Cystic neoplasms of the exocrine pancreas

Histopathology

Volumn 52, Issue 5, 2008, Pages 539-551

  Campbell, F ^a   Azadeh, B ^a  

^a ROYAL LIVERPOOL UNIVERSITY HOSPITAL   (United Kingdom)

Author keywords

Exocrine neoplasms; Intraductal papillary mucinous neoplasm; Mucinous cystic neoplasm; Pancreas; Serous cystic neoplasm; Solid pseudopapillary neoplasm

Indexed keywords

ACTIN; ALPHA 1 ANTITRYPSIN; BETA CATENIN; CA 19-9 ANTIGEN; CD56 ANTIGEN; CHROMOGRANIN A; COMMON ACUTE LYMPHOBLASTIC LEUKEMIA ANTIGEN; CYTOKERATIN 18; CYTOKERATIN 19; CYTOKERATIN 20; CYTOKERATIN 7; CYTOKERATIN 8; DESMIN; DUPAN 2; EPITHELIAL MEMBRANE ANTIGEN; ESTROGEN RECEPTOR BETA; INHIBIN A; KI 67 ANTIGEN; MUCIN 1; MUCIN 5AC; MUCIN 6; NEURON SPECIFIC ENOLASE; PANCREAS HORMONE; PROGESTERONE RECEPTOR; PROTEIN P53; PROTEIN S 100; SYNAPTOPHYSIN; TRYPSIN; UNINDEXED DRUG; VIMENTIN;

CANCER DIAGNOSIS; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; INTRADUCTAL PAPILLARY MUCINOUS TUMOR; MUCINOUS CARCINOMA; PANCREAS ADENOMA; PANCREAS CYST; PANCREAS TUMOR; PRIORITY JOURNAL; REVIEW; VON HIPPEL LINDAU DISEASE;

CARCINOMA, PANCREATIC DUCTAL; CYSTADENOCARCINOMA; CYSTADENOCARCINOMA, MUCINOUS; CYSTADENOCARCINOMA, PAPILLARY; CYSTADENOCARCINOMA, SEROUS; HUMANS; IMMUNOHISTOCHEMISTRY; PANCREAS, EXOCRINE; PANCREATIC DUCTS; PANCREATIC NEOPLASMS; PRECANCEROUS CONDITIONS; TUMOR MARKERS, BIOLOGICAL;

EID: 41149154780     PISSN: 03090167     EISSN: 13652559     Source Type: Journal    
DOI: 10.1111/j.1365-2559.2007.02856.x     Document Type: Review

References (195)

1. Adsay NV. Cystic lesions of the pancreas. Mod. Pathol. 2007 20 S71 S93.
2. Linder JD, Geenen JE, Catalano MF. Cyst fluid analysis obtained by EUS-guided FNA in the evaluation of discrete cystic neoplasms of the pancreas: a prospective single-center experience. Gastrointest. Endosc. 2006 64 697 702.
3. del Vecchio MT, Pergola L, Tripodi SA et al. Microcystic adenoma associated with a mucinous cystadenocarcinoma: a 'collision tumor' of the pancreas. Pancreas 2002 24 106 108.
4. Goh BK, Loh HL, Soo KC. Synchronous pancreatic serous cystic tumor, intraductal papillary mucinous tumor and gastric carcinoma: report of a case. Pancreas 2005 31 195 197.
5. Ban S, Naitoh Y, Ogawa F et al. Intraductal papillary mucinous neoplasm (IPMN) of the gastric type with focal nodular growth of the arborizing papillae: a case of high-grade transformation of the gastric-type IPMN. Virchows Arch. 2006 449 112 116.
6. Kosmahl M, Pauser U, Peters K et al. Cystic neoplasms of the pancreas and tumor-like lesions with cystic features; a review of 418 cases and a classification proposal. Virchows Arch. 2004 445 168 178.
7. Montag AG, Fossati N, Michelassi F. Pancreatic microcystic adenoma co-existent with pancreatic ductal carcinoma: a report of two cases. Am. J. Surg. Pathol. 1990 14 352 355.
8. Quatresooz P, Honore P, Vivario M et al. Multifocal serous cystadenoma of the pancreas synchronous with ampullary adenocarcinoma. Ann. Pathol. 2002 22 317 320.
9. Keel SB, Zukerberg L, Graeme-Cook F, Compton CC. A pancreatic endocrine tumor arising within a serous cystadenoma of the pancreas. Am. J. Surg. Pathol. 1996 20 471 475.
10. Ustun MO, Tugyan N, Tunakan M. Coexistence of an endocrine tumour in a serous cystadenoma (microcystic adenoma) of the pancreas, an unusual association. J. Clin. Pathol. 2000 53 800 802.
11. Alasio TM, Vine A, Sanchez MA et al. Pancreatic endocrine tumor coexistent with serous microcystic adenoma: report of a case and review of the literature. Ann. Diagn. Pathol. 2005 9 234 238.
12. Slukvin II, Hafez GR, Niederhuber JE, Warner TF. Combined serous microcystic adenoma and well-differentiated endocrine pancreatic neoplasm: a case report and review of the literature. Arch. Pathol. Lab. Med. 2003 127 1369 1372.
13. Blandamura S, Parenti A, Famengo B et al. Three cases of pancreatic serous cystadenoma and endocrine tumour. J. Clin. Pathol. 2007 60 278 282.
14. Tseng J, Warshaw A, Sahani D et al. Serous cystadenoma of the pancreas: tumor growth rates and recommendations for treatment. Ann. Surg. 2005 242 413 421.
15. Tanno S, Obara T, Sohma M et al. Multifocal serous cystadenoma of the pancreas. A case report and review of the literature. Int. J. Pancreatol. 1998 24 129 132.
16. Horaguchi J, Fujita N, Kobayashi G et al. Serous cystadenoma of the pancreas associated with obstructive jaundice. J. Gastroenterol. 2003 38 501 506.
17. Compton CC. Serous cystic tumors of the pancreas. Semin. Diagn. Pathol. 2000 17 43 55.
18. Tripodi SA, Civitelli S, Schurfeld K, Cintorino M. Microcystic adenoma of the pancreas (glycogen-rich cystadenoma) with stromal amyloid deposits. Histopathology 2000 37 147 149.
19. Buisine M-P, Devisme L, Degand P et al. Developmental mucin gene expression in the gastroduodenal tract and accessory digestive glands: II. Duodenum and liver, gallbladder, and pancreas. J. Histochem. Cytochem. 2000 48 1667 1676.
20. Kosmahl M, Wagner J, Peters K et al. Serous cystic neoplasms of the pancreas: an immunohistochemical analysis revealing alpha-inhibin, neuron specific enolase and MUC6 as new markers. Am. J. Surg. Pathol. 2004 28 339 346.
21. Hammel P, Levy P, Voitot H et al. Pre-operative cyst fluid analysis is useful for the differential diagnosis of cystic lesions of the pancreas. Gastroenterology 1995 108 1230 1235.
22. Bassi C, Salvia R, Molinari E et al. Management of 100 consecutive cases of pancreatic serous cystadenoma: wait for symptoms and see at imaging or vice versa? World J. Surg. 2003 27 319 323.
23. Lubensky IA, Pack S, Ault D et al. Multiple neuroendocrine tumors of the pancreas in von Hippel-Lindau disease patients. Am. J. Pathol. 1998 153 223 231.
24. Hammel PR, Vilgrain V, Terris B et al. Pancreatic involvement in von Hippel-Lindau disease. Gastroenterology 2000 119 1087 1095.
25. Mohr VH, Vortemeyer AO, Zhuang Z et al. Histopathology and molecular genetics of multiple cysts and microcystic (serous) adenomas of the pancreas in von Hippel-Lindau patients. Am. J. Pathol. 2000 157 1615 1621.
26. Vortemeyer AO, Lubensky IA, Fogt F et al. Allelic deletion and mutation of the von Hippel-Lindau (VHL) tumour suppressor gene in pancreatic microcystic adenomas. Am. J. Pathol. 1997 151 951 956.
27. Latif F, Tory K, Gnarra J et al. Identification of the von Hippel-Lindau disease tumor suppressor gene. Science 1993 260 1317 1320.
28. Moore PS, Zamboni G, Brighenti A et al. Molecular characterization of pancreatic serous microcystic adenomas: evidence for a tumor suppressor gene on chromosome 10q. Am. J. Pathol. 2001 158 317 321.
29. Lewandrowski K, Warshaw A, Compton C. Macrocystic serous cystadenoma of the pancreas: a morphological variant differing from microcystic adenoma. Hum. Pathol. 1992 23 871 875.
30. Sperti C, Pasquali C, Perasole A et al. Macrocystic serous cystadenoma of the pancreas: clinicopathologic features in seven cases. Int. J. Pancreatol. 2000 28 1 7.
31. Chatelain D, Hammel P, O'Toole D et al. Macrocystic form of serous pancreatic cystadenoma. Am. J. Gastroenterol. 2002 97 2566 2571.
32. Egawa N, Maillet B, Schroder S. Serous oligocystic and ill-demarcated adenoma of the pancreas: a variant of serous cystic adenoma. Virchows Arch. 1994 424 13 17.
33. Perez-Ordonez B, Naseem A, Lieberman PH, Klimstra DS. Solid serous adenoma of the pancreas. The solid variant of serous cystadenoma? Am. J. Surg. Pathol. 1996 20 1401 1405.
34. Yamaguchi M. Solid serous adenoma of the pancreas: a solid variant of serous cystadenoma or a separate disease entity. J. Gastroenterol. 2006 41 178 179.
35. Reese S, Traverso LW, Jacobs TW, Longnecker DS. Solid serous adenoma of the pancreas; a rare variant within the family of pancreatic serous cystic neoplasms. Pancreas 2006 33 96 99.
36. Matsumoto M, Iguchi M, Ohtuki Y et al. A case of solid serous adenoma of the pancreas ultrastructurally harbouring ribosome-lamella complexes. Pathology 2006 38 361 364.
37. Stern JR, Frankel WL, Ellison EC, Bloomston M. Solid serous microcystic adenoma of the pancreas. World J. Surg. Oncol. 2007 5 26.
38. George DH, Murphy F, Michalski R, Ulmer BG. Serous cystadenocarcinoma of the pancreas: a new entity? Am. J. Surg. Pathol. 1989 13 61 66.
39. Kamei K, Funabiki T, Ochiai M et al. Multifocal pancreatic serous cystadenoma with atypical cells and focal perineural invasion. Int. J. Pancreatol. 1991 10 161 172.
40. Ohta T, Nagakawa T, Itoh H, Fonseca L, Miyazaki I, Terada T. A case of serous cystadenoma of the pancreas with focal malignant changes. Int. J. Pancreatol. 1993 14 283 289.
41. Yoshimi N, Sugie S, Tanaka T et al. A rare case of cystadenocarcinoma of the pancreas. Cancer 1992 69 2449 2453.
42. Widmaier U, Mattfeldt T, Siech M, Beger HG. Serous cystadenocarcinoma of the pancreas. Int. J. Pancreatol. 1996 20 135 139.
43. Abe H, Kubota K, Mori M et al. Serous cystadenoma of the pancreas with invasive growth; benign or malignant? Am. J. Gastroenterol. 1998 93 1963 1966.
44. Ishikawa T, Nakao A, Nomoto S et al. Immunohistochemical and molecular biological studies of serous cystadenoma of the pancreas. Pancreas 1998 16 40 44.
45. Wu CM, Fishman EK, Hruban RK et al. Serous cystic neoplasm involving the pancreas and liver: an unusual clinical entity. Abdom. Imaging 1999 24 75 77.
46. Eriguchi N, Aoyagi S, Nakayama T et al. Serous cystadenocarcinoma of the pancreas with liver metastases. J. Hepatobiliary Pancreat. Surg. 1998 5 467 470.
47. Strobel O, Z'Graggen K, Schmitz-Winnenthal FH et al. Risk of malignancy in serous cystic neoplasms of the pancreas. Digestion 2003 68 24 33.
48. Friebe V, Keck T, Mattern D et al. Serous cystadenocarcinoma of the pancreas: management of a rare entity. Pancreas 2005 31 182 187.
49. Shintaku M, Arimoto A, Sakita N. Serous cystadenocarcinoma of the pancreas. Pathol. Int. 2005 55 436 439.
50. Matsumoto T, Hirano S, Yada K et al. Malignant serous cystic neoplasm of the pancreas: report of a case and review of the literature. J. Clin. Gastroenterol. 2005 39 253 256.
51. Galanis C, Zamani A, Cameron JL et al. Resected serous cystic neoplasms of the pancreas: a review of 158 patients with recommendations for treatment. J. Gastrointest. Surg. 2007 11 820 826.
52. Goh BK, Tan YM, Chung YF et al. A review of mucinous cystic neoplasms of the pancreas defined by ovarian-type stroma: clinicopathological features of 344 patients. World J. Surg. 2006 30 2236 2245.
53. Goh BK, Tan YM, Kumarasinghe MP, Ooi LL. Mucinous cystic tumor of the pancreas with ovarian-like mesenchymal stroma in a male patient. Dig. Dis. Sci. 2005 50 2170 2177.
54. Suzuki M, Fujita N, Onodera H et al. Mucinous cystic neoplasm in a young male patient. J. Gastroenterol. 2005 40 1070 1074.
55. Kobayashi T, Teruya M, Shimizu S, Miki K, Kobayashi K, Morita K. Mucinous cystic tumor of the pancreas in a man: a rare case. Pancreas 2006 33 312 314.
56. Lopez-Tomassetti Fernandez EM, Martin Malagon A, Arteaga Gonzalez I et al. Mucinous cystic neoplasm of the pancreas during pregnancy: the importance of proper management. J. Hepatobiliary Pancreat. Surg. 2005 12 494 497.
57. Kitagawa H, Okabayashi T, Nishimori I et al. Rapid growth of mucinous cystic adenoma of the pancreas following pregnancy. Int. J. Gastrointest. Cancer 2006 37 45 48.
58. Herring AA, Graubard MB, Gan SI, Schwaitzberg SD. Mucinous cystadenocarcinoma of the pancreas during pregnancy. Pancreas 2007 34 470 473.
59. Ozden S, Haliloglu B, Ilter E, Akin FT, Kebudi A, Peker O. An extremely rare cause of acute abdomen in pregnancy: ruptured pancreatic mucinous cystadenocarcinoma. Pancreas 2007 34 474 476.
60. Tanaka S, Kawamura T, Nakamura N, Teramoto K, Arii S. Mucinous cystadenocarcinoma of the pancreas developing during hormone replacement therapy. Dig. Dis. Sci. 2007 52 1326 1328.
61. Oermann CM, Al-Salmi Q, Seilheimer DK, Finegold M, Tatevian N. Mucinous cystadenocarcinoma of the pancreas in an adolescent with cystic fibrosis. Pediatr. Dev. Pathol. 2005 8 391 396.
62. Naqvi A, de la Roza G. Borderline mucinous cystic tumor in jejunal pancreatic heterotopia. Ann. Diagn. Pathol. 2004 8 151 155.
63. Posen JA. Giant cell tumor of the pancreas of the osteoclastic type associated with a mucous secreting cystadenocarcinoma. Hum. Pathol. 1981 12 944 947.
64. Luttges J, Feyerabend B, Buchelt T, Pacena M, Kloppel G. The mucin profile of non-invasive and invasive mucinous cystic neoplasms of the pancreas. Am. J. Surg. Pathol. 2002 26 466 471.
65. Khalifeh I, Basturk O, Zamboni G et al. Villous intestinal differentiation and progression to colloid carcinoma, characteristic of a major subset of IPMNs, are not features of mucinous cystic neoplasms. Mod. Pathol. 2005 18 281.
66. Wenig BM, Albores-Saavedra J, Buetow PC et al. Pancreatic mucinous cystic neoplasm with sarcomatous stroma: a report of three cases. Am. J. Surg. Pathol. 1997 21 70 80.
67. Bloomston M, Chanona-Vilchis J, Ellison EC, Ramirez NC, Frankel WL. Carcinosarcoma of the pancreas arising in a mucinous cystic neoplasm. Am. Surg. 2006 72 351 355.
68. Zamboni G, Castelli P, Pea M et al. Mucinous cystic tumor of the pancreas recurring after 11 years as cystadenocarcinoma with foci of choriocarcinoma and osteoclast-like giant cell tumor. Surg. Pathol. 1994 5 253 263.
69. Zamboni G, Scarpa A, Bogina G et al. Mucinous cystic tumors of the pancreas: clinicopathologic features, prognosis, and relationship to other mucinous cystic tumours. Am. J. Surg. Pathol. 1999 23 410 422.
70. Nagata K, Horinouchi M, Saitou M et al. Mucin expression profile in pancreatic cancer and the precursor lesions. J. Hepatobiliary Pancreat. Surg. 2007 14 243 254.
71. Handra-Luca A, Flejou J-F, Rufat P et al. Human pancreatic mucinous cystadenoma is characterized by distinct mucin, cytokeratin and CD10 expression compared with intraductal papillary-mucinous adenoma. Histopathology 2006 48 813 821.
72. Yeh M, Tang L, Wang S, Robert M, Zheng W, Jain D. Inhibin expression in ovarian-type stroma in mucinous cystic neoplasms of the pancreas. Appl. Immunohistochem. Mol. Morphol. 2004 12 148 152.
73. Shiono S, Suda K, Nobukawa B et al. Pancreatic, hepatic, splenic, and mesenteric mucinous cystic neoplasms (MCN) are lumped together as extra-ovarian MCN. Pathol. Int. 2006 56 71 77.
74. Gagne LJ, Colacchio T, Longnecker DS. Simultaneous mucinous cystadenoma of ovary and mucinous cystadenocarcinoma of the pancreas. Int. J. Pancreatol. 2000 28 9 13.
75. Erdogan D, Lamers WH, Offerhaus GJ, Busch OR, Gouma DJ, van Gulik TM. Cystadenomas with ovarian stroma in liver and pancreas: an evolving concept. Dig. Surg. 2006 23 186 191.
76. Iacobuzio-Donahue CA, Wilentz RE, Argani P et al. DPC4 protein in mucinous cystic neoplasms of the pancreas: frequent loss of expression in invasive carcinomas suggests a role in genetic progression. Am. J. Surg. Pathol. 2000 24 1544 1548.
77. Kim SG, Wu TT, Lee JH et al. Comparison of epigenetic and genetic alterations in mucinous cystic neoplasm and serous microcystic adenoma of pancreas. Mod. Pathol. 2003 16 1086 1094.
78. Apelqvist A, Li H, Sommer L et al. Notch signalling controls pancreatic cell differentiation. Nature 1999 400 (6747) 877 881.
79. Fukushima N, Sato N, Prasad N, Leach SD, Hruban RH, Goggins M. Characterization of gene expression in mucinous cystic neoplasms of the pancreas using oligonucleotide microarrays. Oncogene 2004 23 9042 9051.
80. Fukushima N, Fukayama M. Mucinous cystic neoplasms of the pancreas: pathology and molecular genetics. J. Hepatobiliary Pancreat. Surg. 2007 14 238 242.
81. Sorio C, Capelli P, Lissandrini D et al. Mucinous cystic carcinoma of the pancreas: a unique cell line and xenograft model of a preinvasive lesion. Virchows Arch. 2005 446 239 245.
82. Wilentz RE, Albores-Saavedra J, Hruban RH. Mucinous cystic neoplasms of the pancreas. Semin. Diagn. Pathol. 2000 17 31 42.
83. Hruban RH, Takaori K, Klimstra DS et al. An illustrated consensus on the classification of pancreatic intraepithelial neoplasia and intraductal papillary mucinous neoplasms. Am. J. Surg. Pathol. 2004 28 977 987.
84. Terris B, Ponsot P, Paye F et al. Intraductal papillary mucinous tumors of the pancreas confined to secondary ducts show less aggressive pathologic features as compared with those involving the main pancreatic duct. Am. J. Surg. Pathol. 2000 24 1372 1377.
85. Tanaka M. Intraductal papillary mucinous neoplasm of the pancreas: diagnosis and treatment. Pancreas 2004 28 282 288.
86. Raut CP, Cleary KR, Staerkel GA et al. Intraductal papillary mucinous neoplasms of the pancreas: effect of invasion and pancreatic margin status on recurrence and survival. Ann. Surg. Oncol. 2006 13 582 594.
87. Azar C, van de Stadt J, Rickaert F et al. Intraductal papillary mucinous tumours of the pancreas. Clinical and therapeutic issues in 32 patients. Gut 1996 39 457 463.
88. Goh BK, Ooi LL, Kumarasinghe MP et al. Clinicopathological features of patients with concomitant intraductal papillary mucinous neoplasm of the pancreas and pancreatic endocrine neoplasm. Pancreatology 2006 6 520 526.
89. Yamaguchi K, Ohuchida J, Ohtsuka T et al. Intraductal papillary-mucinous tumor of the pancreas concomitant with ductal carcinoma of the pancreas. Pancreatology 2002 211 484 490.
90. Sugiyama M, Antomi Y. Extrapancreatic neoplasms occur with unusual frequency in patients with intraductal papillary mucinous tumors of the pancreas. Am. J. Gastroenterol. 1999 94 470 473.
91. Kamisawa T, Tu Y, Egawa N et al. Malignancies associated with intraductal papillary mucinous neoplasm of the pancreas. World J. Gastroenterol. 2005 11 5688 5690.
92. Eguchi H, Ishikawa O, Ohigashi H et al. Patients with pancreatic intraductal papillary mucinous neoplasms are at high risk of colorectal cancer development. Surgery 2006 139 749 754.
93. Su GH, Hruban RH, Bova GS et al. Germline and somatic mutations of the STK11/LKB1 Peutz-Jeghers gene in pancreatic and biliary cancers. Am. J. Pathol. 1999 154 1835 1840.
94. Maire F, Hammel P, Terris B et al. Intraductal papillary and mucinous pancreatic tumor: a new extracolonic tumour in familial adenomatous polyposis. Gut 2002 51 446 449.
95. Sudo T, Murakami Y, Uemura X et al. Development of an intraductal papillary-mucinous neoplasm of the pancreas in a patient with familial adenomatous polyposis. Pancreas 2005 31 428 429.
96. Yamaguchi K, Ogawa Y, Chijiiwa K et al. Mucin-hypersecreting tumors of the pancreas: assessing the grade of malignancy pre-operatively. Am. J. Surg. 1996 171 427 431.
97. Furukawa T, Kloppel G, Adsay NV et al. Classification of types of intraductal papillary-mucinous neoplasm of the pancreas; a consensus study. Virchows Arch. 2005 447 794 799.
98. Terada T, Ohta T, Kitamura Y et al. Endocrine cells in intraductal papillary-mucinous neoplasms of the pancreas. A histochemical and immunohistochemical study. Virchows Arch. 1997 431 31 36.
99. Adsay NV, Merati K, Basturk O et al. Pathologically and biologically distinct types of epithelium in intraductal papillary mucinous neoplasms: delineation of an "intestinal" pathway of carcinogenesis in the pancreas. Am. J. Surg. Pathol. 2004 28 839 848.
100. D'Angelica M, Brennan MF, Suriawinata AA et al. Intraductal papillary mucinous neoplasms of the pancreas: an analysis of clinicopathologic features and outcome. Ann. Surg. 2004 239 400 408.
101. Chari ST, Yadav D, Smyrk TC et al. Study of recurrence after surgical resection of intraductal papillary mucinous neoplasm of the pancreas. Gastroenterology 2002 123 1500 1507.
102. Naitoh Y, Ban S, Tsuchiya C et al. Multicentric invasive carcinomas derived from intraductal papillary mucinous neoplasm (IPMN) of the pancreas: report of a case. Virchows Arch. 2007 450 487 490.
103. Imaoka H, Yamao K, Salem AAS et al. Pseudomyxoma peritonei caused by acute pancreatitis in intraductal papillary mucinous carcinoma of the pancreas. Pancreas 2006 32 223 224.
104. Tanaka M, Chari S, Adsay NV et al. International consensus guidelines for management of intraductal papillary mucinous neoplasms and mucinous cystic neoplasms of the pancreas. Pancreatology 2006 6 17 32.
105. Tobi M, Hatfield J, Adsay NV et al. Prognostic significance of the labelling of Adnab-9 in pancreatic intraductal papillary mucinous neoplasms. Int. J. Pancreatol. 2001 29 141 150.
106. Yonezawa S, Taira M, Osako M et al. MUC-1 mucin expression in invasive areas of intraductal papillary mucinous tumors of the pancreas. Pathol. Int. 1998 48 319 322.
107. Adsay NV, Merati K, Andea A et al. The dichotomy in the preinvasive neoplasia to invasive carcinoma sequence in the pancreas: differential expression of MUC1 and MUC2 supports the existence of two separate pathways of carcinogenesis. Mod. Pathol. 2002 15 1087 1095.
108. Nakamura A, Horinouchi M, Goto M et al. New classification of pancreatic intraductal papillary-mucinous tumour by mucin expression: its relationship with potential for malignancy. J. Pathol. 2002 197 201 210.
109. Terada T, Ohta T, Sasaki M et al. Expression of MUC apomucins in normal pancreas and pancreatic tumours. J. Pathol. 1996 180 160 165.
110. Luttges J, Zamboni G, Longnecker D, Kloppel G. The immunohistochemical mucin expression pattern distinguishes different types of intraductal papillary mucinous neoplasms of the pancreas and determines their relationship to mucinous non-cystic carcinoma and ductal adenocarcinoma. Am. J. Surg. Pathol. 2001 25 942 948.
111. Ban S, Naitoh Y, Mino-Kenudson M et al. Intraductal papillary mucinous neoplasm (IPMN) of the pancreas: its histopathologic difference between 2 major types. Am. J. Surg. Pathol. 2006 30 1561 1569.
112. Kanno A, Satoh K, Kimura K et al. The expression of MUC4 and MUC5AC is related to the biologic malignancy of intraductal papillary mucinous neoplasms of the pancreas. Pancreas 2006 33 391 396.
113. Terada T, Ohta T, Nakanuma Y. Expression of oncogene products, anti-oncogene products and oncofetal antigens in intraductal papillary mucinous neoplasm of the pancreas. Histopathology 1996 29 355 361.
114. Nishikawa N, Kimura Y, Okita K et al. Intraductal papillary mucinous neoplasms of the pancreas: an analysis of protein expression and clinical features. J. Hepatobiliary Pancreat. Surg. 2006 13 327 335.
115. Yamaguchi H, Inoue T, Eguchi T et al. Fascin overexpression in intraductal papillary mucinous neoplasms (adenomas, borderline neoplasms, and carcinomas) of the pancreas, correlated with increased histologic grade. Mod. Pathol. 2007 20 552 561.
116. Kawahira H, Kobayashi S, Kaneko K et al. p53 protein expression in intraductal papillary mucinous tumors (IPMT) of the pancreas as an indicator of tumor malignancy. Hepatogastroenterology 2000 47 973 977.
117. Yoshizawa K, Nagai H, Sakurai S et al. Clonality and K-ras mutation analyses of epithelia in intraductal papillary mucinous tumor and mucinous cystic tumor of the pancreas. Virchows Arch. 2002 441 437 443.
118. Furukawa T. Molecular genetics of intraductal papillary-mucinous neoplasms of the pancreas. J. Hepatobiliary Pancreat. Surg. 2007 14 233 237.
119. Biankin AV, Biankin SA, Kench JG et al. Aberrant p16(INK4A) and DPC4/Smad4 expression in intraductal papillary mucinous tumours of the pancreas is associated with invasive ductal adenocarcinoma. Gut 2002 50 861 868.
120. Fujii H, Inagaki M, Kasai S et al. Genetic progression and heterogeneity in intraductal papillary mucinous neoplasms of the pancreas. Am. J. Surg. Pathol. 1997 151 1447 1454.
121. Sato N, Rosty C, Jansen M et al. STK11/LKB1 Peutz-Jeghers gene inactivation in intraductal papillary mucinous neoplasms of the pancreas. Am. J. Pathol. 2001 159 2017 2022.
122. Schonleben F, Qiu W, Bruckman KC et al. BRAF and KRAS gene mutations in intraductal papillary mucinous neoplasm/carcinoma (IPMN/IPMC) of the pancreas. Cancer Lett. 2007 249 242 248.
123. Schonleben F, Qiu W, Ciau NT et al. PIK3CA mutations in intraductal papillary mucinous neoplasm/carcinoma of the pancreas. Clin. Cancer Res. 2006 12 3851 3855.
124. Chetty R, Serrra S, Salahshor S et al. Expression of Wnt-signalling pathway proteins in intraductal papillary mucinous neoplasms of the pancreas: a tissue microarray analysis. Hum. Pathol. 2006 37 212 217.
125. Nakata B, Yashiro M, Nishioka N et al. Low incidence of microsatellite instability in intraductal papillary-mucinous neoplasm of the pancreas. Int. J. Cancer 2002 102 655 659.
126. House MG, Guo M, Iacobuzio-Donahue CA, Herman JG. Molecular progression of promoter methylation in intraductal papillary mucinous neoplasms (IPMN) of the pancreas. Carcinogenesis 2003 24 193 198.
127. Sato N, Goggins M. Epigenetic alterations in intraductal papillary mucinous neoplasms of the pancreas. J. Hepatobiliary Pancreat. Surg. 2006 13 280 285.
128. Terris B, Blaveri E, Crnogorac-Jurcevic T et al. Characterization of gene expression profiles in intraductal papillary mucinous tumors of the pancreas. Am. J. Pathol. 2002 160 1745 1754.
129. Sato N, Fukushima N, Maitra A et al. Gene expression profiling identifies genes associated with invasive intraductal papillary mucinous neoplasms of the pancreas. Am. J. Pathol. 2004 164 903 914.
130. Inoue H, Tsuchida A, Kawasaki Y et al. Preoperative diagnosis of intraductal papillary mucinous tumors of the pancreas with attention to telomerase activity. Cancer 2001 91 35 41.
131. Longnecker DS, Adsay NV, Fernandez-del Castillo C et al. Histopathological diagnosis of pancreatic intraepithelial neoplasia and intraductal papillary-mucinous neoplasms: interobserver agreement. Pancreas 2005 31 344 349.
132. Murakami Y, Uemura K, Ohge H, Hayashidani Y, Sudo T, Sueda T. Intraductal papillary-mucinous neoplasms and mucinous cystic neoplasms of the pancreas differentiated by ovarian-type stroma. Surgery 2006 140 448 453.
133. Basturk O, Zamboni G, Klimstra DS et al. Intraductal and papillary variants of acinar cell carcinomas. A new addition to the challenging differential diagnosis of intraductal neoplasms. Am. J. Surg. Pathol. 2007 31 363 370.
134. Hruban RH, Pitman MB, Klimstra DS. Tumors of the pancreas. AFIP Atlas of Tumor Pathology. Washington, DC : ARP Press, 2007 88 89.
135. Salvia R, Crippa S, Falconi M et al. Branch-duct intraductal papillary mucinous neoplasms of the pancreas: to operate or not to operate? Results of a prospective protocol on the management of 109 consecutive patients Gut 2007 56 1086 1090.
136. Nakagohri T, Asano T, Kenmochi T et al. Long-term surgical outcome of non-invasive and minimally invasive intraductal papillary mucinous adenocarcinoma of the pancreas. World J. Surg. 2002 26 1166 1169.
137. Adsay NV. The "new kid on the block": intraductal papillary mucinous neoplasms of the pancreas: current concepts and controversies. Surgery 2003 133 459 463.
138. Maire F, Hammel P, Terris B et al. Prognosis of malignant intraductal papillary mucinous tumours of the pancreas after surgical resection. Comparison with pancreatic ductal adenocarcinoma. Gut 2002 51 717 722.
139. Rodriguez JR, Salvia R, Crippa S et al. Branch-duct intraductal papillary mucinous neoplasms: observations in 145 patients who underwent resection. Gastroenterology 2007 133 72 79.
140. Adsay NV, Pierson C, Sarkar F et al. Colloid (mucinous noncystic) carcinoma of the pancreas. Am. J. Surg. Pathol. 2001 25 26 42.
141. Adsay NV, Adair CF, Heffess CS, Klimstra DS. Intraductal oncocytic papillary neoplasms of the pancreas. Am. J. Surg. Pathol. 1996 20 980 984.
142. Adsay NV, Longnecker DS, Klimstra DS. Pancreatic tumors with cystic dilatation of the ducts: intraductal papillary mucinous neoplasms and intraductal oncocytic papillary neoplasms. Semin. Diagn. Pathol. 2000 17 16 30.
143. Patel SA, Adams R, Goldstein M, Moskaluk CA. Genetic analysis of invasive carcinoma arising in intraductal oncocytic papillary neoplasm of the pancreas. Am. J. Surg. Pathol. 2002 26 1071 1077.
144. Bakotic BW, Robinson MJ, Sturm PD, Hruban RH, Offerhaus GJ, Albores-Saavedra J. Pyloric gland adenoma of the main pancreatic duct. Am. J. Surg. Pathol. 1999 23 227 231.
145. Terris B, Dubois S, Buisine MP et al. Mucin gene expression in intraductal papillary mucinous pancreatic tumours and related lesions. J. Pathol. 2002 197 632 637.
146. Albores-Saavedra J, Sheahan K, O'Riain C, Shukla D. Intraductal tubular adenoma, pyloric type, of the pancreas; additional observations on a new type of pancreatic neoplasm. Am. J. Surg. Pathol. 2004 28 233 238.
147. Tajiri T, Tate G, Kunimura T et al. Histologic and immunohistochemical comparison of intraductal tubular carcinoma, intraductal papillary mucinous carcinoma, and ductal adenocarcinoma of the pancreas. Pancreas 2004 29 116 122.
148. Tajiri T, Tate G, Inagaki T et al. Intraductal tubular neoplasms of the pancreas: histogenesis and differentiation. Pancreas 2005 30 115 121.
149. Nakayama Y, Inoue H, Hamada Y et al. Intraductal tubular adenoma of the pancreas, pyloric gland type: a clinicopathologic and immunohistochemical study of 6 cases. Am. J. Surg. Pathol. 2005 29 607 616.
150. Itatsu K, Sano T, Hiraoka N et al. Intraductal tubular carcinoma in an adenoma of the main pancreatic duct of the pancreas head. J. Gastroenterol. 2006 41 702 705.
151. Nishimori I, Kohsaki T, Tochika X et al. Non-cystic solid-pseudopapillary tumor of the pancreas showing nuclear accumulation and activating gene mutation of beta-catenin. Pathol. Int. 2006 56 707 711.
152. Papavramidis T, Papavramidis S. Solid pseudopapillary tumors of the pancreas: review of 718 patients reported in English literature. J. Am. Coll. Surg. 2005 200 965 972.
153. Salvia R, Bassi C, Festa L et al. Clinical and biological behavior of pancreatic solid pseudopapillary tumors: report on 31 consecutive patients. J. Surg. Oncol. 2007 95 304 310.
154. Faraj W, Jamali F, Khalifeh M, Hashash J, Akel S. Solid pseudopapillary neoplasm of the pancreas in a 12-year-old female: case report and review of the literature. Eur. J. Pediatr. Surg. 2006 16 358 361.
155. Choi SH, Kim SM, Oh JT, Park JY, Seo JM, Lee SK. Solid pseudopapillary tumor of the pancreas: a multicenter study of 23 pediatric cases. J. Pediatr. Surg. 2006 41 1992 1995.
156. Orlando CA, Bowman RL, Loose JH. Multicentric papillary-cystic neoplasm of the pancreas. Arch. Pathol. Lab. Med. 1991 115 958 960.
157. Kobayashi T, Kimura T, Takabayashi N, Sugimura H. Two synchronous solid and cystic tumors of the pancreas. J. Gastroenterol. 1998 33 439 442.
158. Takahashi Y, Fukusato T, Aita K et al. Solid pseudopapillary tumor of the pancreas with metastases to the lung and liver. Pathol. Int. 2005 55 792 796.
159. Alexandrescu DT, O'Boyle K, Feliz A, Fueg A, Wiernik PH. Metastatic solid-pseudopapillary tumour of the pancreas: clinico-biological correlates and management. Clin. Oncol. (R. Coll. Radiol.) 2005 17 358 363.
160. Tipton SG, Smyrk TC, Sarr MG, Thompson GB. Malignant potential of solid pseudopapillary neoplasm of the pancreas. Br. J. Surg. 2006 93 733 737.
161. Arias de la Vega F, Gomez Dorronsoro ML, Jimenez FJ. Subcutaneous metastasis as the first manifestation of a solid-pseudopapillary tumor of the pancreas. Clin. Transl. Oncol. 2006 8 136 138.
162. Nagri S, Abdu A, Anand S, Krishnaiah M, Arya V. Liver metastasis four years after Whipple's resection for solid-pseudopapillary tumor of the pancreas. J. Pancreas 2007 108 223 227.
163. Hernandez JM, Centeno BA, Kelley ST. Solid pseudopapillary tumors of the pancreas: case presentation and review of the literature. Am. Surg. 2007 73 290 293.
164. Daum O, Sima R, Mukensnabl P et al. Pigmented solid-pseudopapillary neoplasm of the pancreas. Pathol. Int. 2005 55 280 288.
165. Chen C, Jing W, Gulati P, Vargas H, French SW. Melanocytic differentiation in a solid pseudopapillary tumor of the pancreas. J. Gastroenterol. 2004 39 579 583.
166. Albores-Saavedra J, Simpson KW, Bilello SJ. The clear cell variant of solid pseudopapillary tumor of the pancreas: a previously unrecognized pancreatic neoplasm. Am. J. Surg. Pathol. 2006 30 1237 1242.
167. Tanaka Y, Kato K, Notohara K et al. Frequent beta-catenin mutation and cytoplasmic/nuclear accumulation in pancreatic solid-pseudopapillary neoplasm. Cancer Res. 2001 61 8401 8404.
168. Abraham SC, Klimstra DS, Wilentz RE et al. Solid-pseudopapillary tumors of the pancreas are genetically distinct from pancreatic ductal adenocarcinomas and almost always harbor beta-catenin mutations. Am. J. Pathol. 2002 160 1361 1369.
169. Cao D, Antonescu C, Wong G et al. Positive immunohistochemical staining of KIT in solid-pseudopapillary neoplasms of the pancreas is not associated with KIT/PDGFRA mutations. Mod. Pathol. 2006 19 1157 1163.
170. Mourra N, Couvelard A, Tiret E, Olschwang S, Flejou JF. Clusterin is highly expressed in pancreatic endocrine tumours but not in solid pseudopapillary tumours. Histopathology 2007 50 331 337.
171. Kallichanda N, Tsai S, Stabile BE, Buslon V, Delgado DL, French SW. Histogenesis of solid pseudopapillary tumor of the pancreas: the case for the centroacinar cell of origin. Exp. Mol. Pathol. 2006 81 101 107.
172. Geers C, Moulin P, Gigot JF et al. Solid and pseudopapillary tumor of the pancreas - review and new insights into pathogenesis. Am. J. Surg. Pathol. 2006 30 1243 1249.
173. Min Kim S, Sun CD, Park KC, Kim HG, Lee WJ, Choi SH. Accumulation of beta-catenin protein, mutations in exon-3 of the beta-catenin gene and a loss of heterozygosity of 5q22 in solid pseudopapillary tumor of the pancreas. J. Surg. Oncol. 2006 94 418 425.
174. Tang WW, Stelter AA, French S et al. Loss of cell-adhesion molecule complexes in solid pseudopapillary tumor of pancreas. Mod. Pathol. 2007 20 509 513.
175. Serra S, Salahshor S, Fagih M et al. Nuclear expression of E-cadherin in solid pseudopapillary tumors of the pancreas. J. Pancreas 2007 8 296 303.
176. Maitra A, Weinberg AG, Schneider N, Patterson K. Detection of t(11;22)(q24;q12) translocation and EWS-FLI-1 fusion transcript in a case of solid pseudopapillary tumor of the pancreas. Pediatr. Dev. Pathol. 2000 3 603 605.
177. Tiemann K, Kosmahl M, Ohlendorf J, Krams M, Kloppel G. Solid pseudopapillary neoplasms of the pancreas are associated with FLI-1 expression, but not with EWS/FLI-1 translocation. Mod. Pathol. 2006 19 1409 1413.
178. Kempski HM, Austin N, Chatters SJ et al. Previously unidentified complex cytogenetic changes found in a pediatric case of solid-pseudopapillary neoplasm of the pancreas. Cancer Genet. Cytogenet. 2006 164 54 60.
179. Liu MS, Yang PY, Yeh TS. Sonic hedgehog signalling pathway in pancreatic cystic neoplasms and ductal adenocarcinoma. Pancreas 2007 34 340 346.
180. Yeh TS, Tseng JH, Liu NJ, Chen TC, Jan YY, Chen MF. Significance of cellular distribution of ezrin in pancreatic cystic neoplasms and ductal adenocarcinoma. Arch. Surg. 2005 140 1184 1190.
181. Tang LH, Aydin H, Brennan MF, Klimstra DS. Clinically aggressive solid pseudopapillary tumors of the pancreas: a report of two cases with components of undifferentiated carcinoma and a comparative clinicopathologic analysis of 34 conventional cases. Am. J. Surg. Pathol. 2005 29 512 519.
182. Talamini MA, Pitt HA, Hruban RH, Boitnott JK, Coleman J, Cameron JL. Spectrum of cystic tumors of the pancreas. Am. J. Surg. 1992 163 117 123.
183. Lee LY, Hsu HL, Chen HM et al. Ductal adenocarcinoma of the pancreas with huge cystic degeneration: lesion to be distinguished from pseudocyst and mucinous cystadenocarcinoma. Int. J. Surg. Pathol. 2003 11 235 239.
184. Kosmahl M, Pauser U, Anlauf M et al. Pancreatic ductal adenocarcinomas with cystic features: neither rare nor uniform. Mod. Pathol. 2005 18 1157 1164.
185. Colarian J, Fowler D, Schor J et al. Squamous cell carcinoma of the pancreas with cystic degeneration. South. Med. J. 2000 93 821 822.
186. Oehler U, Jurs M, Kloppel G, Helpap B. Osteoclast-like giant cell tumour of the pancreas presenting as a pseudocyst-like lesion. Virchows Arch. 1997 431 215 218.
187. Cantrell BB, Cubilla AL, Erlandson RA et al. Acinar cell cystadenocarcinoma of human pancreas. Cancer 1981 47 410 441.
188. Stamm B, Burger H, Hollinger A. Acinar cell cystadenocarcinoma of the pancreas. Cancer 1987 60 2542 2547.
189. Colombo P, Arizzi C, Roncalli M. Acinar cell cystadenocarcinoma of the pancreas: report of rare case and review of the literature. Hum. Pathol. 2004 35 1568 1571.
190. Zamboni G, Terris B, Scarpa A et al. Acinar cell cystadenoma of the pancreas. A new entity? Am. J. Surg. Pathol. 2002 26 698 704.
191. Friedman HD. Non-mucinous, glycogen-poor cystadenocarcinoma of the pancreas. Arch. Pathol. Lab. Med. 1990 114 888 891.
192. Adsay NV, Hasteh F, Cheng JD, Klimstra DS. Squamous-lined cysts of the pancreas: lymphoepithelial cysts, dermoid cysts (teratomas), and accessory-splenic epidermoid cysts. Semin. Diagn. Pathol. 2000 17 56 65.
193. Heywood G, Smyrk TC, Donohue JH. Primary angiomyolipoma of the pancreas. Pancreas 2004 28 443 445.
194. Lee JS, Kim HS, Jung JJ et al. Ancient schwannoma of the pancreas mimicking a cystic tumor. Virchows Arch. 2001 439 697 699.
195. Tan G, Vitellas K, Morrison C, Frankel WL. Cystic schwannoma of the pancreas. Ann. Diagn. Pathol. 2003 7 285 291.