-
2
-
-
0037283601
-
The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes
-
Kahn S.E. The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes. Diabetologia 46 (2003) 3-19
-
(2003)
Diabetologia
, vol.46
, pp. 3-19
-
-
Kahn, S.E.1
-
3
-
-
0028817815
-
UK prospective diabetes study 16. Overview of 6 years' therapy of type II diabetes: a progressive disease
-
U.K. Prospective Diabetes Study Group
-
U.K. Prospective Diabetes Study Group. UK prospective diabetes study 16. Overview of 6 years' therapy of type II diabetes: a progressive disease. Diabetes 44 (1995) 1249-1258
-
(1995)
Diabetes
, vol.44
, pp. 1249-1258
-
-
-
4
-
-
0030596338
-
Seminars in medicine of the Beth Israel Hospital, Boston. Non-insulin-dependent diabetes mellitus-a genetically programmed failure of the beta cell to compensate for insulin resistance
-
Polonsky K.S., Sturis J., and Bell G.I. Seminars in medicine of the Beth Israel Hospital, Boston. Non-insulin-dependent diabetes mellitus-a genetically programmed failure of the beta cell to compensate for insulin resistance. N Engl J Med 334 (1996) 777-783
-
(1996)
N Engl J Med
, vol.334
, pp. 777-783
-
-
Polonsky, K.S.1
Sturis, J.2
Bell, G.I.3
-
5
-
-
4143081356
-
First-phase insulin secretion: does it exist in real life? Considerations on shape and function
-
Caumo A., and Luzi L. First-phase insulin secretion: does it exist in real life? Considerations on shape and function. Am J Physiol Endocrinol Metab 287 (2004) E371-385
-
(2004)
Am J Physiol Endocrinol Metab
, vol.287
-
-
Caumo, A.1
Luzi, L.2
-
6
-
-
0021813187
-
Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man
-
Matthews D.R., Hosker J.P., Rudenski A.S., Naylor B.A., Treacher D.F., and Turner R.C. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28 (1985) 412-419
-
(1985)
Diabetologia
, vol.28
, pp. 412-419
-
-
Matthews, D.R.1
Hosker, J.P.2
Rudenski, A.S.3
Naylor, B.A.4
Treacher, D.F.5
Turner, R.C.6
-
7
-
-
0034049630
-
Use of the oral glucose tolerance test to assess insulin release and insulin sensitivity
-
Stumvoll M., Mitrakou A., Pimenta W., et al. Use of the oral glucose tolerance test to assess insulin release and insulin sensitivity. Diabetes Care 23 (2000) 295-301
-
(2000)
Diabetes Care
, vol.23
, pp. 295-301
-
-
Stumvoll, M.1
Mitrakou, A.2
Pimenta, W.3
-
8
-
-
0024834748
-
Lilly lecture 1989. Toward physiological understanding of glucose tolerance. Minimal-model approach
-
Bergman R.N. Lilly lecture 1989. Toward physiological understanding of glucose tolerance. Minimal-model approach. Diabetes 38 (1989) 1512-1527
-
(1989)
Diabetes
, vol.38
, pp. 1512-1527
-
-
Bergman, R.N.1
-
9
-
-
0023618580
-
Reproducibility of beta-cell function estimates in non-insulin-dependent diabetes mellitus
-
Gjessing H.J., Damsgaard E.M., Matzen L.E., Froland A., and Faber O.K. Reproducibility of beta-cell function estimates in non-insulin-dependent diabetes mellitus. Diabetes Care 10 (1987) 558-562
-
(1987)
Diabetes Care
, vol.10
, pp. 558-562
-
-
Gjessing, H.J.1
Damsgaard, E.M.2
Matzen, L.E.3
Froland, A.4
Faber, O.K.5
-
10
-
-
0023894894
-
Oral glucose tolerance test: indications and limitations
-
Nelson R.L. Oral glucose tolerance test: indications and limitations. Mayo Clin Proc 63 (1988) 263-269
-
(1988)
Mayo Clin Proc
, vol.63
, pp. 263-269
-
-
Nelson, R.L.1
-
11
-
-
0018520840
-
Glucose clamp technique: a method for quantifying insulin secretion and resistance
-
DeFronzo R.A., Tobin J.D., and Andres R. Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol 237 (1979) E214-223
-
(1979)
Am J Physiol
, vol.237
-
-
DeFronzo, R.A.1
Tobin, J.D.2
Andres, R.3
-
12
-
-
0028833041
-
Insulin secretion and clearance during low-dose graded glucose infusion
-
Byrne M.M., Sturis J., and Polonsky K.S. Insulin secretion and clearance during low-dose graded glucose infusion. Am J Physiol 268 (1995) E21-27
-
(1995)
Am J Physiol
, vol.268
-
-
Byrne, M.M.1
Sturis, J.2
Polonsky, K.S.3
-
13
-
-
0030695028
-
Diminished insulin and glucagon secretory responses to arginine in nondiabetic subjects with a mutation in the hepatocyte nuclear factor-4alpha/MODY1 gene
-
Herman W.H., Fajans S.S., Smith M.J., Polonsky K.S., Bell G.I., and Halter J.B. Diminished insulin and glucagon secretory responses to arginine in nondiabetic subjects with a mutation in the hepatocyte nuclear factor-4alpha/MODY1 gene. Diabetes 46 (1997) 1749-1754
-
(1997)
Diabetes
, vol.46
, pp. 1749-1754
-
-
Herman, W.H.1
Fajans, S.S.2
Smith, M.J.3
Polonsky, K.S.4
Bell, G.I.5
Halter, J.B.6
-
14
-
-
34247846308
-
The comparison of second phase insulin secretion in patients treated with repaglinide or gliclazide
-
Yang C.C., Lin J.D., Kuo K.L., et al. The comparison of second phase insulin secretion in patients treated with repaglinide or gliclazide. Diabetes Metab Syndr Clin Res Rev 1 (2007) 37-42
-
(2007)
Diabetes Metab Syndr Clin Res Rev
, vol.1
, pp. 37-42
-
-
Yang, C.C.1
Lin, J.D.2
Kuo, K.L.3
-
15
-
-
1842334456
-
Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus
-
American Diabetes Association. Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care 20 (1997) 1183-1197
-
(1997)
Diabetes Care
, vol.20
, pp. 1183-1197
-
-
American Diabetes Association1
-
16
-
-
0000750303
-
Plasma-insulin response to sustained hyperglycemia induced by glucose infusion in human subjects
-
Cerasi E., and Luft R. Plasma-insulin response to sustained hyperglycemia induced by glucose infusion in human subjects. Lancet 2 (1963) 1359-1361
-
(1963)
Lancet
, vol.2
, pp. 1359-1361
-
-
Cerasi, E.1
Luft, R.2
-
17
-
-
0019810028
-
Physiologic evaluation of factors controlling glucose tolerance in man: measurement of insulin sensitivity and beta-cell glucose sensitivity from the response to intravenous glucose
-
Bergman R.N., Phillips L.S., and Cobelli C. Physiologic evaluation of factors controlling glucose tolerance in man: measurement of insulin sensitivity and beta-cell glucose sensitivity from the response to intravenous glucose. J Clin Invest 68 (1981) 1456-1467
-
(1981)
J Clin Invest
, vol.68
, pp. 1456-1467
-
-
Bergman, R.N.1
Phillips, L.S.2
Cobelli, C.3
-
18
-
-
0025100926
-
Islet function and insulin sensitivity in the non-diabetic offspring of conjugal type 2 diabetic patients
-
Johnston C., Ward W.K., Beard J.C., McKnight B., and Porte Jr. D. Islet function and insulin sensitivity in the non-diabetic offspring of conjugal type 2 diabetic patients. Diabet Med 7 (1990) 119-125
-
(1990)
Diabet Med
, vol.7
, pp. 119-125
-
-
Johnston, C.1
Ward, W.K.2
Beard, J.C.3
McKnight, B.4
Porte Jr., D.5
-
19
-
-
0026539663
-
The metabolic profile of NIDDM is fully established in glucose-tolerant offspring of two Mexican-American NIDDM parents
-
Gulli G., Ferrannini E., Stern M., Haffner S., and DeFronzo R.A. The metabolic profile of NIDDM is fully established in glucose-tolerant offspring of two Mexican-American NIDDM parents. Diabetes 41 (1992) 1575-1586
-
(1992)
Diabetes
, vol.41
, pp. 1575-1586
-
-
Gulli, G.1
Ferrannini, E.2
Stern, M.3
Haffner, S.4
DeFronzo, R.A.5
-
20
-
-
0029022819
-
Pancreatic beta-cell dysfunction as the primary genetic lesion in NIDDM. Evidence from studies in normal glucose-tolerant individuals with a first-degree NIDDM relative
-
Pimenta W., Korytkowski M., Mitrakou A., et al. Pancreatic beta-cell dysfunction as the primary genetic lesion in NIDDM. Evidence from studies in normal glucose-tolerant individuals with a first-degree NIDDM relative. JAMA 273 (1995) 1855-1861
-
(1995)
JAMA
, vol.273
, pp. 1855-1861
-
-
Pimenta, W.1
Korytkowski, M.2
Mitrakou, A.3
-
21
-
-
0031890769
-
Insulin secretion in normal glucose-tolerant relatives of type 2 diabetic subjects. Assessments using hyperglycemic glucose clamps and oral glucose tolerance tests
-
Van Haeften T.W., Dubbeldam S., Zonderland M.L., and Erkelens D.W. Insulin secretion in normal glucose-tolerant relatives of type 2 diabetic subjects. Assessments using hyperglycemic glucose clamps and oral glucose tolerance tests. Diabetes Care 21 (1998) 278-282
-
(1998)
Diabetes Care
, vol.21
, pp. 278-282
-
-
Van Haeften, T.W.1
Dubbeldam, S.2
Zonderland, M.L.3
Erkelens, D.W.4
-
22
-
-
0031963964
-
Defects in insulin secretion and insulin action in non-insulin-dependent diabetes mellitus are inherited. Metabolic studies on offspring of diabetic probands
-
Vauhkonen I., Niskanen L., Vanninen E., Kainulainen S., Uusitupa M., and Laakso M. Defects in insulin secretion and insulin action in non-insulin-dependent diabetes mellitus are inherited. Metabolic studies on offspring of diabetic probands. J Clin Invest 101 (1998) 86-96
-
(1998)
J Clin Invest
, vol.101
, pp. 86-96
-
-
Vauhkonen, I.1
Niskanen, L.2
Vanninen, E.3
Kainulainen, S.4
Uusitupa, M.5
Laakso, M.6
-
23
-
-
20144378994
-
Beta-cell function across the spectrum of glucose tolerance in obese youth
-
Weiss R., Caprio S., Trombetta M., Taksali S.E., Tamborlane W.V., and Bonadonna R. Beta-cell function across the spectrum of glucose tolerance in obese youth. Diabetes 54 (2005) 1735-1743
-
(2005)
Diabetes
, vol.54
, pp. 1735-1743
-
-
Weiss, R.1
Caprio, S.2
Trombetta, M.3
Taksali, S.E.4
Tamborlane, W.V.5
Bonadonna, R.6
-
24
-
-
0015324585
-
Decreased sensitivity of the pancreatic beta cells to glucose in prediabetic and diabetic subjects. A glucose dose-response study
-
Cerasi E., Luft R., and Efendic S. Decreased sensitivity of the pancreatic beta cells to glucose in prediabetic and diabetic subjects. A glucose dose-response study. Diabetes 21 (1972) 224-234
-
(1972)
Diabetes
, vol.21
, pp. 224-234
-
-
Cerasi, E.1
Luft, R.2
Efendic, S.3
-
25
-
-
31544468354
-
The insulin sensitivity, glucose sensitivity, and acute insulin response to glucose load in adolescent type 2 diabetes in Taiwanese
-
Pei D., Hsiao C.F., Hung Y.J., et al. The insulin sensitivity, glucose sensitivity, and acute insulin response to glucose load in adolescent type 2 diabetes in Taiwanese. Diabetes Metab Res Rev 22 (2006) 26-33
-
(2006)
Diabetes Metab Res Rev
, vol.22
, pp. 26-33
-
-
Pei, D.1
Hsiao, C.F.2
Hung, Y.J.3
-
26
-
-
0031080351
-
Past and current obesity in Koreans with non-insulin-dependent diabetes mellitus
-
Park J.Y., Lee K.U., Kim C.H., et al. Past and current obesity in Koreans with non-insulin-dependent diabetes mellitus. Diabetes Res Clin Pract 35 (1997) 49-56
-
(1997)
Diabetes Res Clin Pract
, vol.35
, pp. 49-56
-
-
Park, J.Y.1
Lee, K.U.2
Kim, C.H.3
-
27
-
-
0021777067
-
Islet pathology and the pathogenesis of type 1 and type 2 diabetes mellitus revisited
-
Kloppel G., Lohr M., Habich K., Oberholzer M., and Heitz P.U. Islet pathology and the pathogenesis of type 1 and type 2 diabetes mellitus revisited. Surv Synth Pathol Res 4 (1985) 110-125
-
(1985)
Surv Synth Pathol Res
, vol.4
, pp. 110-125
-
-
Kloppel, G.1
Lohr, M.2
Habich, K.3
Oberholzer, M.4
Heitz, P.U.5
-
28
-
-
0023940801
-
Minimal chronic hyperglycemia is a critical determinant of impaired insulin secretion after an incomplete pancreatectomy
-
Leahy J.L., Bonner-Weir S., and Weir G.C. Minimal chronic hyperglycemia is a critical determinant of impaired insulin secretion after an incomplete pancreatectomy. J Clin Invest 81 (1988) 1407-1414
-
(1988)
J Clin Invest
, vol.81
, pp. 1407-1414
-
-
Leahy, J.L.1
Bonner-Weir, S.2
Weir, G.C.3
-
29
-
-
0001210612
-
Quantitative estimation of the pancreatic islet tissue in diabetic subjects
-
Maclean N., and Ogilvie R.F. Quantitative estimation of the pancreatic islet tissue in diabetic subjects. Diabetes 4 (1955) 367-376
-
(1955)
Diabetes
, vol.4
, pp. 367-376
-
-
Maclean, N.1
Ogilvie, R.F.2
-
30
-
-
0018641183
-
Differential volumetry of A, B and D cells in the pancreatic islets of diabetic and nondiabetic subjects
-
Saito K., Yaginuma N., and Takahashi T. Differential volumetry of A, B and D cells in the pancreatic islets of diabetic and nondiabetic subjects. Tohoku J Exp Med 129 (1979) 273-283
-
(1979)
Tohoku J Exp Med
, vol.129
, pp. 273-283
-
-
Saito, K.1
Yaginuma, N.2
Takahashi, T.3
-
31
-
-
0024213009
-
Islet amyloid, increased A-cells, reduced B-cells and exocrine fibrosis: quantitative changes in the pancreas in type 2 diabetes
-
Clark A., Wells C.A., Buley I.D., et al. Islet amyloid, increased A-cells, reduced B-cells and exocrine fibrosis: quantitative changes in the pancreas in type 2 diabetes. Diabetes Res 9 (1988) 151-159
-
(1988)
Diabetes Res
, vol.9
, pp. 151-159
-
-
Clark, A.1
Wells, C.A.2
Buley, I.D.3
-
32
-
-
42449147947
-
Ethnic comparisons of the cross-sectional relationships between measures of body size with diabetes and hypertension
-
Huxley R., James W.P., Barzi F., et al. Ethnic comparisons of the cross-sectional relationships between measures of body size with diabetes and hypertension. Obes Rev 9 Suppl 1 (2008) 53-61
-
(2008)
Obes Rev
, vol.9
, Issue.SUPPL. 1
, pp. 53-61
-
-
Huxley, R.1
James, W.P.2
Barzi, F.3
-
33
-
-
0017236889
-
Relationships between fasting plasma glucose levels and insulin secretion during intravenous glucose tolerance tests
-
Brunzell J.D., Robertson R.P., Lerner R.L., et al. Relationships between fasting plasma glucose levels and insulin secretion during intravenous glucose tolerance tests. J Clin Endocrinol Metab 42 (1976) 222-229
-
(1976)
J Clin Endocrinol Metab
, vol.42
, pp. 222-229
-
-
Brunzell, J.D.1
Robertson, R.P.2
Lerner, R.L.3
-
34
-
-
0024463227
-
Hyperproinsulinemia and amyloid in NIDDM. Clues to etiology of islet beta-cell dysfunction?
-
Porte Jr. D., and Kahn S.E. Hyperproinsulinemia and amyloid in NIDDM. Clues to etiology of islet beta-cell dysfunction?. Diabetes 38 (1989) 1333-1336
-
(1989)
Diabetes
, vol.38
, pp. 1333-1336
-
-
Porte Jr., D.1
Kahn, S.E.2
-
35
-
-
0024494876
-
Insulin deficiency in non-insulin-dependent diabetes
-
Temple R.C., Carrington C.A., Luzio S.D., et al. Insulin deficiency in non-insulin-dependent diabetes. Lancet 1 (1989) 293-295
-
(1989)
Lancet
, vol.1
, pp. 293-295
-
-
Temple, R.C.1
Carrington, C.A.2
Luzio, S.D.3
-
36
-
-
0020593893
-
Hepatic removal of insulin in normal man: dose response to endogenous insulin secretion
-
Eaton R.P., Allen R.C., and Schade D.S. Hepatic removal of insulin in normal man: dose response to endogenous insulin secretion. J Clin Endocrinol Metab 56 (1983) 1294-1300
-
(1983)
J Clin Endocrinol Metab
, vol.56
, pp. 1294-1300
-
-
Eaton, R.P.1
Allen, R.C.2
Schade, D.S.3
-
37
-
-
0035001186
-
Quantitative indexes of beta-cell function during graded up & down glucose infusion from C-peptide minimal models
-
Toffolo G., Breda E., Cavaghan M.K., Ehrmann D.A., Polonsky K.S., and Cobelli C. Quantitative indexes of beta-cell function during graded up & down glucose infusion from C-peptide minimal models. Am J Physiol Endocrinol Metab 280 (2001) E2-E10
-
(2001)
Am J Physiol Endocrinol Metab
, vol.280
-
-
Toffolo, G.1
Breda, E.2
Cavaghan, M.K.3
Ehrmann, D.A.4
Polonsky, K.S.5
Cobelli, C.6
-
39
-
-
0031740402
-
Toxicity of hyperglycaemia in type 2 diabetes
-
Yki-Jarvinen H. Toxicity of hyperglycaemia in type 2 diabetes. Diabetes Metab Rev 14 Suppl 1 (1998) S45-S50
-
(1998)
Diabetes Metab Rev
, vol.14
, Issue.SUPPL. 1
-
-
Yki-Jarvinen, H.1
-
40
-
-
28744454446
-
The capability of glucose toxicity on severe type 2 diabetes
-
Hsieh C.H., Hung Y.J., He C.T., et al. The capability of glucose toxicity on severe type 2 diabetes. Endocr Res 31 (2005) 149-158
-
(2005)
Endocr Res
, vol.31
, pp. 149-158
-
-
Hsieh, C.H.1
Hung, Y.J.2
He, C.T.3
|