Peptide hydrophobicity controls the activity and selectivity of magainin 2 amide in interaction with membranes

Biochemistry

Volumn 36, Issue 20, 1997, Pages 6124-6132

  Wieprecht, Torsten ^a   Dathe, Margitta ^a   Beyermann, Michael ^a   Krause, Eberhard ^a   Maloy, W Lee ^b   MacDonald, Dorothy L ^b   Bienert, Michael ^a  

^a LEIBNIZ INSTITUT FÜR MOLEKULARE PHARMAKOLOGIE   (Germany)

^b Genaera Corporation   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; MAGAININ 2 AMIDE; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLGLYCEROL; PHOSPHOLIPID; SYNTHETIC PEPTIDE;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL MEMBRANE; BINDING AFFINITY; CIRCULAR DICHROISM; DRUG SELECTIVITY; ESCHERICHIA COLI; GRAM NEGATIVE BACTERIUM; HYDROPHOBICITY; LIPID BILAYER; MEMBRANE PERMEABILITY; MEMBRANE VESICLE; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; XENOPUS LAEVIS;

ANTI-BACTERIAL AGENTS; ANTIMICROBIAL CATIONIC PEPTIDES; CIRCULAR DICHROISM; FLUORESCEINS; GRAM-NEGATIVE BACTERIA; HEMOLYSIS; HUMANS; LIPID BILAYERS; MICROBIAL SENSITIVITY TESTS; PEPTIDES; PERMEABILITY; PHOSPHATIDYLCHOLINES; PHOSPHATIDYLGLYCEROLS; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; STRUCTURE-ACTIVITY RELATIONSHIP; XENOPUS PROTEINS;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; EUKARYOTA; NEGIBACTERIA; PROKARYOTA; PSEUDOMONAS; PSEUDOMONAS AERUGINOSA; XENOPUS LAEVIS;

EID: 0030957876     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi9619987     Document Type: Article

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