Synthesis and cellular profiling of diverse organosilicon small molecules

Journal of the American Chemical Society

Volumn 129, Issue 5, 2007, Pages 1020-1021

  Franz, Annaliese K ^a   Dreyfuss, Philip D ^a   Schreiber, Stuart L ^a  

^a HARVARD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ORGANOSILICON DERIVATIVE;

ARTICLE; CHEMICAL BOND; DEPROTECTION REACTION; DESILYLATION; PROTON NUCLEAR MAGNETIC RESONANCE; REACTION ANALYSIS; STEREOCHEMISTRY; SYNTHESIS; X RAY CRYSTALLOGRAPHY;

COMBINATORIAL CHEMISTRY TECHNIQUES; CRYSTALLOGRAPHY, X-RAY; ISATIN; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, CHEMICAL; ORGANOSILICON COMPOUNDS; SILANES; STEREOISOMERISM; SURFACE PROPERTIES;

EID: 33846842437     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja067552n     Document Type: Article

References (20)

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16. Screening was performed at the Broad Institute Chemical Biology Screening Platform with duplicate experiments and mock treatment (DMSO) control wells to determine the statistical significance of the measurements. Refer to Figure S-1 and Table S-1 in the Supporting Information for a summary of assay type and related disease biology.
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18. (b) Data visualization was performed using DecisionSite 8.2; Spotfire. Inc.: Somerville, MA.
19. Refer to Figures S-3 and S-4 in the Supporting Information.
20. Preliminary studies indicate that conversion of the arylsilane affords compounds with reduced activity for the assays described here.