Quantitative indexes of β-cell function during graded up&down glucose infusion from C-peptide minimal models

American Journal of Physiology - Endocrinology and Metabolism

Volumn 280, Issue 1 43-1, 2001, Pages

  Toffolo, Gianna ^a   Breda, Elena ^a   Cavaghan, Melissa K ^b   Ehrmann, David A ^b   Polonsky, Kenneth S ^c   Cobelli, Claudio ^a,d  

^a UNIVERSITY OF PADOVA   (Italy)

^b UNIVERSITY OF CHICAGO   (United States)

^c WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d Dipartimento di Elettronica Ist Naz per la Fis della Materia   (Italy)

Author keywords

Insulin secretion; Kinetics; Mathematical model; cell sensitivity

Indexed keywords

C PEPTIDE; GLUCOSE; INSULIN;

ADULT; ARTICLE; COMPARTMENT MODEL; FEMALE; GLUCOSE INFUSION; GLUCOSE INTOLERANCE; HORMONAL REGULATION; HORMONE SENSITIVITY; HUMAN; HUMAN EXPERIMENT; INSULIN RELEASE; INTRAVENOUS GLUCOSE TOLERANCE TEST; KINETICS; MALE; NORMAL HUMAN; PANCREAS FUNCTION; PANCREAS ISLET BETA CELL; PATHOPHYSIOLOGY; PRIORITY JOURNAL;

EID: 0035001186     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.2001.280.1.e2     Document Type: Article

References (18)

1. Epinephrine exerts opposite effects on peripheral glucose disposal and glucose stimulated insulin secretion
2. SAAMII: Smulation, analysis and modeling software for tracer and pharmacokinetic studies
3. Insulin secretion and clearance during low-dose graded glucose infusion
4. Elevated plasma glucose 2 h postchallenge predicts defects in β-cell function
5. Treatment with the oral antidiabetic agent troglitazone improves beta cell responses to glucose in subjects with impaired glucose tolerance
6. Prehepatic insulin production in man: Kinetic analysis using peripheral connecting peptide behaviour
7. Characterization of seven C-peptide antisera
8. A threshold distribution hypothesis for packet storage of insulin and its mathematical modeling
9. Threshold secretory mechanism: A model of derivative element in biological control
10. Visceral adipose tissue impairs insulin secretion and insulin sensitivity but not energy expenditure in obesity
11. Estimation of β-cell sensitivity from IVGTT C-peptide data. Knowledge of the kinetics avoids errors in modeling the secretion
12. β-Cell function during insulin modified IVGTT successfully assessed by the C-peptide minimal model
13. Estimation of insulin secretion rates from C-peptide levels. Comparison of individual and standard kinetic parameters for C-peptide clearance
14. Resistance exercise and growth hormone administration in older men: Effects on insulin sensitivity and secretion during a stable label intravenous glucose tolerance test