi J., Fujita N., Kobayashi G., Noda Y., Kimura K., Ito K., et al. Serous cystadenoma of the pancreas associated with obstructive jaundice. J Gastroenterol 2003, 38:501-506.
4. Compton C.C. Serous cystic tumors of the pancreas. Semin Diagn Pathol 2000, 17:43-55.
5. Tanno S., Obara T., Sohma M., Tanaka T., Izawa T., Fujii T., et al. Multifocal serous cystadenoma of the pancreas. A case report and review of the literature. Int J Pancreatol 1998, 24:129-132.
6. Sperti C., Pasquali C., Perasole A., Liessi G., Pedrazzoli S. Macrocystic serous cystadenoma of the pancreas: clinicopathologic features in seven cases. Int J Pancreatol 2000, 28:1-7.
7. Chatelain D., Hammel P., O'Toole D., Terris B., Vilgrain V., Palazzo L., et al. Macrocystic form of serous pancreatic cystadenoma. Am J Gastroenterol 2002, 97:2566-2571.
8. Egawa N., Maillet B., Schroder S., Mukai K., Klöppel G. Serous oligocystic and ill-demarcated adenoma of the pancreas: a variant of serous cystic adenoma. Virchows Arch 1994, 424:13-17.
9. Mohr V.H., Vortmeyer A.O., Zhuang Z., Libutti S.K., Walther M.M., Choyke P.L., et al. Histopathology and molecular genetics of multiple cysts and microcystic (serous) adenomas of the pancreas in von Hippel-Lindau patients. Am J Pathol 2000, 157:1615-1621.
10. Hammel P.R., Vilgrain V., Terris B., Penfornis A., Sauvanet A., Correas J.M., et al. Pancreatic involvement in von Hippel-Lindau disease; The Groupe Francophone d'Etude de la Maladie de von Hippel-Lindau. Gastroenterology 2000, 119:1087-1095.
11. Lubensky I.A., Pack S., Ault D., Vortmeyer A.O., Libutti S.K., Choyke P.L., et al. Multiple neuroendocrine tumors of the pancreas in von Hippel-Lindau disease patients: histopathological and molecular genetic analysis. Am J Pathol 1998, 153:223-231.
12. Abe H., Kubota K., Mori M., Miki K., Minagawa M., Noie T., et al. Serous cystadenoma of the pancreas with invasive growth: benign or malignant?. Am J Gastroenterol 1998, 93:1963-1966.
13. Eriguchi N., Aoyagi S., Nakayama T., Hara M., Miyazaki T., Kutami R., et al. Serous cystadenocarcinoma of the pancreas with liver metastases. J Hepatobil Pancreat Surg 1998, 5:467-470.
14. Wu C.M., Fishman E.K., Hruban R.K., Schlott W.D., Cameron J.L. Serous cystic neoplasm involving the pancreas and liver: an unusual clinical entity. Abdom Imaging 1999, 24:75-77.
15. Kosmahl M., Pauser U., Peters K., Sipos B., Lüttges J., Kremer B., et al. Cystic neoplasms of the pancreas and tumor-like lesions with cystic features: a review of 418 cases and a classification proposal. Virchows Arch 2004, 445:168-178.
16. Goh B.K., Tan Y.M., Chung Y.F., Chow P.K., Cheow P.C., Wong W.K., et al. A review of mucinous cystic neoplasms of the pancreas defined by ovarian-type stroma: clinicopathological features of 344 patients. World J Surg 2006, 30:2236-2245.
17. Goh B.K., Tan Y.M., Kumarasinghe M.P., Ooi L.L. Mucinous cystic tumor of the pancreas with ovarian-like mesenchymal stroma in a male patient. Dig Dis Sci 2005, 50:2170-2177.
18. Suzuki M., Fujita N., Onodera H., Kayaba Y., Suzuki S., Kagaya H., et al. Mucinous cystic neoplasm in a young male patient. J Gastroenterol 2005, 40:1070-1074.
19. Kobayashi T., Teruya M., Shimizu S., Miki K., Kobayashi K., Morita K. Mucinous cystic tumor of the pancreas in a man: a rare case. Pancreas 2006, 33:312-314.
20. Basturk O., Coban I., Adsay N.V. Pancreatic cysts: pathologic classification, differential diagnosis, and clinical implications. Arch Pathol Lab Med 2009, 133:423-438.
21. Nagata K., Horinouchi M., Saitou M., Higashi M., Nomoto M., Goto M., et al. Mucin expression profile in pancreatic cancer and the precursor lesions. J Hepatobiliary Pancreat Surg 2007, 14:243-254.
22. Luttges J., Feyerabend B., Buchelt T., Pacena M., Klöppel G. The mucin profile of noninvasive and invasive mucinous cystic neoplasms of the pancreas. Am J Surg Pathol 2002, 26:466-471.
23. Yeh M.M., Tang L.H., Wang S., Robert M.E., Zheng W., Jain D. Inhibin expression in ovarian-type stroma in mucinous cystic neoplasms of the pancreas. Appl Immunohistochem Mol Morphol 2004, 12:148-152.
24. Zamboni G., Scarpa A., Bogina G., Iacono C., Bassi C., Talamini G., et al. Mucinous cystic tumors of the pancreas: clinicopathological features, prognosis, and relationship to other mucinous cystic tumors. Am J Surg Pathol 1999, 23:410-422.
25. Handra-Luca A., Flejou J.F., Rufat P., Corcos O., Belghiti J., Ruszniewski P., et al. Human pancreatic mucinous cystadenoma is characterized by distinct mucin, cytokeratin and CD10 expression compared with intraductal papillary-mucinous adenoma. Histopathology 2006, 48:813-821.
26. Sarr M.G., Carpenter H.A., Prabhakar L.P., Orchard T.F., Hughes S., van Heerden J.A., et al. Clinical and pathologic correlation of 84 mucinous cystic neoplasms of the pancreas: can one reliably differentiate benign from malignant (or premalignant) neoplasms?. Ann Surg 2000, 231:205-212.
27. Fukushima N., Mukai K., Kanai Y., Hasebe T., Shimada K., Ozaki H., et al. Intraductal papillary tumors and mucinous cystic tumors of the pancreas: clinicopathologic study of 38 cases. Hum Pathol 1997, 28:1010-1017.
28. Crippa S., Salvia R., Warshaw A.L., Domínguez I., Bassi C., Falconi M., et al. Mucinous cystic neoplasm of the pancreas is not an aggressive entity: lessons from 163 resected patients. Ann Surg 2008, 247:571-579.
29. Wenig B.M., Albores-Saavedra J., Buetow P.C., Heffess C.S. Pancreatic mucinous cystic neoplasm with sarcomatous stroma: a report of three cases. Am J Surg Pathol 1997, 21:70-80.
30. Posen J.A. Giant cell tumor of the pancreas of the osteoclastic type associated with a mucous secreting cystadenocarcinoma. Hum Pathol 1981, 12:944-947.
31. Sarnaik A.A., Saad A.G., Mutema G.K., Martin S.P., Attar A., Lowy A.M. Osteoclast-like giant cell tumor of the pancreas associated with a mucinous cystadenocarcinoma. Surgery 2003, 133:700-701.
32. Campman S.C., Fajardo M.A., Rippon M.B., Kraegel S.A., Ruebner B.H. Adenosquamous carcinoma arising in a mucinous cystadenoma of the pancreas. J Surg Oncol 1997, 64:159-162.
33. Tanaka M. Intraductal papillary mucinous neoplasm of the pancreas: diagnosis and treatment. Pancreas 2004, 28:282-288.
34. Adsay N.V. Intraductal papillary mucinous neoplasms of the pancreas: pathology and molecular genetics. J Gastrointest Surg 2002, 6:656-659.
35. Gourgiotis S., Ridolfini M.P., Germanos S. Intraductal papillary mucinous neoplasms of the pancreas. Eur J Surg Oncol 2007, 33:678-684.
36. Chari S.T., Yadav D., Smyrk T.C., DiMagno E.P., Miller L.J., Raimondo M., et al. Study of recurrence after surgical resection of intraductal papillary mucinous neoplasm of the pancreas. Gastroenterology 2002, 123:1500-1507.
37. Falconi M., Salvia R., Bassi C., Zamboni G., Talamini G., Pederzoli P. Clinicopathological features and treatment of intraductal papillary mucinous tumour of the pancreas. Br J Surg 2001, 88:376-381.
38. Azadeh C.F.B. Cystic neoplasms of the exocrine pancreas. Histopathology 2008, 52:539-551.
39. Raut C.P., Cleary K.R., Staerkel G.A., Abbruzzese J.L., Wolff R.A., Lee J.H., et al. Intraductal papillary mucinous neoplasms of the pancreas: effect of invasion and pancreatic margin status on recurrence and survival. Ann Surg Oncol 2006, 13:582-594.
40. Atomi S.M.Y. Extrapancreatic neoplasms occur with unusual frequency in patients with intraductal papillary mucinous tumors of the pancreas. Am J Gastroenterol 1999, 94:470-473.
41. Baumgaertner I., Corcos O., Couvelard A., Sauvanet A., Rebours V., Vullierme M.P., et al. Prevalence of extrapancreatic cancers in patients with histologically proven intraductal papillary mucinous neoplasms of the pancreas: a case-control study. Am J Gastroenterol 2008, 103:2878-2882.
42. Sato N., Rosty C., Jansen M., Fukushima N., Ueki T., Yeo C.J., et al. STK11/LKB1 Peutz-Jeghers gene inactivation in intraductal papillary-mucinous neoplasms of the pancreas. Am J Pathol 2001, 159:2017-2022.
43. Maire F., Hammel P., Terris B., Olschwang S., O'Toole D., Sauvanet A., et al. Intraductal papillary and mucinous pancreatic tumour: a new extracolonic tumour in familial adenomatous polyposis. Gut 2002, 51:446-449.
44. Salvia R., Fernandez-del Castillo C., Bassi C., Thayer S.P., Falconi M., Mantovani W., et al. Main-duct intraductal papillary mucinous neoplasms of the pancreas: clinical predictors of malignancy and long-term survival following resection. Ann Surg 2004, 239:678-685. discussion 85-7.
45. Kobari M., Egawa S., Shibuya K., Shimamura H., Sunamura M., Takeda K., et al. Intraductal papillary mucinous tumors of the pancreas comprise 2 clinical subtypes: differences in clinical characteristics and surgical management. Arch Surg 1999, 134:1131-1136.
46. Furukawa T., Klöppel G., Volkan Adsay N., Albores-Saavedra J., Fukushima N., Horii A., et al. Classification of types of intraductal papillary-mucinous neoplasm of the pancreas: a consensus study. Virchows Arch 2005, 447:794-799.
47. Katabi N., Klimstra D.S. Intraductal papillary mucinous neoplasms of the pancreas: clinical and pathological features and diagnostic approach. J Clin Pathol 2008, 61:1303-1313.
48. Yonezawa S., Taira M., Osako M., Kubo M., Tanaka S., Sakoda K., et al. MUC-1 mucin expression in invasive areas of intraductal papillary mucinous tumors of the pancreas. Pathol Int 1998, 48:319-322.
49. Adsay N.V., Merati K., Basturk O., Iacobuzio-Donahue C., Levi E., Cheng J.D., et al. Pathologically and biologically distinct types of epithelium in intraductal papillary mucinous neoplasms: delineation of an "intestinal" pathway of carcinogenesis in the pancreas. Am J Surg Pathol 2004, 28:839-848.
50. Nakamura A., Horinouchi M., Goto M., Nagata K., Sakoda K., Takao S., et al. New classification of pancreatic intraductal papillary-mucinous tumour by mucin expression: its relationship with potential for malignancy. J Pathol 2002, 197:201-210.
51. Nakanuma T.T.Y. Expression of mucin carbohydrate antigens (T, Tn and sialyl Tn) and MUC-1 gene product in intraductal papillary-mucinous neoplasm of the pancreas. Am J Clin Pathol 1996, 105:613-620.
52. Luttges J., Zamboni G., Longnecker D., Klöppel G. The immunohistochemical mucin expression pattern distinguishes different types of intraductal papillary mucinous neoplasms of the pancreas and determines their relationship to mucinous noncystic carcinoma and ductal adenocarcinoma. Am J Surg Pathol 2001, 25:942-948.
53. Nobukawa B., Suda K., Suyama M., Ariyama J., Beppu T., Futagawa S. Intraductal oncocytic papillary carcinoma with invasion arising from the accessory pancreatic duct. Gastrointest Endosc 1999, 50:864-866.
54. Ito K., Fujita N., Noda Y., Kobayashi G., Kimura K., Horaguchi J., et al. Intraductal tubular adenocarcinoma of the pancreas diagnosed before surgery by transpapillary biopsy: case report and review. Gastrointest Endosc 2005, 61:325-329.
55. Tajiri T., Tate G., Inagaki T., Kunimura T., Inoue K., Mitsuya T., et al. Intraductal tubular neoplasms of the pancreas: histogenesis and differentiation. Pancreas 2005, 30:115-121.
56. Tajiri T., Tate G., Kunimura T., Inoue K., Mitsuya T., Yoshiba M., et al. Histologic and immunohistochemical comparison of intraductal tubular carcinoma, intraductal papillary-mucinous carcinoma, and ductal adenocarcinoma of the pancreas. Pancreas 2004, 29:116-122.
57. Nakayama Y., Inoue H., Hamada Y., Takeshita M., Iwasaki H., Maeshiro K., et al. Intraductal tubular adenoma of the pancreas, pyloric gland type: a clinicopathologic and immunohistochemical study of 6 cases. Am J Surg Pathol 2005, 29:607-616.
58. Klimstra D.S., Wenig B.M., Heffess C.S. Solid-pseudopapillary tumor of the pancreas: a typically cystic carcinoma of low malignant potential. Semin Diagn Pathol 2000, 17:66-80.
59. Kosmahl K.G.M. Cystic lesions and neoplasms of the pancreas. The features are becoming clearer. Pancreatology 2001, 1:648-655.
60. Chetty R., Jain D., Serra S. p120 catenin reduction and cytoplasmic relocalization leads to dysregulation of E-cadherin in solid pseudopapillary tumors of the pancreas. Am J Clin Pathol 2008, 130:71-76.
61. Serra C.R.S. Membrane loss and aberrant nuclear localization of E-cadherin are consistent features of solid pseudopapillary tumour of the pancreas. An immunohistochemical study using two antibodies recognizing different domains of the E-cadherin molecule. Histopathology 2008, 52:325-330.
62. Tang W.W., Stelter A.A., French S., Shen S., Qiu S., Venegas R., et al. Loss of cell-adhesion molecule complexes in solid pseudopapillary tumor of pancreas. Mod Pathol 2007, 20:509-513.
63. Notohara K., Hamazaki S., Tsukayama C., Nakamoto S., Kawabata K., Mizobuchi K., et al. Solid-pseudopapillary tumor of the pancreas: immunohistochemical localization of neuroendocrine markers and CD10. Am J Surg Pathol 2000, 24:1361-1371.
64. Cao D., Antonescu C., Wong G., Winter J., Maitra A., Adsay N.V., et al. Positive immunohistochemical staining of KIT in solid-pseudopapillary neoplasms of the pancreas is not associated with Kit/PDGFRA mutations. Mod Pathol 2006, 19:1157-1163.
65. Tiemann K., Kosmahl M., Ohlendorf J., Krams M., Klöppel G. Solid pseudopapillary neoplasms of the pancreas are associated with FLI-1 expression, but not with EWS/FLI-1 translocation. Mod Pathol 2006, 19:1409-1413.
66. Morales A., Duarte-Rojo A., Angeles-Angeles A., Mery C.M., Ruíz-Molina J.M., Díaz-Sánchez V., et al. The beta form of the estrogen receptor is predominantly expressed in the papillary cystic neoplasm of the pancreas. Pancreas 2003, 26:258-263.
67. Alexandrescu D.T., O'Boyle K., Feliz A., Fueg A., Wiernik P.H. Metastatic solid-pseudopapillary tumour of the pancreas: clinico-biological correlates and management. Clin Oncol R Coll Radiol 2005, 17:358-363.
68. Takahashi Y., Fukusato T., Aita K., Toida S., Fukushima J., Imamura T., et al. Solid pseudopapillary tumor of the pancreas with metastases to the lung and liver. Pathol Int 2005, 55:792-796.
69. Tipton S.G., Smyrk T.C., Sarr M.G., Thompson G.B. Malignant potential of solid pseudopapillary neoplasm of the pancreas. Br J Surg 2006, 93:733-737.
70. Nagri S., Abdu A., Anand S., Krishnaiah M., Arya V. Liver metastasis four years after Whipple's resection for solid-pseudopapillary tumor of the pancreas. JOP 2007, 8:223-227.
71. Tang L.H., Aydin H., Brennan M.F., Klimstra D.S. Clinically aggressive solid pseudopapillary tumors of the pancreas: a report of two cases with components of undifferentiated carcinoma and a comparative clinicopathologic analysis of 34 conventional cases. Am J Surg Pathol 2005, 29:512-519.
72. Cantrell B.B., Cubilla A.L., Erlandson R.A., Fortner J., Fitzgerald P.J. Acinar cell cystadenocarcinoma of human pancreas. Cancer 1981, 47:410-416.
73. Ishizaki A., Koito K., Namieno T., Nagakawa T., Murashima Y., Suga T. Acinar cell carcinoma of the pancreas: a rare case of an alpha-fetoprotein-producing cystic tumor. Eur J Radiol 1995, 21:58-60.
74. Stamm B., Burger H., Hollinger A. Acinar cell cystadenocarcinoma of the pancreas. Cancer 1987, 60:2542-2547.
75. Colombo P., Arizzi C., Roncalli M. Acinar cell cystadenocarcinoma of the pancreas: report of rare case and review of the literature. Hum Pathol 2004, 35:1568-1571.
76. Basturk O., Zamboni G., Klimstra D.S., Capelli P., Andea A., Kamel N.S., et al. Intraductal and papillary variants of acinar cell carcinomas: a new addition to the challenging differential diagnosis of intraductal neoplasms. Am J Surg Pathol 2007, 31:363-370.
77. Talamini M.A., Pitt H.A., Hruban R.H., Boitnott J.K., Coleman J., Cameron J.L. Spectrum of cystic tumors of the pancreas. Am J Surg 1992, 163:117-123. discussion: 123-4.
78. Lee L.Y., Hsu H.L., Chen H.M., Hsueh C. Ductal adenocarcinoma of the pancreas with huge cystic degeneration: a lesion to be distinguished from pseudocyst and mucinous cystadenocarcinoma. Int J Surg Pathol 2003, 11:235-239.
79. Kosmahl M., Pauser U., Anlauf M., Klöppel G. Pancreatic ductal adenocarcinomas with cystic features: neither rare nor uniform. Mod Pathol 2005, 18:1157-1164.
80. Oehler U., Jürs M., Klöppel G., Helpap B. Osteoclast-like giant cell tumour of the pancreas presenting as a pseudocyst-like lesion. Virchows Arch 1997, 431:215-218.
81. Colarian J., Fowler D., Schor J., Poolos S. Squamous cell carcinoma of the pancreas with cystic degeneration. South Med J 2000, 93:821-822.
82. Fernandez-del Castillo C., Targarona J., Thayer S.P., Rattner D.W., Brugge W.R., Warshaw A.L. Incidental pancreatic cysts: clinicopathologic characteristics and comparison with symptomatic patients. Arch Surg 2003, 138:427-433. discussion: 433-4.
83. Sperti C., Pasquali C., Chierichetti F., Liessi G., Ferlin G., Pedrazzoli S. Value of 18-fluorodeoxyglucose positron emission tomography in the management of patients with cystic tumors of the pancreas. Ann Surg 2001, 234:675-680.
84. Demos T.C., Posniak H.V., Harmath C., Olson M.C., Aranha G. Cystic lesions of the pancreas. AJR Am J Roentgenol 2002, 179:1375-1388.
85. Balci N.C., Semelka R.C. Radiologic features of cystic, endocrine and other pancreatic neoplasms. Eur J Radiol 2001, 38:113-119.
86. Johnson C.D., Stephens D.H., Charboneau J.W., Carpenter H.A., Welch T.J. Cystic pancreatic tumors: CT and sonographic assessment. AJR Am J Roentgenol 1988, 151:1133-1138.
87. Curry C.A., Eng J., Horton K.M., Urban B., Siegelman S., Kuszyk B.S., et al. CT of primary cystic pancreatic neoplasms: can CT be used for patient triage and treatment?. AJR Am J Roentgenol 2000, 175:99-103.
88. Cohen-Scali F., Vilgrain V., Brancatelli G., Hammel P., Vullierme M.P., Sauvanet A., et al. Discrimination of unilocular macrocystic serous cystadenoma from pancreatic pseudocyst and mucinous cystadenoma with CT: initial observations. Radiology 2003, 228:727-733.
89. Sahani D.V., Kadavigere R., Saokar A., Fernandez-del Castillo C., Brugge W.R., Hahn P.F. Cystic pancreatic lesions: a simple imaging-based classification system for guiding management. Radiographics 2005, 25:1471-1484.
90. Sahani D., Prasad S., Saini S., Mueller P. Cystic pancreatic neoplasms evaluation by CT and magnetic resonance cholangiopancreatography. Gastrointest Endosc Clin North Am 2002, 12:657-672.
91. Loftus E.V., Olivares-Pakzad B.A., Batts K.P., Adkins M.C., Stephens D.H., Sarr M.G., et al. Intraductal papillary-mucinous tumors of the pancreas: clinicopathologic features, outcome, and nomenclature. Members of the Pancreas Clinic, and Pancreatic Surgeons of Mayo Clinic. Gastroenterology 1996, 110:1909-1918.
92. Buetow P.C., Rao P., Thompson L.D. From the archives of the AFIP. Mucinous cystic neoplasms of the pancreas: radiologic-pathologic correlation. Radiographics 1998, 18:433-449.
93. Procacci C., Carbognin G., Accordini S., Biasiutti C., Guarise A., Lombardo F., et al. CT features of malignant mucinous cystic tumors of the pancreas. Eur Radiol 2001, 11:1626-1630.
94. Procacci C., Biasiutti C., Carbognin G., Accordini S., Bicego E., Guarise A., et al. Characterization of cystic tumors of the pancreas: CT accuracy. J Comput Assist Tomogr 1999, 23:906-912.
95. Tanaka M., Chari S., Adsay V., Fernandez-del Castillo C., Falconi M., Shimizu M., et al. International consensus guidelines for management of intraductal papillary mucinous neoplasms and mucinous cystic neoplasms of the pancreas. Pancreatology 2006, 6:17-32.
96. Procacci C., Graziani R., Bicego E., Bergamo-Andreis I.A., Mainardi P., Zamboni G., et al. Intraductal mucin-producing tumors of the pancreas: imaging findings. Radiology 1996, 198:249-257.
97. Kobayashi G., Fujita N., Noda Y., Ito K., Horaguchi J., Takasawa O., et al. Mode of progression of intraductal papillary-mucinous tumor of the pancreas: analysis of patients with follow-up by EUS. J Gastroenterol 2005, 40:744-751.
98. Carbognin G., Zamboni G., Pinali L., Chiara E.D., Girardi V., Salvia R., et al. Branch duct IPMTs: value of cross-sectional imaging in the assessment of biological behavior and follow-up. Abdom Imaging 2006, 31:320-325.
99. Jang J.Y., Kim S.W., Ahn Y.J., Yoon Y.S., Choi M.G., Lee K.U., et al. Multicenter analysis of clinicopathologic features of intraductal papillary mucinous tumor of the pancreas: is it possible to predict the malignancy before surgery?. Ann Surg Oncol 2005, 12:124-132.
100. Sahani D.V., Kadavigere R., Blake M., Fernandez-Del Castillo C., Lauwers G.Y., Hahn P.F. Intraductal papillary mucinous neoplasm of pancreas: multi-detector row CT with 2D curved reformations-correlation with MRCP. Radiology 2006, 238:560-569.
101. Mergo P.J., Helmberger T.K., Buetow P.C., Helmberger R.C., Ros P.R. Pancreatic neoplasms: MR imaging and pathologic correlation. Radiographics 1997, 17:281-301.
102. Minami M., Itai Y., Ohtomo K., Yoshida H., Yoshikawa K., Iio M. Cystic neoplasms of the pancreas: comparison of MR imaging with CT. Radiology 1989, 171:53-56.
103. Waters J.A., Schmidt C.M., Pinchot J.W., White P.B., Cummings O.W., Pitt H.A., et al. CT vs MRCP: optimal classification of IPMN type and extent. J Gastrointest Surg 2008, 12:101-109.
104. Song S.J., Lee J.M., Kim Y.J., Kim S.H., Lee J.Y., Han J.K., et al. Differentiation of intraductal papillary mucinous neoplasms from other pancreatic cystic masses: comparison of multirow-detector CT and MR imaging using ROC analysis. J Magn Reson Imaging 2007, 26:86-93.
105. Irie H., Honda H., Aibe H., Kuroiwa T., Yoshimitsu K., Shinozaki K., et al. MR cholangiopancreatographic differentiation of benign and malignant intraductal mucin-producing tumors of the pancreas. AJR Am J Roentgenol 2000, 174:1403-1408.
106. Macari M., Lee T., Kim S., Jacobs S., Megibow A.J., Hajdu C., et al. Is gadolinium necessary for MRI follow-up evaluation of cystic lesions in the pancreas?. Preliminary results. AJR Am J Roentgenol 2009, 192:159-164.
107. Sperti C., Bissoli S., Pasquali C., Frison L., Liessi G., Chierichetti F., et al. 18-Fluorodeoxyglucose positron emission tomography enhances computed tomography diagnosis of malignant intraductal papillary mucinous neoplasms of the pancreas. Ann Surg 2007, 246:932-937. discussion: 937-9.
108. Waxman D.C.E.I. Endoscopic ultrasound. Gastroenterol Clin North Am 2002, 31:863-879.
109. Scheiman J.M. Management of cystic lesions of the pancreas. J Gastrointest Surg 2008, 12:405-407.
110. Brugge W.R. Management and outcomes of pancreatic cystic lesions. Dig Liver Dis 2008, 40:854-859.
111. Brugge W.R. The use of EUS to diagnose cystic neoplasms of the pancreas. Gastrointest Endosc 2009, 69:S203-S209.
112. Hutchins G.F., Draganov P.V. Cystic neoplasms of the pancreas: a diagnostic challenge. World J Gastroenterol 2009, 15:48-54.
113. Moparty B., Logrono R., Nealon W.H., Waxman I., Raju G.S., Pasricha P.J., et al. The role of endoscopic ultrasound and endoscopic ultrasound-guided fine-needle aspiration in distinguishing pancreatic cystic lesions. Diagn Cytopathol 2007, 35:18-25.
114. Brugge W.R., Lewandrowski K., Lee-Lewandrowski E., Centeno B.A., Szydlo T., Regan S., et al. Diagnosis of pancreatic cystic neoplasms: a report of the cooperative pancreatic cyst study. Gastroenterology 2004, 126:1330-1336.
115. Aljebreen A.M., Romagnuolo J., Perini R., Sutherland F. Utility of endoscopic ultrasound, cytology and fluid carcinoembryonic antigen and CA 19-9 levels in pancreatic cystic lesions. World J Gastroenterol 2007, 13:3962-3966.
116. Linder J.D., Geenen J.E., Catalano M.F. Cyst fluid analysis obtained by EUS-guided FNA in the evaluation of discrete cystic neoplasms of the pancreas: a prospective single-center experience. Gastrointest Endosc 2006, 64:697-702.
117. Shami V.M., Sundaram V., Stelow E.B., Conaway M., Moskaluk C.A., White G.E., et al. The level of carcinoembryonic antigen and the presence of mucin as predictors of cystic pancreatic mucinous neoplasia. Pancreas 2007, 34:466-469.
118. Schoedel K.E., Finkelstein S.D., Ohori N.P. K-Ras and microsatellite marker analysis of fine-needle aspirates from intraductal papillary mucinous neoplasms of the pancreas. Diagn Cytopathol 2006, 34:605-608.
119. Schmidt C.M., Yip-Schneider M.T., Ralstin M.C., Wentz S., DeWitt J., Sherman S., et al. PGE(2) in pancreatic cyst fluid helps differentiate IPMN from MCN and predict IPMN dysplasia. J Gastrointest Surg 2008, 12:243-249.
120. Sugiyama M., Atomi Y., Saito M. Intraductal papillary tumors of the pancreas: evaluation with endoscopic ultrasonography. Gastrointest Endosc 1998, 48:164-171.
121. Uehara H., Nakaizumi A., Ishikawa O., Iishi H., Tatsumi K., Takakura R., et al. Development of ductal carcinoma of the pancreas during follow-up of branch duct intraductal papillary mucinous neoplasm of the pancreas. Gut 2008, 57:1561-1565.
122. Okabayashi T., Kobayashi M., Nishimori I., Sugimoto T., Namikawa T., Okamoto K., et al. Clinicopathological features and medical management of intraductal papillary mucinous neoplasms. J Gastroenterol Hepatol 2006, 21:462-467.
123. Telford J.J., Carr-Locke D. The role of ERCP and pancreatoscopy in cystic and intraductal tumors. Gastrointest Endosc Clin North Am 2002, 12:747-757.
124. Sugiyama M., Atomi Y., Hachiya J. Intraductal papillary tumors of the pancreas: evaluation with magnetic resonance cholangiopancreatography. Am J Gastroenterol 1998, 93:156-159.
125. Gan S.I., Thompson C.C., Lauwers G.Y., Bounds B.C., Brugge W.R. Ethanol lavage of pancreatic cystic lesions: initial pilot study. Gastrointest Endosc 2005, 61:746-752.
126. Oh H.C., Seo D.W., Lee T.Y., Kim J.Y., Lee S.S., Lee S.K., et al. New treatment for cystic tumors of the pancreas: EUS-guided ethanol lavage with paclitaxel injection. Gastrointest Endosc 2008, 67:636-642.
127. Ho K.Y., Brugge W.R. Document: evaluation of EUS-guided pancreatic-cyst ablation. Gastrointest Endosc 2009, 69:S22-S27. EUS 2008 Working Group.
128. Lewandrowski K.B., Southern J.F., Pins M.R., Compton C.C., Warshaw A.L. Cyst fluid analysis in the differential diagnosis of pancreatic cysts. A comparison of pseudocysts, serous cystadenomas, mucinous cystic neoplasms, and mucinous cystadenocarcinoma. Ann Surg 1993, 217:41-47.
129. Belsley N.A., Pitman M.B., Lauwers G.Y., Brugge W.R., Deshpande V. Serous cystadenoma of the pancreas: limitations and pitfalls of endoscopic ultrasound-guided fine-needle aspiration biopsy. Cancer 2008, 114:102-110.
130. van der Waaij L.A., van Dullemen H.M., Porte R.J. Cyst fluid analysis in the differential diagnosis of pancreatic cystic lesions: a pooled analysis. Gastrointest Endosc 2005, 62:383-389.
131. Leung K.K., Ross W.A., Evans D., Fleming J., Lin E., Tamm E.P., et al. Pancreatic cystic neoplasm: the role of cyst morphology, cyst fluid analysis, and expectant management. Ann Surg Oncol 2009, 16:2818-2824.
132. Allen P.J., Qin L.X., Tang L., Klimstra D., Brennan M.F., Lokshin A. Pancreatic cyst fluid protein expression profiling for discriminating between serous cystadenoma and intraductal papillary mucinous neoplasm. Ann Surg 2009, 250:754-760.
133. Shen J., Brugge W.R., Dimaio C.J., Pitman M.B. Molecular analysis of pancreatic cyst fluid: a comparative analysis with current practice of diagnosis. Cancer Cytopathol 2009, 117:217-227.
134. Sreenarasimhaiah J., Lara L.F., Jazrawi S.F., Barnett C.C., Tang S.J. A comparative analysis of pancreas cyst fluid CEA and histology with DNA mutational analysis in the detection of mucin producing or malignant cysts. JOP 2009, 10:163-168.
135. Khalid A., Zahid M., Finkelstein S.D., LeBlanc J.K., Kaushik N., Ahmad N., et al. Pancreatic cyst fluid DNA analysis in evaluating pancreatic cysts: a report of the PANDA study. Gastrointest Endosc 2009, 69:1095-1102.
136. Yonezawa S., Goto M., Yamada N., Higashi M., Nomoto M. Expression profiles of MUC1, MUC2, and MUC4 mucins in human neoplasms and their relationship with biological behavior. Proteomics 2008, 8:3329-3341.
137. Yonezawa S., Sueyoshi K., Nomoto M., Kitamura H., Nagata K., Arimura Y., et al. MUC2 gene expression is found in noninvasive tumors but not in invasive tumors of the pancreas and liver: its close relationship with prognosis of the patients. Hum Pathol 1997, 28:344-352.
138. Yonezawa S., Nakamura A., Horinouchi M., Sato E. The expression of several types of mucin is related to the biological behavior of pancreatic neoplasms. J Hepatobiliary Pancreat Surg 2002, 9:328-341.
139. Fritz S., Fernandez-del Castillo C., Mino-Kenudson M., Crippa S., Deshpande V., Lauwers G.Y., et al. Global genomic analysis of intraductal papillary mucinous neoplasms of the pancreas reveals significant molecular differences compared to ductal adenocarcinoma. Ann Surg 2009, 249:440-447.
140. Terada T., Ohta T., Sasaki M., Nakanuma Y., Kim Y.S. Expression of MUC apomucins in normal pancreas and pancreatic tumours. J Pathol 1996, 180:160-165.
141. Fukushima N., Sato N., Prasad N., Leach S.D., Hruban R.H., Goggins M. Characterization of gene expression in mucinous cystic neoplasms of the pancreas using oligonucleotide microarrays. Oncogene 2004, 23:9042-9051.
142. Arumugam T., Simeone D.M., Van Golen K., Logsdon C.D. S100P promotes pancreatic cancer growth, survival, and invasion. Clin Cancer Res 2005, 11:5356-5364.
143. Ohuchida K., Mizumoto K., Egami T., Yamaguchi H., Fujii K., Konomi H., et al. S100P is an early developmental marker of pancreatic carcinogenesis. Clin Cancer Res 2006, 12:5411-5416.
144. Dowen S.E., Crnogorac-Jurcevic T., Gangeswaran R., Hansen M., Eloranta J.J., Bhakta V., et al. Expression of S10 0P and its novel binding partner S100PBPR in early pancreatic cancer. Am J Pathol 2005, 166:81-92.
145. Marsh W.L., Colonna J., Yearsley M., Bloomston M., Frankel W.L. Calponin is expressed in serous cystadenomas of the pancreas but not in adenocarcinomas or endocrine tumors. Appl Immunohistochem Mol Morphol 2009, 17:216-219.
146. Sharma R.R., London M.J., Magenta L.L., Posner M.C., Roggin K.K. Preemptive surgery for premalignant foregut lesions. J Gastrointest Surg 2009, 13:1874-1887.
147. DeWitt J., McGreevy K., Schmidt C.M., Brugge W.R. EUS-guided ethanol versus saline solution lavage for pancreatic cysts: a randomized, double-blind study. Gastrointest Endosc 2009, 70:710-723.
148. Kendall D.M., Sutherland D.E., Najarian J.S., Goetz F.C., Robertson R.P. Effects of hemipancreatectomy on insulin secretion and glucose tolerance in healthy humans. N Engl J Med 1990, 322:898-903.
149. Roggin K.K., Rudloff U., Blumgart L.H., Brennan M.F. Central pancreatectomy revisited. J Gastrointest Surg 2006, 10:804-812.
150. Blanc B., Sauvanet A., Couvelard A., Pessaux P., Dokmak S., Vullierme M.P., et al. [Limited pancreatic resections for intraductal papillary mucinous neoplasm]. J Chir 2008, 145:568-578.
151. Park A., Schwartz R., Tandan V., Anvari M. Laparoscopic pancreatic surgery. Am J Surg 1999, 177:158-163.
152. Talamini M.A., Moesinger R., Yeo C.J., Poulose B., Hruban R.H., Cameron J.L., et al. Cystadenomas of the pancreas: is enucleation an adequate operation?. Ann Surg 1998, 227:896-903.
153. Gagner A.A.M. Laparoscopic pancreatic surgery for islet cell tumors of the pancreas. World J Surg 2004, 28:1239-1247.
154. Beger H.G., Gansauge F., Siech M., Schwarz M., Poch B. Duodenum-preserving total pancreatic head resection for cystic neoplastic lesions in the head of the pancreas. J Hepatobiliary Pancreat Surg 2008, 15:149-156.
155. Shoup A.G.V.M. Nonstandard pancreatic resections for unusual lesions. Am J Surg 2005, 189:223-228.
156. Gouma D.J., van Geenen R.C., van Gulik T.M., de Haan R.J., de Wit L.T., Busch O.R., et al. Rates of complications and death after pancreaticoduodenectomy: risk factors and the impact of hospital volume. Ann Surg 2000, 232:786-795.
157. Cameron J.L., Riall T.S., Coleman J., Belcher K.A. One thousand consecutive pancreaticoduodenectomies. Ann Surg 2006, 244:10-15.
158. Kooby D.A., Gillespie T., Bentrem D., Nakeeb A., Schmidt M.C., Merchant N.B., et al. Left-sided pancreatectomy: a multicenter comparison of laparoscopic and open approaches. Ann Surg 2008, 248:438-446.
159. Müller M.W., Friess H., Kleeff J., Dahmen R., Wagner M., Hinz U., et al. Is there still a role for total pancreatectomy?. Ann Surg 2007, 246:966-974. discussion: 974-5.
160. Nathan H., Wolfgang C.L., Edil B.H., Choti M.A., Herman J.M., Schulick R.D., et al. Peri-operative mortality and long-term survival after total pancreatectomy for pancreatic adenocarcinoma: a population-based perspective. J Surg Oncol 2009, 99:87-92.
161. Reddy R.P., Smyrk T.C., Zapiach M., Levy M.J., Pearson R.K., Clain J.E., et al. Pancreatic mucinous cystic neoplasm defined by ovarian stroma: demographics, clinical features, and prevalence of cancer. Clin Gastroenterol Hepatol 2004, 2:1026-1031.
162. Wilentz R.E., Albores-Saavedra J., Zahurak M., Talamini M.A., Yeo C.J., Cameron J.L., et al. Pathologic examination accurately predicts prognosis in mucinous cystic neoplasms of the pancreas. Am J Surg Pathol 1999, 23:1320-1327.
163. Fernandez-del Castillo C. Mucinous cystic neoplasms. J Gastrointest Surg 2008, 12:411-413.
164. Tanno S., Nakano Y., Nishikawa T., Nakamura K., Sasajima J., Minoguchi M., et al. Natural history of branch duct intraductal papillary-mucinous neoplasms of the pancreas without mural nodules: long-term follow-up results. Gut 2008, 57:339-343.
165. Tanno S., Nakano Y., Koizumi K., Sugiyama Y., Nakamura K., Sasajima J., et al. Pancreatic ductal adenocarcinomas in Long-term follow-up patients with Branch Duct Intraductal Papillary Mucinous Neoplasms. Pancreas 2010, 39:36-40.
166. Sawhney M.S., Al-Bashir S., Cury M.S., Brown A., Chuttani R., Pleskow D.K., et al. International consensus guidelines for surgical resection of mucinous neoplasms cannot be applied to all cystic lesions of the pancreas. Clin Gastroenterol Hepatol 2009, 7:1373-1376.
167. Tang R.S., Weinberg B., Dawson D.W., Reber H., Hines O.J., Tomlinson J.S., et al. Evaluation of the guidelines for management of pancreatic branch-duct intraductal papillary mucinous neoplasm. Clin Gastroenterol Hepatol 2008, 6:815-819. Quiz: 719.
168. Woo S.M., Ryu J.K., Lee S.H., Yoon W.J., Kim Y.T., Yoon Y.B. Branch duct intraductal papillary mucinous neoplasms in a retrospective series of 190 patients. Br J Surg 2009, 96:405-411.
169. Allen P.J., D'angelica M., Gonen M., Jaques D.P., Coit D.G., Jarnagin W.R., et al. A selective approach to the resection of cystic lesions of the pancreas: results from 539 consecutive patients. Ann Surg 2006, 244:572-582.
170. Bassi C., Sarr M.G., Lillemoe ha Reber K.D. Natural history of intraductal papillary mucinous neoplasms (IPMN): current evidence and implications for management. J Gastrointest Surg 2008, 12:645-650.
171. Grobmyer S.R., Cance W.G., Copeland E.M., Vogel S.B., Hochwald S.N. Is there an indication for initial conservative management of pancreatic cystic lesions?. J Surg Oncol 2009, 100:372-374.
172. Fernandez-del Castillo C.S.C. A selective approach to the resection of cystic lesions of the pancreas: results from 539 consecutive patients. Ann Surg 2007, 245:826-827. Author reply: 527-8.
173. Rodriguez J.R., Salvia R., Crippa S., Warshaw A.L., Bassi C., Falconi M., et al. Branch-duct intraductal papillary mucinous neoplasms: observations in 145 patients who underwent resection. Gastroenterology 2007, 133:72-79. Quiz: 309-10.
174. Sohn T.A., Yeo C.J., Cameron J.L., Hruban R.H., Fukushima N., Campbell K.A., et al. Intraductal papillary mucinous neoplasms of the pancreas: an updated experience. Ann Surg 2004, 239:788-797. discussion: 797-9.
175. Sakorafas G.H., Sarr M.G., van de Velde C.J., Peros G. Intraductal papillary mucinous neoplasms of the pancreas: a surgical perspective. Surg Oncol 2005, 14:155-178.
176. Lee C.J., Scheiman J., Anderson M.A., Hines O.J., Reber H.A., Farrell J., et al. Risk of malignancy in resected cystic tumors of the pancreas < or =3 cm in size: is it safe to observe asymptomatic patients?. A multi-institutional report. J Gastrointest Surg 2008, 12:234-242.
177. Sugiyama M., Izumisato Y., Abe N., Masaki T., Mori T., Atomi Y. Predictive factors for malignancy in intraductal papillary-mucinous tumours of the pancreas. Br J Surg 2003, 90:1244-1249.
178. Schmidt C.M., White P.B., Waters J.A., Yiannoutsos C.T., Cummings O.W., Baker M., et al. Intraductal papillary mucinous neoplasms: predictors of malignant and invasive pathology. Ann Surg 2007, 246:644-651. discussion: 51-4.