Cell selectivity and anti-inflammatory activity of a Leu/Lys-rich α-helical model antimicrobial peptide and its diastereomeric peptides

Peptides

Volumn 31, Issue 7, 2010, Pages 1251-1261

  Wang, Peng ^a   Nan, Yong Hai ^a   Yang, Sung Tae ^b   Kang, Shin Won ^c   Kim, Yangmee ^d   Park, Il Seon ^a,e   Hahm, Kyung Soo ^a,e   Shin, Song Yub ^a,e  

^a Chosun University   (South Korea)

^b EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^c Pusan National University   (South Korea)

^d Konkuk University   (South Korea)

^e Chosun University College of Medicine   (South Korea)

Author keywords

Anti inflammatory activity; Antimicrobial activity; Cell selectivity; Diastereomeric peptides; Hemolytic activity; Leu Lys rich model antimicrobial peptide

Indexed keywords

ESCHERICHIA COLI LIPOPOLYSACCHARIDE; INDUCIBLE NITRIC OXIDE SYNTHASE; LEUCINE; LYSINE; LYSINE DEXTRO LEUCYLLYSINE DEXTRO LYSYLLEUCINE DEXTRO LEUCYLLYSINE DEXTRO LYSYLTRYPTOPHAN DEXTRO LEUCYLLYSINE DEXTRO LEUCYLLEUCINE DEXTRO LYSYLLYSINE DEXTRO LEUCYLLEUCINE DEXTRO LYSINE AMIDE; LYSYLLEUCINE DEXTRO LYSYLLYSYLLEUCINE DEXTRO LEUCYLLYSYLLYSINE DEXTRO TRYPTOPHANYLLEUCYLLYSINE DEXTRO LEUCYLLEUCYLLYSINE DEXTRO LYSYLLEUCYLLEUCINE DEXTRO LYSINE AMIDE; LYSYLLEUCYLLYSINE DEXTRO LYSYLLEUCYLLEUCYLLYSINE DEXTRO LYSYLTRYPTOPHANYLLEUCYLLYSINE DEXTRO LEUCYLLEUCYLLYSYLLYSINE DEXTRO LEUCYLLEUCYLLYSINE AMIDE; LYSYLLEUCYLLYSYLLYSINE DEXTRO LEUCYLLEUCYLLYSYLLYSYLTRYPTOPHAN DEXTRO LEUCYLLYSYLLEUCYLLEUCYLLYSINE DEXTRO LYSYLLEUCYLLEUCYLLYSINE AMIDE; LYSYLLEUCYLLYSYLLYSYLLEUCINE DEXTRO LEUCYLLYSYLLYSYLTRYPTOPHANYLLEUCYLLYSINE DEXTRO LEUCYLLEUCYLLYSYLLYSYLLEUCYLLEUCINE DEXTRO LYSINE AMIDE; LYSYLLEUCYLLYSYLLYSYLLEUCYLLEUCYLLYSYLLYSYLTRYPTOPHAN DEXTRO LEUCINE DEXTRO LYSINE DEXTRO LEUCINE DEXTRO LEUCINE DEXTRO LYSINE DEXTRO LYSINE DEXTRO LEUCINE DEXTRO LEUCINE DEXTRO LYSINE AMIDE; LYSYLLEUCYLLYSYLLYSYLLEUCYLLEUCYLLYSYLLYSYLTRYPTOPHANYLLEUCYLLYSYLLEUCYLLEUCYLLYSYLLYSYLLEUCYLLEUCYLLYSINE AMIDE; MESSENGER RNA; NITRIC OXIDE; POLYPEPTIDE ANTIBIOTIC AGENT; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ALPHA HELIX; ANIMAL CELL; ANTIBACTERIAL ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BACTERICIDAL ACTIVITY; CONTROLLED STUDY; CYTOKINE RELEASE; DIASTEREOISOMER; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HYDROPHOBICITY; MACROPHAGE; MINIMUM INHIBITORY CONCENTRATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEPSIS; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; ANIMALS; ANTI-INFECTIVE AGENTS; ANTI-INFLAMMATORY AGENTS; ANTIMICROBIAL CATIONIC PEPTIDES; HEMOLYSIS; HUMANS; LEUCINE; LYSINE; MICE; MICROBIAL SENSITIVITY TESTS; MOLECULAR SEQUENCE DATA; PROTEIN STRUCTURE, SECONDARY; STEREOISOMERISM;

EID: 77952548132     PISSN: 01969781     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.peptides.2010.03.032     Document Type: Article

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