MUC2 gene expression is found in noninvasive tumors but not in invasive tumors of the pancreas and liver: Its close relationship with prognosis of the patients

Human Pathology

Volumn 28, Issue 3, 1997, Pages 344-352

  Yonezawa, Suguru ^a   Sueyoshi, Kazunobu ^b   Nomoto, Mitsuharu ^b   Kitamura, Hiroshi ^b   Nagata, Kohji ^b   Arimura, Yoshiko ^b   Tanaka, Sadao ^b   Hollingsworth, Michael A ^b   Siddiki, Bader ^b   Kim, Young S ^b   Sato, Eiichi ^b  

^a KAGOSHIMA UNIVERSITY   (Japan)

^b NONE

Author keywords

in situ hybridization; liver; MUC2 apomucin; MUC2 messenger RNA; pancreas

Indexed keywords

COMPLEMENTARY DNA; MESSENGER RNA; MUCIN;

ARTICLE; BILE DUCT CARCINOMA; CANCER INVASION; CANCER SURVIVAL; EXTRACELLULAR MATRIX; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IN SITU HYBRIDIZATION; LIVER TUMOR; MALIGNANT TRANSFORMATION; METASTASIS; PANCREAS CARCINOMA; PANCREAS TUMOR; PROTEIN LOCALIZATION; TANDEM REPEAT;

EID: 12644267300     PISSN: 00468177     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0046-8177(97)90134-9     Document Type: Article

References (26)

1. Itzkowitz SH, Yuan M, Montgomery CK, et al: Expression of Tn, Sialosyl-Tn, and T antigens in human colon cancer. Cancer Res 49:197-204, 1989
2. Neutra MR, Forstner JF: Gastrointestinal mucus: Synthesis, secretion, and function, in Johnson LR (ed): Physiology of the Gastrointestinal Tract. New York, NY, Raven, 1987, pp 975-1009
3. Kim YS: Mucin glycoproteins in gastrointestinal malignancies and metastasis: Mucinous glycoproteins in the gastrointestinal tract. Eur J Gastroenterol Hepatol 5:219-225, 1993
4. Kim YS, Byrd JC: Colonic and pancreatic mucin glycoproteins expressed in neoplasia, in Pretlow TG, Pretlow TP (eds): Biochemical and Molecular Aspect of Selected Cancers (vol 1). New York, NY, Academic, 1991, pp 277-311
5. Ho SB, Kim YS: Carbohydrate antigens on cancer-associated mucin-like molecules, in Logenecker BM (ed): Seminars in Cancer Biology (vol 2). Philadelphia, PA, Saunders, 1991, pp 389-400
6. Yonezawa S, Byrd JC, Dahiya R, et al: Differential mucin gene expression in human pancreatic and colon cancer cells. Biochem J 276:599-605, 1991
7. Gum JR: Mucin genes and the proteins they encode: Structure, diversity, and regulation. Am J Respir Cell Mol Biol 7:557-564, 1992
8. Osako M, Yonezawa S, Siddiki B, et al: Immunohistochemical study of mucin carbohydrates and core proteins in human pancreatic tumors. Cancer 71:2191-2199, 1993
9. Yamashita K, Yonezawa S, Tanaka S, et al: Immunohistochemical study of mucin carbohydrates and core proteins in hepatolithiasis and cholangiocarcinoma. Int J Cancer 55:82-91, 1993
10. Toribara NW, Gum JR, Culhane PJ, et al: MUC-2 human small intestinal mucin gene structure: Repeated arrays and polymorphism. J Clin Invest 88:1005-1013, 1991
11. Gum JR, Hicks JW, Toribara NW, et al: Molecular cloning of human intestinal mucin (MUC2) cDNA: Identification of the amino terminus and overall sequence similarity to Pre-Pro-von Willebrand factor. J Biol Chem 269:2440-2446, 1994
12. Jany BH, Gallup MW, Yan P-S, et al: Human bronchus and intestine express the same mucin gene. J Clin Invest 87:77-82, 1991
13. Saiki RK, Scharf S, Faloona F, et al: Enzymatic amplification of β-globin genomic sequences and restriction site analysis for diagnosis of sickle cell anemia. Science 230:1350-1354, 1985
14. Angerer L, Angerer R: In situ hybridization to cellular RNA with RNA probes, in Wilkinson D (ed): In Situ Hybridization: A Practical Approach. New York, NY, Oxford, 1992, pp 15-32
15. Gum JR, Byrd JC, Hicks JW, et al: Molecular cloning of human intestinal mucin cDNAs. J Biol Chem 264:6480-6487, 1989
16. Chan S-K, Dohrman AF, Basbaum CB, et al: Localization of mucin (MUC2 and MUC3) messenger RNA and peptide expression in human normal intestine and colon cancer. Gastroenterology 107:28-36, 1994
17. Hollingsworth MA, Strawhecker JM, Caffrey TC, et al: Expression of MUC1, MUC2, MUC3 and MUC4 mucin mRNAs in human pancreatic and intestinal tumor cell lines. Int J Cancer 57:198-203, 1994
18. Balague C, Gambus G, Carrato C, et al: Altered expression of MUC2, MUC4, and MUC5 mucin genes in pancreas cancer cell lines and tissues. Gastroenterology 106:1054-1061, 1994
19. Ho SB, Niehans GA, Lyftogt C, et al: Heterogeneity of mucin expression in normal and neoplastic tissues. Cancer Res 53:641-651, 1993
20. Balague C, Audie J-P, Porchet N, et al: In situ hybridization shows distinct patterns of mucin gene expression in normal, benign, and malignant pancreatic tissues. Gastroenterology 109:953-964, 1995
21. Sessa F, Solcia E, Capella C, et al: Intraductal papillary-mucinous tumours represent a distinct group of pancreatic neoplasms: An investigation of tumour cell differentiation and K-ras, p53 and c-erbB-2 abnormalities in 26 patients. Virchows Arch 425:357-367, 1994
22. Gudjonsson B: Cancer of the pancreas: 50 years of surgery. Cancer 60:2284-2303, 1987
23. Peters JH, Carey LC: Historical review of pancreaticoduodenectomy. Am J Surg 161:219-225, 1991
24. Connolly MM, Dawson PJ, Michelassi F, et al: Survival in 1001 patients with carcinoma of the pancreas. Ann Surg 206:366-373, 1987
25. Komaki K, Sakamoto G, Sugano H, et al: Mucinous carcinoma of the breast in Japan: A prognostic analysis based on morphologic features. Cancer 61:989-996, 1988
26. Yonezawa S, Nomoto M, Matsukita S, et al: Expression of MUC2 gene product in mucinous carcinoma of the breast: Comparison with invasive ductal carcinoma. Acta Histochem Cytochem 28:239-246, 1995