메뉴 건너뛰기




Volumn 8, Issue 16, 2008, Pages 3329-3341

Expression profiles of MUC1, MUC2, and MUC4 mucins in human neoplasms and their relationship with biological behavior

Author keywords

Biological behavior; Human neoplasm; Malignancy potential; Mucin

Indexed keywords

HISTONE; MESSENGER RNA; MUCIN 1; MUCIN 2; MUCIN 4;

EID: 50449111478     PISSN: 16159853     EISSN: 16159861     Source Type: Journal    
DOI: 10.1002/pmic.200800040     Document Type: Review
Times cited : (110)

References (69)
  • 1
    • 0347123435 scopus 로고    scopus 로고
    • Mucins in cancer: Protection and control of the cell surfacves
    • Hollingsworth, M. A., Swanson, B. J., Mucins in cancer: Protection and control of the cell surfacves. Nat. Rev. Cancer 2004, 4, 45-60.
    • (2004) Nat. Rev. Cancer , vol.4 , pp. 45-60
    • Hollingsworth, M.A.1    Swanson, B.J.2
  • 2
    • 0024791128 scopus 로고
    • MUC18, a marker of tumor progression in human melanoma, shows sequence similarity to the neural cell adhesion molecules of the immunoglobulin superfamily
    • Lehmann, J. M., Riethmuller, G., Johnson, J. P., MUC18, a marker of tumor progression in human melanoma, shows sequence similarity to the neural cell adhesion molecules of the immunoglobulin superfamily. Proc. Natl. Acad. Sci. USA 1989, 86, 9891-9895.
    • (1989) Proc. Natl. Acad. Sci. USA , vol.86 , pp. 9891-9895
    • Lehmann, J.M.1    Riethmuller, G.2    Johnson, J.P.3
  • 3
    • 0742272657 scopus 로고    scopus 로고
    • Genome-wide search and identification of a novel gel-forming mucin MUC19/Muc19 in glandular tissues
    • Chen, Y., Zhao, Y. H., Kalaslavadi, T. B., Hamati, E. et al., Genome-wide search and identification of a novel gel-forming mucin MUC19/Muc19 in glandular tissues. Am. J. Respir. Cell Mol. Biol. 2004, 30, 155-165.
    • (2004) Am. J. Respir. Cell Mol. Biol , vol.30 , pp. 155-165
    • Chen, Y.1    Zhao, Y.H.2    Kalaslavadi, T.B.3    Hamati, E.4
  • 4
    • 9144253978 scopus 로고    scopus 로고
    • Molecular cloning, genomic structure, and expression analysis of MUC20, a novel mucin protein, up-regulated in injured kidney
    • Higuchi, T., Orita, T., Nakanishi, S., katsuya, K. et al., Molecular cloning, genomic structure, and expression analysis of MUC20, a novel mucin protein, up-regulated in injured kidney. J. Biol. Chem. 2004, 279, 1968-1979.
    • (2004) J. Biol. Chem , vol.279 , pp. 1968-1979
    • Higuchi, T.1    Orita, T.2    Nakanishi, S.3    katsuya, K.4
  • 6
    • 0027401288 scopus 로고
    • Immunohistochemical study of mucin carbohydrates and core proteins in human pancreatic tumors
    • Osako, M., Yonezawa, S., Siddiki, B., Huang, J. et al., Immunohistochemical study of mucin carbohydrates and core proteins in human pancreatic tumors. Cancer 1993, 71, 2191-2199.
    • (1993) Cancer , vol.71 , pp. 2191-2199
    • Osako, M.1    Yonezawa, S.2    Siddiki, B.3    Huang, J.4
  • 7
    • 0027317735 scopus 로고
    • Immunohistochemical study of mucin carbohydrates and core proteins in hepatolithiasis and cholangiocarcinoma
    • Yamashita, K., Yonezawa, S., Tanaka, S., Shirahama, H. et al., Immunohistochemical study of mucin carbohydrates and core proteins in hepatolithiasis and cholangiocarcinoma. Int. J. Cancer 1993, 55, 82-91.
    • (1993) Int. J. Cancer , vol.55 , pp. 82-91
    • Yamashita, K.1    Yonezawa, S.2    Tanaka, S.3    Shirahama, H.4
  • 8
    • 0030018601 scopus 로고    scopus 로고
    • Expression of mucin carbohydrates and core proteins in carcinomas of the ampulla of Vater: Their relationship to prognosis
    • Kitamura, H., Yonezawa, S., Tanaka, S., Kim, Y. S., Sato, E., Expression of mucin carbohydrates and core proteins in carcinomas of the ampulla of Vater: Their relationship to prognosis. Jpn. J. Cancer Res. 1996, 87, 631-640.
    • (1996) Jpn. J. Cancer Res , vol.87 , pp. 631-640
    • Kitamura, H.1    Yonezawa, S.2    Tanaka, S.3    Kim, Y.S.4    Sato, E.5
  • 9
    • 12644267300 scopus 로고    scopus 로고
    • MUC2 gene expression is found in noninvasive tumors but not in invasive tumors of the pancreas and liver: Its close relationship with prognosis of the patients
    • Yonezawa, S., Sueyoshi, K., Nomoto, M., Kitamura, H. et al., MUC2 gene expression is found in noninvasive tumors but not in invasive tumors of the pancreas and liver: Its close relationship with prognosis of the patients. Hum. Pathol. 1997, 28, 344-352.
    • (1997) Hum. Pathol , vol.28 , pp. 344-352
    • Yonezawa, S.1    Sueyoshi, K.2    Nomoto, M.3    Kitamura, H.4
  • 10
    • 6844265556 scopus 로고    scopus 로고
    • Expression of mucin antigens in human cancers and its relationship with malignancy potential
    • Yonezawa, S., Sato, E., Expression of mucin antigens in human cancers and its relationship with malignancy potential. Pathol. Int. 1997, 47, 813-830.
    • (1997) Pathol. Int , vol.47 , pp. 813-830
    • Yonezawa, S.1    Sato, E.2
  • 11
    • 0031756619 scopus 로고    scopus 로고
    • Expression of MUC1 and MUC2 mucins in gastric carcinomas: Its relationship with the prognosis of the patients
    • Utsunomiya, T., Yonezawa, S., Sakamoto, H., Kitamura, H. et al., Expression of MUC1 and MUC2 mucins in gastric carcinomas: Its relationship with the prognosis of the patients. Clin. Cancer Res. 1998, 4, 2605-2614.
    • (1998) Clin. Cancer Res , vol.4 , pp. 2605-2614
    • Utsunomiya, T.1    Yonezawa, S.2    Sakamoto, H.3    Kitamura, H.4
  • 12
    • 0032722785 scopus 로고    scopus 로고
    • Expression of MUC1 and MUC2 mucin antigens in intrahepatic bile duct tumors: Its relationship with a new morphological classification of cholangiocarcinoma
    • Higashi, M., Yonezawa, S., Ho, J. J., Tanaka, S. et al., Expression of MUC1 and MUC2 mucin antigens in intrahepatic bile duct tumors: Its relationship with a new morphological classification of cholangiocarcinoma. Hepatology 1999, 30, 1347-1355.
    • (1999) Hepatology , vol.30 , pp. 1347-1355
    • Higashi, M.1    Yonezawa, S.2    Ho, J.J.3    Tanaka, S.4
  • 13
    • 0036036341 scopus 로고    scopus 로고
    • The expression of several types of mucin is related to the biological behavior of pancreatic neoplasms
    • Yonezawa, S., Nakamura, A., Horinouchi, M., Sato, E., The expression of several types of mucin is related to the biological behavior of pancreatic neoplasms. J. Hepatobiliary Pancreat. Surg. 2002, 9, 328-341.
    • (2002) J. Hepatobiliary Pancreat. Surg , vol.9 , pp. 328-341
    • Yonezawa, S.1    Nakamura, A.2    Horinouchi, M.3    Sato, E.4
  • 14
    • 0036262152 scopus 로고    scopus 로고
    • New classification of pancreatic intraductal papillary-mucinous tumour by mucin expression: Its relationship with potential for malignancy
    • Nakamura, A., Horinouchi, M., Goto, M., Nagata, K. et al., New classification of pancreatic intraductal papillary-mucinous tumour by mucin expression: Its relationship with potential for malignancy. J. Pathol. 2002, 197, 201-210.
    • (2002) J. Pathol , vol.197 , pp. 201-210
    • Nakamura, A.1    Horinouchi, M.2    Goto, M.3    Nagata, K.4
  • 15
    • 0036460505 scopus 로고    scopus 로고
    • Expression of MUC1 and MUC2 mucins in extrahepatic bile duct carcinomas: Its relationship with tumor progression and prognosis
    • Tamada, S., Goto, M., Nomoto, M., Nagata, K. et al., Expression of MUC1 and MUC2 mucins in extrahepatic bile duct carcinomas: Its relationship with tumor progression and prognosis. Pathol. Int. 2002, 52, 713-723.
    • (2002) Pathol. Int , vol.52 , pp. 713-723
    • Tamada, S.1    Goto, M.2    Nomoto, M.3    Nagata, K.4
  • 17
    • 1442330985 scopus 로고    scopus 로고
    • MUC4 is a novel prognostic factor of intrahepatic cholangiocarcinoma-mass forming type
    • Shibahara, H., Tamada, S., Higashi, M., Goto, M. et al., MUC4 is a novel prognostic factor of intrahepatic cholangiocarcinoma-mass forming type. Hepatology 2004, 39, 220-229.
    • (2004) Hepatology , vol.39 , pp. 220-229
    • Shibahara, H.1    Tamada, S.2    Higashi, M.3    Goto, M.4
  • 18
    • 23444448425 scopus 로고    scopus 로고
    • MUC4 expression is a novel prognostic factor in patients with invasive ductal carcinoma of the pancreas
    • Saitou, M., Goto, M., Horinouchi, M., Tamada, S. et al., MUC4 expression is a novel prognostic factor in patients with invasive ductal carcinoma of the pancreas. J. Clin. Pathol. 2005, 58, 845-852.
    • (2005) J. Clin. Pathol , vol.58 , pp. 845-852
    • Saitou, M.1    Goto, M.2    Horinouchi, M.3    Tamada, S.4
  • 19
    • 33846660562 scopus 로고    scopus 로고
    • MUC4 is a novel prognostic factor of extrahepatic bile duct carcinoma
    • Tamada, S., Shibahara, H., Higashi, M., Goto, M. et al., MUC4 is a novel prognostic factor of extrahepatic bile duct carcinoma. Clin. Cancer Res. 2006, 12, 4257-4264.
    • (2006) Clin. Cancer Res , vol.12 , pp. 4257-4264
    • Tamada, S.1    Shibahara, H.2    Higashi, M.3    Goto, M.4
  • 20
    • 33846092127 scopus 로고    scopus 로고
    • MUC4 expression correlates with poor prognosis in small-sized lung adenocarcinoma
    • Tsutsumida, H., Goto, M., Kitajima, S., Kubota, I. et al., MUC4 expression correlates with poor prognosis in small-sized lung adenocarcinoma. Lung Cancer 2007, 55, 195-203.
    • (2007) Lung Cancer , vol.55 , pp. 195-203
    • Tsutsumida, H.1    Goto, M.2    Kitajima, S.3    Kubota, I.4
  • 21
    • 0242408959 scopus 로고    scopus 로고
    • Expression of different glycoforms of membrane mucin (MUC1) and secretory mucin (MUC2, MUC5AC and MUC6) in pancreatic neoplasms
    • Horinouchi, M., Nagata, K., Nakamura, A., Goto, M. et al., Expression of different glycoforms of membrane mucin (MUC1) and secretory mucin (MUC2, MUC5AC and MUC6) in pancreatic neoplasms. Acta Histochem. Cytochem. 2003, 36, 443-453.
    • (2003) Acta Histochem. Cytochem , vol.36 , pp. 443-453
    • Horinouchi, M.1    Nagata, K.2    Nakamura, A.3    Goto, M.4
  • 22
    • 0035724964 scopus 로고    scopus 로고
    • Expression of MUC1 and MUC2 mucins and relationship with cell proliferative activity in human colorectal neoplasia
    • Li, A., Goto, M., Horinouchi, M., Tanaka, S. et al., Expression of MUC1 and MUC2 mucins and relationship with cell proliferative activity in human colorectal neoplasia. Pathol. Int. 2001, 51, 853-860.
    • (2001) Pathol. Int , vol.51 , pp. 853-860
    • Li, A.1    Goto, M.2    Horinouchi, M.3    Tanaka, S.4
  • 23
    • 0028106680 scopus 로고
    • Molecular cloning of human intestinal mucin (MUC2) cDNA: Identification of the amino terminus and overall sequence similarity to preprovon Willebrand factor
    • Gum, J. R., Jr., Hicks, J. W., Toribara, N. W., Siddiki, B., Kim, Y. S., Molecular cloning of human intestinal mucin (MUC2) cDNA: Identification of the amino terminus and overall sequence similarity to preprovon Willebrand factor. J. Biol. Chem. 1994, 269, 2440-2446.
    • (1994) J. Biol. Chem , vol.269 , pp. 2440-2446
    • Gum Jr., J.R.1    Hicks, J.W.2    Toribara, N.W.3    Siddiki, B.4    Kim, Y.S.5
  • 24
    • 0001421744 scopus 로고
    • ERCP and imaging diagnosis of pancreatic cancer
    • Ohhashi, K., Takagi, K., ERCP and imaging diagnosis of pancreatic cancer. Gastroenterol. Endosc. 1980, 22, 1493-1495.
    • (1980) Gastroenterol. Endosc , vol.22 , pp. 1493-1495
    • Ohhashi, K.1    Takagi, K.2
  • 25
    • 0028597442 scopus 로고
    • An investigation of tumour cell differentiation and K-ras, p53 and c-erbB-2 abnormalities in 26 patients
    • Intraductal papillary-mucinous tumours represent a distinct group of pancreatic neoplasms
    • Sessa, F., Solcia, E., Capella, C., Bonato, M. et al., Intraductal papillary-mucinous tumours represent a distinct group of pancreatic neoplasms: An investigation of tumour cell differentiation and K-ras, p53 and c-erbB-2 abnormalities in 26 patients. Virchows Archiv. 1994, 425, 357-367.
    • (1994) Virchows Archiv , vol.425 , pp. 357-367
    • Sessa, F.1    Solcia, E.2    Capella, C.3    Bonato, M.4
  • 26
    • 85008579699 scopus 로고
    • Application of immunohistochemistry for diagnosis of neoplasms: Mucin antigens expression and biological behavior
    • Yonezawa, S., Application of immunohistochemistry for diagnosis of neoplasms: Mucin antigens expression and biological behavior. Acta Histochem. Cytochem. 1994, 27, 561-566.
    • (1994) Acta Histochem. Cytochem , vol.27 , pp. 561-566
    • Yonezawa, S.1
  • 27
    • 0032829578 scopus 로고    scopus 로고
    • Gene expression of gastric type mucin (MUC5AC) in pancreatic tumors: Its relationship with the biological behavior of the tumors
    • Yonezawa, S., Horinouchi, M., Osako, M., Kubo, M. et al., Gene expression of gastric type mucin (MUC5AC) in pancreatic tumors: Its relationship with the biological behavior of the tumors. Pathol. Int. 1999, 49, 45-54.
    • (1999) Pathol. Int , vol.49 , pp. 45-54
    • Yonezawa, S.1    Horinouchi, M.2    Osako, M.3    Kubo, M.4
  • 28
    • 28444458875 scopus 로고    scopus 로고
    • Classification of types of intraductal papillary-mucinous neoplasm of the pancreas: A consensus study
    • Furukawa, T., Klöppel, G., Adsay, N. V., Saavedra, J. A. et al., Classification of types of intraductal papillary-mucinous neoplasm of the pancreas: A consensus study. Virchows Arch. 2005, 447, 794-799.
    • (2005) Virchows Arch , vol.447 , pp. 794-799
    • Furukawa, T.1    Klöppel, G.2    Adsay, N.V.3    Saavedra, J.A.4
  • 29
    • 15144354735 scopus 로고    scopus 로고
    • MUC1 mucin expression in invasive areas of intraductal papillary mucinous tumors of the pancreas
    • Yonezawa, S., Taira, M., Osako, M., Kubo, M. et al., MUC1 mucin expression in invasive areas of intraductal papillary mucinous tumors of the pancreas. Pathol. Int. 1998, 48, 319-322.
    • (1998) Pathol. Int , vol.48 , pp. 319-322
    • Yonezawa, S.1    Taira, M.2    Osako, M.3    Kubo, M.4
  • 30
    • 10744224538 scopus 로고    scopus 로고
    • Pathologic features of mucin-producing bile duct tumors: Two histopathologic categories as counterparts of pancreatic intraductal papillary-mucinous neoplasms
    • Shibahara, H., Tamada, S., Goto, M., Oda, K. et al., Pathologic features of mucin-producing bile duct tumors: Two histopathologic categories as counterparts of pancreatic intraductal papillary-mucinous neoplasms. Am. J. Surg. Pathol. 2004, 28, 327-338.
    • (2004) Am. J. Surg. Pathol , vol.28 , pp. 327-338
    • Shibahara, H.1    Tamada, S.2    Goto, M.3    Oda, K.4
  • 31
    • 0032992349 scopus 로고    scopus 로고
    • Expression of mucin 1 (MUC1) in esophageal squamous-cell carcinoma: Its relationship with prognosis
    • Sagara, M., Yonezawa, S., Nagata, K., Tezuka, Y. et al., Expression of mucin 1 (MUC1) in esophageal squamous-cell carcinoma: Its relationship with prognosis. Int. J. Cancer 1999, 84, 251-257.
    • (1999) Int. J. Cancer , vol.84 , pp. 251-257
    • Sagara, M.1    Yonezawa, S.2    Nagata, K.3    Tezuka, Y.4
  • 32
    • 0037224889 scopus 로고    scopus 로고
    • Expression of mucins (MUC1, MUC2, MUC5AC and MUC6) in mucinous carcinoma of the breast: Comparison with invasive ductal carcinoma
    • Matsukita, S., Nomoto, M., Kitajima, S., Tanaka, S. et al., Expression of mucins (MUC1, MUC2, MUC5AC and MUC6) in mucinous carcinoma of the breast: Comparison with invasive ductal carcinoma. Histopathology 2003, 42, 26-36.
    • (2003) Histopathology , vol.42 , pp. 26-36
    • Matsukita, S.1    Nomoto, M.2    Kitajima, S.3    Tanaka, S.4
  • 33
    • 1542330018 scopus 로고    scopus 로고
    • Combined status of MUC1 mucin and surfactant apoprotein A expression can predict the outcome of patients with small-size lung adenocarcinoma
    • Tsutsumida, H., Goto, M., Kitajima, S., Kubota, I. et al., Combined status of MUC1 mucin and surfactant apoprotein A expression can predict the outcome of patients with small-size lung adenocarcinoma. Histopathology 2004, 44, 147-155.
    • (2004) Histopathology , vol.44 , pp. 147-155
    • Tsutsumida, H.1    Goto, M.2    Kitajima, S.3    Kubota, I.4
  • 34
    • 0035678782 scopus 로고    scopus 로고
    • A potential role of MUC4 as a tumor marker of diagnostic significance
    • Mucin (MUC) gene expression in human pancreatic adenocarcinoma and chronic pancreatitis
    • Andrianifahanana, M., Moniaux, N., Schmied, B. M., Ringel, J. et al., Mucin (MUC) gene expression in human pancreatic adenocarcinoma and chronic pancreatitis: A potential role of MUC4 as a tumor marker of diagnostic significance. Clin. Cancer Res. 2001, 7, 4033-4040.
    • (2001) Clin. Cancer Res , vol.7 , pp. 4033-4040
    • Andrianifahanana, M.1    Moniaux, N.2    Schmied, B.M.3    Ringel, J.4
  • 35
    • 0036233702 scopus 로고    scopus 로고
    • MUC4 expression increases progressively in pancreatic intraepithelial neoplasia
    • Swartz, M. J., Batra, S. K., Varshney, G. C., Hollingsworth, M. A. et al., MUC4 expression increases progressively in pancreatic intraepithelial neoplasia. Am. J. Clin. Pathol. 2002, 117, 791-796.
    • (2002) Am. J. Clin. Pathol , vol.117 , pp. 791-796
    • Swartz, M.J.1    Batra, S.K.2    Varshney, G.C.3    Hollingsworth, M.A.4
  • 36
    • 0028180345 scopus 로고
    • Altered expression of MUC2, MUC4, and MUC5 mucin genes in pancreas tissues and cancer cell lines
    • Balague, C., Gambus, G., Carrato, C., Porchet, N. et al., Altered expression of MUC2, MUC4, and MUC5 mucin genes in pancreas tissues and cancer cell lines. Gastroenterology 1994, 106, 1054-1061.
    • (1994) Gastroenterology , vol.106 , pp. 1054-1061
    • Balague, C.1    Gambus, G.2    Carrato, C.3    Porchet, N.4
  • 37
    • 0029162381 scopus 로고
    • In situ hybridization shows distinct patterns of mucin gene expression in normal, benign, and malignant pancreas tissues
    • Balague, C., Audie, J. P., Porchet, N., Real, F. X., In situ hybridization shows distinct patterns of mucin gene expression in normal, benign, and malignant pancreas tissues. Gastroenterology 1995, 109, 953-964.
    • (1995) Gastroenterology , vol.109 , pp. 953-964
    • Balague, C.1    Audie, J.P.2    Porchet, N.3    Real, F.X.4
  • 39
    • 0026623301 scopus 로고
    • Suppression of cellular aggregation by high level of episialin
    • Ligtenberg, M. J., Buijs, F., Vos, H. L., Hilkens, J., Suppression of cellular aggregation by high level of episialin. Cancer Res. 1992, 52, 2318-2324.
    • (1992) Cancer Res , vol.52 , pp. 2318-2324
    • Ligtenberg, M.J.1    Buijs, F.2    Vos, H.L.3    Hilkens, J.4
  • 40
    • 0029894472 scopus 로고    scopus 로고
    • Effect of MUC1 mucin, and anti-adhesion molecule, on tumor cell growth
    • Makiguchi, Y., Hinoda, Y., Imai, K., Effect of MUC1 mucin, and anti-adhesion molecule, on tumor cell growth. Jpn. J. Cancer Res. 1996, 87, 505-511.
    • (1996) Jpn. J. Cancer Res , vol.87 , pp. 505-511
    • Makiguchi, Y.1    Hinoda, Y.2    Imai, K.3
  • 41
    • 0032080901 scopus 로고    scopus 로고
    • Decreased MUC1 expression induces E-cadherin-mediated cell adhesion of breast cancer cell lines
    • Kondo, K., Kohno, N., Yokoyama, A., Hiwada, K., Decreased MUC1 expression induces E-cadherin-mediated cell adhesion of breast cancer cell lines. Cancer Res. 1998, 58, 2014-2019.
    • (1998) Cancer Res , vol.58 , pp. 2014-2019
    • Kondo, K.1    Kohno, N.2    Yokoyama, A.3    Hiwada, K.4
  • 42
    • 0028950808 scopus 로고
    • Episialin (MUC1) over-expression inhibits integrin-mediated cell adhesion to extracellular matrix components
    • Wesseling, J., Van der Valk, S. W., Vos, H. L., Sonnenberg, A. et al., Episialin (MUC1) over-expression inhibits integrin-mediated cell adhesion to extracellular matrix components. J. Cell Biol. 1995, 129, 255-265.
    • (1995) J. Cell Biol , vol.129 , pp. 255-265
    • Wesseling, J.1    Van der Valk, S.W.2    Vos, H.L.3    Sonnenberg, A.4
  • 44
    • 0029937975 scopus 로고    scopus 로고
    • A mechanism for inhibition of E-cadherin mediated cell-cell adhesion by the membrane-associated mucin episialin/MUC1
    • Wesseling, J., Van der Valk, S. W., Hikens, J., A mechanism for inhibition of E-cadherin mediated cell-cell adhesion by the membrane-associated mucin episialin/MUC1. Mol. Biol. Cell. 1996, 7, 565-577.
    • (1996) Mol. Biol. Cell , vol.7 , pp. 565-577
    • Wesseling, J.1    Van der Valk, S.W.2    Hikens, J.3
  • 45
    • 0031777599 scopus 로고    scopus 로고
    • Increased invasiveness of MUC1 cDNA-transfected human gastric cancer MKN74 cells
    • Suwa, T., Hinoda, Y., Makiguti, Y., Increased invasiveness of MUC1 cDNA-transfected human gastric cancer MKN74 cells. Int. J. Cancer 1998, 76, 377-382.
    • (1998) Int. J. Cancer , vol.76 , pp. 377-382
    • Suwa, T.1    Hinoda, Y.2    Makiguti, Y.3
  • 46
    • 0042941382 scopus 로고    scopus 로고
    • Contribution of the MUC1 tandem repeat and cytoplasmic tail to invasive and metastatic properties of a pancreatic cancer cell line
    • Kohlgraf, K. G., Gawron, A. J., Higashi, M., Meza, J. L. et al., Contribution of the MUC1 tandem repeat and cytoplasmic tail to invasive and metastatic properties of a pancreatic cancer cell line. Cancer Res. 2003, 63, 5011-5020.
    • (2003) Cancer Res , vol.63 , pp. 5011-5020
    • Kohlgraf, K.G.1    Gawron, A.J.2    Higashi, M.3    Meza, J.L.4
  • 47
    • 33745942997 scopus 로고    scopus 로고
    • MUC1 alters oncogenic events and transcrption in human breast cancer cells
    • Hattrup, C. L., Gendler, S. J., MUC1 alters oncogenic events and transcrption in human breast cancer cells. Breast Cancer Res. 2006, 8, R37.
    • (2006) Breast Cancer Res , vol.8
    • Hattrup, C.L.1    Gendler, S.J.2
  • 48
    • 33847752147 scopus 로고    scopus 로고
    • Human mucin 1 oncoprotein represses transcription of the p53 tumor supressor gene
    • Wei, X., Xu, H., Kufe, D., Human mucin 1 oncoprotein represses transcription of the p53 tumor supressor gene. Cancer Res. 2007, 67, 1853-1858.
    • (2007) Cancer Res , vol.67 , pp. 1853-1858
    • Wei, X.1    Xu, H.2    Kufe, D.3
  • 49
    • 0025936105 scopus 로고
    • Repeated arrays and polymorphism
    • MUC-2 human small intestinal mucin gene structure
    • Toribara, N. W., Gum, J. R., Culhane, P. J., Lagace, R. E. et al., MUC-2 human small intestinal mucin gene structure: Repeated arrays and polymorphism. J. Clin. Invest. 1991, 88, 1005-1013.
    • (1991) J. Clin. Invest , vol.88 , pp. 1005-1013
    • Toribara, N.W.1    Gum, J.R.2    Culhane, P.J.3    Lagace, R.E.4
  • 50
    • 84998435045 scopus 로고
    • Mucin structure and function: Insights from molecular biology
    • Carraway, K. L., Fregien, N., Mucin structure and function: Insights from molecular biology. Glycosci. Glycotechnol. 1995, 33, 31-44.
    • (1995) Glycosci. Glycotechnol , vol.33 , pp. 31-44
    • Carraway, K.L.1    Fregien, N.2
  • 51
    • 0025881102 scopus 로고
    • Molecular cloning and chromosomal localization of a novel human tracheo-bronchial mucin cDNA containing tandemly repeated sequences of 48 base pairs
    • Porchet, N., Nguyen, V. C., Dufosse, J., Audie, J. P. et al., Molecular cloning and chromosomal localization of a novel human tracheo-bronchial mucin cDNA containing tandemly repeated sequences of 48 base pairs. Biochem. Biophys. Res. Commun. 1991, 175, 414-422.
    • (1991) Biochem. Biophys. Res. Commun , vol.175 , pp. 414-422
    • Porchet, N.1    Nguyen, V.C.2    Dufosse, J.3    Audie, J.P.4
  • 52
    • 0027320315 scopus 로고
    • Expression of human mucin genes in respiratory, digestive, and reproductive tracts ascertained by in situ hybridization
    • Audie, J. P., Janin, A., Porchet, N., Copin, M. C. et al., Expression of human mucin genes in respiratory, digestive, and reproductive tracts ascertained by in situ hybridization. J. Histochem. Cytochem. 1993, 41, 1479-1485.
    • (1993) J. Histochem. Cytochem , vol.41 , pp. 1479-1485
    • Audie, J.P.1    Janin, A.2    Porchet, N.3    Copin, M.C.4
  • 53
    • 0028939290 scopus 로고
    • Mucin gene expression in the human endocervix
    • Audie, J. P., Tetaert, D., Pigny, P., Buisine, M. P. et al., Mucin gene expression in the human endocervix. Hum. Reprod. 1995, 10, 98-102.
    • (1995) Hum. Reprod , vol.10 , pp. 98-102
    • Audie, J.P.1    Tetaert, D.2    Pigny, P.3    Buisine, M.P.4
  • 54
    • 0032923042 scopus 로고    scopus 로고
    • MUC4 and MUC5B transcripts are the prevalent mucin messenger ribonucleic acids of the human endocervix
    • Gipson, I. K., Spurr-Michaud, S., Moccia, R., Zhan, Q. et al., MUC4 and MUC5B transcripts are the prevalent mucin messenger ribonucleic acids of the human endocervix. Biol. Reprod. 1999, 60, 58-64.
    • (1999) Biol. Reprod , vol.60 , pp. 58-64
    • Gipson, I.K.1    Spurr-Michaud, S.2    Moccia, R.3    Zhan, Q.4
  • 56
    • 0033105407 scopus 로고    scopus 로고
    • Complete sequence of the human mucin MUC4: A putative cell membrane-associated mucin
    • Moniaux, N., Nollet, S., Porchet, N., Degand, P. et al., Complete sequence of the human mucin MUC4: A putative cell membrane-associated mucin. Biochem. J. 1999, 338, 325-333.
    • (1999) Biochem. J , vol.338 , pp. 325-333
    • Moniaux, N.1    Nollet, S.2    Porchet, N.3    Degand, P.4
  • 57
    • 0033605267 scopus 로고    scopus 로고
    • An intramembrane modulator of the ErbB2 receptor tyrosine kinase that potentiates neuregulin signaling
    • Carraway, K. L., III, Rossi, E. A., Komatsu, M., Price-Schiavi, S. A. et al., An intramembrane modulator of the ErbB2 receptor tyrosine kinase that potentiates neuregulin signaling. J. Biol. Chem. 1999, 274, 5263-5266.
    • (1999) J. Biol. Chem , vol.274 , pp. 5263-5266
    • Carraway III, K.L.1    Rossi, E.A.2    Komatsu, M.3    Price-Schiavi, S.A.4
  • 58
    • 0021688634 scopus 로고
    • The neu oncogene: An erb-B-related gene encoding a 185,000-Mr tumour antigen
    • Schechter, A. L., Stern, D. F., Vaidyanathan, L., Decker, S. J. et al., The neu oncogene: An erb-B-related gene encoding a 185,000-Mr tumour antigen. Nature (London) 1984, 312, 513-516.
    • (1984) Nature (London) , vol.312 , pp. 513-516
    • Schechter, A.L.1    Stern, D.F.2    Vaidyanathan, L.3    Decker, S.J.4
  • 59
    • 0022588467 scopus 로고
    • Similarity of protein encoded by the human c-erb-B-2 gene to epidermal growth factor receptor
    • Yamamoto, T., Ikawa, S., Akiyama, T., Semba, K. et al., Similarity of protein encoded by the human c-erb-B-2 gene to epidermal growth factor receptor. Nature 1986, 319, 230-234.
    • (1986) Nature , vol.319 , pp. 230-234
    • Yamamoto, T.1    Ikawa, S.2    Akiyama, T.3    Semba, K.4
  • 60
    • 0037168129 scopus 로고    scopus 로고
    • Muc4/sialomucin complex, the intramembrane ErbB2 ligand, induces specific phosphorylation of ErbB2 and enhances expression of p27(kip), but does not activate mitogen-activated kinase or protein kinaseB/Akt pathways
    • Jepson, S., Komatsu, M., Haq, B., Arango, M. E. et al., Muc4/sialomucin complex, the intramembrane ErbB2 ligand, induces specific phosphorylation of ErbB2 and enhances expression of p27(kip), but does not activate mitogen-activated kinase or protein kinaseB/Akt pathways. Oncogene 2002, 21, 7524-7532.
    • (2002) Oncogene , vol.21 , pp. 7524-7532
    • Jepson, S.1    Komatsu, M.2    Haq, B.3    Arango, M.E.4
  • 61
    • 0028179669 scopus 로고
    • p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest
    • Polyak, K., Kato, J. Y., Solomon, M. J., Sherr, C. J. et al., p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest. Genes Dev. 1994, 8, 9-22.
    • (1994) Genes Dev , vol.8 , pp. 9-22
    • Polyak, K.1    Kato, J.Y.2    Solomon, M.J.3    Sherr, C.J.4
  • 62
    • 0036500996 scopus 로고    scopus 로고
    • Colorectal cancer in mice genetically deficient in the mucin Muc2
    • Velcich, A., Yang, W., Heyer, J., Fragale, A. et al., Colorectal cancer in mice genetically deficient in the mucin Muc2. Science 2002, 295, 1726-1729.
    • (2002) Science , vol.295 , pp. 1726-1729
    • Velcich, A.1    Yang, W.2    Heyer, J.3    Fragale, A.4
  • 63
    • 0026100952 scopus 로고
    • Human bronchus and intestine express the same mucin gene
    • Jany, B. H., Gallup, M. W., Yan, P. S., Gallup, J. R. et al., Human bronchus and intestine express the same mucin gene. J. Clin. Invest. 1991, 87, 77-82.
    • (1991) J. Clin. Invest , vol.87 , pp. 77-82
    • Jany, B.H.1    Gallup, M.W.2    Yan, P.S.3    Gallup, J.R.4
  • 64
    • 0041660978 scopus 로고    scopus 로고
    • Methylation status of promoters and expression of MUC2 and MUC5AC mucins in pancreatic cancer cells
    • Ho, J. J., Han, S. W., Pan, P. L., Deng, G. et al., Methylation status of promoters and expression of MUC2 and MUC5AC mucins in pancreatic cancer cells. Int. J. Oncol. 2003, 22, 273-279.
    • (2003) Int. J. Oncol , vol.22 , pp. 273-279
    • Ho, J.J.1    Han, S.W.2    Pan, P.L.3    Deng, G.4
  • 65
    • 0031474251 scopus 로고    scopus 로고
    • MUC2 gene suppression in human colorectal carcinomas and their metastases: In vitro evidence of the modulatory role of DNA methylation
    • Hanski, C., Riede, E., Gratchev, A., Foss, H. D. et al., MUC2 gene suppression in human colorectal carcinomas and their metastases: In vitro evidence of the modulatory role of DNA methylation. Lab. Invest. 1997, 77, 685-695.
    • (1997) Lab. Invest , vol.77 , pp. 685-695
    • Hanski, C.1    Riede, E.2    Gratchev, A.3    Foss, H.D.4
  • 66
    • 0142186358 scopus 로고    scopus 로고
    • Increased methylation of promotor region suppresses expression of MUC2 gene in colon carcinoma cells
    • Riede, E., Gratchev, A., Foss, H. D., Mann, B. et al., Increased methylation of promotor region suppresses expression of MUC2 gene in colon carcinoma cells. Langenbecks Arch. Chir. Suppl. Kongressbd. 1998, 115, 299-302.
    • (1998) Langenbecks Arch. Chir. Suppl. Kongressbd , vol.115 , pp. 299-302
    • Riede, E.1    Gratchev, A.2    Foss, H.D.3    Mann, B.4
  • 67
    • 0035838585 scopus 로고    scopus 로고
    • Regulation of the intestinal mucin MUC2 gene expression in vivo: Evidence for the role of promoter methylation
    • Gratchev, A., Siedow, A., Bumke-Vogt, C., Hummel, M. et al., Regulation of the intestinal mucin MUC2 gene expression in vivo: Evidence for the role of promoter methylation. Cancer Lett. 2001, 168, 71-80.
    • (2001) Cancer Lett , vol.168 , pp. 71-80
    • Gratchev, A.1    Siedow, A.2    Bumke-Vogt, C.3    Hummel, M.4
  • 68
    • 23844445282 scopus 로고    scopus 로고
    • Mapping of the methylation pattern of the MUC2 promoter in pancreatic cancer cell lines, using bisulfite genomic sequencing
    • Hamada, T., Goto, M., Tsutsumida, H., Nomoto, M. et al., Mapping of the methylation pattern of the MUC2 promoter in pancreatic cancer cell lines, using bisulfite genomic sequencing. Cancer Lett. 2005, 227, 175-184.
    • (2005) Cancer Lett , vol.227 , pp. 175-184
    • Hamada, T.1    Goto, M.2    Tsutsumida, H.3    Nomoto, M.4
  • 69
    • 33748482616 scopus 로고    scopus 로고
    • MUC2 expression is regulated by histone H3 modification and DNA methylation in pancreatic cancer
    • Yamada, N., Hamada, T., Goto, M., Tsutsumida, H. et al., MUC2 expression is regulated by histone H3 modification and DNA methylation in pancreatic cancer. Int. J. Cancer 2006, 119, 1850-1857.
    • (2006) Int. J. Cancer , vol.119 , pp. 1850-1857
    • Yamada, N.1    Hamada, T.2    Goto, M.3    Tsutsumida, H.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.