Progression from chronic atrophic gastritis to gastric cancer; Tangle, toggle, tackle with korea red ginseng

Journal of Clinical Biochemistry and Nutrition

Volumn 46, Issue 3, 2010, Pages 195-204

  Kim, Yoon Jae ^a   Chung, Jun Won ^a   Lee, So Jung ^a   Choi, Ki Seok ^b   Kim, Ju Hyun ^a   Hahm, Ki Baik ^a,b  

^a Inha University School of Medicine   (South Korea)

^b Gachon University   (South Korea)

Author keywords

Cancer prevention; Carcinogenesis; Inflammation; Korea red ginseng; Rejuvenation

Indexed keywords

GINSENG EXTRACT; HERBACEOUS AGENT; PLACEBO;

ATROPHIC GASTRITIS; CANCER PREVENTION; CHRONIC DISEASE; DISEASE ASSOCIATION; DISEASE COURSE; DRUG EFFECT; DRUG EFFICACY; HELICOBACTER PYLORI; HUMAN; IMMUNOMODULATION; KOREAN RED GINSENG; MEDICINAL PLANT; REVIEW; STOMACH CANCER;

HELICOBACTER PYLORI; PANAX GINSENG;

EID: 77952511791     PISSN: 09120009     EISSN: None     Source Type: Journal    
DOI: 10.3164/jcbn.10-03     Document Type: Review

References (51)

1. Federico, A., Morgillo, F., Tuccillo, C., Ciardiello, F., and Loguercio, C.: Chronic inflammation and oxidative stress in human carcinogenesis. Int. J. Cancer, 121, 2381-2386, 2007.
2. Aggarwal, B.B., Shishodia, S., Sandur, S.K., Pandey, M.K., and Sethi, G.: Inflammation and cancer; how hot is the link? Biochem. Pharmacol., 72, 1605-1621, 2006.
3. Lu, H., Ouyang, W., and Huang, C.: Inflammation, a key event in cancer development. Mol. Cancer Res., 4, 221-233, 2006.
4. Moss, S.F. and Blasé, M.J.: Mechanism of disease: inflammation and the origin of cancer. Nature Clin. Prat. Oncol., 2, 90-97, 2005.
5. Ono, M.: Molecular links between tumor angiogenesis and inflammation: inflammatory stimuli of macrophages and cancer cells as targets for therapeutic strategy. Cancer Sci., 99, 1501-1506, 2008.
6. Oshima, H., Tazawa, H., Sylla, B.S., and Sawa, T.: Prevention of human cancer by modulation of chronic inflammatory process. Mutat. Res., 591, 110-122, 2005.
7. Pollard, J.W.: Tumor-educated macrophages promote tumor progression and metastasis. Nature Rev. Cancer, 4, 71-78, 2004.
8. Hussain, S.P., Hofseth, L.J., and Harris, C.C.: Radical causes of cancer. Nature Rev. Cancer, 3, 276-285, 2003.
9. Coussens, L. and Werb, Z.: Inflammation and Cancer. Nature, 420, 860-867, 2002.
10. Balkwill, F. and mantovani, A.: Inflammation and cancer. Back to Virchow?. Lancet, 357, 539-545, 2001.
11. Bode, A.M. and Dong, Z.: Cancer prevention research - then and now. Nature Rev. Cancer, 9, 508-516, 2009.
12. Suzuki, M., Suzuki, H., and Hibi, H.: Proton pump inhibitors and gastritis. J. Clin. Biochem. Nutr., 42, 71-75, 2008.
13. Nakajima, N., Ito, Y., Yokoyama, K., Uno, A., Kinukawa, N., Nemoto, N., and Moriyama, M.: The Expression of murine double minute 2 (MDM2) on Helicobacter pylori-infected intestinal metaplasia and gastric cancer. J. Clin. Biochem. Nutr., 44, 196-202, 2009.
14. Uemura, N., Okamoto, S., Yamamoto, S., Matsumura, N., Yamaguchi, S., Yamakido, M., Taniyama, K., Sasaki, N., and Schlemper, R.J.: Helicobacter pylori infection and the development of gastric cancer. New Engl. J. Med., 345, 784-789, 2001.
15. You, W.C., Zhang, L., Gail, M.H., Chang, Y.S., Liu, W.D., Ma, J.L., Li, J.Y., Jin, M.L., Hu, Y.R., Yang, C.S., Blaser, M.J., Correa, P., Biot, W.J., Fraumeni, J.F., and Xu, G.W.: Gastric dysplasia and gastric cancer: Helicobacter pylori, serum vitamin C, and other risk factors. J. Natl. Cancer Inst., 92, 1607-1612, 2000.
16. Wong, B.C., Lam, S.K., Wong, W.M., Chen, J.S., Zheng, T.T., Feng, R.F., Lai, K.C., Hu, W.H., Yuen, S.T., Leung, S.Y., Fong, D.Y., Ho, J., Ching, C.K., Chen, J.S., and China Gasrtric cancer Study Group: Helicobacter pylori eradication to prevent gastric cancer in a high-risk region of China: a randomized controlled trial. J.A.M.A., 291, 187-194, 2004.
17. Leung, W.K., Lin, S.R., Ching, J.Y., To, F.T., Ng, E.K., Chan, F.K., Lau, J.Y., and Sung, J.J.: Factors predicting progression of gastric intestinal metaplasia: results of a randomized trial on Helicobacter pylori eradication. Gut, 53, 1244-1249, 2004.
18. Mera, R., Fontham, E.T., Bravo, L.E., Bravo, J.C., Piazuelo, M.B., Camago, M.C., and Correa, P.: Long term follow up of patients treated for Helicobacter pylori infection. Gut, 54, 1536-1540, 2005. (Pubitemid 41531767)
19. Take, S., Mizuno, M., Ishiki, K., Nagahara, Y., Yoshida, T., Yokota, K., Oguma, K., Okada, H., and Shiratori, Y.: The effect of eradicating Helicobacter pylori on the development of gastric cancer in patients with peptic ulcer disease. Am. J. Gastroenterol., 100, 1037-1042, 2005.
20. Kato, M., Asaka, M., Nakamura, T., Azuma, T., Tomita, E., and Kamoshida, T.: Helicobacter pylori eradication prevents the development of gastric cancer- results of a long-term retrospective study in Japan. Aliment. Pharmacol. Ther., 24, 203-206, 2006.
21. Takenaka, R., Okada, H., Kato, J., Makidono, C., Hori, S., Kawahara, Y., Miyoshi, M., Yumoto, E., Imagawa, A., Toyokawa, Y., Sakaguchi, K., and Shiratori, Y.: Helicobacter pylori eradication reduced the incidence of gastric cancer, especially of the intestinal type. Aliment. Pharmacol. Ther., 25, 805-812, 2007.
22. Kabir, S.: Effect of Helicobacter pylori eradication on incidence of gastric cancer in human and animal models: underlying biochemical and molecular events. Helicobacter, 14, 159-171, 2009.
23. Fukase, K., Kato, M., Kikuchi, S., Inoue, K., Uemura, N., Okamoto, S., Terao, S., Amagai, K., Hayashi, S., Asaka, M., and Japan Gast Study Group: Effect of eradication of Helicobacter pylori on incidence of metachronous gastric carcinoma after endoscopic resection of early gastric cancer: an open-label, randomized controlled trial. Lancet, 372, 392-397, 2008.
24. Forbes, G.M., Warren, J.R., Glaser, M.E., Cullen, D.J., Marshall, B.J., and Collins, B.J.: Long-term follow-up of gastric histology after Helicobacter pylori eradication. J. Gastroenterol. Hepatol., 11, 670-763, 1996.
25. Sung, J.J., Lin, S.R., Ching, J.Y., Zhou, L.Y., To, K.F., Wang, R.T., Leung, W.K., Ng, E.K., Lau, J.Y., Lee, Y.T., Yeung, C.K., Chao, W., and Chung, S.C.: Atrophy and intestinal metaplasia one year after cure of H. pylori infection: a prospective, randomized study. Gastroenterology, 119, 7-14, 2000. (Pubitemid 30452573)
26. Park, S., Kim, W.S., Choi, U.J., Han, S.U., Kim, Y.S., Kim, Y.B., Chung, M.H., Nam, K.T., Kim, D.Y., Cho, S.W., and Hahm, K.B.: Amelioration of oxidative stress with ensuing inflammation contributes to chemoprevention of H. pyloriassociated gastric carcinogenesis. Antioxd. Redox. Signal., 6, 549-560, 2004.
27. Lee, D.H. and Hahm, K.B.: Inflammatory cytokine gene polymorphisms and gastric cancer. J. Gastroenterol. Hepatol., 23, 1465-1472, 2008.
28. Chung, J.W. and Mahm, K.B.: Rejuvenation of atrophic gastritis in the elderly. J. Gastroenterol. Hepatol., 25, 434-435, 2010.
29. Helms, S.: Cancer prevention and therapeutics: Panax Ginseng. Alternative Med. Rev., 9, 259-274, 2004.
30. Attele, A.S., Wu, J.A., and Yuan, C.S.: Ginseng pharmacology Multiple constituents and multiple actions. Biochem. Pharmacol., 58, 1685-1693, 1999.
31. Yun, T.K., Lee, Y.S., Lee, Y.H., Kim, S.I., and Yun, H.Y.: Anticarcinogenic effect of Panax ginseng C.A. Meyer and identification of active compounds. J. Korean Med. Sci., 16S, S6-S18, 2001.
32. Odashima, S., Ohta, T., Kohno, H., Matsuda, T., Kitagawa, I., Abe, H., and Arichi, S.: Control of phenotypic expression of cultured B16 melanoma cells by plant glycosides. Cancer Res., 45, 2781-2784, 1985. (Pubitemid 15232750)
33. Yun, T.K., Yun, Y.S., and Han, I.W.: Anticarcinogenic effect of long-term oral administration of red ginseng on newborn mice exposed to various chemical carcinogens. Cancer Detect. Prev., 6, 515-525, 1983.
34. Surh, Y.J., Na, H.K., Lee, J.Y., and Keum, Y.S.: Molecular mechanisms underlying anti-tumor promoting activities of heat-processed Panax ginseng C.A. Meyer. J. Korean Med. Sci., 16, S38-S41, 2001.
35. Keum, Y.S., Park, K.K., Lee, J.M., Chun, K.S., Park, J.H., Lee, S.K., Kwon, H., and Surh, Y.J.: Antioxidant and anti-tumor promoting activities of the methanol extract of heatprocessed ginseng. Cancer Lett., 150, 41-48, 2000. (Pubitemid 30123046)
36. Lee, S.J., Ko, W.G., Kim, J.H., Sung, J.H., Moon, C.K., and Lee, B.H.: Induction of apoptosis by a novel intestinal metabolite of ginseng saponin via cytochrome c-mediated activation of caspase-3 protease. Biochem. Pharmacol., 60, 677-685, 2000.
37. Sato, K., Mochizuki, M., Saiki, I., Yoo, Y.C., Samukawa, K., and Azuma, I.: Inhibition of tumor angiogenesis and metastasis by a saponin of Panax ginseng, ginsenoside-Rb2. Biol. Pharm. Bull., 17, 635-639, 1994.
38. Lee, Y.S., Chung, I.S., Lee, I.R., Kim, K.H., Hong, W.S., and Yun, Y.S.: Activation of multiple effector pathways of immune system by the antineoplastic immunostimulating acidic polysaccharide ginsan isolated from Panax ginseng. Anticancer Res., 17, 323-331, 1997.
39. Kim, E.H., Park, J.D., Pyo, S.N., and Rhee, D.K.: Effects of non-saponin red ginseng compounds on multi-drug resistance. J. Ginseng Res., 31, 74-78, 2007.
40. Yue, P.Y., Mak, N.K., Cheng, Y.K., Leung, K.W., Ng, T.B., Ping Fan, D.T., Yeung, H.W., and Wong, R.N.: Pharmacogenomics and the Yin/Yang actions of ginseng: anti-tumor, angiomodulating and steroid-like activities of ginsenosides. Chin. Med., 2, 1-21, 2007.
41. Yun, T.K.: Panax ginseng - a non-organ-specific cancer preventive?. Lancet Oncol., 2, 49-55, 2001.
42. Hofseth, L.J. and Wargovich, M.J.: Inflammation, cancer, and target of ginseng. J. Nutr., 137, 183S-185S, 2007.
43. Lee, W.M., Kim, S.D., Kim, K.S., Song, Y.B., Kwak, Y.S., Cho, J.Y., Park, H.J., Oh, J.W., and Rhee, M.H.: Protopanaxadiol modulates LPS-induced inflammatory activity in murine macrophage RAW264.7 cells. J. Ginseng Res., 30, 181-187, 2006.
44. Lee, Y.K., Im, Y.J., Kim, Y.L., Sackcet, S.J., Lim, S.M., Kim, K., Kim, H.L., Ko, S.R., and Im, D.S.: Increase of membrane potential by ginsenosides in prostate cancer and glioma cells. J. Ginseng Res., 30, 70-77, 2006.
45. Joo, H.K., Lee, S.K., Kim, H.S., Song, Y.J., Kang, G., Park, J.B., Lee, K.H., Cho, E.J., Lee, J.H., Seong, I.W., Kim, S.H., Cho, C.H., and Jeon, B.H.: Korean red ginseng extract inhibits tumor necrosis factor-alpha-induced monocyte adhesion in the human endothelial cells. J. Ginseng Res., 32, 244-249, 2008.
46. Park, S., Yeo, M., Jin, J.H., Lee, K.M., Jung, J.Y., Choue, R., Cho, S.W., and Hahm, K.B.: Rescue of Helicobacter pyloriinduced cytotoxicity by red ginseng. Dig. Dis. Sci., 50, 1218-1227, 2005.
47. Park, S., Yeo, M., Jin, J.H., Lee, K.M., Kim, S.S., Choi, S.Y., and Hahm, K.B.: Inhibitory activities and attenuated expressions of 5-LOX with red ginseng in Helicobacter pyloriinfected gastric epithelial cells. Dig. Dis. Sci., 52, 973-982, 2007.
48. Kim, D.K., Lee, J.A., Kim, Y.B., Lee, K.M., and Hahm, K.B.: A randomized controlled trial assessing Korean red ginseng treatment of Helicobacter pylori-associated chronic gastritis. Kor. J Med., 72, 20-28, 2007.
49. Yoo, S.H., Jung, H.S., Sohn, W.S., Kim, B.H., Ku, B.H., Kim, Y.S., Park, S.W., and Hahm, K.B.: Volatile sulfure compounds as a predictor for esophagogastroduodenal mucosal injury. Gut Liver, 2, 113-118, 2008.
50. Lee, J.S., Kwon, K.A., Jung, H.S., Kim, J.H., and Hahm, K.B.: Korea red ginseng on Helicobacter pylori-induced halitosis; newer therapeutic strategy and a plausible mechanism. Digestion, 80, 192-199, 2009.
51. Lee, S.Y., Shin, Y.W., and Hahm, K.B.: Phytoceuticals: mighty but ignored weapons against Helicobacter pylori infection. J. Dig. Dis., 9, 129-139, 2008.