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Volumn 160, Issue 4, 2003, Pages 467-477

Wortmannin-enhanced X-ray-induced apoptosis of human T-cell leukemia MOLT-4 cells possibly through the JNK/SAPK pathway

Author keywords

[No Author keywords available]

Indexed keywords

ACETIC ACID DERIVATIVE; ATM PROTEIN; BENZYLOXYCARBONYLPHENYLALANYLALANYL FLUOROMETHYL KETONE; CASPASE INHIBITOR; CERAMIDE; INHIBITOR OF APOPTOSIS PROTEIN; JANUS KINASE; LIPOCORTIN 5; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BCL 2; PROTEIN KINASE B; PROTEIN P21; PROTEIN P53; SERINE; STRESS ACTIVATED PROTEIN KINASE; WORTMANNIN;

EID: 0141652967     PISSN: 00337587     EISSN: None     Source Type: Journal    
DOI: 10.1667/RR3055     Document Type: Article
Times cited : (14)

References (44)
  • 1
    • 0015394127 scopus 로고
    • Rosette-forming human lymphoid cell lines. 1. Establishment and evidence for origin of thymus-derived lymphocytes
    • J. Minowada, T. Ohmura and G. E. Moore, Rosette-forming human lymphoid cell lines. 1. Establishment and evidence for origin of thymus-derived lymphocytes. J. Natl. Cancer Inst. 49, 891-895 (1972).
    • (1972) J. Natl. Cancer Inst. , vol.49 , pp. 891-895
    • Minowada, J.1    Ohmura, T.2    Moore, G.E.3
  • 2
    • 0027437289 scopus 로고
    • Interphase death and reproductive death in X-irradiated MOLT-4 cells
    • K. Shinohara and H. Nakano, Interphase death and reproductive death in X-irradiated MOLT-4 cells. Radiat. Res. 135, 197-205 (1993).
    • (1993) Radiat. Res. , vol.135 , pp. 197-205
    • Shinohara, K.1    Nakano, H.2
  • 3
    • 0031590004 scopus 로고    scopus 로고
    • A possible mechanism for hyperthermic radiosensitization mediated through hyperthermic lability of Ku subunits in DNA-dependent protein kinase
    • Y. Matsumoto, N. Suzuki, K. Sakai, A. Morimatsu, K. Hirano and H. Murofushi, A possible mechanism for hyperthermic radiosensitization mediated through hyperthermic lability of Ku subunits in DNA-dependent protein kinase. Biochem. Biophys. Res. Commun. 234, 568-572 (1997).
    • (1997) Biochem. Biophys. Res. Commun. , vol.234 , pp. 568-572
    • Matsumoto, Y.1    Suzuki, N.2    Sakai, K.3    Morimatsu, A.4    Hirano, K.5    Murofushi, H.6
  • 4
    • 0033022344 scopus 로고    scopus 로고
    • Correlation between unirradiated cell TP53 protein levels and radiosensitivity in MOLT-4 cells
    • H. Nakano and K. Shinohara, Correlation between unirradiated cell TP53 protein levels and radiosensitivity in MOLT-4 cells. Radiat. Res. 151, 686-693 (1999).
    • (1999) Radiat. Res. , vol.151 , pp. 686-693
    • Nakano, H.1    Shinohara, K.2
  • 6
    • 0034736121 scopus 로고    scopus 로고
    • p41 as a possible marker for cell death is generated by caspase cleavage of p42/SETβ in irradiated MOLT-4 cells
    • A. Morita, N. Suzuki, Y. Matsumoto, K. Hirano, A. Enomoto, J. Zhu and K. Sakai, p41 as a possible marker for cell death is generated by caspase cleavage of p42/SETβ in irradiated MOLT-4 cells. Biochem. Biophys. Res. Commun. 278, 627-632 (2000).
    • (2000) Biochem. Biophys. Res. Commun. , vol.278 , pp. 627-632
    • Morita, A.1    Suzuki, N.2    Matsumoto, Y.3    Hirano, K.4    Enomoto, A.5    Zhu, J.6    Sakai, K.7
  • 7
    • 0034738785 scopus 로고    scopus 로고
    • Involvement of SAPK/JNK pathway in X-ray-induced rapid cell death of human T-cell leukemia cell line MOLT-4
    • A. Enomoto, N. Suzuki, K. Hirano, Y. Matsumoto, A. Morita, K. Sakai and H. Koyama, Involvement of SAPK/JNK pathway in X-ray-induced rapid cell death of human T-cell leukemia cell line MOLT-4. Cancer Lett. 155, 137-144 (2000).
    • (2000) Cancer Lett. , vol.155 , pp. 137-144
    • Enomoto, A.1    Suzuki, N.2    Hirano, K.3    Matsumoto, Y.4    Morita, A.5    Sakai, K.6    Koyama, H.7
  • 8
    • 0034200369 scopus 로고    scopus 로고
    • Sensitization by wortmannin of heat- or X-ray-induced cell death in cultured Chinese hamster V79 cells
    • M. Tomita, N. Suzuki, Y. Matsumoto, K. Hirano, N. Umeda and K. Sakai, Sensitization by wortmannin of heat- or X-ray-induced cell death in cultured Chinese hamster V79 cells. J. Radiat. Res. 41, 93-102 (2000).
    • (2000) J. Radiat. Res. , vol.41 , pp. 93-102
    • Tomita, M.1    Suzuki, N.2    Matsumoto, Y.3    Hirano, K.4    Umeda, N.5    Sakai, K.6
  • 9
    • 0030066023 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-kinase inhibitor wortmannin sensitizes murine fibroblasts and human tumor cells to radiation and blocks induction of p 53 following DNA damage
    • B. D. Price and M. B. Youmell, The phosphatidylinositol 3-kinase inhibitor wortmannin sensitizes murine fibroblasts and human tumor cells to radiation and blocks induction of p53 following DNA damage. Cancer Res. 56, 246-250 (1996).
    • (1996) Cancer Res. , vol.56 , pp. 246-250
    • Price, B.D.1    Youmell, M.B.2
  • 10
    • 0029803485 scopus 로고    scopus 로고
    • Wortmannin is a potent inhibitor of DNA double strand break but not single strand break repair in Chinese hamster ovary cells
    • S. Boulton, S. Kyle, L. Yalcintepe and B. W. Durkacz, Wortmannin is a potent inhibitor of DNA double strand break but not single strand break repair in Chinese hamster ovary cells. Carcinogenesis 17, 2285-2290 (1996).
    • (1996) Carcinogenesis , vol.17 , pp. 2285-2290
    • Boulton, S.1    Kyle, S.2    Yalcintepe, L.3    Durkacz, B.W.4
  • 12
    • 0031925138 scopus 로고    scopus 로고
    • Wortmannin inhibits repair of DNA double-strand breaks in irradiated normal human cells
    • R. Okayasu, K. Suetomi and R. L. Ullrich, Wortmannin inhibits repair of DNA double-strand breaks in irradiated normal human cells. Radiat. Res. 149, 440-445 (1998).
    • (1998) Radiat. Res. , vol.149 , pp. 440-445
    • Okayasu, R.1    Suetomi, K.2    Ullrich, R.L.3
  • 13
    • 0031765340 scopus 로고    scopus 로고
    • A phosphatidylinositol 3-kinase inhibitor wortmannin induces radioresistant DNA synthesis and sensitizes cells to bleomycin and ionizing radiation
    • Y. Hosoi, H. Miyachi, Y. Matsumoto, H. Ikehata, J. Komura, K. Ishii, H-J. Zhao, M. Yoshida, Y. Takai and T. Ono, A phosphatidylinositol 3-kinase inhibitor wortmannin induces radioresistant DNA synthesis and sensitizes cells to bleomycin and ionizing radiation. Int. J. Cancer. 78, 642-647 (1998).
    • (1998) Int. J. Cancer. , vol.78 , pp. 642-647
    • Hosoi, Y.1    Miyachi, H.2    Matsumoto, Y.3    Ikehata, H.4    Komura, J.5    Ishii, K.6    Zhao, H.-J.7    Yoshida, M.8    Takai, Y.9    Ono, T.10
  • 14
    • 0032189483 scopus 로고    scopus 로고
    • Inhibition of phosphoinositide 3-kinase related kinases by the radiosensitizing agent wortmannin
    • J. N. Sarkaria, R. S. Tibbetts, E. C. Busby, A. P. Kennedy, D. E. Hill and R. T. Abraham, Inhibition of phosphoinositide 3-kinase related kinases by the radiosensitizing agent wortmannin. Cancer Res. 58, 4375-4382 (1998).
    • (1998) Cancer Res. , vol.58 , pp. 4375-4382
    • Sarkaria, J.N.1    Tibbetts, R.S.2    Busby, E.C.3    Kennedy, A.P.4    Hill, D.E.5    Abraham, R.T.6
  • 15
    • 0032916940 scopus 로고    scopus 로고
    • Wortmannin sensitizes mammalian cells to radiation by inhibiting the DNA-dependent protein kinase-mediated rejoining of double-strand breaks
    • S. B. Chernikova, R. L. Wells and M. M. Elkind, Wortmannin sensitizes mammalian cells to radiation by inhibiting the DNA-dependent protein kinase-mediated rejoining of double-strand breaks. Radiat. Res. 151, 159-166 (1999).
    • (1999) Radiat. Res. , vol.151 , pp. 159-166
    • Chernikova, S.B.1    Wells, R.L.2    Elkind, M.M.3
  • 16
    • 2642689658 scopus 로고    scopus 로고
    • Proteases to die for
    • V. Cryns and J. Yuan, Proteases to die for. Genes Dev. 12, 1551-1570 (1998).
    • (1998) Genes Dev. , vol.12 , pp. 1551-1570
    • Cryns, V.1    Yuan, J.2
  • 17
    • 0033179760 scopus 로고    scopus 로고
    • BCL-2 family members and the mitochondria in apoptosis
    • A. Gross, J. M. McDonnell and S. J. Korsmeyer, BCL-2 family members and the mitochondria in apoptosis. Genes Dev. 13, 1899-1911 (1999).
    • (1999) Genes Dev. , vol.13 , pp. 1899-1911
    • Gross, A.1    McDonnell, J.M.2    Korsmeyer, S.J.3
  • 20
    • 0032752063 scopus 로고    scopus 로고
    • Cellular survival: A play in three Akts
    • S. R. Datta, A. Brunet and M. E. Greenberg, Cellular survival: a play in three Akts. Genes Dev. 13, 2905-2927 (1999).
    • (1999) Genes Dev. , vol.13 , pp. 2905-2927
    • Datta, S.R.1    Brunet, A.2    Greenberg, M.E.3
  • 21
    • 0033021253 scopus 로고    scopus 로고
    • Attenuation of caspase-3-dependent apoptosis by Trolox post-treatment of X-irradiated MOLT-4 cells
    • O. Inanami, K. Takahashi and M. Kuwabara, Attenuation of caspase-3-dependent apoptosis by Trolox post-treatment of X-irradiated MOLT-4 cells. Int. J. Radiat. Biol. 75, 155-163 (1999).
    • (1999) Int. J. Radiat. Biol. , vol.75 , pp. 155-163
    • Inanami, O.1    Takahashi, K.2    Kuwabara, M.3
  • 22
    • 0033856462 scopus 로고    scopus 로고
    • PI3-kinase inhibition: A target for drug development?
    • R. C. Stein and M. D. Waterfield, PI3-kinase inhibition: a target for drug development? Mol. Med. Today 6, 347-357 (2000).
    • (2000) Mol. Med. Today , vol.6 , pp. 347-357
    • Stein, R.C.1    Waterfield, M.D.2
  • 24
    • 0035815701 scopus 로고    scopus 로고
    • Activation of the phosphatidylinositol 3-kinase/Akt pathway protects against interleukin-3 starvation but not DNA damage-induced cell death
    • A-L. Mathieu, S. Gonin, Y. Leverrier, B. Blanquier, J. Thomas, C. Dantin, G. Martin, G. Baverel and J. Marvel, Activation of the phosphatidylinositol 3-kinase/Akt pathway protects against interleukin-3 starvation but not DNA damage-induced cell death. J. Biol. Chem. 276, 10935-10942 (2001).
    • (2001) J. Biol. Chem. , vol.276 , pp. 10935-10942
    • Mathieu, A.-L.1    Gonin, S.2    Leverrier, Y.3    Blanquier, B.4    Thomas, J.5    Dantin, C.6    Martin, G.7    Baverel, G.8    Marvel, J.9
  • 25
    • 0037134431 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-kinase (PI3K)-Akt pathway suppresses Bax translocation to mitochondria
    • F. Tsuruta, N. Masuyama and Y. Gotoh, The phosphatidylinositol 3-kinase (PI3K)-Akt pathway suppresses Bax translocation to mitochondria. J. Biol. Chem. 277, 14040-14047 (2002).
    • (2002) J. Biol. Chem. , vol.277 , pp. 14040-14047
    • Tsuruta, F.1    Masuyama, N.2    Gotoh, Y.3
  • 26
    • 0034672378 scopus 로고    scopus 로고
    • Akt negatively regulates the cJun N-terminal kinase pathway in PC 12 cells
    • V. Levresse, L. Butterfield, E. Zentrich and L. E. Heasley, Akt negatively regulates the cJun N-terminal kinase pathway in PC12 cells. J. Neurosci. Res. 62, 799-808 (2000).
    • (2000) J. Neurosci. Res. , vol.62 , pp. 799-808
    • Levresse, V.1    Butterfield, L.2    Zentrich, E.3    Heasley, L.E.4
  • 27
    • 0034803529 scopus 로고    scopus 로고
    • Evaluation of the relative contribution of p53-mediated pathway in X-ray-induced apoptosis in human leukemic MOLT- 4 cells by transfection with a mutant p53 gene at different expression levels
    • H. Nakano, M. Kohara and K. Shinohara, Evaluation of the relative contribution of p53-mediated pathway in X-ray-induced apoptosis in human leukemic MOLT-4 cells by transfection with a mutant p53 gene at different expression levels. Cell Tissue Res. 306, 101-106 (2001).
    • (2001) Cell Tissue Res. , vol.306 , pp. 101-106
    • Nakano, H.1    Kohara, M.2    Shinohara, K.3
  • 28
    • 0033212125 scopus 로고    scopus 로고
    • ATM: The protein encoded by the gene mutated in the radiosensitive syndrome ataxia-telangiectasia
    • M. F. Lavin and K. K. Khanna, ATM: The protein encoded by the gene mutated in the radiosensitive syndrome ataxia-telangiectasia. Int. J. Radiat. Biol. 75, 1201-1214 (1999).
    • (1999) Int. J. Radiat. Biol. , vol.75 , pp. 1201-1214
    • Lavin, M.F.1    Khanna, K.K.2
  • 29
    • 0033088948 scopus 로고    scopus 로고
    • Effects of protein kinase inhibitors on the accumulation kinetics of p53 protein in normal human embryo cells following X-irradiation
    • J. C. Ghosh, K. Suzuki, S. Kodama and M. Watanabe, Effects of protein kinase inhibitors on the accumulation kinetics of p53 protein in normal human embryo cells following X-irradiation. J. Radiat. Res. 40, 23-37 (1999).
    • (1999) J. Radiat. Res. , vol.40 , pp. 23-37
    • Ghosh, J.C.1    Suzuki, K.2    Kodama, S.3    Watanabe, M.4
  • 30
    • 0032054723 scopus 로고    scopus 로고
    • Signal transduction by the c-Jun N-terminal kinase (JNK)-from inflammation to development
    • Y. T. Ip and R. J. Davis, Signal transduction by the c-Jun N-terminal kinase (JNK)-from inflammation to development. Curr. Opin. Cell. Biol. 10, 205-219 (1998).
    • (1998) Curr. Opin. Cell. Biol. , vol.10 , pp. 205-219
    • Ip, Y.T.1    Davis, R.J.2
  • 31
    • 0034644522 scopus 로고    scopus 로고
    • Signal transduction by the JNK group of MAP kinases
    • R. J. Davis, Signal transduction by the JNK group of MAP kinases. Cell 103, 239-252 (2000).
    • (2000) Cell , vol.103 , pp. 239-252
    • Davis, R.J.1
  • 33
    • 0028880649 scopus 로고
    • Ataxia-telangiectasia and cellular responses to DNA damage
    • M. S. Meyn, Ataxia-telangiectasia and cellular responses to DNA damage. Cancer Res. 55, 5991-6001 (1995).
    • (1995) Cancer Res. , vol.55 , pp. 5991-6001
    • Meyn, M.S.1
  • 34
    • 0029987944 scopus 로고    scopus 로고
    • Deregulated apoptosis in ataxia telangiectasia: Association with clinical stigmata and radiosensitivity
    • E. Duchanud, A. Ridet, D. Stoppa-Lyonnet, N. Janin, E. Moustacchi and F. Rosselli, Deregulated apoptosis in ataxia telangiectasia: Association with clinical stigmata and radiosensitivity. Cancer Res. 56, 1400-1404 (1996).
    • (1996) Cancer Res. , vol.56 , pp. 1400-1404
    • Duchanud, E.1    Ridet, A.2    Stoppa-Lyonnet, D.3    Janin, N.4    Moustacchi, E.5    Rosselli, F.6
  • 35
    • 0029134790 scopus 로고
    • Defective induction of stress-activated protein kinase activity in ataxia-telangiectasia cells exposed to ionizing radiation
    • T. D. Shafman, A. Saleem, J. Kyriakis, R. Weichselbaum, S. Kharbanda and D. W. Kufe, Defective induction of stress-activated protein kinase activity in ataxia-telangiectasia cells exposed to ionizing radiation. Cancer Res. 55, 3242-3245 (1995).
    • (1995) Cancer Res. , vol.55 , pp. 3242-3245
    • Shafman, T.D.1    Saleem, A.2    Kyriakis, J.3    Weichselbaum, R.4    Kharbanda, S.5    Kufe, D.W.6
  • 36
    • 0032443366 scopus 로고    scopus 로고
    • Determination of cell fate by c-Abl activation in the response to DNA damage
    • S. Kharbanda, Z-M. Yuan, R. Weichselbaum and D. Kufe, Determination of cell fate by c-Abl activation in the response to DNA damage. Oncogene 17, 3309-3318 (1998).
    • (1998) Oncogene , vol.17 , pp. 3309-3318
    • Kharbanda, S.1    Yuan, Z.-M.2    Weichselbaum, R.3    Kufe, D.4
  • 39
    • 0032411879 scopus 로고    scopus 로고
    • Stress signals for apoptosis: Ceramide and c-Jun kinase
    • S. Basu and R. Kolesnick, Stress signals for apoptosis: ceramide and c-Jun kinase. Oncogene 17, 3277-3285 (1998).
    • (1998) Oncogene , vol.17 , pp. 3277-3285
    • Basu, S.1    Kolesnick, R.2
  • 44
    • 0035927536 scopus 로고    scopus 로고
    • Variations in Prkdc encoding the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) and susceptibility to radiation-induced apoptosis and lymphomagenesis
    • N. Mori, Y. Matsumoto, M. Okumoto, N. Suzuki and J. Yamate, Variations in Prkdc encoding the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) and susceptibility to radiation-induced apoptosis and lymphomagenesis. Oncogene 20, 3609-3619 (2001).
    • (2001) Oncogene , vol.20 , pp. 3609-3619
    • Mori, N.1    Matsumoto, Y.2    Okumoto, M.3    Suzuki, N.4    Yamate, J.5


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