Leptin intake during the suckling period improves the metabolic response of adipose tissue to a high-fat diet

International Journal of Obesity

Volumn 34, Issue 5, 2010, Pages 809-819

  Priego, T ^a,b   Sanchez J ^a,b   Palou, A ^a,b   Pico C ^a,b  

^a UNIVERSITAT DE LES ILLES BALEARS   (Spain)

^b Instituto de Salud Carlos III   (Spain)

Author keywords

Adipose tissue; Lactation; Leptin; Metabolic imprinting; OB Rb

Indexed keywords

CARNITINE PALMITOYLTRANSFERASE I; CD36 ANTIGEN; GLUCOSE TRANSPORTER 4; LEPTIN; LEPTIN RECEPTOR; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROTEIN; UNCOUPLING PROTEIN 3; FAT INTAKE; FATTY ACID; ION CHANNEL; MITOCHONDRIAL PROTEIN; MITOCHONDRIAL UNCOUPLING PROTEIN 3; SLC2A4 PROTEIN, RAT;

ADIPOSE TISSUE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIET SUPPLEMENTATION; ENERGY METABOLISM; FATTY ACID OXIDATION; FOOD INTAKE; GENE EXPRESSION; INGUINAL REGION; LIPID DIET; LIPID METABOLISM; LIPOGENESIS; LIVER METABOLISM; MALE; MESENTERY; NONHUMAN; PRIORITY JOURNAL; RAT; RETROPERITONEUM; SUCKLING; WEANING; ADMINISTRATION AND DOSAGE; ANIMAL; BODY WEIGHT; DRUG EFFECTS; FAT INTAKE; GENE EXPRESSION REGULATION; METABOLISM; PHYSIOLOGY; SUCKLING ANIMAL; WESTERN BLOTTING; WISTAR RAT;

ADIPOSE TISSUE; ANIMALS; ANIMALS, SUCKLING; ANTIGENS, CD36; BLOTTING, WESTERN; BODY WEIGHT; DIETARY FATS; ENERGY METABOLISM; FATTY ACIDS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GLUCOSE TRANSPORTER TYPE 4; ION CHANNELS; LEPTIN; MALE; MITOCHONDRIAL PROTEINS; PPAR ALPHA; PPAR GAMMA; RATS; RATS, WISTAR; RECEPTORS, LEPTIN; RNA, MESSENGER; WEANING;

ANIMALIA; RATTUS;

EID: 77952292093     PISSN: 03070565     EISSN: 14765497     Source Type: Journal    
DOI: 10.1038/ijo.2010.18     Document Type: Article

References (49)

1. Ahima RS, Flier JS. Leptin. Annu Rev Physiol 2000; 62: 413-437.
2. Ostlund Jr RE, Yang JW, Klein S, Gingerich R. Relation between plasma leptin concentration and body fat, gender, diet, age, and metabolic covariates. J Clin Endocrinol Metab 1996; 81: 3909-3913. (Pubitemid 26380395)
3. Margetic S, Gazzola C, Pegg GG, Hill RA. Leptin: a review of its peripheral actions and interactions. Int J Obes Relat Metab Disord 2002; 26: 1407-1433. (Pubitemid 36007818)
4. Tartaglia LA. The leptin receptor. J Biol Chem 1997; 272: 6093-6096.
5. Fruhbeck G. Intracellular signalling pathways activated by leptin. Biochem J 2006; 393: 7-20. (Pubitemid 43049298)
6. Baskin DG, Seeley RJ, Kuijper JL, Lok S, Weigle DS, Erickson JC et al. Increased expression of mRNA for the long form of the leptin receptor in the hypothalamus is associated with leptin hypersensitivity and fasting. Diabetes 1998; 47: 538-543. (Pubitemid 28160442)
7. Sweeney G. Leptin signalling. Cell Signal 2002; 14: 655-663. (Pubitemid 34518619)
8. Ceddia RB. Direct metabolic regulation in skeletal muscle and fat tissue by leptin: implications for glucose and fatty acids homeo-stasis. Int J Obes (London) 2005; 29: 1175-1183.
9. Orci L, Cook WS, Ravazzola M, Wang MY, Park BH, Montesano R et al. Rapid transformation of white adipocytes into fat-oxidizing machines. Proc Natl Acad Sci USA 2004; 101: 2058-2063. (Pubitemid 38229014)
10. Zhang W, Della-Fera MA, Hartzell DL, Hausman D, Baile CA. Adipose tissue gene expression profiles in ob/ob mice treated with leptin. Life Sci 2008; 83: 35-42.
11. Huan JN, Li J, Han Y, Chen K, Wu N, Zhao AZ. Adipocyte-selective reduction of the leptin receptors induced by antisense RNA leads to increased adiposity, dyslipidemia, and insulin resistance. J Biol Chem 2003; 278: 45638-45650. (Pubitemid 37432706)
12. Wang MY, Orci L, Ravazzola M, Unger RH. Fat storage in adipocytes requires inactivation of leptin's paracrine activity: implications for treatment of human obesity. Proc Natl Acad Sci USA 2005; 102: 18011-18016. (Pubitemid 41798493)
13. Bouret SG, Draper SJ, Simerly RB. Trophic action of leptin on hypothalamic neurons that regulate feeding. Science 2004; 304: 108-110.
14. Udagawa J, Hashimoto R, Hioki K, Otani H. The role of leptin in the development of the cortical neuron in mouse embryos. Brain Res 2006; 1120: 74-82. (Pubitemid 44648021)
15. Simerly RB. Hypothalamic substrates of metabolic imprinting. Physiol Behav 2008; 94: 79-89.
16. Palou A, Pico C. Leptin intake during lactation prevents obesity and affects food intake and food preferences in later life. Appetite 2009; 52: 249-252.
17. Miralles O, Sanchez J, Palou A, Pico C. A physiological role of breast milk leptin in body weight control in developing infants. Obesity (Silver Spring) 2006; 14: 1371-1377. (Pubitemid 46219662)
18. Pico C, Oliver P, Sanchez J, Miralles O, Caimari A, Priego T et al. The intake of physiological doses of leptin during lactation in rats prevents obesity in later life. Int J Obes (London) 2007; 31: 1199-1209. (Pubitemid 47172621)
19. Oliver P, Pico C, De Matteis R, Cinti S, Palou A. Perinatal expression of leptin in rat stomach. Dev Dyn 2002; 223: 148-154. (Pubitemid 34038807)
20. Sanchez J, Oliver P, Miralles O, Ceresi E, Pico C, Palou A. Leptin orally supplied to neonate rats is directly uptaken by the immature stomach and may regulate short-term feeding. Endocrinology 2005; 146: 2575-2582. (Pubitemid 40695560)
21. Sanchez J, Priego T, Palou M, Tobaruela A, Palou A, Pico C. Oral supplementation with physiological doses of leptin during lactation in rats improves insulin sensitivity and affects food preferences later in life. Endocrinology 2008; 149: 733-740. (Pubitemid 351159328)
22. Weiss R. Fat distribution and storage: how much, where, and how? Eur J Endocrinol 2007; 157 (Suppl 1): S39-S45. (Pubitemid 47434129)
23. Palou M, Sanchez J, Priego T, Rodriguez AM, Pico C, Palou A. Regional differences in the expression of genes involved in lipid metabolism in adipose tissue in response to short-and medium-term fasting and refeeding. J Nutr Biochem 2010; 21: 23-33.
24. Folch J, Lees M, Sloane Stanley GH. A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem 1957; 226: 497-509.
25. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976; 72: 248-254.
26. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970; 227: 680-685.
27. Fuster A, Pico C, Sanchez J, Oliver P, Zingaretti MC, Murano I et al. Effects of 6-month daily supplementation with oral beta-carotene in combination or not with benzo[a]pyrene on cell-cycle markers in the lung of ferrets. J Nutr Biochem 2008; 19: 295-304.
28. Priego T, Sanchez J, Pico C, Palou A. Sex-differential expression of metabolism-related genes in response to a high-fat diet. Obesity (Silver Spring) 2008; 16: 819-826.
29. Fruhbeck G, Aguado M, Martinez JA. In vitro lipolytic effect of leptin on mouse adipocytes: evidence for a possible autocrine/paracrine role of leptin. Biochem Biophys Res Commun 1997; 240: 590-594.
30. Siegrist-Kaiser CA, Pauli V, Juge-Aubry CE, Boss O, Pernin A, Chin WW et al. Direct effects of leptin on brown and white adipose tissue. J Clin Invest 1997; 100: 2858-2864.
31. Seron K, Corset L, Vasseur F, Boutin P, Gomez-Ambrosi J, Salvador J et al. Distinct impaired regulation of SOCS3 and long and short isoforms of the leptin receptor in visceral and subcutaneous fat of lean and obese women. Biochem Biophys Res Commun 2006; 348: 1232-1238.
32. Priego T, Sanchez J, Palou A, Pico C. Effect of high-fat diet feeding on leptin receptor expression in white adipose tissue in rats: depot-and sex-related differential response. Genes Nutr 2009; 4: 151-156.
33. Ceddia RB, William Jr WN, Lima FB, Flandin P, Curi R, Giacobino JP. Leptin stimulates uncoupling protein-2 mRNA expression and Krebs cycle activity and inhibits lipid synthesis in isolated rat white adipocytes. Eur J Biochem 2000; 267: 5952-5958.
34. Wang MY, Lee Y, Unger RH. Novel form of lipolysis induced by leptin. J Biol Chem 1999; 274: 17541-17544.
35. Palou M, Priego T, Sánchez J, Rodriguez AM, Palou A, Pico C. Gene expression patterns in visceral and subcutaneous adipose depots in rats are linked to their morphologic features. Cell Physiol Biochem 2009; 24: 547-556.
36. Dulloo AG, Seydoux J, Jacquet J. Adaptive thermogenesis and uncoupling proteins: a reappraisal of their roles in fat metabolism and energy balance. Physiol Behav 2004; 83: 587-602.
37. Despres JP. Health consequences of visceral obesity. Ann Med 2001; 33: 534-541.
38. Masuzaki H, Paterson J, Shinyama H, Morton NM, Mullins JJ, Seckl JR et al. A transgenic model of visceral obesity and the metabolic syndrome. Science 2001; 294: 2166-2170.
39. Palou A, Priego T, Pico C. Sex-dependent differences in lipid handling and the implications for obesity-linked disorders. Future Lipidology 2008; 3: 359-361.
40. Vidal-Puig AJ, Considine RV, Jimenez-Linan M, Werman A, Pories WJ, Caro JF et al. Peroxisome proliferator-activated receptor gene expression in human tissues. Effects of obesity, weight loss, and regulation by insulin and glucocorticoids. J Clin Invest 1997; 99: 2416-2422.
41. Rosen ED, Spiegelman BM. PPARgamma: a nuclear regulator of metabolism, differentiation, and cell growth. J Biol Chem 2001; 276: 37731-37734.
42. Slawik M, Vidal-Puig AJ. Lipotoxicity, overnutrition and energy metabolism in aging. Ageing Res Rev 2006; 5: 144-164.
43. Seppala-Lindroos A, Vehkavaara S, Hakkinen AM, Goto T, Westerbacka J, Sovijarvi A et al. Fat accumulation in the liver is associated with defects in insulin suppression of glucose production and serum free fatty acids independent of obesity in normal men. J Clin Endocrinol Metab 2002; 87: 3023-3028.
44. Dobrzyn A, Ntambi JM. The role of stearoyl-CoA desaturase in body weight regulation. Trends Cardiovasc Med 2004; 14: 77-81. (Pubitemid 38340851)
45. Cohen P, Miyazaki M, Socci ND, Hagge-Greenberg A, Liedtke W, Soukas AA et al. Role for stearoyl-CoA desaturase-1 in leptin-mediated weight loss. Science 2002; 297: 240-243. (Pubitemid 34761283)
46. Berti L, Kellerer M, Capp E, Haring HU. Leptin stimulates glucose transport and glycogen synthesis in C2C12 myotubes: evidence for a P13-kinase mediated effect. Diabetologia 1997; 40: 606-609.
47. Ceddia RB, William Jr WN, Curi R. Comparing effects of leptin and insulin on glucose metabolism in skeletal muscle: evidence for an effect of leptin on glucose uptake and decarboxylation. Int J Obes Relat Metab Disord 1999; 23: 75-82.
48. Dulloo AG, Stock MJ, Solinas G, Boss O, Montani JP, Seydoux J. Leptin directly stimulates thermogenesis in skeletal muscle. FEBS Lett 2002; 515: 109-113.
49. Kus V, Prazak T, Brauner P, Hensler M, Kuda O, Flachs P et al. Induction of muscle thermogenesis by high-fat diet in mice: association with obesity-resistance. Am J Physiol Endocrinol Metab 2008; 295: E356-E367.