Polyplexes Assembled with Internally Quaternized PAMAM-OH Dendrimer and Plasmid DNA Have a Neutral Surface and Gene Delivery Potency

Bioconjugate Chemistry

Volumn 14, Issue 6, 2003, Pages 1214-1221

  Lee, Jung Hoon ^a   Lim, Yong Beom ^a   Choi, Joon Sig ^a   Lee, Yan ^a   Kim, Tae Il ^a   Kim, Hyun Jin ^a   Yoon, Jae Keun ^a   Kim, Kwan ^a   Park, Jong Sang ^a  

^a Seoul National University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYLATION; DENDRIMERS; DNA; GENE TRANSFER; LIGHT SCATTERING; METHYLATION;

CATIONICS; CHARGE RATIO; GENE DELIVERY; HYDROXYL-TERMINATED; NEUTRAL SURFACES; PLASMID DNA; POLYAMIDOAMINES; POLYPLEXES; POSITIVE CHARGES; TERTIARY AMINE GROUPS;

BIOMOLECULES;

DENDRIMER; HYDROXYL GROUP; PLASMID DNA; POLYAMINE DERIVATIVE; POLYETHYLENEIMINE; POLYMER; QUATERNARY AMMONIUM DERIVATIVE; TERTIARY AMINE; VIRUS VECTOR;

ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG POTENCY; ELECTRICITY; EMBRYO CELL; HUMAN; HUMAN CELL; KIDNEY CELL; LIGHT SCATTERING; METHYLATION; NONVIRAL GENE DELIVERY SYSTEM; PARTICLE SIZE; POLYMERIZATION; ZETA POTENTIAL;

EID: 0344494597     PISSN: 10431802     EISSN: None     Source Type: Journal    
DOI: 10.1021/bc034095g     Document Type: Article

References (37)

1. Verma, I. M., and Somia, N. (1997) Gene therapy promises, problems and prospects. Nature 389 239-242.
2. Lotze, M. T., and Kost, T. A. (2002) Viruses as gene delivery vectors: application to gene function, target validation, and assay development. Cancer Gene Ther. 9, 692-699.
3. Walther, W., and Stein, U. (2000) Viral vectors for gene transfer: a review of their use in the treatment of human diseases. Drugs 60, 249-271.
4. Nishikawa, M., and Huang, L. (2001) Nonviral vectors in the new millennium: delivery barriers in gene transfer. Hum. Gene Ther. 12, 861-870.
5. Li, S., and Huang, L. (2000) Nonviral gene therapy: promises and challenges. Gene Ther. 7, 31-34.
6. Ferber, D. (2001) Gene therapy. Safer and virus-free? Science 294, 1638-1642.
7. Lehrman, S. (1999) Virus treatment questioned after gene therapy death. Nature 401, 517-518.
8. Brown, M. D., Schatzlein, A. G., and Uchegbu, I. F. (2001) Gene delivery with synthetic (non viral) carriers. Int. J. Pharm. 229, 1-21.
9. Choi, J. S., Lee, E. J., Choi, Y. H., Jeong, Y. J., and Park, J. S. (1999) Poly(ethylene glycol)-block-poly(l-lysine) Dendrimer: Novel linear polymer/dendrimer block copolymer forming a spherical water-soluble polyionic complex with DNA. Bioconjugate Chem. 10, 62-65.
10. Kim, T. I., Jang, H. S., Joo, D. K., Choi, J. S., and Park, J. S. (2003) Synthesis of diblock copolymer, methoxypoly-(ethylene golycol)-block-polyamidoamine dendrimer and its generation-depenent self-assembly with plasmid DNA. Bull. Korean Chem. Soc. 24, 123-125.
11. Boussif, O., Delair, T., Brua, C., Veron, L., Pavirani, A., and Kolbe, H. V. (1999) Synthesis of polyallylamine derivatives and their use as gene transfer vectors in vitro. Bioconjugate Chem. 10, 877-883.
12. Ahn, C. H., Chae, S. Y., Bae, Y. H., and Kim, S. W. (2002) Biodegradable poly(ethylenimine) for plasmid DNA delivery. J. Controlled Release 80, 273-282.
13. Ward, C. M., Pechar, M., Oupicky, D., Ulbrich, K., and Seymour, L. W. (2002) Modification of pLL/DNA complexes with a multivalent hydrophilic polymer permits folate-mediated targeting in vitro and prolonged plasma circulation in vivo. J. Gene Med. 4, 536-547.
14. Luo, D., Haverstick, B., Nadya, K., Han, E., and Saltzman, W. M. (2002) Poly(ethylene glycol)-Conjugated PAMAM Dendrimer for Biocompatible, High-Efficiency DNA Delivery. Macromolecules 35, 3456-3462.
15. Mannisto, M., Vanderkerken, S., Toncheva, V., Elomaa, M., Ruponen, M., Schacht, E., and Urtti, A. (2002) Structure-activity relationships of poly(L-lysines): effects of pegylation and molecular shape on physicochemical and biological properties in gene delivery. J. Controlled Release 83, 169-182.
16. Kukowska-Latallo, J. F., Bielinska, A. U., Johnson, J., Spindler, R., Tomalia, D. A., and Baker, J. R., Jr. (1996) Efficient transfer of genetic material into mammalian cells using Starburst polyamidoamine dendrimers. Proc. Natl. Acad. Sci. U.S.A. 93, 4897-4902.
17. Eichman, J. D., Bielinska, A. U., Kukowska-Latallo, J. F., and Baker, J. R., Jr. (2000) The use of PAMAM dendrimers in the efficient transfer of genetic material into cells. Pharm. Sci. Teck. Today 3, 232-245.
18. Klajnert, B., and Bryszewska, M., (2002) Fluorescence studies on PAMAM dendrimers interactions with bovine serum albumin. Bioelectrochemistry 55, 33-35.
19. Godbey, W. T., and Mikos, A. G. (2001) Recent progress in gene delivery using nonviral transfer complexes. J. Controlled Release 72, 115-125.
20. Tomalia, D. A., Baker, H., Dewald, J., Hall, M., Kallos, G., Martin, S., Roeck, J., Ryder, J., and Smith, P. (1985) A new class of polymers: Starburst-dendritic macromolecules. Polym. J. 17, 177-182.
21. Wolfert, M. A., Dash, P., Nazarova, R., O., Oupicky, D., Seymour, L. W., Smart, S., Strohalm, J., and Ulbrich, K. (1999) Polyelectrolyte vectors for gene delivery: influence of cationic polymer on biophysical properties of complexes formed with DNA. Bioconjugate Chem. 10, 993-1004.
22. Bronich, T. K., Nguyen, H. K., Eisenberg, A., and Kabanov, A. V., (2000) Recognition of DNA Topology in Reactions between Plasmid DNA and Cationic Copolymers. J. Am. Chem. Soc. 122, 8339-8343.
23. Hansen, M. B., Nielsen, S. E., and Berg, K. (1989) Reexamination and further development of a precise and rapid dye method for measuring cell growth/cell kill. J. Immunol. Methods 119, 203-210.
24. Choi, J. S., Joo, D. K., Kim, C. H., Kim, K., and Park, J. S. (2000) Synthesis of a Barbell-like Triblock Copolymer, Poly-(L-lysine) Dendrimer-block-Poly(ethylene glycol)-block-Poly-(L-lysine) Dendrimer, and Its Self-Assembly with Plasmid DNA. J. Am. Chem. Soc. 122, 474-480.
25. Yaroslavov, A. A., Sukhishvili, S. A., Obolsky, O. L., Yaroslavova, E. G., Kabanov, A. V., and Kabanov, V. A. (1996) DNA affinity to biological membranes is enhanced due to complexation with hydrophobized polycation. FEBS Lett. 384, 177-180.
26. Jeong, J. H., Song, S. H., Lim, D. W., Lee, H., and Park, T. G. (2001) DNA transfection using linear poly(ethylenimine) prepared by controlled acid hydrolysis of poly(2-ethyl-2-oxazoline). J. Controlled Release 73, 391-399.
27. Perales, J. C., Ferkol, T., Molas, M., and Hanson, R. W. (1994) An evaluation of receptor-mediated gene transfer using synthetic DNA-ligand complexes. Eur. J. Biochem. 226, 255-266.
28. Carnahan, M. A., and Grinstaff, M. W. (2001) Synthesis and characterization of polyether-ester dendrimers from glycerol and lactic acid. J. Am. Chem. Soc. 123, 2905-2906.
29. Fischer, D., Lib, Y., Ahlemeyerc, B., Krieglsteinc, J., and Kissel, T. (2003) In vitro cytotoxicity testing of polycations: influence of polymer structure on cell viability and hemolysis. Biomaterials 24, 1121-1131.
30. Malik, N., Wiwattanapatapee, R., Klopsch, R., Lorenz, K., Frey, H., J. Weener, W., Meijer, E. W., Paulus, W., and Duncan, R. (2000) Dendrimers: relationship between structure and biocompatibility in vitro, and preliminary studies on the biodistribution of 125I-labeled polyamidoamine dendrimers in vivo. J. Controlled Release 65, 133-148.
31. Jevprasesphant, R., Penny, J., Jalal, R., Attwood, A., Mckeown, N. B., and D'Emanuele, A. (2003) The influence of surface modification on the cytotoxicity of PAMAM dendrimers. Int. J. Pharm. 252, 263-266.
32. Dekie, L., Toncheva, V., Dubruel, P., E., Schacht, H. Barrett, L., and Seymour, L. W. (2000) Poly L-glutamic acid derivatives as vectors for gene therapy. J. Controlled Release 65, 187-202.
33. Brownlie, A., Uchegbu, I. F., and Schatzlein, A. G. (2002) Controlled Release Society 29th Annual Meeting Proceedings, #105, Controlled Release Society, Memphis, TN.
34. Zelikin, A. N., Putnam, D., Shastri, P., Langer, R., and Izumrudov, V. A. (2002) Aliphatic ionenes as gene delivery agents: Elucidation of structure-function relationship through modification of charge density and polymer length. Bioconjugate Chem. 13, 548-553.
35. Brown, M. D., Schatzlein, A., Brownlie, A., Jack, V., Wang, W., Tetley, L., Gray, A. I., and Uchegbu, I. F. (2000) Preliminary characterization of novel amino acid based olymeric vesicles as gene and drug delivery agents. Bioconjugate Chem. 11, 880-891.
36. Blessing, T., Remy, J. S., and Behr, J. P. (1998) Monomolecular collapse of plasmid DNA into stable virus-like particles. Proc. Natl. Acad. Sci. U.S.A. 95, 1427-1431.
37. Zuber, G., Dauty, E., Nothisen, M., Belguise, P., and Behr, J. P. (2001) Towards synthetic viruses. Adv. Drug Delivery Rev. 52, 245-253.