Phytoceuticals: Mighty but ignored weapons against Helicobacter pylori infection

Journal of Digestive Diseases

Volumn 9, Issue 3, 2008, Pages 129-139

  Lee, Sun Young ^a   Shin, Yong Woon ^b   Hahm, Ki Baik ^b,c,d  

^a Konkuk University School of Medicine   (South Korea)

^b Inha University School of Medicine   (South Korea)

^c Bundang Jesaeng Hospital   (South Korea)

^d Inha University   (South Korea)

Author keywords

Cancer prevention; Carcinogenesis; Helicobacter pylori; Inflammation; Phytoceutical

Indexed keywords

ALLYL SULFIDE; ALPHA TOCOPHEROL; ANTIBIOTIC AGENT; ANTIOXIDANT; ASCORBIC ACID; CAFFEIC ACID PHENETHYL ESTER; CAPSAICIN; CATECHIN; CHEMOKINE; CLARITHROMYCIN; CYTOKINE; DNA; EPIGALLOCATECHIN GALLATE; FLAVONOID; GARLIC EXTRACT; GINSENG EXTRACT; GINSENOSIDE; GREEN TEA EXTRACT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; METRONIDAZOLE; NUTRACEUTICAL; PLANT EXTRACT; PLANT MEDICINAL PRODUCT; PROBIOTIC AGENT; RESVERATROL; SAPONIN; SULFORAPHANE; UNINDEXED DRUG; VACCINE; VITAMIN;

ANTIINFLAMMATORY ACTIVITY; ANTIMICROBIAL ACTIVITY; APOPTOSIS; BACTERIAL COLONIZATION; BROCCOLI; CARCINOGENESIS; CHRONIC INFLAMMATION; CYTOKINE RELEASE; CYTOTOXICITY; DNA BINDING; DRUG EFFICACY; ERADICATION THERAPY; GASTRITIS; HELICOBACTER INFECTION; HELICOBACTER PYLORI; HUMAN; INHIBITION KINETICS; MINIMUM INHIBITORY CONCENTRATION; MUCOSA ASSOCIATED LYMPHOID TISSUE LYMPHOMA; MUTAGENESIS; NONHUMAN; PATHOGENESIS; PEPTIC ULCER; PRECANCER; PRIORITY JOURNAL; RED WINE; REVIEW; STOMACH ADENOCARCINOMA;

FLAVONOIDS; GARLIC; GASTRIC MUCOSA; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HUMANS; PANAX; PHYTOTHERAPY; PLANT PREPARATIONS; STILBENES; TEA;

EID: 48249152198     PISSN: 17512972     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1751-2980.2008.00334.x     Document Type: Review

References (61)

1. Graham DY. Helicobacter pylori infection in the pathogenesis of duodenal ulcer and gastric cancer: A model. Gastroenterology 1997; 113: 1983-91.
2. Dhar SK, Soni RK, Das BK et al. Molecular mechanism of action of major Helicobacter pylori virulence factors. Mol Cell Biochem 2003; 253: 207-15.
3. Stoicov C, Saffari R, Cai X et al. Molecular biology of gastric cancer: Helicobacter infection and gastric adenocarcinoma: Bacterial and host factors responsible for altered growth signaling. Gene 2004; 341: 1-17.
4. Park S, Kim WS, Choi UJ et al. Amelioration of oxidative stress with ensuing inflammation contributes to chemoprevention of H. pylori - associated gastric carcinogenesis. Antioxid Redox Signal 2004; 6: 549-60.
5. Nam KT, Oh SY, Ahn B et al. Decreased Helicobacter pylori associated gastric carcinogenesis in mice lacking inducible nitric oxide synthase. Gut 2004; 53: 1250-5.
6. Ulmer HJ, Beckerling A, Gatz G. Recent use of proton pump inhibitor-based triple therapies for the eradication of H. pylori: A broad data review. Helicobacter 2003; 8: 95-104.
7. Han SU, Kim YB, Joo HT et al. Helicobacter pylori infection promotes gastric carcinogenesis in a mice model. J Gastroenterol Hepatol 2002; 17: 253-61.
8. Lesbros-Pantoflickova D, Corthesy-Theulaz I, Blum AL. Helicobacter pylori and probiotics. J Nutr 2007; 137(Suppl 2): S812-18.
9. Kim DK, Lee JA, Kim YB et al. A randomized controlled trial assessing Korea red ginseng treatment of Helicobacter pylori - associated chronic gastritis. Korean J Med 2007; 72: 20-8.
10. Park S, Yeo M, Jin JH et al. Rescue of Helicobacter pylori - induced cytotoxicity by red ginseng. Dig Dis Sci 2005; 50: 1218-27.
11. Lee JH, Shim JS, Lee JS et al. Pectin-like acidic polysaccharide from Panax ginseng with selective antiadhesive activity against pathogenic bacteria. Carbohydr Res 2006; 341: 1154-63.
12. Park S, Yeo M, Jin JH et al. Inhibitory activities and attenuated expressions of 5-LOX with red ginseng in Helicobacter pylori-infected gastric epithelial cells. Dig Dis Sci 2007; 52: 973-82.
13. Lee JH, Park EK, Uhm CS et al. Inhibition of Helicobacter pylori adhesion to human gastric adenocarcinoma epithelial cells by acidic polysaccharides from Artemisia capillaris and Panax ginseng. Planta Med 2004; 70: 615-19.
14. Bae EA, Han MJ, Kim EJ et al. Transformation of ginseng saponins to ginsenoside Rh2 by acids and human intestinal bacteria and biological activities of their transformants. Arch Pharm Res 2004; 27: 61-7.
15. Bae EA, Han MJ, Baek NI et al. In vitro anti-Helicobacter pylori activity of panaxytriol isolated from ginseng. Arch Pharm Res 2001; 24: 297-9.
16. Belogortseva NI, Yoon JY, Kim KH. Inhibition of Helicobacter pylori hemagglutination by polysaccharide fractions from roots of Panax ginseng. Planta Med 2000; 66: 217-20.
17. Weisburger JH, Chung FL. Mechanisms of chronic disease causation by nutritional factors and tobacco products and their prevention by tea polyphenols. Food Chem Toxicol 2002; 40: 1145-54.
18. Fujiki H, Suganuma M, Okabe S et al. Involvement of TNF-alpha changes in human cancer development, prevention and palliative care. Mech Ageing Dev 2002; 123: 1655-63.
19. Matsubara S, Shibata H, Ishikawa F et al. Suppression of Helicobacter pylori-induced gastritis by green tea extract in Mongolian gerbils. Biochem Biophys Res Commun 2003; 310: 715-19.
20. Lee JH, Shim JS, Lee JS et al. Inhibition of pathogenic bacterial adhesion by acidic polysaccharide from green tea (Camellia sinensis). J Agric Food Chem 2006; 54: 8717-23.
21. Ruggiero P, Rossi G, Tombola F et al. Red wine and green tea reduce H. pylori - or VacA-induced gastritis in a mouse model. World J Gastroenterol 2007; 13: 349-54.
22. Song JM, Seong BL. Tea catechins as a potential alternative anti-infectious agent. Expert Rev Anti Infect Ther 2007; 5: 497-506.
23. Tombola F, Campello S, De Luca L et al. Plant polyphenols inhibit VacA, a toxin secreted by the gastric pathogen Helicobacter pylori. FEBS Lett 2003; 543: 184-9.
24. Tombola F, Campello S, Luca LD, Roggiero P, Giudice GD, Papini E, Zoratti M. Plant polyphenols inhibit VacA, a toxin secreted by the gastric pathogen Helicobacter pylori. FEBS Lett 2003; 543: 184-9.
25. Lee KM, Yeo M, Choue JS et al. Protective mechanism of epigallocatechin-3-gallate against Helicobacter pylori-induced gastric epithelial cytotoxicity via the blockage of TLR-4 signaling. Helicobacter 2004; 9: 632-42.
26. Lee JS, Oh TY, Kim YK et al. Protective effects of green tea polyphenol extracts against ethanol-induced gastric mucosal damages in rats: stress-responsive transcription factors and MAP kinases as potential targets. Mutat Res 2005; 579: 214-24.
27. Takabayashi F, Harada N, Yamada M et al. Inhibitory effect of green tea catechins in combination with sucralfate on Helicobacter pylori infection in Mongolian gerbils. J Gastroenterol 2004; 39: 61-3.
28. Yanagawa Y, Yamamoto Y, Hara Y et al. A combination effect of epigallocatechin gallate, a major compound of green tea catechins, with antibiotics on Helicobacter pylori growth in vitro. Curr Microbiol 2003; 47: 244-9.
29. Ito LS, Oba SM, Hamajima N et al. Helicobacter pylori seropositivity among 963 Japanese Brazilians according to sex, age, generation, and lifestyle factors. Jpn J Cancer Res 2001; 92: 1150-6.
30. Shinchi K, Ishii H, Imanishi K et al. Relationship of cigarette smoking, alcohol use, and dietary habits with Helicobacter pylori infection in Japanese men. Scand J Gastroenterol 1997; 32: 651-5.
31. Murano A, Morinaga N, Iwamaru Y et al. Acidic conditions enhance bactericidal effects of sodium bisulfite on Helicobacter pylori. Helicobacter 2005; 10: 132-5.
32. + strains of Helicobacter pylori in vitro. Am J Gastroenterol 2003; 98: 1440-1.
33. Daroch F, Hoeneisen M, Gonzαlez CL et al. In vitro antibacterial activity of Chilean red wines against Helicobacter pylori. Microbios 2001; 104: 79-85.
34. Murray LJ, Lane AJ, Harvey IM et al. Inverse relationship between alcohol consumption and active Helicobacter pylori infection: The Bristol Helicobacter project. Am J Gastroenterol 2002; 97: 2750-5.
35. Rosenstock SJ, Jørgensen T, Andersen LP et al. Association of Helicobacter pylori infection with lifestyle, chronic disease, body-indices, and age at menarche in Danish adults. Scand J Public Health 2000; 28: 32-40.
36. Brenner H, Rothenbacher D, Bode G et al. Inverse graded relation between alcohol consumption and active infection with Helicobacter pylori. Am J Epidemiol 1999; 149: 571-6.
37. Bovicelli P, D'Angelo V, Collalto D et al. Efficient synthesis of polyoxygenated flavones from naturally occurring flavanones. J Pharm Pharmacol 2007; 59: 1697-701.
38. Lee JS, Kim HS, Hahm KB et al. Inhibitory effects of 7-carboxymethyloxy-3′,4′,5-trimethoxyflavone (DA-6034) on Helicobacter pylori -induced NF-kappa B activation and iNOS expression in AGS cells. Ann NY Acad Sci 2007; 1095: 527-35.
39. Li HQ, Xu C, Li HS et al. Metronidazole-flavonoid derivatives as anti- Helicobacter pylori agents with potent inhibitory activity against HPE-induced interleukin-8 production by AGS cells. Chem Med Chem 2007; 2: 1361-9.
40. Zhu Y, Zhang P, Yu H et al. Anti-Helicobacter pylori and thrombin inhibitory components from Chinese dragon's blood, Dracaena cochinchinensis. J Nat Prod 2007; 70: 1570-7.
41. Nakagawa H, Takaishi Y, Tanaka N et al. Chemical constituents from the peels of Citrus sudachi. J Nat Prod 2006; 69: 1177-9.
42. Ustün O, Ozçelik B, Akyön Y et al. Flavonoids with anti-Helicobacter pylori activity from Cistus laurifolius leaves. J Ethnopharmacol 2006; 108: 457-61.
43. Cañizares P, Gracia I, Gómez LA et al. Allyl-thiosulfinates, the bacteriostatic compounds of garlic against Helicobacter pylori. Biotechnol Prog 2004; 20: 397-401.
44. Iimuro M, Shibata H, Kawamori T et al. Suppressive effects of garlic extract on Helicobacter pylori -induced gastritis in Mongolian gerbils. Cancer Lett 2002; 187: 61-8.
45. Cañizares P, Gracia I, Gómez LA et al. Optimization of Allium sativum solvent extraction for the inhibition of in vitro growth of Helicobacter pylori. Biotechnol Prog 2002; 18: 1227-32.
46. O'Gara EA, Maslin DJ, Nevill AM et al. The effect of simulated gastric environments on the anti-Helicobacter activity of garlic oil. J Appl Microbiol 2007 20 November Epub ahead of print.
47. O'Gara EA, Hill DJ, Maslin DJ. Activities of garlic oil, garlic powder, and their diallyl constituents against Helicobacter pylori. Appl Environ Microbiol 2000; 66: 2269-73.
48. Gail MH, You WC. A factorial trial including garlic supplements assesses effect in reducing precancerous gastric lesions. J Nutr 2006; 136(Suppl 3): S813-5.
49. Gail MH, Pfeiffer RM, Brown LM et al. Garlic, vitamin, and antibiotic treatment for Helicobacter pylori: A randomized factorial controlled trial. Helicobacter 2007; 12: 575-8.
50. Fani A, Fani I, Delavar M et al. Combined garlic-omeprazole versus standard quadruple therapy for eradication of Helicobacter pylori infection. Indian J Gastroenterol 2007; 26: 145-6.
51. You WC, Brown LM, Zhang L et al. Randomized double-blind factorial trial of three treatments to reduce the prevalence of precancerous gastric lesions. J Natl Cancer Inst 2006; 98: 974-83.
52. Salih BA, Abasiyanik FM. Does regular garlic intake affect the prevalence of Helicobacter pylori in asymptomatic subjects? Saudi Med J 2003; 24: 842-5.
53. Nowack R. Cranberry juice-a well-characterized folk-remedy against bacterial urinary tract infection. Wien Med Wochenschr 2007; 157: 325-30.
54. Xiao SD, Shi T. Is cranberry juice effective in the treatment and prevention of Helicobacter pylori infection of mice? Chin J Dig Dis 2003; 4: 136-9.
55. O'Mahony R, Al-Khtheeri H, Weerasekera D et al. Bactericidal and anti-adhesive properties of culinary and medicinal plants against Helicobacter pylori. World J Gastroenterol 2005; 11: 7499-507.
56. Abdel-Latif MMM, Windle HJ, El Homasany BS, Sabra K, Kelleher D. Caffeic acid phenethyl ester modulates Helicobacter pylori-induced nuclear factor-kappa B and activator protein-1 expression in gastric epithelial cells. Br J Pharmacol 2005; 146: 1139-47.
57. Wu CS, Chen MF, Lee IL, Tung SY. Predictive role of nuclear factor-kB activity in gastric cancer. A promising adjuvant approach with caffeic acid phenethyl ester. J Clin Gastroenterol 2007; 10: 894-900.
58. Oh TY, Yeo M, Han SU et al. Synergism of Helicobacter pylori infection and stress on the augmentation of gastric mucosal damage and its prevention with α-tocopherol. Free Radic Biol Med 2005; 38: 1447-57.
59. Kim HJ, Kim MK, Chang WK et al. Effect of nutrient intake and Helicobacter pylori infection on gastric cancer in Korea: A case-control study. Nutr Cancer 2005; 52: 138-46.
60. Shibara H, Kimura-Takagi I, Nagaoka M et al. Inhibitory effect of Cladosiphon fucoidan on the adhesion of Helicobacter pylori to human gastric cells. J Nutr Sci Vitaminol 1999; 16: 19-26.
61. Shibata H, Limuro M, Uchiya N et al. Preventive effects of Cladosiphon fucoidan against Helicobacter pylori infection in Mongolian gerbils. Helicobacter 2003; 8: 59-65.