Cystic neoplasms of the pancreas: A diagnostic challenge

World Journal of Gastroenterology

Volumn 15, Issue 1, 2009, Pages 48-54

  Hutchins, Grant F ^a   Draganov, Peter V ^a  

^a UNIVERSITY OF FLORIDA   (United States)

Author keywords

Cystic neoplasm; Endoscopic ultrasound; Pancreas; Pancreatic cyst; Pancreatitis

Indexed keywords

ABDOMINAL RADIOGRAPHY; ALGORITHM; ANAMNESIS; ASPIRATION BIOPSY; COMPUTER ASSISTED TOMOGRAPHY; CYST FLUID; DIAGNOSTIC ACCURACY; DIFFERENTIAL DIAGNOSIS; ENDOSCOPIC ECHOGRAPHY; ENDOSCOPIC RETROGRADE CHOLANGIOPANCREATOGRAPHY; HUMAN; IMAGE ANALYSIS; LABORATORY TEST; MALIGNANT TRANSFORMATION; NUCLEAR MAGNETIC RESONANCE IMAGING; PANCREAS CYST; PANCREAS PSEUDOCYST; PREVALENCE; REVIEW; SENSITIVITY AND SPECIFICITY; TUMOR CLASSIFICATION;

EID: 59249090401     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.15.48     Document Type: Review

References (57)

1. Fernandez-del Castillo C, Warshaw AL. Cystic neoplasms of the pancreas. Pancreatology 2001; 1: 641-647
2. Mulkeen AL, Yoo PS, Cha C. Less common neoplasms of the pancreas. World J Gastroenterol 2006; 12: 3180-3185
3. Sakorafas GH, Sarr MG. Cystic neoplasms of the pancreas; what a clinician should know. Cancer Treat Rev 2005; 31: 507-535
4. Megibow AJ, Lombardo FP, Guarise A, Carbognin G, Scholes J, Rofsky NM, Macari M, Balthazar EJ, Procacci C. Cystic pancreatic masses: cross-sectional imaging observations and serial follow-up. Abdom Imaging 2001; 26: 640-647
5. Compagno J, Certel JE. Mucinous cystic neoplasms of the pancreas with overt and latent malignancy (cystadenocarcinoma and cystadenoma). A clinicopathologic study of 41 cases. Am J Clin Pathol 1978; 69: 573-580
6. Compagno J, Oertel JE. Microcystic adenomas of the pancreas (glycogen-rich cystadenomas): a clinicopathologic study of 34 cases. Am J Clin Pathol 1978; 69: 289-298
7. Sahani DV, Kadavigere R, Saokar A, Fernandez-del Castillo C, Brugge WR, Hahn PF. Cystic pancreatic lesions: a simple imaging-based classification system for guiding management. Radiographics 2005; 25: 1471-1484
8. Gerke H, Jaffe TA, Mitchell RM, Byrne MF, Stiffler HL, Branch MS, Baillie J, Jowell PS. Endoscopic ultrasound and computer tomography are inaccurate methods of classifying cystic pancreatic lesions. Dig Liver Dis 2006; 38: 39-44
9. Scarlett CJ, Samra JS, Xue A, Baxter RC, Smith RC. Classification of pancreatic cystic lesions using SELDI-TOF mass spectrometry. ANZ J Surg 2007; 77: 648-653
10. Ohhashi K, Murakami Y, Maruyama M, Takekoshi T, Ohta H, Ohhashi I, Takagi K, Kato Y. Four cases of mucin-producing cancer of the pancreas on specific findings of the papilla of Vater. Prog Dig Endosc 1982; 20: 348-351
11. Klöppel G, Solcia E, Longnecker DS, Capella C, Sobin LH. World Health Organization International Histologic Classification of Tumours 2. Histologic typing of tumours of the exocrine pancreas. Berlin: Springer-Verlag, 1996
12. Izumo A, Yamaguchi K, Eguchi T, Nishiyama K, Yamamoto H, Yonemasu H, Yao T, Tanaka M, Tsuneyoshi M. Mucinous cystic tumor of the pancreas: immunohistochemical assessment of "ovarian-type stroma". Oncol Rep 2003; 10: 515-525
13. Kobari M, Egawa S, Shibuya K, Shimamura H, Sunamura M, Takeda K, Matsuno S, Furukawa T. Intraductal papillary mucinous tumors of the pancreas comprise 2 clinical subtypes: differences in clinical characteristics and surgical management. Arch Surg 1999; 134: 1131-1136
14. Terris B, Ponsot P, Paye F, Hammel P, Sauvanet A, Molas G, Bernades P, Belghiti J, Ruszniewski P, Flejou JF. Intraductal papillary mucinous tumors of the pancreas confined to secondary ducts show less aggressive pathologic features as compared with those involving the main pancreatic duct. Am J Surg Pathol 2000; 24: 1372-1377
15. Doi R, Fujimoto K, Wada M, Imamura M. Surgical management of intraductal papillary mucinous tumor of the pancreas. Surgery 2002; 132: 80-85
16. Kitagawa Y, Unger TA, Taylor S, Kozarek RA, Traverso LW. Mucus is a predictor of better prognosis and survival in patients with intraductal papillary mucinous tumor of the pancreas. J Gastrointest Surg 2003; 7: 12-18; discussion 18-19
17. Sugiyama M, Izumisato Y, Abe N, Masaki T, Mori T, Atomi Y. Predictive factors for malignancy in intraductal papillary-mucinous tumours of the pancreas. Br J Surg 2003; 90: 1244-1249
18. Sohn TA, Yeo CJ, Cameron JL, Hruban RH, Fukushima N, Campbell KA, Lillemoe KD. Intraductal papillary mucinous neoplasms of the pancreas: an updated experience. Ann Surg 2004; 239: 788-797; discussion 797-799
19. Reddy RP, Smyrk TC, Zapiach M, Levy MJ, Pearson RK, Clain JE, Farnell MB, Sarr MG, Chari ST. Pancreatic mucinous cystic neoplasm defined by ovarian stroma: demographics, clinical features, and prevalence of cancer. Clin Gastroenterol Hepatol 2004; 2: 1026-1031
20. Thompson LD, Becker RC, Przygodzki RM, Adair CF, Heffess CS. Mucinous cystic neoplasm (mucinous cystadenocarcinoma, of low-grade malignant potential) of the pancreas: a clinicopathologic study of 130 cases. Am J Surg Pathol 1999; 23: 1-16
21. Tanaka M, Chari S, Adsay V, Fernandez-del Castillo C, Falconi M, Shimizu M, Yamaguchi K, Yamao K, Matsuno S. International consensus guidelines for management of intraductal papillary mucinous neoplasms and mucinous cystic neoplasms of the pancreas. Pancreatology 2006; 6: 17-32
22. Zhang XM, Mitchell DG, Dohke M, Holland GA, Parker L. Pancreatic cysts: depiction on single-shot fast spin-echo MR images. Radiology 2002; 223: 547-553
23. Sarr MG, Murr M, Smyrk TC, Yeo CJ, Fernandez-del- Castillo C, Hawes RH, Freeny PC. Primary cystic neoplasms of the pancreas. Neoplastic disorders of emerging importance-current state-of-the-art and unanswered questions. J Gastrointest Surg 2003; 7: 417-428
24. Kimura W, Nagai H, Kuroda A, Muto T, Esaki Y. Analysis of small cystic lesions of the pancreas. Int J Pancreatol 1995; 18: 197-206
25. Warshaw AL, Rutledge PL. Cystic tumors mistaken for pancreatic pseudocysts. Ann Surg 1987; 205: 393-398
26. Fernandez-del Castillo C, Warshaw AL. Cystic tumors of the pancreas. Surg Clin North Am 1995; 75: 1001-1016
27. Loftus EV Jr, Olivares-Pakzad BA, Batts KP, Adkins MC, Stephens DH, Sarr MG, DiMagno EP. Intraductal papillarymucinous tumors of the pancreas: clinicopathologic features, outcome, and nomenclature. Members of the Pancreas Clinic, and Pancreatic Surgeons of Mayo Clinic. Gastroenterology 1996; 110: 1909-1918
28. Salvia R, Fernandez-del Castillo C, Bassi C, Thayer SP, Falconi M, Mantovani W, Pederzoli P, Warshaw AL. Mainduct intraductal papillary mucinous neoplasms of the pancreas: clinical predictors of malignancy and long-term survival following resection. Ann Surg 2004; 239: 678-685; discussion 685-687
29. Scheiman JM. Cystic lesion of the pancreas. Gastroenterology 2005; 128: 463-469
30. Azar C, Van de Stadt J, Rickaert F, Deviere M, Baize M, Kloppel G, Gelin M, Cremer M. Intraductal papillary mucinous tumours of the pancreas. Clinical and therapeutic issues in 32 patients. Gut 1996; 39: 457-464
31. Pettinato G, Di Vizio D, Manivel JC, Pambuccian SE, Somma P, Insabato L. Solid-pseudopapillary tumor of the pancreas: a neoplasm with distinct and highly characteristic cytological features. Diagn Cytopathol 2002; 27: 325-334
32. Oh HC, Kim MH, Hwang CY, Lee TY, Lee SS, Seo DW, Lee SK. Cystic lesions of the pancreas: challenging issues in clinical practice. Am J Gastroenterol 2008; 103: 229-239; quiz 228, 240
33. Johnson CD, Stephens DH, Charboneau JW, Carpenter HA, Welch TJ. Cystic pancreatic tumors: CT and sonographic assessment. AJR Am J Roentgenol 1988; 151: 1133-1138
34. Curry CA, Eng J, Horton KM, Urban B, Siegelman S, Kuszyk BS, Fishman EK. CT of primary cystic pancreatic neoplasms: can CT be used for patient triage and treatment? AJR Am J Roentgenol 2000; 175: 99-103
35. Procacci C, Biasiutti C, Carbognin G, Accordini S, Bicego E, Guarise A, Spoto E, Andreis IA, De Marco R, Megibow AJ. Characterization of cystic tumors of the pancreas: CT accuracy. J Comput Assist Tomogr 1999; 23: 906-912
36. Le Borgne J, de Calan L, Partensky C. Cystadenomas and cystadenocarcinomas of the pancreas: a multiinstitutional retrospective study of 398 cases. French Surgical Association. Ann Surg 1999; 230: 152-161
37. Bassi C, Salvia R, Molinari E, Biasutti C, Falconi M, Pederzoli P. Management of 100 consecutive cases of pancreatic serous cystadenoma: wait for symptoms and see at imaging or vice versa? World J Surg 2003; 27: 319-323
38. Koito K, Namieno T, Nagakawa T, Shyonai T, Hirokawa N, Morita K. Solitary cystic tumor of the pancreas: EUSpathologic correlation. Gastrointest Endosc 1997; 45: 268-276
39. Gress F, Gottlieb K, Cummings O, Sherman S, Lehman G. Endoscopic ultrasound characteristics of mucinous cystic neoplasms of the pancreas. Am J Gastroenterol 2000; 95: 961-965
40. Koito K, Namieno T, Ichimura T, Yama N, Hareyama M, Morita K, Nishi M. Mucin-producing pancreatic tumors: comparison of MR cholangiopancreatography with endoscopic retrograde cholangiopancreatography. Radiology 1998; 208: 231-237
41. Sahani D, Prasad S, Saini S, Mueller P. Cystic pancreatic neoplasms evaluation by CT and magnetic resonance chol angiopancreatography. Gastrointest Endosc Clin N Am 2002; 12: 657-672
42. Fukukura Y, Fujiyoshi F, Hamada H, Takao S, Aikou T, Hamada N, Yonezawa S, Nakajo M. Intraductal papillary mucinous tumors of the pancreas. Comparison of helical CT and MR imaging. Acta Radiol 2003; 44: 464-471
43. Yamao K, Nakamura T, Suzuki T, Sawaki A, Hara K, Kato T, Okubo K, Matsumoto K, Shimizu Y. Endoscopic diagnosis and staging of mucinous cystic neoplasms and intraductal papillary-mucinous tumors. J Hepatobiliary Pancreat Surg 2003; 10: 142-146
44. O'Toole D, Palazzo L, Hammel P, Ben Yaghlene L, Couvelard A, Felce-Dachez M, Fabre M, Dancour A, Aubert A, Sauvanet A, Maire F, Levy P, Ruszniewski P. Macrocystic pancreatic cystadenoma: The role of EUS and cyst fluid analysis in distinguishing mucinous and serous lesions. Gastrointest Endosc 2004; 59: 823-829
45. Sedlack R, Affi A, Vazquez-Sequeiros E, Norton ID, Clain JE, Wiersema MJ. Utility of EUS in the evaluation of cystic pancreatic lesions. Gastrointest Endosc 2002; 56: 543-547
46. Ahmad NA, Kochman ML, Brensinger C, Brugge WR, Faigel DO, Gress FG, Kimmey MB, Nickl NJ, Savides TJ, Wallace MB, Wiersema MJ, Ginsberg GG. Interobserver agreement among endosonographers for the diagnosis of neoplastic versus non-neoplastic pancreatic cystic lesions. Gastrointest Endosc 2003; 58: 59-64
47. Hernandez LV, Mishra G, Forsmark C, Draganov PV, Petersen JM, Hochwald SN, Vogel SB, Bhutani MS. Role of endoscopic ultrasound (EUS) and EUS-guided fine needle aspiration in the diagnosis and treatment of cystic lesions of the pancreas. Pancreas 2002; 25: 222-228
48. Frossard JL, Amouyal P, Amouyal G, Palazzo L, Amaris J, Soldan M, Giostra E, Spahr L, Hadengue A, Fabre M. Performance of endosonography-guided fine needle aspiration and biopsy in the diagnosis of pancreatic cystic lesions. Am J Gastroenterol 2003; 98: 1516-1524
49. Brugge WR, Lewandrowski K, Lee-Lewandrowski E, Centeno BA, Szydlo T, Regan S, del Castillo CF, Warshaw AL. Diagnosis of pancreatic cystic neoplasms: a report of the cooperative pancreatic cyst study. Gastroenterology 2004; 126:1330-1336
50. Walsh RM, Henderson JM, Vogt DP, Baker ME, O'malley CM jr, Herts B, Zuccaro C Jr, Vargo JJ, Dumot JA, Conwell DL, Biscotti CV, Brown N. Prospective preoperative determination of mucinous pancreatic cystic neoplasms. Surgery 2002; 132: 628-633; discussion 633-634
51. van der Waaij LA, van Dullemen HM, Porte RJ. Cyst fluid analysis in the differential diagnosis of pancreatic cystic lesions: a pooled analysis. Gastrointest Endosc 2005; 62: 383-389
52. Moparty B, Logrono R, Nealon WH, Waxman I, Raju GS, Pasricha PJ, Bhutani MS. The role of endoscopic ultrasound and endoscopic ultrasound-guided fine-needle aspiration in distinguishing pancreatic cystic lesions. Diagn Cytopathol 2007; 35: 18-25
53. Federle MP, McGrath KM. Cystic neoplasms of the pancreas. Gastroenterol Clin North Am 2007; 36: 365-376, ix
54. Ryu JK, Woo SM, Hwang JH, Jeong JB, Yoon YB, Park IA, Han JK, Kim YT. Cyst fluid analysis for the differential diagnosis of pancreatic cysts. Diagn Cytopathol 2004; 31: 100-105
55. Hammel P, Voitot H, Vilgrain V, Levy P, Ruszniewski P, Bernades P. Diagnostic value of CA 72-4 and carcinoembryonic antigen determination in the fluid of pancreatic cystic lesions. Eur J Gastroenterol Hepatol 1998; 10: 345-348
56. Sperti C, Pasquali C, Pedrazzoli S, Guolo P, Liessi G. Expression of mucin-like carcinoma-associaied antigen in the cyst fluid differentiates mucinous from nonmucinous pancreatic cysts. Am J Gastroenterol 1997; 92: 672-675
57. Hammel PR, Forgue-Lafitte ME, Levy P, Voitot H, Vilgrain V, Flejou JF, Molas G, Gespach C, Ruszniewski P, Bernades P, Bara J. Detection of gastric mucins (M1 antigens) in cyst fluid for the diagnosis of cystic lesions of the pancreas. Int J Cancer 1997; 74: 286-290