Pathology of steatohepatitis

Bailliere's Best Practice and Research in Clinical Gastroenterology

Volumn 16, Issue 5, 2002, Pages 691-707

  Brunt, Elizabeth M ^a   Tiniakos, Dina G ^b  

^a SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

Author keywords

Histological features of steatosis; Steatohepatitis

Indexed keywords

ALCOHOL; IRON; AMIODARONE; PERHEXILINE MALEATE;

ALCOHOL CONSUMPTION; CHOLESTASIS; CLINICAL EXAMINATION; CORRELATION ANALYSIS; DIAGNOSTIC PROCEDURE; DIFFERENTIAL DIAGNOSIS; DISEASE CLASSIFICATION; DISEASE COURSE; DISEASE SEVERITY; FATTY LIVER; HEPATITIS; HISTOPATHOLOGY; HUMAN; IRON OVERLOAD; LIVER BIOPSY; LIVER DISEASE; LIVER FIBROSIS; LIVER NECROSIS; MALLORY BODY; MITOCHONDRION; PATHOGENESIS; PATHOLOGIST; PATHOPHYSIOLOGY; PROGNOSIS; REVIEW; ALCOHOL LIVER DISEASE; CHRONIC DISEASE; NOMENCLATURE; PATHOLOGY; RISK FACTOR; ALCOHOLIC FATTY LIVER; CELL INFILTRATION; DISORDERS OF MITOCHONDRIAL FUNCTIONS; IMMUNOHISTOCHEMISTRY; LIVER CELL DAMAGE; LIVER PARENCHYMA; NONALCOHOLIC FATTY LIVER;

CHRONIC DISEASE; DIAGNOSIS, DIFFERENTIAL; DISEASE PROGRESSION; FATTY LIVER; HEPATITIS, ALCOHOLIC; HUMANS; RISK FACTORS; TERMINOLOGY;

EID: 0036782444     PISSN: 15216918     EISSN: None     Source Type: Journal    
DOI: 10.1053/bega.2002.0326     Document Type: Article

References (118)

1. Diehl A M Nonalcoholic steatohepatitis Seminars in Liver Disease 19 1999 221-229
2. Ludwig J Viggiano T R McGill D B et al. Nonalcoholic steatohepatitis. Mayo Clinic experiences with a hitherto unnamed disease Mayo Clinic Proceedings 55 1980 434-438
3. Reid A E Nonalcoholic steatohepatitis Gastroenterology 121 2001 710-723
4. Diehl A M Alcoholic liver disease: natural history Liver Transplantation and Surgery 3 1997 206-211
5. de la Hall P Alcoholic liver disease In MacSween RNM Anthony P P Scheuer P J (eds.) Pathology of the Liver 1994 317-349 Churchill Livingstone London
6. Matteoni C A Younossi Z M Gramlich T et al. Nonalcoholic fatty liver disease: a spectrum of clinical and pathological severity Gastroenterology 116 1999 1413-1419
7. Marchesini G Brizi M Morselli-Labate A M et al. Association of nonalcoholic fatty liver disease with insulin resistance American Journal of Medicine 107 1999 450-455
8. Nanki T Koike R Miyasaka H et al. Subacute severe steatohepatitis during prednisolone therapy for systemic lupus erythematosus American Journal of Gastroenterology 94 1999 3379
9. Oien K A Moffat D Curry G W et al. Cirrhosis with steatohepatitis after adjuvant tamoxifen Lancet 353 1999 36-37
10. James O Day C Non-alcoholic steatohepatitis: another disease of affluence Lancet 353 1999 1634-1636
11. Cotrim H P Adrade Z A Parana R et al. Nonalcoholic steatohepatitis. A toxic liver disease in industrial workers Liver 19 1999 299-304
12. Marchesini G Brizi M Bianchi G et al. Nonalcoholic fatty liver disease: a feature of the metabolic syndome Diabetes 50 2001 1844-1850
13. Luyckx F H Lefebvre P J Scheen A J Non-alcoholic steatohepatitis: association with obesity and insulin resistance, and influence of weight loss Diabetes and Metabolism 26 2000 98-106
14. Chitturi S Farrell G C Etiopathogenesis of nonalcoholic steatohepatitis Seminars in Liver Disease 21 2001 27-42
15. Sanyal A J Insulin resistance and nonalcoholic steatohepatitis: fat or fiction? American Journal of Gastroenterology 96 2001 274-276
16. Comert B Mas M R Erdem H et al. Insulin resistance in non-alcoholic steatohepatitis Digestive Liver Disease 33 2001 353-358
17. Falck-Ytter Y Younossi Z M Marchesini G et al. Clinical features and natural history of nonalcoholic steatosis syndromes Seminars in Liver Disease 21 2001 17-26
18. Blendis L Oren R Halpern Z NASH: can we iron out the pathogenesis? Selected summary Gastroenterology 118 2000 981-983
19. Bonkovsky H L Jawaid Q Tortorelli K et al. Non-alcoholic steatohepatitis and iron: increased prevalence of mutations of the HFE gene in non-alcoholic steatohepatitis J Hepatol 31 1999 421-429
20. Lee R G Nonalcoholic steatohepatitis: tightening the morphologic screws on a hepatic ramber Hepatology 21 1995 1742-1743
21. Brunt E M Nonalcoholic steatohepatitis: definition and pathology Seminars in Liver Disease 21 2001 3-16
22. Adler M Schaffner F Fatty liver hepatitis and cirrhosis in obese patients American Journal of Medicine 67 1979 811-816
23. Itoh S Yougel T Kawagoe K Comparison between nonalcoholic steatohepatitis and alcoholic hepatitis American Journal of Gastroenterology 82 1987 650-654
24. Nagore N Scheuer P J The pathology of diabetic hepatitis Journal of Pathology 156 1988 155-160
25. Diehl A M Goodman Z Ishak K G Alcohollike liver disease in nonalcoholics. A clinical and histologic comparison with alcohol-induced liver injury Gastroenterology 95 1988 1056-1062
26. Lee R G Nonalcoholic steatohepatitis: a study of 49 patients Human Pathology 20 1989 594-598
27. Wanless I R Bargman J M Oreopoulos D G et al. Subcapsular steatonecrosis in response to peritoneal insulin delivery: a clue to the pathogenesis of steatonecrosis in obesity Modern Pathology 2 1989 69-74
28. Powell E E Cooksley W GE Hanson R et al. The natural history of nonalcoholic steatohepatitis: a follow-up study of forty-two patients for up to 21 years Hepatology 11 1990 74-80
29. Bacon B R Farahvash M J Janney C G et al. Nonalcoholic steatohepatitis: an expanded clinical entity Gastroenterology 107 1994 1103-1109
30. Baldridge A D Perez-Atayde A R Graeme-Cook F et al. Idiopathic steatohepatitis in childhood: a multicenter retrospective study Journal of Pediatrics 127 1995 700-704
31. Pinto H C Baptista A Camilo M E et al. Nonalcoholic steatohepatitis clinicopathologic comparison with alcoholic hepatitis in ambulatory and hospitalized patients Digestive Diseases and Sciences 41 1996 172-179
32. Brunt E M Janney C G Di Bisceglie A M et al. Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions American Journal of Gastroenterology 94 1999 2467-2474
33. Rashid M Roberts E A Nonalcoholic steatohepatitis in children Journal of Pediatric Gastroenterology and Nutrition 30 2000 48-53
34. Angulo P Keach J C Batts K P et al. Independent predictors of liver fibrosis in patients with nonalcoholic steatohepatitis Hepatology 30 1999 1356-1362
35. Burt A D Mutton A Day C Diagnosis and interpretation of steatosis and steatohepatitis Seminars in Diagnostic Pathology 15 1998 246-258
36. Caldwell S H Oelsner D H Iezzoni J C et al. Cryptogenic cirrhosis: clinical characterization and risk factors for underlying disease Hepatology 29 1999 664-669
37. Pooawala A Nair S P Thuluvath P J Prevalence of obesity and diabetes in patients with cryptogenic cirrhosis: a case control study Hepatology 34 2000 689-692
38. Takahashi T Kamaimura T Ichida H Ultrastructural findings on polymorphonuclear leucocyte infiltration and acute hepatocellular damage in alcoholic hepatitis Liver 7 1987 347-358
39. Natori S Rust C Stadheim L M et al. Hepatocyte apoptosis is a pathologic feature of human alcoholic hepatitis Journal of Hepatology 34 2001 248-253
40. Ziol M Tepper M Lohez M et al. Clinical and biological relevance of hepatocyte apoptosis in alcoholic hepatitis Journal of Hepatology 34 2001 254-260
41. Lee R G Fatty change and steatohepatitis In Diagnostic Liver Pathology 1995 Mosby St. Louis p. 167-194
42. Manton N D Lipsett J Moore D J et al. Non-alcoholic steatohepatitis in children and adults Medical Journal of Australia 173 2000 476-479
43. Struben V M Hespenheide E E Caldwell S H Nonalcoholic steatohepatitis and cryptogenic cirrhosis within kindreds American Journal of Medicine 108 2000 9-13
44. MacSween R N M Burt A D Histologic spectrum of alcoholic liver disease Seminars in Liver Disease 6 1986 221-232
45. French S W Nash J Shitabata P et al. Pathology of alcoholic liver disease Seminars in Liver Disease 13 1993 154-169
46. Denk H Stumptner C Zatloukal K Mallory bodies revisited Journal of Hepatology 32 2000 689-702
47. Zatloukal K Stumptner C Lehner M et al. Cytokeratin 8 protects from hepatotoxicity, and its ratio to cytokeratin 18 determines the ability of hepatocytes to form Mallory bodies American Journal of Pathology 156 2000 1263-1274
48. Le T H Redick J A Sheppard B L et al. The distribution of mitochondria containing crystalline inclusions within the hepatic lobule in NASH Hepatology 34 2001 461A
49. Caldwell S H Swerdlow R H Khan E M et al. Mitochondrial abnormalities in non-alcoholic steatohepatitis Journal of Hepatology 31 1999 430-434
50. Sanyal A J Campbell-Sargent C Mirshahi F et al. Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities Gastroenterology 120 2001 1183-1192
51. Lefkowitch J H Fatty liver and lesions in the alcoholic In Scheuer P J Lefkowitch J (eds) Liver Biopsy Interpretation 1994 111-133 WB Saunders
52. Reeves H L Burt A D Wood S et al. Hepatic stellate cell activation occurs in the absence of hepatitis in alcoholic liver disease and correlates with the severity of steatosis Journal of Hepatology 75 1996 677-683
53. Washington K Wright K Hunter E et al. Hepatic stellate cell activation in non-alcoholic steatohepatitis and fatty liver Human Pathology 31 2000 822-828
54. Brunt E M Nonalcoholic steatohepatitis (NASH): further expansion of this clinical entity? Liver 19 1999 263-264
55. Baptista A Bianchi L de Groote J et al. Alcoholic liver disease: morphological manifestations. Review by an international group Lancet 1 1981 707-711
56. George D K Goldwurm S Macdonald G A et al. Increased hepatic iron concentration in nonalcoholic steatohepatitis is associated with increased fibrosis Gastroenterology 114 1998 311-318
57. Younossi Z M Gramlich T Bacon B R et al. Hepatic iron and nonalcoholic fatty liver disease Hepatology 30 1999 847-850
58. Bacon B R Hemochromatosis: diagnosis and management Gastroenterology 120 2001 718-725
59. Ludwig J McGill D B Lindor K D Review: nonalcoholic steatohepatitis Journal of Gastroenterology and Hepatology 12 1997 398-403
60. Thung S N Gerber M A Alcoholic hepatitis vs nonalcoholic steatohepatitis In Thung S N & Gerber M A (eds) Differential Diagnosis in Pathology: Liver Disorders 1995 24-26 Igaku-Shoin New York
61. Mallory F B Cirrhosis of the liver, five different types of lesions from which it may arise Bulletin of John's Hopkins Hospital 22 1911 69-74
62. Galambos J T Natural history of alcoholic hepatitis III: histologic changes Gastroenterology 63 1972 1026-1035
63. Goodman Z D Ishak K G Occlusive venous lesions in alcoholic liver disease Gastroenterology 83 1982 786-796
64. Edmondson H A Peters R L Reynolds T B et al. Sclerosing hyaline necrosis in the liver of the chronic alcoholic. A recognizable lesion Annals of Internal Medicine 59 1963 646-673
65. Savolainen V Perola M Lalu K et al. Early perivenular fibrogenesis - precirrhotic lesions among moderate alcohol consumers and chronic alcoholics Journal of Hepatology 23 1995 524-531
66. Burt A D MacSween R NM Hepatic vein lesions in alcoholic liver disease: retrospective biopsy and necropsy study Journal of Clinical Pathology 39 1986 63-67
67. Falchuk K R Conlin D The intestinal and liver complications of diabetes mellitus Advances in Internal Medicine 38 1993 269-286
68. Garcia-Monzon C Martin-Perez E Iacono O L et al. Characterization of pathogenetic and prognostic factors of nonalcoholic steatohepatitis associated with obesity Journal of Hepatology 33 2000 716-724
69. Marubbio A T Buchwald H Schwartz M Z et al. Hepatic lesions of central pericellular fibrosis in morbid obesity and after jejunoileal bypass American Journal of Clinical Pathology 66 1976 684-691
70. Silverman J F O'Brien K F Long S et al. Liver pathology in morbidly obese patients with and without diabetes American Journal of Gastroenterology 85 1990 1349-1355
71. Ratziu V Giral P Charlotte F et al. Liver fibrosis in overweight patients Gastroenterology 118 2000 1117-1123
72. Wanless I R Lentz J S Fatty liver hepatitis (steatohepatitis) and obesity: an autopsy study with analysis of risk factors Hepatology 12 1990 1106-1110
73. Stone B G Van Thiel D H Diabetes mellitus and the liver Seminars in Liver Disease 5 1985 8-28
74. Latry P Bioulac-Sage P Echinard E et al. Perisinusoidal fibrosis and basement membrane-like material in the livers of diabetic patients Human Pathology 18 1987 775-780
75. Andersen T Gluud C Franzmann M-B et al. Hepatic effects of dietary weight loss in morbidly obese subjects Journal of Hepatology 12 1991 224-229
76. Peters R L Gay T Reynolds T B Post-jejunoileal bypass hepatic disease. Its similarity to alcoholic liver disease American Journal of Clinical Pathology 63 1975 318-331
77. Vyberg M Ravn V Andersen B Pattern of progression in liver injury following jejunoileal bypass for morbid obesity Liver 7 1987 271-276
78. Lewis J H Mullick F Ishak K G et al. Histopathologic analysis of suspected amiodarone hepatotoxicity Human Pathology 21 1990 59-67
79. Kalantzis N Gabriel P Mouzas J et al. Acute amiodarone-induced hepatitis Hepato-Gastroenterology 38 1991 71-74
80. Brunt E M Nonalcoholic steatohepatitis: grading and staging the histological lesions In Leuschner U James O Dancygier H (eds) Steato-hepatitis (NASH and ASH), Falk Symposium 121 2001 26-34 Kluwer Academic Publishers Dordrecht
81. Brunt E M Grading and staging the histopathological lesions of chronic hepatitis: the Knodell Activity Index and beyond Hepatology 31 2000 241-246
82. Younossi Z M Gramlich T Chang Y et al. Nonalcoholic fatty liver disease: assessment of variability in pathologic interpretations Modern Pathology 11 1998 560-565
83. Ishak K G Baptista A Bianchi L et al. Histological grading and staging of chronic hepatitis Journal of Hepatology 22 1995 696-699
84. Brunt E M Neuschwander-Tetri B A Di Bisceglie A M et al. Can steatohepatitis coexist with other forms of chronic liver disease? Modern Pathology 13 2000 1061A
85. Ong J P Younossi Z M Speer C et al. Chronic hepatitis C superimposed nonalcoholic fatty liver disease Liver 21 2001 266-271
86. Lonardo A Loria P Carulli N Concurrent non-alcoholic steatohepatitis and psoriasis. Report of three cases from the POLI.St.E.N.A. study Digestive and Liver Disease 33 2001 86-87
87. Caldwell S H Jeffers L J Ditomaso A et al. Antibody to hepatitis C is common among patients with alcoholic liver disease with and without risk factors American Journal of Gastroenterology 86 1991 1219-1223
88. Kyriacou E Simmonds P Miller E et al. Liver biopsy findings in patients with alcoholic liver disease complicated by chronic hepatitis C virus infection European Journal of Gastroenterology and Hepatology 7 1995 331-334
89. Rosman A S Paronetto F Galvin K et al. Hepatitis C virus antibody in alcoholic patients. Association with the presence of portal and/or lobular hepatitis Archives of Internal Medicine 153 1993 965-969
90. Uchimura Y Sata M Kage M et al. A histopathological study of alcoholics with chronic hepatitis C infection: comparison with chronic hepatitis C and alcoholic liver disease Liver 15 1995 300-306
91. Cooksley WGE Chronic liver disease: do alcohol and hepatitis C virus interact? Journal of Gastroenterology and Hepatology 11 1996 187-192
92. Clouston A D Jonsson J R Purdie D M et al. Steatosis and chronic hepatitis C: an analysis of fibrosis and stellate cell activation Journal of Hepatology 34 2001 314-320
93. Tajiri K Tekenawa H Yamaoka K et al. Nonalcoholic steatohepatitis masquerading as autoimmune hepatitis Journal of Clinical Gastroenterology 25 1997 538-540
94. Tanaka T Yabusako T Yamashita T et al. Contribution of hepatitis C virus to the progression of alcoholic liver disease Alcoholism, Clinical and Experimental Research 24 2000 112S-116S
95. Nalpas B Brechot C Berthelot P Hepatitis B virus and alcoholism. A puzzling association Hepatology 18 1988 11-14
96. Sobue S Higashi K Nakao H et al. Hepatitis G virus infection in patients with alcoholic liver disease Alcoholism, Clinical and Experimental Research 22 1998 156S-160S
97. Bacon B R Olynyk J K Brunt E M Britton R S Wolff R K HFE genotype in patients with hemochromatosis and other liver diseases Annals of Internal Medicine 130 1999 953-962
98. Brunt E M Tavill A S Bacon B R A 49-year-old man with alpha 1-antitrypsin deficiency and abnormal iron study results Seminars in Liver Disease 16 1996 97-101
99. Mehta S H Brancati F L Sulkowski M S et al. Prevalence of type 2 diabetes mellitus among persons with hepatitis C virus infection in the United States Hepatology 33 2001 1554
100. Mason A L Lau J Y Hoang N et al. Association of diabetes mellitus and chronic hepatitis C virus infection Hepatology 29 1999 328-333
101. Contos M Garcia N Sterling R K et al. The impact of nonalcoholic fatty liver disease on the progression of hepatitis C Hepatology 34 2001 457A
102. Li J Corregidor A Monteiro C et al. Association of liver steatosis and chronic hepatitis C Hepatology 34 2001 424A
103. Fiel M I Reddy N G Barritta D Russo M W Jacobson I M The intrazonal distribution of steatosis in chronic hepatitis C and the impact of hepatic steatosis on fibrosis and necroinflammatory activity Hepatology 34 2001 221A
104. Scheuer P J Ashrafzadeh P Sherlock S et al. The pathology of hepatitis C Hepatology 15 1992 567-571
105. Teli M R James O FW Burt A D et al. The natural history of nonalcoholic fatty liver: a follow-up study Hepatology 22 1995 1714-1719
106. Teli M R Day C P Burt A D et al. Determinants of progression to cirrhosis or fibrosis in pure alcoholic fatty liver Lancet 346 1995 987-990
107. Schaffner F Thaler H Nonalcoholic fatty liver disease Progress in Liver Disease 8 1986 283-298
108. Contos M J Cales W Sterling R K et al. Development of nonalcoholic fatty liver disease after liver transplantation for cryptogenic cirrhosis Liver Transplantation 7 2001 363-373
109. Zen Y Katayanagi K Tsuneyama K et al. Hepatocellular carcinoma arising in non-alcoholic steatohepatitis Pathology International 51 2001 127-131
110. Cotrim H P Parana R Braga E et al. Nonalcoholic steatohepatitis and hepatocellular carcinoma: natural history? (Letter) American Journal of Gastroenterology 95 2000 3018-3019
111. Day C P Who gets alcoholic liver disease: nature or nurture? Journal of the Royal College of Physicians, London 34 2000 557-562
112. Jarvelainen H A Orpana A Perola M et al. Promoter polymorphism of the CD 14 endotoxin receptor gene as a risk factor for alcoholic liver disease Hepatology 33 2001 1148-1153
113. Chedid A Mendenhall C L Gartside P et al. Prognostic factors in alcoholic liver disease American Journal of Gastroenterology 86 1991 210-216
114. Orrego H Blake J E Blendis L M et al. Prognosis of alcoholic cirrhosis in the presence and absence of alcoholic hepatitis Gastroenterology 92 1987 208-214
115. Sorensen TIA Bentsen K D Eghoje K et al. Prospective evaluation of alcohol abuse and alcoholic liver injury in men as predictors of development of cirrhosis Lancet ii 1984 241-244
116. Fang J W S Bird G L A Nakamura T et al. Hepatocyte proliferation as an indicator of outcome in acute alcoholic hepatitis Lancet 343 1994 820-823
117. Dixon J B Bhathal P S O'Brien P E Nonalcoholic fatty liver disease: predictors of nonalcoholic steatohepatitis and liver fibrosis in the severely obese Gastroenterology 121 2001 91-100
118. Paradis V Perlemuter G Bonvoust F et al. High glucose and hyperinsulinemia stimulate connective tissue growth factor expression: a potential mechanism involved in progression to fibrosis in nonalcoholic steatohepatitis Hepatology 34 2001 738-744