Effects of single D-amino acid substitutions on disruption of β-sheet structure and hydrophobicity in cyclic 14-residue antimicrobial peptide analogs related to gramicidin S

Journal of Peptide Research

Volumn 63, Issue 2, 2004, Pages 69-84

  Lee, D L ^a,d   Powers, J P S ^b   Pflegerl, K ^c   Vasil, M L ^d   Hancock, R E W ^b   Hodges, R S ^d  

^a UNIVERSITY OF ALBERTA   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^c UNIVERSITY OF AGRICULTURAL SCIENCES   (Austria)

^d UNIVERSITY OF COLORADO   (United States)

Author keywords

Antimicrobial peptides; Cationic peptides; Cyclic peptides; D amino acids; Gramicidin S; Peptide diastereomers; Structure activity relationship; sheet

Indexed keywords

AMINO ACID; ANTIINFECTIVE AGENT; CYCLOVALYLLYSYLLEUCYLASPARAGINYLVALYLTYROSYLPROLYLLEUCYLLYSYLVALYLLYSYLLEUC YLTYROSYLPROLINE; CYCLOVALYLLYSYLLEUCYLGLYCYLVALYLTYROSYLPROLYLLEUCYLLYSYLVALYLLYSYLLEUCYLTYR OSYLPROLINE; CYCLOVALYLLYSYLLEUCYLLEUCYLVALYLTYROSYLPROLYLLEUCYLLYSYLVALYLLYSYLLEUCYLTYR OSYLPROLINE; CYCLOVALYLLYSYLLEUCYLLYSYLVALYLTYROSYLPROLYLLEUCYLLYSYLVALYLLYSYLLEUCYLTYRO SYLPROLINE; CYCLOVALYLLYSYLLEUCYLTYROSYLVALYLTYROSYLPHENYLALANYLLEUCYLLYSYLVALYLLYSYLLE UCYLTYROSYLPROLINE; CYCLOVALYLLYSYLPHENYLALANYLVALYLTYROSYLPROLYLLEUCYLLYSYLVALYLLYSYLLEUCYLTYR OSYLPROLINE; GRAMICIDIN S; PEPTIDE DERIVATIVE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANTIBACTERIAL ACTIVITY; ANTIFUNGAL ACTIVITY; ANTIMICROBIAL ACTIVITY; ARTICLE; BACILLUS SUBTILIS; BACTERIOLYSIS; BETA SHEET; CANDIDA ALBICANS; CONTROLLED STUDY; ENANTIOMER; ESCHERICHIA COLI; HYDROPHILICITY; HYDROPHOBICITY; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; NONHUMAN; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTEIN STRUCTURE; SALMONELLA TYPHIMURIUM; STRUCTURE ACTIVITY RELATION; YEAST;

BACILLUS SUBTILIS; CANDIDA; CANDIDA ALBICANS; ESCHERICHIA COLI; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; SALMONELLA TYPHIMURIUM; STAPHYLOCOCCUS; STAPHYLOCOCCUS AUREUS;

EID: 1542511360     PISSN: 1397002X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1399-3011.2003.00106.x     Document Type: Article

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