Los contaminantes ambientales bifenilos policlorinados (PCB) y sus efectos sobre el Sistema Nervioso y la salud

Salud Mental

Volumn 32, Issue 4, 2009, Pages 335-346

  Miller Pérez, Carolina ^a   Sánchez Islas, Eduardo ^a   Mucio Ramírez, Samuel ^a   Mendoza Sotelo, José ^a   León Olea, Martha ^a  

^a INSTITUTO NACIONAL DE PSIQUIATRÍA RAMÓN DE LA FUENTE MUÑIZ   (Mexico)

Author keywords

Askarels; Neurodevelopment; Neurotoxicity; PCBs; Pollutants

Indexed keywords

EID: 77952119929     PISSN: 01853325     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (133)

1. Breivik K, Sweetman A, Pacyna JM, Jones KC. «Towards a global historical emission inventory for selected PCB congeners a mass balance approach 1. Global production and consumption». Science Total Environment 2002;290:181-198.
2. Black KK, Carlisle J, Siegel D, Salinas J. Health concerns and environmental issue with PVC-containing building materials in green buildings integrated wast management board. USA: California Environmental Protection Agency; 2006; p. 11.
3. Safe S, Safe L, Mullin M. Polychlorinated biphenyls: environmental occurrence and analysis. En: Polychlorinated biphenyls (PCBs): Mammalian and environmental toxicology. Safe S, Hutzinger O (eds.). Berlin: Springer-Verlag; 1987; 1-13.
4. Evans MS, Noguchi GE, Rice CP. The biomagnification of polychlorinated biphenyls, toxaphene and DDT compounds in a lake Michigan offshore food web. Arch Environ Contam Toxicol 1991;20:87-93.
5. Tilson HA, Kodavanti PR, Mundy WR, Bushnell PJ. Neurotoxicity of environmental chemicals and their mechanism of action. Toxicol Lett 1998;102-103:631-635.
6. Stewart P, Reihman J, Lonky E, Darvill T, Pagano J. Prenatal PCB exposure and neonatal behavioral assessment scale (NBAS) performance. Neurotoxicol Teratol 2000;22:21-29.
7. Muir D, Sverko E. Analytical methods for PCBs and organochlorine pesticides in environmental monitoring and surveillance: a critical appraisal. Anal Bioanal Chem 2006;386:769-789.
8. EPA. Method 8082. Polychlorinated biphenyls (PCBs) by capillary column gas chromatography. USA: Environmental Protection Agency; 1995.
9. EPA. Method 1668, Revision A: Chlorinated biphenyl congeners in water, soil, sediment, and tissue by HRGC/HRMS. USA: Environmental Protection Agency. Office of Water; 1999.
10. Hess P, de Boer J, Cofino WP et al. Critical review of the analysis of non- and mono-orthochlorobiphenyls. J Chromatogr 1995;703:417-465.
11. Analytical methods en http://www.atsdr.cdc.gov/toxprofiles/tp17-c7.pdf.
12. Sherry J. Environmental immunoassays and other bioanalytical methods: overview and update. Chemosphere 1997;34:1011-25.
13. Behnisch PA, Hosoe K, Sakai S. Combinatorial bio/chemical analysis of dioxin and dioxin-like compounds in waste recycling, feed/food, humans/wildlife and the environment. Environ Int 2001;27:495-519.
14. Schmidt JV, Bradfield CA. Ah receptor signaling pathways. Annu Rev Cell Dev Biol 1996;12:55-89.
15. Safe S, Bandiera S, Sawyer T, Robertson L, Safe L et al. PCBs: Structure- function relationships and mechanism of action. Environmental Health Perspectives 1985;60:47-56.
16. McKinney JD, Chae K, McConnelit EE, Birnbaumt LS. Structure-induction versus structure-toxicity relationships for polychiorinated biphenyls and related aromatic hydrocarbons. Environmental Health Perspectives 1985;60:57-68.
17. Rowlands JC, Gustafsson JA. Aryl hydrocarbon receptor-mediated signal transduction. Crit Rev Toxicol 1997;27:109-34.
18. Gauger KJ, Giera S, Sharlin DS, Bansal R, Iannacone E et al. Polychlorinated biphenyls 105 and 118 form thyroid hormone receptor agonists after cytochrome P4501A1 activation in rat pituitary GH3 cells. Environ Health Perspect 2007;115:1623-30.
19. Martinez JM, Afshari CA, Bushel PR, Masuda A, Takahashi T et al. «Differential toxicogenomic responses to 2,3,7,8-tetrachlorodibenzopdioxin in malignant and nonmalignant human airway epithelial cells». Toxicol Sci 2002;69:409-23.
20. Denison MS, Nagy SR. Activation of the aryl hydrocarbon receptor by structurally diverse exogenous and endogenous chemicals. Annu Rev Pharmacol Toxicol 2003;43:309-34.
21. McKinney JD, Waller CL. Polychlorinated biphenyls as hormonally active structural analogues. Environ Health Perspect 1994;102:290-7.
22. Hagmar L. Polychlorinated biphenyls and thyroid status in humans: a review. Thyroid 2003;13:1021-8.
23. La Rocca C, Mantovani A. From environment to food: the case of PCB. Ann Ist Super Sanita 2006;42:410-6.
24. Langer P. Persistent organochlorinated pollutants (PCB, DDE, HCB, dioxins, furans) and the thyroid-review 2008. Endocr Regul 2008;42:79-104.
25. Golden RJ, Noller KL, Titus-Emstoff L, Kaufman RH, Mittendorf R et al. Environmental endocrine modulators and human health: an assessment of the biological evidence. Crit Rev Toxicol 1998;28:109-227.
26. Van den Berg KJ, Zurcher C, Brouwer A. Effects of 3,4,3',4'-tetrachloro- biphenyl on thyroid function and histology in marmoset monkeys. Toxicol Lett 1988;41:77-86.
27. Brouwer A, Morse DC, Lans MC, Schuur AG, Murk AJ et al. Interactions of persistent environmental organohalogens with the thyroid hormone system: mechanisms and possible consequences for animal and human health. Toxicol Ind Health 1998;14:59-84.
28. Bastomsky CH. Effects of a polychlorinated biphenyl mixture (aroclor 1254) and DDT on biliary thyroxine excretion in rats. Endocrinology 1974;95:1150-5.
29. Ness DK, Schantz SL, Moshtaghian J, Hansen LG. Effects of perinatal exposure to specific PCB congeners on thyroid hormone concentrations and thyroid histology in the rat. Toxicol Lett 1993;68:311-23.
30. Seo BW, Li MH, Hansen LG, Moore RW, Peterson RE et al. Effects of gestational and lactational exposure to coplanar polychlorinated biphenyl (PCB) congeners or 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on thyroid hormone concentrations in weanling rats. Toxicol Lett 1995;78:253-62.
31. Morse DC, Wehler EK, Wesseling W, Koeman JH, Brouwer A. Alterations in rat brain thyroid hormone status following pre- and postnatal exposure to polychlorinated biphenyls (Aroclor 1254). Toxicol Appl Pharmacol 1996;136:269-79.
32. Hallgren S, Sinjari T, Håkansson H, Darnerud PO. Effects of polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs) on thyroid hormone and vitamin A levels in rats and mice. Arch Toxicol 2001;75:200-8.
33. Wade MG, Parent S, Finnson KW, Foster W, Younglai E et al. Thyroid toxicity due to subchronic exposure to a complex mixture of 16 organochlorines, lead, and cadmium. Toxicol Sci 2002;67:207-18.
34. Meerts IA, Hoving S, Van den Berg JH, Weijers BM, Swarts HJ et al. Effects of in utero exposure to 4-hydroxy-2,3,3',4',5-pentachlorobiphenyl (4-OH-CB107) on developmental landmarks, steroid hormone levels, and female estrous cyclicity in rats. Toxicol Sci 2004;82:259-67.
35. Roegge CS, Morris JR, Villareal S, Wang VC, Powers BE et al. Purkinje cell and cerebellar effects following developmental exposure to PCBs and/or MeHg. Neurotoxicol Teratol 2006;28:74-85.
36. McLanahan ED, Campbell JL Jr, Ferguson DC, Harmon B, Hedge JM et al. Low-dose effects of ammonium perchlorate on the hypothalamic-pituitary-thyroid axis of adult male rats pretreated with PCB126. Toxicol Sci 2007;97:308-17.
37. Fisher JW, Campbell J, Muralidhara S, Bruckner JV, Ferguson D et al. Effect of PCB 126 on hepatic metabolism of thyroxine and perturbations in the hypothalamicpituitary-thyroid axis in the rat. Toxicol Sci 2006;90:87-95.
38. Hood A, Hashmi R, Klaassen CD. Effects of microsomal enzyme inducers on thyroid-follicular cell proliferation, hyperplasia, and hypertrophy. Toxicol Appl Pharmacol 1999;160:163-170.
39. Eriksson P, Fischer C, Fredriksson A. Polybrominated diphenyl ethers, a group of brominated flame retardants, can interact with polychlorinated biphenyls in enhancing developmental neurobehavioral defects. Toxicological Sciences 2006;94:302-309.
40. Lamb MR, Taylor S, Liu X, Wolff MS, Borrell L et al. Prenatal exposure to polychlorinated biphenyls and postnatal growth: a structural analysis. Environ Health Perspect 2006;114:779-85.
41. León-Olea M, Talavera-Cuevas E, Sánchez-Islas E, Mucio-Ramírez S, Miller-Pérez C et al. Effects of polychlorinated biphenyls on nitrergic neurons and nitric oxide synthase activity in rat pups brain. Program No. 759.10. San Diego, CA: Society for Neuroscience Abstract; 2004.
42. Coburn CG, Currás-Collazo MC, Kodavanti PR. Polybrominated diphenyl ethers and ortho-substituted polychlorinated biphenyls as neuroendocrine disruptors of vasopressin release: effects during physiological activation in vitro and structure-activity relationships. Toxicol Sci 2007;98:178-86.
43. Coburn CG, Gillard ER, Currás-Collazo MC. Dietary exposure to aroclor 1254 alters central and peripheral vasopressin release in response to dehydration in the rat. Toxicol Sci 2005;84:149-56.
44. Carpenter OD. Polychlorinated biphenyls (PCBs): Routes of exposure and effects on human health. Reviews Enviromental Health 2006;21:1-23.
45. Codru N, Schymura MJ, Negoita S. Akwesasne task Force on Environment, Rej R, Carpenter DODiabetes in relation to serum levels of polychlorinated biphenyls and chlorinated pesticides in adult Native Americans. Environ Health Perspect 2007;115:1442-7.
46. Kovaceviæ R, Vojinoviæ-Miloradov M, Teodoroviæ I, Andriæ S. Effect of PCBs on androgen production by suspension of adult rat Leydig cells in vitro. J Steroid Biochem Mol Biol 1995;52:595-7.
47. Andric SA, Kostic TS, Dragisic SM, Andric NL, Stojilkovic SS et al. Acute effects of polychlorinated biphenyl-containing and -free transformer fluids on rat testicular steroidogenesis. Environ Health Perspect 2000;108:955-9.
48. Portigal CL, Cowell SP, Fedoruk MN, Butler CM, Rennie PS et al. Polychlorinated biphenyls interfere with androgen-induced transcriptional activation and hormone binding. Toxicol Appl Pharmacol 2002;179:185-94.
49. Bush B, Bennett AH, Snow JT. Polychlorobiphenyl congeners, p,p'-DDE, and sperm function in humans. Arch Environ Contam Toxicol 1986;15:333-41.
50. Hauser R, Altshul L, Chen Z, Ryan L, Overstreet J et al. Environmental organo chlorines and semen quality: results of a pilot study. Environ Health Perspect 2002;110:229-33.
51. Hsu PC, Huang W, Yao WJ, Wu MH, Guo YL et al. Sperm changes in men exposed to polychlorinated biphenyls and dibenzofurans. JAMA 2003;289:2943-4.
52. Guo YL, Hsu CC, Lambert GH. Effects of environmental chemicals (EC) on sexual maturation. Pediatr Res 1996;39:74A.
53. Hardell L, Bavel B, Lindström G, Eriksson M, Carlberg M. In utero exposure to persistent organic pollutants in relation to testicular cancer risk. Int J Androl 2006;29:228-34.
54. Cooper GS, Klebanoff MA, Promislow J, Brock JW, Longnecker MP. Polychlorinated biphenyls and menstrual cycle characteristics. Epidemiology 2005;16:191-200.
55. Toft G, Axmon A, Lindh CH, Giwercman A, Bonde JP. Menstrual cycle characteristics in European and Inuit women exposed to persistent organochlorine pollutants. Hum Reprod 2008;23:193-200.
56. Pauwels A, Schepens PJ, D'Hooghe T, Delbeke L, Dhont M et al. The risk of endometriosis and exposure to dioxins and polychlorinated biphenyls: a case-control study of infertile women. Hum Reprod 2001;16:2050-5.
57. Rier SE, Turner WE, Martin DC, Morris R, Lucier GW et al. Serum levels of TCDD and dioxin-like chemicals in Rhesus monkeys chronically exposed to dioxin: correlation of increased serum PCB levels with endometriosis. Toxicol Sci 2001;59:147-59.
58. Mocarelli P, Gerthoux PM, Ferrari E, Patterson DG Jr, Kieszak SM et al. Paternal concentrations of dioxin and sex ratio of offspring. Lancet 2000;355:1858-63.
59. Weisskopf MG, Anderson HA, Hanrahan LP. Great Lakes Consortium. Decreased sex ratio following maternal exposure to polychlorinated biphenyls from contaminated Great Lakes sport-caught fish: a retrospective cohort study. Environ Health 2003;2:2.
60. Simmons SL, Cummings JA, Clemens LG, Nunez AA. Exposure to PCB 77 affects the maternal behavior of rats. Physiol Behav 2005;84:81-6.
61. Cummings JA, Nunez AA, Clemens LG. A cross-fostering analysis of the effects of PCB 77 on the maternal behavior of rats. Physiol Behav 2005;85:83-91.
62. Cromwell HC, Johnson A, McKnight L, Horinek M, Asbrock C et al. Effects of polychlorinated biphenyls on maternal odor conditioning in rat pups. Physiol Behav 2007;91:658-66.
63. Vos JG, van Driel-Grootenhuis L. PCB-induced suppression of the humoral and cell-mediated immunity in guinea pigs. Sci Total Environ 1972;1:289-302.
64. Allen JR, Barsotti DA. The effects of transplacental and mammary movement of PCBs on infant rhesus monkeys. Toxicology 1976;6:331-40.
65. Smialowicz RJ, Andrews JE, Riddle MM, Rogers RR, Luebke RW et al. Evaluation of the immunotoxicity of low level PCB exposure in the rat. Toxicology 1989;56:197-211.
66. Knobil E. Hormonally active agents in the environment Washington, D.C.: National Academy Press; 1999; p. 430.
67. Lyche J, Larsen H, Skaare JU, Tverdal A, Dahl E et al. Effects of perinatal exposure to low doses of PCB 153 and PCB 126 on lymphocyte proliferation and hematology in goat kids. J Toxicol Environ Health 2004;67:889-904.
68. Lu YC, Wu YC. Clinical findings and immunological abnormalities in Yu-Cheng patients. Environ Health Perspect 1985;59:17-29.
69. Weisglas-Kuperus N, Sas TC, Koopman-Esseboom C, van der Zwan CW, De Ridder MA et al. Immunologic effects of background prenatal and postnatal exposure to dioxins and polychlorinated biphenyls in Dutch infants. Pediatr Res 1995;38:404-410.
70. Weisglas-Kuperus N, Patandin S, Berbers GA, Sas TC, Mulder PG et al. Immunologic effects of background exposure to polychlorinated biphenyls and dioxins in Dutch preschool children. Environ Health Perspect 2000;108:1203-1207.
71. Agrawal AK, Tilson HA, Bondy SC. 3,4,3',4'-Tetrachlorobiphenyl given to mice prenatally produces long-term decreases in striatal dopamine and receptor binding sites in the caudate nucleus. Toxicol Lett 1981;7:417-24.
72. Safe S. Toxicology, structure-function relationship, and human and environmental health impacts of polychlorinated biphenyls: progress and problems. Environ Health Perspect 1993;100:259-68.
73. Seegal RF, Brosch KO, Okoniewski RJ. Effects of in utero and lactational exposure of the laboratory rat to 2,4,2',4'- and 3,4,3',4'-tetrachlorobiphenyl on dopamine function. Toxicol Appl Pharmacol 1997;146:95-103.
74. Jacobson JL, Fein GG, Jacobson SW, Schwartz PM, Dowler JK. The transfer of polychlorinated biphenyls (PCBs) and polybrominated biphenyls(PBBs) across the human placenta and into maternal milk. Am J Public Health 1984;74:378-9.
75. Goldey ES, Kehn LS, Lau C, Rehnberg GL, Crofton KM. Developmental exposure to polychlorinated biphenyls (Aroclor 1254) reduces circulating thyroid hormone concentrations and causes hearing deficits in rats. Toxicol Appl Pharmacol 1995;135:77-88.
76. Brouwer A, Longnecker MP, Birnbaum LS, Cogliano J, Kostyniak P et al. Characterization of potential endocrine-related health effects at low-dose levels of exposure to PCBs. Environ Health Perspect 1999;107:639-49.
77. Darnerud PO, Morse D, Klasson-Wehler E, Brouwer A. Binding of a 3,3',4,4'tetrachlorobiphenyl (CB-77) metabolite to fetal transthyretin and effects on fetal thyroid hormone levels in mice. Toxicology 1996;106:105-14.
78. Rhind SM. Endocrine disrupting compounds and farm animals: their properties, actions and routes of exposure. Domest Anim Endocrinol 2002;23:179-87.
79. Murai K, Okamura K, Tsuji H, Kajiwara E, Watanabe H et al. Thyroid function in «yusho» patients exposed to polychlorinated biphenyls (PCB). Environ Res 1987;44:179-87.
80. Herr DW, Goldey ES, Crofton KM. Developmental exposure to Aroclor 1254 produces low-frequency alterations in adult rat brainstem auditory evoked responses. Fundam Appl Toxicol 1996;33:120-8.
81. Uziel A. Periods of sensitivity to thyroid hormone during the development of the organ of Corti. Acta Otolaryngol 1986;429(sulp.):23-7.
82. Crofton KM, Ding D, Padich R, Taylor M, Henderson D. Hearing loss following exposure during development to polychlorinated biphenyls: la cochlear site of action. Hear Res 2000;144:196-204.
83. Kenet T, Froemke RC, Schreiner CE, Pessah IN, Merzenich MM. Perinatal exposure to a noncoplanar polychlorinated biphenyl alters tonotopy, receptive fields, and plasticity in rat primary auditory cortex. Proc Natl Acad Sci USA 2007;104:7646-51.
84. Fritsche E, Cline JE, Nguyen NH, Scanlan TS, Abel J. Polychlorinated biphenyls disturb differentiation of normal human neural progenitor cells: clue for involvement of thyroid hormone receptors. Environ Health Perspect 2005;113:871-6.
85. Seegal RF. Epidemiological and laboratory evidence of PCB- induced neurotoxicity. Crit Rev Toxicol 1996;26:709-737.
86. Tilson HA, Kodavanti PR. Neurochemical effects of polychlorinated biphenyls: an overview and identification of research needs. Neurotoxicology 1997;18:727-743.
87. Gorell JM, Johnson CC, Rybicki BA, Peterson EL et al. The risk of Parkinson's disease with exposure to pesticides, farming, well water, and rural living. Neurology 1998;50:1346-50.
88. Fischer LJ, Seegal RF, Ganey PE, Pessah IN, Kodavanti PR. Symposium overview: toxicity of non coplanar PCBs. Toxicol Sci 1998;41:49-61.
89. Angus WG, Contreras ML. The effects of Aroclor 1254 on undifferentiated and NGF-stimulated differentiating PC12 cells. Neurotoxicology 1994;15:809-18.
90. Corrigan FM, French M, Murray L. Organochlorine compounds in human brain. Hum Exp Toxicol 1996;15:262-4.
91. Corrigan FM, Murray L, Wyatt CL, Shore RF. Diorthosubstituted polychlorinated biphenyls in caudate nucleus in Parkinson's disease. Exp Neurol 1998;150:339-42.
92. Seegal RF, Bush B, Brosch KO. Decreases in dopamine concentrations in adult, non-human primate brain persist following removal from polychlorinated biphenyls. Toxicology 1994;86:71-87.
93. Mariussen E, Fonnum F. The effect of polychlorinated biphenyls on the high affinity uptake of the neurotransmitters, dopamine, serotonin, glutamate and GABA, into rat brain synap-tosomes. Toxicology 2001;159:11-21.
94. Mariussen E, Andersson PL, Tysklind M, Fonnum F. Effect of polychlorinated biphenyls on the uptake of dopamine into rat brain synaptic vesicles: a structure-activity study. Toxicol Appl Pharmacol 2001;175:176-183.
95. Bemis JC, Seegal RE. PCB-induced inhibition of the vesicu-lar monoamine transporter predicts reduction in the synaptosomal dopamine content. Toxicol Sci 2004;80:295-299.
96. Richardson JR, Miller GW. Acute exposure to aroclor 1016 or 1260 differentially affects dopamine transporter and vesicular monoamine transporter 2 levels. Toxicol Lett 2004;148:29-40.
97. Malkiewicz K, Mohammed R, Folkesson R, Winblad B, Szutowski M et al. Polychlorinated biphenyls alter expression of alpha-synuclein, synaptophysin and parkin in the rat brain. Toxicol Lett 2006;161:152-8.
98. Burke RE. Cl-Synuclein and parkin: coming together of pieces in puzzle of Parkinson's disease. Lancet 2001;358:1567-1568.
99. Di Rosa G, Puzzo D, Sant'Angelo A, Trinchese E, Arancio, O. Cl-Synuclein: between synaptic function and dysfunction. Histol Histopathol 2003;18:1257-1266.
100. Giasson BI, Lee VM. Parkin and the molecular pathways of Parkinson's disease. Neuron 2001;31:885-888.
101. Dev KK, van der Putten H, Sommer B, Rovelli G. Part 1: Parkin-associated proteins and Parkinson's disease. Neuropharmacology 2003;45:1-13.
102. Tumer PR, O'Connor K, Tate WP, Abraham WC. Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory. Prog Neurobiol 2003;70:1-32.
103. Recchia A, Debetto P, Negro A, Guidolin D, Skaper SD et al. a-Synuclein and Parkinson's disease. FASEB J 2004;18:617-626.
104. Canzoniero LM, Adornetto A, Secondo A, Magi S, Dell'aversano C et al. Involvement of the nitric oxide/protein kinase G pathway in polychlorinated biphenyl-induced cell death in SH-SY 5Y neuroblastoma cells. J Neurosci Res 2006;84:692-7.
105. Yuansheng T, Renji S, David L, David O. Carpenter. Ortho-substituted but not coplanar PCBs rapidly kill cerebelar granule cells. Toxicological Sciences 2004;79:147-156.
106. Lee DW, Opanashuk LA. Polychlorinated biphenyl mixture aroclor 1254-induced oxidative stress plays a role in dopaminergic cell injury. Neurotoxicology 2004;25:925-939.
107. Fitzgerald EF [My paper], Belanger EE, Gomez MI, Cayo M, Mccaffrey RJ et al. Polychlorinated Biphenyl Exposure and Neuropsychological Status among Older Residents of Upper Hudson River Communities. Environmental Health Perspectives 2008;116:209-215.
108. Kao-Chang L, Nai-Wen G, Pei-Chien T, Chiu-Yueh Y, Yue L et al. Neurocognitive changes among elderly exposed to PCBs/PCDFs in Taiwan. Environmental Health Perspectives 2008;116:184-189.
109. Fellows LK, Farah MJ. Ventromedial frontal cortex mediates affective shifting in humans: evidence from a reversal learning paradigm. Brain 2003;126:1830-1837.
110. Seegal RF, Okoniewski RJ, Brosch KO, Bemis JC. Polychlorinated biphenyls alter extraneuronal but not tissue dopamine concentrations in adult rat striatum: an in vivo microdialysis study. Environ Health Perspect 2002;110:1113-7.
111. Lyng GD, Snyder-Keller A, Seegal RF. Polychlorinated biphenyl-induced neurotoxicity in organotypic cocultures of developing rat ventral mesencephalon and striatum. Toxicol Sci 2007;97:128-39.
112. Daniels JL, Longnecker MP, Klebanoff MA, Gray KA, Brock JW et al. Prenatal exposure to low-level polychlorinated biphenyls in relation to mental and motor development at 8 months. Am J Epidemiol 2003;157:485-92.
113. Bayley N. Manual for the Bayley scales of infants development. Segunda edición. New York: Psychological Corporation; 1993.
114. Nakajima S, Saijo Y, Kato S, Sasaki S, Uno A et al. Effects of prenatal exposure to polychlorinated biphenyls and dioxins on mental and motor development in Japanese children at 6 months of age. Environmental Health Perspectives 2006;114:773-778.
115. Jacobson JL, Jacobson SW, Humphrey HE. Effects of exposure to PCBs and related compounds on growth and activity in children. Neurotoxicol Teratol 1990;12:319-26.
116. Patandin S, Lanting CI, Mulder PG, Boersma ER, Sauer PJ et al. Effects of environmental exposure to polychlorinated biphenyls and dioxins on cognitive abilities in Dutch children at 42 months of age. J Pediatr 1999;134:33-41.
117. Jacobson JL, Jacobson SW. Prenatal exposure to polychlorinated biphenyls and attention at school age. J Pediatr 2003;143:780-8.
118. Gray KA, Klebanoff MA, Brock JW, Zhou H, Darden R et al. In utero exposure to background levels of polychlorinated biphenyls and cognitive functioning among school-age children. J Epidemiol 2005;162:17-26.
119. Orito K, Gotanda N, Murakami M, Ikeda T, Egashira N et al. Prenatal exposure to 3,3',4,4',5-pentachlorobiphenyl (PCB126) promotes anxiogenic behavior in rats. Tohoku J Exp Med 2007;212:151-7.
120. Levin ED, Schantz SL, Bowman RE. Delayed spatial alternation deficits resulting from perinatal PCB exposure in monkeys. Arch Toxicol 1988;62:267-73.
121. Schantz SL, Levin ED, Bowman RE, Heironimus MP, Laughlin NK Effects of perinatal PCB exposure on discrimination-reversal learning in monkeys. Neurotoxicol Teratol 1989;11:243-50.
122. Gilbert ME, Crofton KM. Developmental exposure to a commercial PCB mixture (Aroclor 1254) produces a persistent impairment in long-term potentiation in the rat dentate gyrus in vivo. Brain Res 1999;850:87-95.
123. Gilbert ME. Perinatal exposure to polychlorinated biphenyls alters excitatory synaptic transmission and short-term plasticity in the hippocampus of the adult rat. Neurotoxicology 2003;24:851-60.
124. Bushnell PJ, Rice DC. Behavioral assessments of learning and attention in rats exposed perinatally to 3,3',4,4',5-pentachlorobiphenyl (PCB 126) Neurotoxicol Teratol 1999;21:381-92.
125. Niemi WD, Audi J, Bush B, Carpenter DO. PCBs reduce long-term potentiation in the CA1 region of rat hippocampus. Exp Neurol 1998;151:26-34.
126. Ozcan M, Yilmaz B, King WM, Carpenter DO. Hippocampal long-term potentiation (LTP) is reduced by a coplanar PCB congener. Neurotoxicology 2004;25:981-8.
127. Tharappel JC, Lee EY, Robertson LW, Spear BT, Glauert HP. Regulation of cell proliferation, apoptosis, and transcription factor activities during the promotion of liver carcinogenesis by polychlorinated biphenyls. Toxicol Appl Pharmacol 2002;179:172-84.
128. Silberhorn EM, Glauert HP, Robertson LW. Carcinogenicity of polyhalogenated biphenyls: PCBs and PBBs. Crit Rev Toxicol 1990;20:439-496.
129. Espandiari P, Glauert HP, Lehmler HJ, Lee EY, Srinivasan C et al. Polychlorinated biphenyls as initiators in liver carcinogenesis: resistant hepatocyte model. Toxicol Appl Pharmacol 2003;186:55-62.
130. Oakley GG, Devanaboyina U, Robertson LW, Gupta RC. Oxidative DNA damage induced by activation of polychlorinated biphenyls (PCBs): implications for PCB-induced oxidative stress in breast cancer. Chem Res Toxicol 1996;9:1285-1292.
131. Laden F, Ishibe N, Hankinson SE, Wolff MS, Gertig DM et al. Polychlorinated biphenyls, cytochrome P450 1A1, and breast cancer risk in the Nurses' Health Study. Cancer Epidemiol Biomarkers Prev 2002;11:1560-5.
132. Zhang Y, Wise JP, Holford TR, Xie H, Boyle P et al. Serum polychlorinated biphenyls, cytochrome P-450 1A1 polymorphisms, and risk of breast cancer in Connecticut women. Am J Epidemiol 2004;160:1177-83.
133. Strathmann J, Schwarz M, Tharappel JC, Glauert HP, Spear BT et al. PCB 153, a non-dioxin-like tumor promoter, selects for beta-catenin(Catnb)-mutated mouse liver tumors. Toxicol Sci 2006;93:34-40.