Mucinous cystic tumors of the pancreas: Clinicopathological features, prognosis, and relationship to other mucinous cystic tumors

American Journal of Surgical Pathology

Volumn 23, Issue 4, 1999, Pages 410-422

  Zamboni, Giuseppe ^a   Scarpa, Aldo ^b   Bogina, Giuseppe ^b   Iacono, Calogero ^b   Bassi, Claudio ^b   Talamini, Giorgio ^b   Sessa, Fausto ^b   Capella, Carlo ^b   Solcia, Enrico ^b   Rickaert, Fabienne ^b   Mariuzzi, Gian Mario ^b   Klöppel, Günter ^b  

^a UNIVERSITY OF VERONA   (Italy)

^b NONE

Author keywords

Clinicopathological features; Mucinous cystic tumor; Origin; Pancreas; Prognosis

Indexed keywords

ARTICLE; CANCER INVASION; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; LUTEINIZATION; MAJOR CLINICAL STUDY; PANCREAS TUMOR; TUMOR CLASSIFICATION;

EID: 0032903296     PISSN: 01475185     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000478-199904000-00005     Document Type: Article

References (67)

1. Akwari OE, Turker A, Seigler HF, Itani KMF. Hepatobiliary cystadenoma with mesenchymal stroma. Ann Surg 1990; 211:18-27.
2. Albores-Saavedra J, Angeles-Angeles A, Nadji M, Henson ED, Alvarez L. Mucinous cystadenocarcinoma of the pancreas. Morphologic and immunohistochemical observations. Am J Surg Pathol 1987; 11:11-20.
3. Albores-Saavedra J, Gould EW, Angeles-Angeles A, Henson DE. Cystic tumors of the pancreas. Pathol Ann Part II 1990; 19-50.
4. Albores-Saavedra J, Nadji M, Henson ED, Angeles-Angeles A. Enteroendocrine cell differentiation in carcinomas of the gallbladder and mucinous cystadenocarcinomas of the pancreas. Pathol Res Pract 1988; 183:169-175.
5. Armitage B, Berry G. Statistical methods in medical research. Oxford: Blackwell Scientific Publications; 1987:421-439.
6. Bostwick DG, Tazelaar HD, Ballon SC, Endrickson MR, Kempson RE. Ovarian epithelial tumors of borderline malignancy: A clinical and pathologic study of 109 cases. Cancer 1986; 58:2052-2065.
7. Cantrell BB, Cubilla AL, Erlandson RA, Fortner J, Fitzgerald PJ. Acinar cell cystadenocarcinoma of human pancreas. Cancer 1981; 47:410-416.
8. Compagno J, Oertel J. Microcystic adenomas of the pancreas (glycogen-rich cystadenomas): a clinicopathological study of 34 cases. Am J Clin Pathol 1978; 69:289-298.
9. Compagno J, Oertel J. Mucinous cystic neoplasms of the pancreas with overt and latent malignancy (cystadenocarcinoma and cystadenoma): a clinicopathologic study of 41 cases. Am J Clin Pathol 1978; 69:573-580.
10. Cox D R. Regression models and life-tables. J R Stat Soc [B] 1972; 34:187-220.
11. Czernobilsky B, Shezen E, Lifshitz-Mercer B, al et. Alpha smooth muscle actin (a-SM actin) in normal human ovaries, in ovarian stromal hyperplasia and ovarian neoplasms. Virch Arch B Cell Pathol 1989; 57:55-61.
12. Davidoff MS, Schulze W, Middendorff R, Holstein AF. The Leydig cell of the human testis - a new member of the diffuse neuroendocrine system. Cell Tissue Res 1993; 271:429-439.
13. Devaney K, Goodman ZD, Ishak KG. Hepatobiliary cystadenoma and cystadenocarcinoma. A light microscopic and immunohistochemical study of 70 patients. Am J Surg Pathol 1994; 18:1078-1091.
14. Egawa N, Maillet B, Schröder S, Mukai K, Klöppel G. Serous oligocystic and ill-demarcated adenoma of the pancreas: a variant of serous cystic adenoma. Virchows Archiv 1994; 424:13-17.
15. Flejou JF, Boulange B, Bernades P, Belghiti J, Henin D. p53 protein expression and DNA ploidy in cystic tumors of the pancreas. Pancreas 1996; 13:247-252.
16. Flemming P, Grothe W, Maschek H, Petry KU, Wellmann A, Geogii A. The site of inhibin production in ovarian neoplasms. Histopathology 1996; 29:465-468.
17. Furukawa T, Takahashi T, Kobari M, Matsuno S. The mucus-hypersecreting tumor of the pancreas. Development and extension visualized by three-dimensional computerized mapping. Cancer 1992; 70: 1505-1513.
18. Gibson JB, Sobin LH. Histological typing of tumor of the liver, biliary tract and pancreas. Geneva: 1978.
19. Gourley WK, Kumar D, Bouton MS, Fish JC, Nealon W. Cystadenoma and cystadenocarcinoma with mesenchymal stroma of the liver. Immunohistochemical analysis. Arch Pathol Lab Med 1992; 116: 1047-1050.
20. Gray W, Teare J, Myburgh JA, Paterson AC. Immunohistochemical demonstration of progesterone receptor in hepatobiliary cystadenoma with mesenchymal stroma. Histopathology 1996; 29: 461-463.
21. Healy DL, Burger HG, Mamers P, Jobling T, Bangh M, Quinn M, Grant P, Day AJ, Rome R, Campbell JJ. Elevated serum inhibin concentrations in postmenopausal women with ovarian tumors. N Engl J Med 1993; 329:1539-1542.
22. Hodgkinson DJ, ReMine WH, Weiland LH. A clinicopathologic study of 45 cases of pancreatic cystadenocarcinoma. Ann Surg 1978; 188:679-684.
23. Hoorens A, Lemoine NR, McLellan E, Morohoshi T, Kamisawa T, Heitz PU, Stamm B, Rüschoff J, Wiedenmann B, Klöppel G. Pancreatic acinar cell carcinoma. An analysis of cell lineage markers, p53 expression, and Ki-ras mutations. Am J Pathol 1993; 143:685-698.
24. Iacono C, Serio G, Fugazzola C, Zamboni G, Bergamo Andreis IA, Iannuci A, Zicari M, Dagradi A. Cystic islet cell tumor of the pancreas. A clinico-pathological report of two nonfunctionig cases and review of the literature. Int J Pancreatol 1992; 11:199-208.
25. Itai Y, Ohhashi K, Nagai H, Murakami Y, Kokubo T, Makita K, Ohtomo K. Ductectatic mucinous cystadenoma and cystadenocarcinoma of the pancreas. Radiology 1986; 161:697-700.
26. Klimstra DS, Heftes CS, Oertl J, Rosai J. Acinar cell carcinoma of the pancreas. A clinicopathologic study of 28 cases. Am J Surg Pathol 1992; 16:815-837.
27. Klöppel G, Maurer R, Hofmann E, Luthold K, Oscarson J, Forsby N, Ihse I, Ljungberg O, Heitz PU. Solid-cystic (papillary-cystic) tumours within and outside the pancreas in men: report of two cases. Virchows Arch (A) 1991; 418:179-183.
28. Klöppel G, Morohoshi T, John HD, Oehmichen W, Opitz K, Angelkort A, Lietz H, Ruc̈kert K. Solid and cystic acinar cell tumour of the pancreas. A tumour in young women with favourable prognosis. Virchows Arch 1981; 392:171-183.
29. Klöppel G, Solcia E, Longnecker DS, Capella C, Sobin LH. Histological typing of tumours of the exocrine pancreas. Berlin: Springer-Verlag; 1996.
30. Lane RB, Sanguëza OP. Anaplastic carcinoma occurring in association with a mucinous cystic neoplasm of the pancreas. Arch Pathol Lab Med 1997; 121:533-535.
31. Lewandrowski KB, Warshaw AL, Compton CC. Macrocystic serous cystadenoma of the pancreas: A morphologic variant differing from microcystic adenoma. Hum Pathol 1992; 23:871-875.
32. Lieber MR, Lack EE, Robert JR, Patterson K, Restrepo C, Solomon D, Chandra R, Triche TJ. Solid and papillary epithelial neoplasm of the pancreas. An ultrastructural and immunohistochemical study of six cases. Am J Surg Pathol 1987; 11:185-93.
33. Mantel N, Haenszel W. Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst 1959; 22:719-748.
34. Matsunou H, Konishi F, Yamamichi N, Takayanagi N, Mukai M. Solid, infiltrating variety of papillary cystic neoplasm of the pancreas. Cancer 1990; 65:2747-2757.
35. Molberg KH, Heffess CS, Delgado R, Albores-Saavedra J. Undifferentiated carcinoma with osteoclast-like giant cells of the pancreas and periampullary region. Cancer 1998; 82:1279-1287.
36. Nishimura H. Atlas of human prenatal histology. Tokyo-New York: Igaku-Shoin, 1983.
37. ReMine SG, Frey D, Rossi RL, Munson JL, Braasch JW. Cystic neoplasms of the pancreas. Arch Surg 1987; 122:443-446.
38. Rickaert F, Cremer M, Deviére J, Tavares L, Lambilliotte JP, Schröder S, Wurbs D, Klöppel G. Intraductal mucin-hypersecreting neoplasms of the pancreas. A clinicopathologic study of eight patients. Gastroenterology 1991; 101:512-519.
39. Rome RM, Fortune DW, Quinn MA, Brown JB. Functioning ovarian tumors in postmenopausal women. Obstet Gynecol 1981; 57: 705-710.
40. Russell P. Surface epithelial-stromal tumours of the ovary. In: Fox H, eds. Obstetrical and gynecological pathology. 1995: 767.
41. Rutgers JL, Scully RE. Ovarian mullerian mucinous papillary cystadenomas of borderline malignancy. A clinicopathologic analysis. Cancer 1988; 61:340-348.
42. Sachs JR, Deren JJ, Sohn M, Nusbaum M. Mucinous cystadenoma: pitfalls of differential diagnosis. Am J Gastroenterol 1989; 84: 811-816.
43. Scott FR, More L, Dhillon AP. Hepatobiliary cystadenoma with mesenchymal stroma: expression of oestrogen receptors in formalin-fixed tissue. Histopathology 1995; 26:555-558.
44. Scully RE. Tumors of the ovary and maldevelopment gonads. Washington, DC: Armed Forces Institute of Pathology; 1979: 353.
45. Sessa F, Bonato M, Frigerio B, Capella C, Solcia E, Prat M, Bara J, Samloff IM. Ductal cancers of the pancreas frequently express markers of gastrointestinal epithelial cells. Gastroenterology 1990; 98:1655-1665.
46. Shyr YM, Su CH, Tsay SH, Lui WY. Mucin-producing neoplasms of the pancreas. Intraductal papillary and mucinous cystic neoplasms. Ann Surg 1996; 223:141-146.
47. Solcia E, Capella C, Klöppel G. Tumors of the pancreas. Washington, DC: Armed Forces Institute of Pathology, 1997.
48. Southern JF, Warshaw AL, Lewandrowski KB, DNA ploidy analysis of mucinous cystic tumors of the pancreas. Correlation of aneuploidy with malignancy and poor prognosis. Cancer 1996; 77: 58-62.
49. Stamm BH, Burger H, Hollinger A. Acinar cell cystadenocarcinoma of the pancreas. Cancer 1987; 60:2542-2547.
50. Subramony C, Herrera GA, Turbat-Herrera EA. Hepatobiliary cystadenoma. A study of five cases with reference to histogenesis. Arch Pathol Lab Med 1993; 117:1036-1042.
51. Talamini MA, Pitt HA, Hruban RH, Boitnott JK, Coleman JA, Cameron JL. Spectrum of cystic tumors of the pancreas. Am J Surg 1992; 163:117-124.
52. Tenti P, Aguzzi A, Riva C, Usellini L, Zappatore R, Bara J, Samloff M, Solcia E. Ovarian mucinous tumors frequently express markers of gastric, intestinal, and pancreatobiliary epithelial cells. Cancer 1992; 69:2131-2142.
53. Tenti P, Romagnoli S, Pellegata NS, Zappatore R, Giunta P, Ranzani GN, Carnevali L. Primary retroperitoneal mucinous cystadenocarcinomas: an immunohistochemical and molecular study. Virchows Arch 1994; 424:53-57.
54. Tsujimura T, Kawano K, Taniguchi M, Yoshikawa K, Tsukaguchi I. Malignant fibrous histiocytoma coexistent with mucinous cystadenoma of the pancreas. Cancer 1992; 70:2792-2796.
55. Tuchmann-Duplessis H. Embryologie. Travaux pratiques et enseignement di'rigè. Paris: Masson, 1968.
56. Vuitch F, Battifora H, Albores-Saavedra J. Demonstration of steroid hormone receptors in pancreato-biliary mucinous cystic neoplasms. Lab Invest 1993; 68:114A.
57. Warshaw AL, Compton CC, Lewandrowsk KB, Cardenosa G, Mueller PR. Cystic tumors of the pancreas. New clinical, radiologic, and pathologic observations in 67 patients. Ann Surg 1990; 4:432-445.
58. Warshaw AL, Rutledge PL. Cystic tumors mistaken for pancreatic pseudocysts. Ann Surg 1987; 205:393-398.
59. Wenig BM, Albores-Saavedra J, Buetow PC, Heffes CS. Pancreatic mucinous cystic neoplasm with sarcomatous stroma. Report of three cases. Am J Surg Pathol 1997; 21:70-80.
60. Wheeler DA, Edmondson HA. Cystadenoma with mesenchymal stroma (CMS) in the liver and bile ducts. A clinicopathologic study of 17 cases, 4 with malignant changes. Cancer 1985; 56:1434-1445.
61. Wouters K, Ectors N, Van Steenbergen W, Aerts R, Driessen A, Van Hoe L, Geboes K. A pancreatic mucinous cystadenoma in a man with mesenchymal stroma, expressing oestrogen and progesterone receptors. Virchows Arch 1998; 432:187-189.
62. Yamada M, Kozuka S, Yamano K, Nakazawa S, Naitoh Y, Tsukamoto Y. Mucin-producing tumor of the pancreas. Cancer 1991; 68: 159-168.
63. Yamaguchi K, Enjoji M. Cystic neoplasms of the pancreas. Gastroenterology 1987; 92:1934-1943.
64. Zamboni G, Bonetti F, Castelli P, Balercia G, Pea M, Martignoni G, Iacono C, Donati L Fiore. Mucinous cystic tumor of the pancreas recurring after 11 years as cystadenocarcinoma with foci of choriocarcinoma and osteoclast-like giant cell tumor. Surg Pathol 1994; 5:253-262.
65. Zamboni G, Bonetti F, Scarpa A, Pelosi G, Doglioni C, Iannucci A, Castelli P, Balercia G, Aldovini D, Bellomi A, Iacono C, Serio G, Mariuzzi GM. Expression of progesterone receptors in solid-cystic tumour of the pancreas: a clinicopathological and immunohistochemical study of ten cases. Virchows Archiv A 1993; 423: 425-431.
66. Zamboni G, Scarpa A, Franzin G, Capelli P, Bogina G, Iannucci A, Bassi C, Pederzoli P, Iacono C, Serio G, Procacci C, Mariuzzi GM. Pathology of cystic tumors of the pancreas. In: Pederzoli P, Bassi C, Cavallini G & Falconi M, eds. Facing the pancreatic dilemma. Berlin: Springer Verlag; 1994:368-397.
67. Zheng W, Sung CJ, Hanna I, DePetris G, Lambert-Messrlian G, Steinhoff M, Lauchlan SC. α and β subunits of inhibin/activin as sex cord-stromal differentiation markers. Int J Gynecol Pathol 1997; 16:263-271.