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Volumn 51, Issue 5, 2010, Pages 2548-2557

Mechanisms of immune suppression for CD8++ T Cells by human corneal endothelial cells via membrane-bound TGFβ

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 2 RECEPTOR ALPHA; PROGRAMMED DEATH 1 LIGAND 1; PROGRAMMED DEATH 1 LIGAND 2; THROMBOSPONDIN 1; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA2; BLOCKING ANTIBODY; CD274 PROTEIN, HUMAN; CYTOKINE; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, HUMAN; IL2RA PROTEIN, HUMAN; LEUKOCYTE ANTIGEN; PDCD1LG2 PROTEIN, HUMAN; SIGNAL PEPTIDE; SMALL INTERFERING RNA;

EID: 77952540031     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.09-4233     Document Type: Article
Times cited : (29)

References (38)
  • 1
    • 0028146308 scopus 로고
    • Corneal endothelial cells inhibit T cell proliferation by blocking IL-2 production
    • Kawashima H, Prasad SA, Gregerson DS. Corneal endothelial cells inhibit T cell proliferation by blocking IL-2 production. J Immunol. 1994;153:1982-1989.
    • (1994) J Immunol. , vol.153 , pp. 1982-1989
    • Kawashima, H.1    Prasad, S.A.2    Gregerson, D.S.3
  • 2
    • 0026707324 scopus 로고
    • Inhibition of in vitro T cell activation by corneal endothelial cells
    • Obritsch WF, Kawashima H, Evangelista A, et al. Inhibition of in vitro T cell activation by corneal endothelial cells. Cell Immunol. 1992;144:80-94.
    • (1992) Cell Immunol. , vol.144 , pp. 80-94
    • Obritsch, W.F.1    Kawashima, H.2    Evangelista, A.3
  • 4
    • 0037815115 scopus 로고    scopus 로고
    • Iris pigment epithelium expressing CD86 (B7-2) directly suppresses T cell activation in vitro via binding to CTLA-4
    • Sugita S, Streilein JW. Iris pigment epithelium expressing CD86 (B7-2) directly suppresses T cell activation in vitro via binding to CTLA-4. J Exp Med. 2003;198:161-171.
    • (2003) J Exp Med. , vol.198 , pp. 161-171
    • Sugita, S.1    Streilein, J.W.2
  • 5
    • 1642310491 scopus 로고    scopus 로고
    • CTLA-4+ CD8+ T cells that encounter B7-2+ iris pigment epithelial cells express their own B7-2 to achieve global suppression of T cell activation
    • Sugita S, Ng TF, Schwartzkopff J, Streilein JW. CTLA-4+ CD8+ T cells that encounter B7-2+ iris pigment epithelial cells express their own B7-2 to achieve global suppression of T cell activation. J Immunol. 2004;172:4184-4194.
    • (2004) J Immunol. , vol.172 , pp. 4184-4194
    • Sugita, S.1    Ng, T.F.2    Schwartzkopff, J.3    Streilein, J.W.4
  • 6
    • 29644445596 scopus 로고    scopus 로고
    • B7+ iris pigment epithelium (IPE) induce CD8+ T regulatory cells; both suppress CTLA-4+ T cells
    • Sugita S, Ng TF, Lucus PJ, Gress RE, Streilein JW. B7+ iris pigment epithelium (IPE) induce CD8+ T regulatory cells; both suppress CTLA-4+ T cells. J Immunol. 2006;176:118-127.
    • (2006) J Immunol. , vol.176 , pp. 118-127
    • Sugita, S.1    Ng, T.F.2    Lucus, P.J.3    Gress, R.E.4    Streilein, J.W.5
  • 7
    • 34249781399 scopus 로고    scopus 로고
    • Role of thrombospondin-1 in T cell response to ocular pigment epithelial cells
    • Futagami Y, Sugita S, Vega J, et al. Role of thrombospondin-1 in T cell response to ocular pigment epithelial cells. J Immunol. 2007; 178:6994-7005.
    • (2007) J Immunol. , vol.178 , pp. 6994-7005
    • Futagami, Y.1    Sugita, S.2    Vega, J.3
  • 8
    • 67349146510 scopus 로고    scopus 로고
    • Human iris pigment epithelium suppresses activation of bystander T cells via TGFβ-TGFβ receptor interaction
    • Horie S, Sugita S, Futagami Y, et al. Human iris pigment epithelium suppresses activation of bystander T cells via TGFβ-TGFβ receptor interaction. Exp Eye Res. 2009;88:1033-1042.
    • (2009) Exp Eye Res. , vol.88 , pp. 1033-1042
    • Horie, S.1    Sugita, S.2    Futagami, Y.3
  • 9
    • 33947513298 scopus 로고    scopus 로고
    • Ocular immunosuppressive microenvironment
    • Taylor AW. Ocular immunosuppressive microenvironment. Chem Immunol Allergy. 2007;92:71-85.
    • (2007) Chem Immunol Allergy. , vol.92 , pp. 71-85
    • Taylor, A.W.1
  • 10
    • 0030886870 scopus 로고    scopus 로고
    • Aqueous humor induces transforming growth factor-beta (TGF-beta)-producing regulatory T-cells
    • Taylor AW, Alard P, Yee DG, Streilein JW. Aqueous humor induces transforming growth factor-beta (TGF-beta)-producing regulatory T-cells. Curr Eye Res. 1997;16:900-908.
    • (1997) Curr Eye Res. , vol.16 , pp. 900-908
    • Taylor, A.W.1    Alard, P.2    Yee, D.G.3    Streilein, J.W.4
  • 11
    • 0025707731 scopus 로고
    • Aqueous humor contains transforming growth factor-beta and a small (less than 3500 daltons) inhibitor of thymocyte proliferation
    • Granstein RD, Staszewski R, Knisely TL, et al. Aqueous humor contains transforming growth factor-beta and a small (less than 3500 daltons) inhibitor of thymocyte proliferation. J Immunol. 1990;144:3021-3027.
    • (1990) J Immunol. , vol.144 , pp. 3021-3027
    • Granstein, R.D.1    Staszewski, R.2    Knisely, T.L.3
  • 12
    • 0035158272 scopus 로고    scopus 로고
    • Effect of donor age on morphologic variation of cultured human corneal endothelial cells
    • Miyata K, Drake J, Osakabe Y, et al. Effect of donor age on morphologic variation of cultured human corneal endothelial cells. Cornea. 2001;20:59-63.
    • (2001) Cornea. , vol.20 , pp. 59-63
    • Miyata, K.1    Drake, J.2    Osakabe, Y.3
  • 13
    • 0037438385 scopus 로고    scopus 로고
    • Ex vivo expansion of human umbilical cord hematopoietic progenitor cells using a coculture system with human telomerase catalytic subunit (hTERT)-transfected human stromal cells
    • Kawano Y, Kobune M, Yamaguchi M, et al. Ex vivo expansion of human umbilical cord hematopoietic progenitor cells using a coculture system with human telomerase catalytic subunit (hTERT)-transfected human stromal cells. Blood. 2003;101:532-540.
    • (2003) Blood. , vol.101 , pp. 532-540
    • Kawano, Y.1    Kobune, M.2    Yamaguchi, M.3
  • 14
    • 0034679560 scopus 로고    scopus 로고
    • Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4
    • Takahashi T, Tagami T, Yamazaki S, et al. Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4. J Exp Med. 2000;192:303-310.
    • (2000) J Exp Med. , vol.192 , pp. 303-310
    • Takahashi, T.1    Tagami, T.2    Yamazaki, S.3
  • 15
    • 0035801335 scopus 로고    scopus 로고
    • Cell contact-dependent immunosuppression by CD4(+)CD25(+) regulatory T cells is mediated by cell surface-bound transforming growth factor beta
    • Nakamura K, Kitani A, Strober W. Cell contact-dependent immunosuppression by CD4(+)CD25(+) regulatory T cells is mediated by cell surface-bound transforming growth factor beta. J Exp Med. 2001;194:629-644.
    • (2001) J Exp Med. , vol.194 , pp. 629-644
    • Nakamura, K.1    Kitani, A.2    Strober, W.3
  • 16
    • 0035186416 scopus 로고    scopus 로고
    • Induction and mechanism of action of transforming growth factor-beta-secreting Th3 regulatory cells
    • Weiner HL. Induction and mechanism of action of transforming growth factor-beta-secreting Th3 regulatory cells. Immunol Rev. 2001;182:207-214.
    • (2001) Immunol Rev. , vol.182 , pp. 207-214
    • Weiner, H.L.1
  • 17
    • 0034844841 scopus 로고    scopus 로고
    • Oral tolerance: Immune mechanisms and the generation of Th3-type TGF-beta-secreting regulatory cells
    • Weiner HL. Oral tolerance: immune mechanisms and the generation of Th3-type TGF-beta-secreting regulatory cells. Microbes Infect. 2001;3:947-954.
    • (2001) Microbes Infect. , vol.3 , pp. 947-954
    • Weiner, H.L.1
  • 18
    • 0026055359 scopus 로고
    • Identification of transforming growth factor-beta as an immunosuppressive factor in aqueous humor
    • Cousins SW, McCabe MM, Danielpour D, Streilein JW. Identification of transforming growth factor-beta as an immunosuppressive factor in aqueous humor. Invest Ophthalmol Vis Sci. 1991;32: 2201-2211.
    • (1991) Invest Ophthalmol Vis Sci. , vol.32 , pp. 2201-2211
    • Cousins, S.W.1    McCabe, M.M.2    Danielpour, D.3    Streilein, J.W.4
  • 19
    • 0037308613 scopus 로고    scopus 로고
    • The effects of proinflammatory cytokines on cytokine-chemokine gene expression profiles in the human corneal endothelium
    • Yamagami H, Yamagami S, Inoki T, Amano S, Miyata K. The effects of proinflammatory cytokines on cytokine-chemokine gene expression profiles in the human corneal endothelium. Invest Ophthalmol Vis Sci. 2003;44:514-520.
    • (2003) Invest Ophthalmol Vis Sci. , vol.44 , pp. 514-520
    • Yamagami, H.1    Yamagami, S.2    Inoki, T.3    Amano, S.4    Miyata, K.5
  • 20
    • 0029150110 scopus 로고
    • Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
    • Sakaguchi S, Sakaguchi N, Asano M, Itoh M, Toda M. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol. 1995;155:1151-1164.
    • (1995) J Immunol. , vol.155 , pp. 1151-1164
    • Sakaguchi, S.1    Sakaguchi, N.2    Asano, M.3    Itoh, M.4    Toda, M.5
  • 21
    • 0034716925 scopus 로고    scopus 로고
    • Regulatory T cells: Key controllers of immunologic self tolerance
    • Sakaguchi S. Regulatory T cells: key controllers of immunologic self tolerance. Cell. 2000;101:455-458.
    • (2000) Cell. , vol.101 , pp. 455-458
    • Sakaguchi, S.1
  • 22
    • 0034084162 scopus 로고    scopus 로고
    • Regulatory T cells in autoimmunity
    • Shevach EM. Regulatory T cells in autoimmunity. Annu Rev Immunol. 2000;18:423-449.
    • (2000) Annu Rev Immunol. , vol.18 , pp. 423-449
    • Shevach, E.M.1
  • 23
    • 0037379654 scopus 로고    scopus 로고
    • TGF-beta: The missing link in CD4+CD25+ regulatory T cell-mediated immunosuppression
    • Chen W, Wahl SM. TGF-beta: the missing link in CD4+CD25+ regulatory T cell-mediated immunosuppression. Cytokine Growth Factor Rev. 2003;14:85-89.
    • (2003) Cytokine Growth Factor Rev. , vol.14 , pp. 85-89
    • Chen, W.1    Wahl, S.M.2
  • 24
    • 3042703866 scopus 로고    scopus 로고
    • TGF-beta: The perpetrator of immune suppression by regulatory T cells and suicidal T cells
    • Wahl SM, Swisher J, McCartney-Francis N, Chen W. TGF-beta: the perpetrator of immune suppression by regulatory T cells and suicidal T cells. J Leukoc Biol. 2004;76:15-24.
    • (2004) J Leukoc Biol. , vol.76 , pp. 15-24
    • Wahl, S.M.1    Swisher, J.2    McCartney-Francis, N.3    Chen, W.4
  • 25
    • 0037026003 scopus 로고    scopus 로고
    • Phenotype, localization, and mechanism of suppression of CD4(+)CD25(+) human thymocytes
    • Annunziato F, Cosmi L, Liotta F, et al. Phenotype, localization, and mechanism of suppression of CD4(+)CD25(+) human thymocytes. J Exp Med. 2002;196:379-387.
    • (2002) J Exp Med. , vol.196 , pp. 379-387
    • Annunziato, F.1    Cosmi, L.2    Liotta, F.3
  • 26
    • 0027213710 scopus 로고
    • Pleiotropic effects of transforming growth factor-beta on cells of the immune system
    • Ruscetti F, Varesio L, Ochoa A, Ortaldo J. Pleiotropic effects of transforming growth factor-beta on cells of the immune system. Ann N Y Acad Sci. 1993;685:488-500.
    • (1993) Ann N Y Acad Sci. , vol.685 , pp. 488-500
    • Ruscetti, F.1    Varesio, L.2    Ochoa, A.3    Ortaldo, J.4
  • 27
    • 0028020587 scopus 로고
    • Spontaneous elaboration of transforming growth factor beta suppresses host defense against bacterial infection in autoimmune MRL/lpr mice
    • Lowrance JH, O'Sullivan FX, Caver TE, Waegell W, Gresham HD. Spontaneous elaboration of transforming growth factor beta suppresses host defense against bacterial infection in autoimmune MRL/lpr mice. J Exp Med. 1994;180:1693-1703.
    • (1994) J Exp Med. , vol.180 , pp. 1693-1703
    • Lowrance, J.H.1    O'Sullivan, F.X.2    Caver, T.E.3    Waegell, W.4    Gresham, H.D.5
  • 28
    • 0028180315 scopus 로고
    • The TGF-beta superfamily: New members, new receptors, and new genetic tests of function in different organisms
    • Kingsley DM. The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms. Genes Dev. 1994;8:133-146.
    • (1994) Genes Dev. , vol.8 , pp. 133-146
    • Kingsley, D.M.1
  • 29
    • 0026799402 scopus 로고
    • Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease
    • Shull MM, Ormsby I, Kier AB, et al. Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease. Nature. 1992;359:693-696.
    • (1992) Nature. , vol.359 , pp. 693-696
    • Shull, M.M.1    Ormsby, I.2    Kier, A.B.3
  • 30
    • 0034600070 scopus 로고    scopus 로고
    • Disruption of T cell homeostasis in mice expressing a T cell-specific dominant negative transforming growth factor beta II receptor
    • Lucas PJ, Kim SJ, Melby SJ, et al. Disruption of T cell homeostasis in mice expressing a T cell-specific dominant negative transforming growth factor beta II receptor. J Exp Med. 2000;191:1187-1196.
    • (2000) J Exp Med. , vol.191 , pp. 1187-1196
    • Lucas, P.J.1    Kim, S.J.2    Melby, S.J.3
  • 31
    • 35448982671 scopus 로고    scopus 로고
    • + T cells induced by iris pigment epithelial cells display regulatory phenotype and acquire regulatory functions
    • + T cells induced by iris pigment epithelial cells display regulatory phenotype and acquire regulatory functions. Exp Eye Res. 2007;85:626-636.
    • (2007) Exp Eye Res. , vol.85 , pp. 626-636
    • Sugita, S.1    Futagami, Y.2    Horie, S.3    Mochizuki, M.4
  • 32
    • 71849111126 scopus 로고    scopus 로고
    • Retinal pigment epitheliumderived cytotoxic T lymphocyte antigen-2α induces TGFβ-producing T regulatory cells
    • Sugita S, Horie S, Nakamura O, et al. Retinal pigment epitheliumderived cytotoxic T lymphocyte antigen-2α induces TGFβ-producing T regulatory cells. J Immunol. 2008;181:7525-7536.
    • (2008) J Immunol. , vol.181 , pp. 7525-7536
    • Sugita, S.1    Horie, S.2    Nakamura, O.3
  • 33
    • 0035876913 scopus 로고    scopus 로고
    • A role for TGFbeta in the generation and expansion of CD4+CD25+ regulatory T cells from human peripheral blood
    • Yamagiwa S, Gray JD, Hashimoto S, Horwitz DA. A role for TGFbeta in the generation and expansion of CD4+CD25+ regulatory T cells from human peripheral blood. J Immunol. 2001;166:7282-7289.
    • (2001) J Immunol. , vol.166 , pp. 7282-7289
    • Yamagiwa, S.1    Gray, J.D.2    Hashimoto, S.3    Horwitz, D.A.4
  • 34
    • 0348223787 scopus 로고    scopus 로고
    • Conversion of peripheral CD4+CD25-naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3
    • Chen W, Jin W, Hardegen N, et al. Conversion of peripheral CD4+CD25-naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3. J Exp Med. 2003;198:1875-1886.
    • (2003) J Exp Med. , vol.198 , pp. 1875-1886
    • Chen, W.1    Jin, W.2    Hardegen, N.3
  • 35
    • 2142645808 scopus 로고    scopus 로고
    • Cutting edge: TGF-beta induces a regulatory phenotype in CD4+CD25-T cells through Foxp3 induction and down-regulation of Smad7
    • Fantini MC, Becker C, Monteleone G, et al. Cutting edge: TGF-beta induces a regulatory phenotype in CD4+CD25-T cells through Foxp3 induction and down-regulation of Smad7. J Immunol. 2004; 172:5149-5153.
    • (2004) J Immunol. , vol.172 , pp. 5149-5153
    • Fantini, M.C.1    Becker, C.2    Monteleone, G.3
  • 36
    • 9144219649 scopus 로고    scopus 로고
    • Cutting edge: TGF-beta signaling is required for the in vivo expansion and immunosuppressive capacity of regulatory CD4+CD25+ T cells
    • Huber S, Schramm C, Lehr HA, et al. Cutting edge: TGF-beta signaling is required for the in vivo expansion and immunosuppressive capacity of regulatory CD4+CD25+ T cells. J Immunol. 2004;173:6526-6531.
    • (2004) J Immunol. , vol.173 , pp. 6526-6531
    • Huber, S.1    Schramm, C.2    Lehr, H.A.3
  • 37
    • 0033862741 scopus 로고    scopus 로고
    • IL-6 antagonizes TGF-beta and abolishes immune privilege in eyes with endotoxininduced uveitis
    • Ohta K, Yamagami S, Taylor AW, Streilein JW. IL-6 antagonizes TGF-beta and abolishes immune privilege in eyes with endotoxininduced uveitis. Invest Ophthalmol Vis Sci. 2000;41:2591-2599.
    • (2000) Invest Ophthalmol Vis Sci. , vol.41 , pp. 2591-2599
    • Ohta, K.1    Yamagami, S.2    Taylor, A.W.3    Streilein, J.W.4
  • 38
    • 35148837549 scopus 로고    scopus 로고
    • Characterization of IL-17+ interphotoreceptor retinoid-binding protein-specific T cells in experimental autoimmune uveitis
    • Peng Y, Han G, Shao H, Wang Y, Kaplan HJ, Sun D. Characterization of IL-17+ interphotoreceptor retinoid-binding protein-specific T cells in experimental autoimmune uveitis. Invest Ophthalmol Vis Sci. 2007;48:4153-4161.
    • (2007) Invest Ophthalmol Vis Sci. , vol.48 , pp. 4153-4161
    • Peng, Y.1    Han, G.2    Shao, H.3    Wang, Y.4    Kaplan, H.J.5    Sun, D.6


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