Histopathological diagnose of non-alcoholic and alcoholic fatty liver disease;Histopathologische diagnose der nicht alkoholischen und alkoholischen fettlebererkrankung

Zeitschrift fur Gastroenterologie

Volumn 48, Issue 4, 2010, Pages 486-498

  Tannapfel, A ^a   Denk, H ^b   Dienes, H P ^c   Langner, C ^b   Schirmacher, P ^d   Trauner, M ^b   Flott Rahmel, B ^a  

^a INSTITUT FÜR PATHOLOGIE   (Germany)

^b MEDICAL UNIVERSITY OF GRAZ   (Austria)

^c UNIVERSITY OF COLOGNE   (Germany)

^d UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

Author keywords

Alcoholic steatohepatitis; Ballooning; Chemotherapy; Cirrhosis; Differential diagnosis; Fibrosis; Liver biopsy; NASH in children; Non alcoholic steatohepatitis; Scoring

Indexed keywords

ACETYLSALICYLIC ACID; AMIODARONE; AMPHETAMINE; DIDANOSINE; FLUOROURACIL; IRINOTECAN; OXALIPLATIN; STAVUDINE; TAMOXIFEN; TAXANE DERIVATIVE; TETRACYCLINE; VALPROIC ACID;

ALCOHOLIC FATTY LIVER; ARTICLE; FATTY LIVER; HISTOPATHOLOGY; HUMAN; LIPID STORAGE; LIVER BIOPSY; LIVER CELL; LIVER CIRRHOSIS; LIVER FATTY DEGENERATION; LIVER FIBROSIS; LIVER TOXICITY; NONALCOHOLIC FATTY LIVER;

BIOPSY, NEEDLE; FATTY LIVER; HUMANS;

EID: 77952519387     PISSN: 00442771     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0029-1245278     Document Type: Article

References (81)

1. Adams LA, Talwalkar JA. Diagnostic evaluation of nonalcoholic fatty liver disease. J Clin Gastroenterol 2006; 40: 34-38
2. AGA. American Gastroenterological Association medical position statement: nonalcoholic fatty liver disease. Gastroenterology 2002; 123: 1702-1704
3. Alfire ME, Treem WR. Nonalcoholic fatty liver disease. Pediatr Ann 2006; 35: 290-299
4. Aloia T, Sebagh M, Plasse M et al. Liver histology and surgical outcomes after preoperative chemotherapy with fluorouracil plus oxaliplatin in colorectal cancer liver metastases. J Clin Oncol 2006; 24: 4983-4990 (Pubitemid 46631400)
5. Angulo P, Hui JM, Marchesini G et al. The NAFLD fibrosis score: a noninvasive system that identifies liver fibrosis in patients with NAFLD. Hepatology 2007; 45: 846-854 (Pubitemid 46631552)
6. Angulo P, Lindor KD. Non-alcoholic fatty liver disease. J Gastroenterol Hepatol 2002; 17: S186-S190
7. Bacon BR, Farahvash MJ, Janney CG et al. Nonalcoholic steatohepatitis: an expanded clinical entity. Gastroenterology 1994; 107: 1103-1109
8. Baumann U. Die kindliche Fettlebererkrankung. Dtsch Ärzteblatt 2005; 102: A2634-A2639
9. Bellentani S, Bedogni G, Miglioli L et al. The epidemiology of fatty liver. Eur J Gastroenterol Hepatol 2004; 16: 1087-1093
10. Bonekamp S, Kamel I, Solga S et al. Can imaging modalities diagnose and stage hepatic fibrosis and cirrhosis accurately? J Hepatol 2009; 50: 17-35
11. Brunt EM. Nonalcoholic steatohepatitis: definition and pathology. Semin Liver Dis 2001; 21: 3-16
12. Brunt EM. Alcoholic and nonalcoholic steatohepatitis. Clin Liver Dis 2002; 6: 399-420
13. Brunt EM. Pathology of fatty liver disease. Mod Pathol 2007; 20: S40-S48 (Suppl. 1)
14. Brunt EM. Nonalcoholic steatohepatitis: pathologic features and differential diagnosis. Semin Diagn Pathol 2005; 22: 330-338
15. Brunt EM. Pathology of nonalcoholic steatohepatitis. Hepatol Res 2005; 33: 68-71
16. Brunt EM, Janney CG, Di Bisceglie AM et al. Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions. Am J Gastroenterol 1999; 94: 2467-2474
17. Brunt EM, Neuschwander-Tetri BA, Oliver D et al. Nonalcoholic steatohepatitis: histologic features and clinical correlations with 30 blinded biopsy specimens. Hum Pathol 2004; 35: 1070-1082 (Pubitemid 39165338)
18. Brunt EM, Ramrakhiani S, Cordes BG et al. Concurrence of histologic features of steatohepatitis with other forms of chronic liver disease. Mod Pathol 2003; 16: 49-56 (Pubitemid 36152686)
19. Brunt EM, Tiniakos DG. Pathology of steatohepatitis. Best Pract Res Clin Gastroenterol 2002; 16: 691-707
20. Brunt EM, Tiniakos DG. Pathological features of NASH. Front Biosci 2005; 10: 1475-1484
21. Burt AD, Mutton A, Day CP. Diagnosis and interpretation of steatosis and steatohepatitis. Semin Diagn Pathol 1998; 15: 246-258
22. Caldwell SH, Oelsner DH, Iezzoni JC et al. Cryptogenic cirrhosis: clinical characterization and risk factors for underlying disease. Hepatology 1999; 29: 664-669 (Pubitemid 29109578)
23. Castera L, Fonts X, Alberti A. Non-invasive evaluation of liver fibrosis using transient elastography. J Hepatol 2008; 48: 835-847 (Pubitemid 351224001)
24. Chitturi S, Abeygunasekera S, Farrell GC et al. NASH and insulin resistance: Insulin hypersecretion and specific association with the insulin resistance syndrome. Hepatology 2002; 35: 373-379 (Pubitemid 34106377)
25. Church TS, Kuk JL, Ross R et al. Association of cardiorespiratory fitness, body mass index, and waist circumference to nonalcoholic fatty liver disease. Gastroenterology 2006; 130: 2023-2030 (Pubitemid 43816951)
26. Cortez-Pinto H, de Moura MC, Day CP. Non-alcoholic steatohepatitis: from cell biology to clinical practice. J Hepatol 2006; 44: 197-208 (Pubitemid 41772535)
27. Dancygier H. Pathogenese und Therapie der nichtalkoholischen Fettlebererkrankungen. Dtsch Ärzteblatt 2006; 103: A1301-A1307
28. Day CP. Non-alcoholic fatty liver disease: current concepts and management strategies. Clin Med 2006; 6: 19-25 (Pubitemid 43302594)
29. Day CP. Pathogenesis of steatohepatitis. Best Pract Res Clin Gastroenterol 2002; 16: 663-678
30. Day CP, James OF. Steatohepatitis: a tale of two "hits"? Gastroenterology 1998; 114: 842-845
31. DeLeve LD, Shulman HM, McDonald GB. Toxic injury to hepatic sinusoids: sinusoidal obstruction syndrome (veno-occlusive disease). Semin Liver Dis 2002; 22: 27-42
32. Dufour JF, Oneta CM. Alcoholic and non-alcoholic steatohepatitis. Ther Umsch 2004; 61: 505-512
33. Duvnjak M, Lerotic I, Barsic N et al. Pathogenesis and management issues for non-alcoholic fatty liver disease. World J Gastroenterol 2007; 13: 4539-4550 (Pubitemid 47455230)
34. Edmison J, McCullough AJ. Pathogenesis of non-alcoholic steatohepatitis: human data. Clin Liver Dis 2007; 11: 75-104 (Pubitemid 46829977)
35. Falck-Ytter Y, Younossi ZM, Marchesini G et al. Clinical features and natural history of nonalcoholic steatosis syndromes. Semin Liver Dis 2001; 21: 17-26 (Pubitemid 32240483)
36. Farrell GC, Larter CZ. Nonalcoholic fatty liver disease: from steatosis to cirrhosis. Hepatology 2006; 43: S99-S112 (Pubitemid 43303974)
37. Friedrich-Rust M, Ong MF, Martens S et al. Performance of transient elastography for the staging of liver fibrosis: a meta-analysis. Gastroenterology 2008; 134: 960-974 (Pubitemid 351451980)
38. Gentilucci UV, Santini D, Vincenzi B et al. Chemotherapy-induced steatohepatitis in colorectal cancer patients. J Clin Oncol 2006; 24: 5467-5468 (Pubitemid 46623183)
39. Gramlich T, Kleiner DE, McCullough AJ et al. Pathologic features associated with fibrosis in nonalcoholic fatty liver disease. Hum Pathol 2004; 35: 196-199 (Pubitemid 38240902)
40. Harrison SA, Torgerson S, Hayashi PH. The natural history of nonalcoholic fatty liver disease: a clinical histopathological study. Am J Gastroenterol 2003; 98: 2042-2047 (Pubitemid 37185803)
41. Hubscher SG. Role of liver biopsy in the assessment of non-alcoholic fatty liver disease. Eur J Gastroenterol Hepatol 2004; 16: 1107-1115 (Pubitemid 39488779)
42. Joy D, Thava VR, Scott BB. Diagnosis of fatty liver disease: is biopsy necessary? Eur J Gastroenterol Hepatol 2003; 15: 539-543
43. Kacerovsky M, Roden M. Nichtalkoholische Fettleber. Diabetologe 2007; 3: 176-183
44. Karoui M, Penna C, min-Hashem M et al. Influence of preoperative chemotherapy on the risk of major hepatectomy for colorectal liver metastases. Ann Surg 2006; 243: 1-7
45. Kleiner DE, Brunt EM, Van Natta M et al. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology 2005; 41: 1313-1321 (Pubitemid 40770284)
46. Lackner C, Gogg-Kamerer M, Zatloukal K et al. Ballooned hepatocytes in steatohepatitis: the value of keratin immunohistochemistry for diagnosis. J Hepatol 2008; 48: 821-828
47. Ludwig J, McGill DB, Lindor KD. Review: nonalcoholic steatohepatitis. J Gastroenterol Hepatol 1997; 12: 398-403
48. Ludwig J, Viggiano TR, McGill DB et al. Nonalcoholic steatohepatitis: Mayo Clinic experiences with a hitherto unnamed disease. Mayo Clin Proc 1980; 55: 434-438 (Pubitemid 10057164)
49. Matteoni CA, Younossi ZM, Gramlich T et al. Nonalcoholic fatty liver disease: a spectrum of clinical and pathological severity. Gastroenterology 1999; 116: 1413-1419 (Pubitemid 29258890)
50. Medina J, Fernandez-Salazar LI, Garcia-Buey L et al. Approach to the pathogenesis and treatment of nonalcoholic steatohepatitis. Diabetes Care 2004; 27: 2057-2066 (Pubitemid 38989257)
51. Mendez-Sancnez N, Arrese M, Zamora-Valdes D et al. Current concepts in the pathogenesis of nonalcoholic fatty liver disease. Liver Int 2007; 27: 423-433
52. Mendler MH, Kanel G, Govindarajan S. Proposal for a histological scoring and grading system for non-alcoholic fatty liver disease. Liver Int 2005; 25: 294-304 (Pubitemid 40500563)
53. Mofrad P, Contos MJ, Haque M et al. Clinical and histologic spectrum of nonalcoholic fatty liver disease associated with normal ALT values. Hepatology 2003; 37: 1286-1292 (Pubitemid 36667307)
54. Moss A, Wabitsch M, Kromeyer-Hauschild K et al. Prevalence of overweight and adiposity in German school children. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 2007; 50: 1424-1431
55. Nakano H, Oussoultzoglou E, Rosso E et al. Sinusoidal injury increases morbidity after major hepatectomy in patients with colorectal liver metastases receiving preoperative chemotherapy. Ann Surg 2008; 247: 118-124
56. Neuschwander-Tetri BA. Evolving pathophysiologic concepts in nonalcoholic steatohepatitis. Curr Gastroenterol Rep 2002; 4: 31-36
57. Neuschwander-Tetri BA, Caldwell SH. Nonalcoholic steatohepatitis: summary of an AASLD Single Topic Conference. Hepatology 2003; 37: 1202-1219
58. Nocito A, El-Badry AM, Clavien PA. When is steatosis too much for transplantation? J Hepatol 2006; 45: 494-499
59. Nordlinger B, Van Cutsem E, Rougier P et al. Does chemotherapy prior to liver resection increase the potential for cure in patients with metastatic colorectal cancer? A report from the European Colorectal Metastases Treatment Group. Eur J Cancer 2007; 43: 2037-2045 (Pubitemid 47380368)
60. Oneta CM, Dufour JF. Diagnostik, Prognose und therapeutische Möglichkeiten der nicht-alkoholischen Fettlebererkrankung. Schweiz Med Forum 2003; 37: 862-868
61. Papandreou D, Rousso I, Mavromichalis I. Update on non-alcoholic fatty liver disease in children. Clin Nutr 2007; 26: 409-415 (Pubitemid 47091479)
62. Rashid M, Roberts E. Nonalcoholic steatohepatitis in children. J Pediatr Gastroenterol Nutr 2000; 30: 48-53
63. Ratziu V, Charlotte F, Heurtier A et al. Sampling variability of liver biopsy in nonalcoholic fatty liver disease. Gastroenterology 2005; 128: 1898-1906 (Pubitemid 40824701)
64. Reid AE. Nonalcoholic steatohepatitis. Gastroenterology 2001; 121: 710-723
65. Roberts EA. Steatohepatitis in children. Best Pract Res Clin Gastroenterol 2002; 16: 749-765
66. Roberts EA. Non-alcoholic steatohepatitis in children. Clin Liver Dis 2007; 11: 155-172
67. Rousselet MC, Michalak S, Dupre F et al. Sources of variability in histological scoring of chronic viral hepatitis. Hepatology 2005; 41: 257-264 (Pubitemid 40165369)
68. Sanyal AJ, Banas C, Sargeant C et al. Similarities and differences in outcomes of cirrhosis due to nonalcoholic steatohepatitis and hepatitis C. Hepatology 2006; 43: 682-689
69. Schwimmer JB. Definitive diagnosis and assessment of risk for nonalcoholic fatty liver disease in children and adolescents. Semin Liver Dis 2007; 27: 312-318
70. Schwimmer JB, Behling C, Newbury R et al. Histopathology of pediatric nonalcoholic fatty liver disease. Hepatology 2005; 42: 641-649 (Pubitemid 41233657)
71. Sonsuz A, Basaranoglu M, Ozbay G. Relationship between aminotransferase levels and histopathological findings in patients with nonalcoholic steatohepatitis. Am J Gastroenterol 2000; 95: 1370-1371 (Pubitemid 30263549)
72. Strassburg CP, Manns MP. Approaches to liver biopsy techniques - revisited. Semin Liver Dis 2006; 26: 318-327
73. Tannapfel A, Geissler F, Witzigmann H et al. Analysis of liver allograft rejection related genes using cDNA-microarrays in liver allograft specimen. Transplant Proc 2001; 33: 3283-3284 (Pubitemid 34042573)
74. Tannapfel A, Reinacher-Schick A. Chemotherapy associated hepatotoxicity in the treatment of advanced colorectal cancer (CRC). Z Gastroenterol 2008; 46: 435-440 (Pubitemid 352016656)
75. Targher G, Bertolini L, Rodella S et al. Associations between plasma adiponectin concentrations and liver histology in patients with nonalcoholic fatty liver disease. Clin Endocrinol (Oxf) 2006; 64: 679-683 (Pubitemid 43775007)
76. Teli MR, James OF, Burt AD et al. The natural history of nonalcoholic fatty liver: a follow-up study. Hepatology 1995; 22: 1714-1719
77. Vauthey JN, Pawlik TM, Ribero D. Chemotherapy regimen predicts steatohepatitis and an increase in 90-day mortality after surgery for hepatic colorectal metastases. J Clin Oncol 2006; 24: 2065-2072 (Pubitemid 46622116)
78. Wieckowska A, McCullough AJ, Feldstein AE. Noninvasive diagnosis and monitoring of nonalcoholic steatohepatitis: present and future. Hepatology 2007; 46: 582-589 (Pubitemid 47344794)
79. Wieckowska A, Zein NN, Yerian LM et al. In vivo assessment of liver cell apoptosis as a novel biomarker of disease severity in nonalcoholic fatty liver disease. Hepatology 2006; 44: 27-33
80. Younossi ZM, Janar M, Nugent C et al. A Novel Diagnostic Biomarker Panel for Obesity-related Nonalcoholic Steatohepatitis (NASH). Obes Surg 2008; 18: 1430-1437
81. Zivkovic AM, German JB, Sanyal AJ. Comparative review of diets for the metabolic syndrome: implications for nonalcoholic fatty liver disease. Am J Clin Nutr 2007; 86: 285-300 (Pubitemid 47256910)