Inhibition of radiation-induced DNA damage in plasmid pBR322 by chlorophyllin and possible mechanism(s) of action

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 425, Issue 1, 1999, Pages 71-79

  Kumar, S Santosh ^a   Chaubey, R C ^a   Devasagayam, T P A ^a   Priyadarsini, K I ^a   Chauhan, P S ^a  

^a BHABHA ATOMIC RESEARCH CENTRE   (India)

Author keywords

Chlorophyllin; DNA damage; Free radical; Gamma radiation; Natural antioxidant; Plasmid DNA; Pulse radiolysis

Indexed keywords

CHLOROPHYLL;

ARTICLE; DNA DAMAGE; DNA STRAND BREAKAGE; DOSE RESPONSE; GAMMA IRRADIATION; IN VITRO STUDY; PLASMID; PRIORITY JOURNAL; RADIATION PROTECTION;

ANTIMUTAGENIC AGENTS; CHLOROPHYLLIDES; DNA; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, RADIATION; GAMMA RAYS; PLASMIDS; RADIATION-PROTECTIVE AGENTS;

EID: 0032992167     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0027-5107(98)00250-4     Document Type: Article

References (41)

1. Ames B.N., Shigenaga M.K., Hagen T.M. Oxidants, antioxidants, and the degenerative diseases of ageing. Proc. Natl. Acad. Sci. USA. 90:1993;7915-7922.
2. Stavric B. Antimutagens and anticarcinogens in foods. Food Chem. Toxicol. 32:1994;79-90. (Review).
3. P.S. Chauhan, H.N. Bhilwade, R.C. Chaubey, M. Aravindakshan, Diet as a source of inhibitors of mutagenesis, in: M.L. Mendelsohn, R.S. Albertins (Eds.), Genotoxicity, Risk and Modulation, Wiley, New York, 1990, pp. 339-349.
4. Ito N., Hirose M. Antioxidants: carcinogenic and chemopreventive properties. Adv. Cancer Res. 53:1989;247-302.
5. C. Von Sonntag, The Chemical Basis of Radiation Biology, Taylor and Francis, London, 1987.
6. Ong T.M., Whong W.Z., Stewart J., Brockman H.E. Comparative antimutagenicity of 5 compounds against 5 mutagenic complex mixtures in Salmonella typhimurium strain TA98. Mutat. Res. 222:1989;19-25.
7. Arimoto S., Fukuoka S., Itome C., Nakano H., Rai H., Hayatsu H. Binding of polycyclic planar mutagens to chlorophyllin resulting in inhibition of the mutagenic activity. Mutat. Res. 287:1993;293-305.
8. Waters M.D., Stack H.E., Jackson M.A., Brockman H.E., De Flora S. Activity profiles of antimutagens: in vitro and in vivo data. Mutat. Res. 350:1996;109-129.
9. Tachino N., Guo D., Dashwood W.M., Yamane S., Larsen R., Dashwood R. Mechanisms of the in vitro antimutagenic action of chlorophyllin against benz(α)pyrene: studies of enzyme inhibition, molecular complex formation and degradation of the ultimate carcinogen. Mutat. Res. 308:1994;191-203.
10. Okai Y., Higashiokai K., Yano Y., Otani S. Suppressive effects of chlorophyllin on mutagen-induced umuC gene expression in Salmonella typhimurium (TA 1535/pSK 1002) and tumor promoter-dependent ornithine decarboxylase induction in BALB/c 3T3 fibroblast cells. Mutat. Res. 370:1996;11-17.
11. Te C., Gentile J.M., Baguley B.C., Pearson A.E., Gregory T., Ferguson L.R. In vivo effects of chlorophyllin on the antitumor agent cyclophosphamide. Int. J. Cancer. 70:1997;84-89.
12. Dashwood R., Guo D. Antimutagenic potency of chlorophyllin in the Salmonella assay and its correlation with binding constants of mutagen-inhibitor complexes. Environ. Mol. Mutagen. 22:1993;164-171.
13. 1: a review of antimutagenicity and anticarcinogenicity data in rainbow trout. Mutat. Res. 399:1998;245-253.
14. Negishi T., Arimoto S., Nishizaki C., Hayatsu H. Inhibitory effect of chlorophyll on the genotoxicity of 3-amino-1-methyl-5H-pyrido[4,3-b]indole (Trp-P-2). Carcinogenesis. 10:1989;145-149.
15. Zimmering S., Olvera O., Hernandez M.E., Cruces M.P., Arceo C., Pimentel E. Evidence for radioprotective effect of chlorophyllin in Drosophila. Mutat. Res. 245:1990;47-49.
16. Abraham S.K., Sarma L., Kesavan P.C. Role of chlorophyllin as an in vivo anticlastogen: protection against gamma-radiation and chemical clastogens. Mutat. Res. 322:1994;209-212.
17. Morales-Ramirez P., Garcia-Rodriguez M.C. In vivo effect of chlorophyllin on γ-ray-induced sister chromatid exchanges in murine bone marrow cells. Mutat. Res. 320:1994;329-334.
18. Morales-Ramirez P., Mendiola-Cruz M.T. In vivo radioprotective effect of chlorophyllin on sister chromatid exchange induction in murine spermatogonial cells. Mutat. Res. 344:1995;73-78.
19. Morales-Ramirez P., Vallarino-Kelley T., Rodriguez-Reyes R. Effect of chlorophyllin on gamma-ray induced micronuclei in polychromatic erythrocytes of murine peripheral blood determined by the ABC strategy. Mutat. Res. 367:1996;51-56.
20. Sato M., Imai K., Kimura R., Murata T. Effect of sodium copper chlorophyllin on lipid peroxidation: VI. Effect of its administration on mitochondrial and microsomal lipid peroxidation in rat liver. Chem. Pharm. Bull. 32:1984;716-722.
21. Sato M., Fujimoto I., Toshimori S., Tachio A., Ryohei K., Murata T. Effect of sodium copper chlorophyllin on lipid peroxidation: IX. On the antioxidative components in commercial preparations of sodium copper chlorophyllin. Chem. Pharm. Bull. 34:1986;2428-2434.
22. Ramel C., Alekperov U.K., Ames B.N., Kada T., Wattenberg L.W. Inhibitors of mutagenesis and their relevance to carcinogenesis. Mutat. Res. 168:1986;47-65.
23. Devasagayam T.P.A., Subramanian M., Singh B.B., Ramanathan R., Das N.P. Protection of plasmid pBR322 DNA by flavonoids against single-strand breaks induced by singlet molecular oxygen. J. Photochem. Photobiol. B: Biol. 30:1995;97-103.
24. Devasagayam T.P.A., Kamat J.P., Mohan H., Kesavan P.C. Caffeine as an antioxidant: inhibition of lipid peroxidation induced by reactive oxygen species. Biochim. Biophys. Acta. 1282:1996;63-70.
25. Cynshi O., Takashima Y., Katoh Y., Tamura K., Sato M., Fujita Y. Action of phenolic antioxidants on various active oxygen species. J. Biolumin. Chemilumin. 10:1995;261-269.
26. Salgo M.G., Bermudez E., Squadrito G.L., Pryor W.A. DNA damage and oxidation of thiols peroxynitrite causes in rat thymocytes. Arch. Biochem. Biophys. 322:1995;500-505.
27. Di Mascio P., Wefers H., Do-Thi H.-P., Lafleur M.V.M., Sies H. Singlet molecular oxygen causes loss of biological activity in plasmid and bacteriophage DNA and induces single-strand breaks. Biochim. Biophys. Acta. 1007:1989;151-157.
28. Schneider J.E., Price S., Maidt L., Gutteridge J.M.C., Floyd R.A. Methylene blue plus light mediates 8-hydroxy 2′-deoxyguanosine formation in DNA preferentially over strand breakage. Nucleic Acids Res. 18:1990;631-635.
29. P. O'Neill, E.M. Fielden, Primary Free Radical Processes in DNA: Advances in Radiation Biology, Academic Press, 1993, pp. 53-120.
30. Das T.N., Priyadarsini K.I. Characterization of transients produced in aqueous medium by pulse radiolytic oxidation of 3,5-diiodotyrosine. J. Phys. Chem. 98:1994;5272-5278.
31. Milligan J.R., Aguilera J.A., Ward J.F. Variation of single-strand break yield with scavenger concentration for plasmid DNA irradiated in aqueous solution. Radiat. Res. 133:1993;151-157.
32. Sies H., Stahl W., Sundquist A.R. Antioxidant functions of vitamins, Vitamin E and C, beta-carotene, and other carotenoids. Ann. New York Acad. Sci. 669:1992;7-20.
33. Odin A.P. Vitamins as antimutagens: advantages and some possible mechanisms of antimutagenic action. Mutat. Res. 386:1997;39-67.
34. Takaba K., Hirose M., Yoshida Y., Kimura J., Ito N., Shirai T. Effects of n-tritriacontane-16,18-dione, curcumin, chlorophyllin, dihydroguaiaretic acid, tannic acid and phytic acid on the initiation stage in a rat multi-organ carcinogenesis model. Cancer Lett. 113:1997;39-46.
35. Greenstock C.L. Radiation and ageing: free radical damage, biological response and possible antioxidant intervention. Med. Hypotheses. 41:1993;473-482.
36. Hasegawa R., Hirose M., Kato T., Hagiwara A., Boonyaphiphat P., Nagao M., Ito N., Shirai T. Inhibitory effect of chlorophyllin on PhIP-induced mammary carcinogenesis in female F344 rats. Carcinogenesis. 16:1995;2243-2246.
37. 1 hepatocarcinogenesis in rainbow trout. Cancer Res. 55:1995;57-62.
38. Surh Y.J., Park K.K., Shlyankevich M. Inhibitory effects of chlorophyllin on chemically induced mutagenesis and carcinogenesis. Ann. New York Acad. Sci. 768:1995;246-249.
39. Yun C.H., Jeong H.G., Jhuon J.W., Guengerich F.P. Non-specific inhibition of cytochrome P450 activities by chlorophyllin in human and rat liver microsomes. Carcinogenesis. 16:1995;1437-1440.
40. Dashwood R., Guo D. Inhibition of 2-amino-3-methylimidizo[4,5-f]quinoline (IQ)-DNA binding by chlorophyllin: studies of enzyme inhibition and molecular complex formation. Carcinogenesis. 13:1992;1121-1126.
41. Buxton G.V., Greenstock C.L., Helman W.P., Ross A.B. Critical review of rate constants for reactions of hydrated electrons, hydrogen atoms and hydroxyl radicals (OH/O ) in aqueous solution J. Phys. Chem. 17:1988;513-886.