Identification of metabolite profiles of the catechol-O-methyl transferase inhibitor tolcapone in rat urine using LC/MS-based metabonomics analysis

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 877, Issue 24, 2009, Pages 2557-2565

  Sun, Jinchun ^a   Von Tungeln, Linda S ^b   Hines, Wade ^c   Beger, Richard D ^a  

^a NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

^b CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^c BG Medicine Inc   (United States)

Author keywords

Metabolite metabolism; Metabonomics; Tolcapone; UPLC MS; Urine

Indexed keywords

METABOLITE/METABOLISM; METABONOMICS; TOLCAPONE; UPLC/MS; URINE;

BIOMOLECULES; BODY FLUIDS; DISEASES; ENZYMES; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LABELS; MASS SPECTROMETERS; MASS SPECTROMETRY; METABOLITES; MULTIVARIANT ANALYSIS; RADIOACTIVITY; TOXICITY;

METABOLISM;

DRUG METABOLITE; RADIOACTIVE MATERIAL; RADIOISOTOPE; TOLCAPONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG COST; DRUG DETERMINATION; DRUG IDENTIFICATION; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IONIZATION; MALE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PARKINSON DISEASE; PRIORITY JOURNAL; RAT; TANDEM MASS SPECTROMETRY; URINALYSIS;

ANIMALS; BENZOPHENONES; CATECHOL O-METHYLTRANSFERASE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ENZYME INHIBITORS; FEMALE; MALE; MASS SPECTROMETRY; METABOLOMICS; NITROPHENOLS; RATS; RATS, SPRAGUE-DAWLEY;

RATTUS;

EID: 67650726440     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2009.06.033     Document Type: Article

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